Tag: M.W:100-200

Reference of 3001-72-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, molecular weight is 124.1836, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of DBN (124 mg, 1 mmol) in MeCN (4 mL), a solution of methyl 4-hydroxy-4-methyl-2-pentynoate (1a; 142 mg, 1 mmol) in MeCN (3 mL) and H2O (1 mL) was added dropwise over 10 min. The reaction mixture was stirred at 20-25 C for 48 h. Solvent was evaporated in vacuo and the residue was washed with a mixture of hexane-acetone (1:1) to give the desired product 2a.

Statistics shows that 3001-72-7 is playing an increasingly important role. we look forward to future research findings about 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine.

Reference:
Article; Shemyakina, Olesya A.; Volostnykh, Olga G.; Stepanov, Anton V.; Mal’Kina, Anastasiya G.; Ushakov, Igor A.; Trofimov, Boris A.; Synthesis; vol. 50; 4; (2018); p. 853 – 858;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 20781-06-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

(5) Preparation of IA-1 (target): A mixture of 0.188 g (1 mmol) of compound of formula V and 0.447 g (1.5 mmol) of compound of formula III-1, 0.126 g (2 mmol) of sodium cyanoborohydride was added and maintained in a reflux state for 24 hours in 15 mL of methanol, The residue was purified by silica gel column chromatography (eluent: methanol: dichloromethane = 1: 10, and the residue was washed with ethyl acetate, washed with ethyl acetate, and the organic phase was washed with saturated brine. The organic phase was concentrated (the solvent was removed under reduced pressure) v / v) to give a white solid (IA-I) in 65% yield

According to the analysis of related databases, 20781-06-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China University of Science and Technology; Zhu Jin; Huang Jin; Chen Wenhua; Yao Xue; Ling Dazheng; Wang Manjiong; Jiang Hualiang; Li Jian; (21 pag.)CN106938997; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 769-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1,3-dimethylbarbituric acid (compound SM1) (7 kg, 44.9mmo1) dissolved in 120 kg phosphorus oxychloride (POCl3). To it, slowly drop water (2.2 kg, 22mo1). After dropping. slowly heating to reflux 6 hours; HPLC monitoring, after the reaction, the temperature, the reaction liquid slowly poured into a large amount of ice water (100L), then 50L dichloromethane extraction two times, the combined organic phase, saturated salt water washing (20L), anhydrous sodium sulfate drying, filtering, concentrating the organic phase, dried under vacuum to get yellow solid 7.2 kg, SM2 is the compound, yield 92.3%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-42-6, 1,3-Dimethylbarbituric acid.

Reference:
Patent; Shanghai Baiteyin Pharmaceutical Technology Co., Ltd.; Zhu Yiping; Sun Lianhua; (7 pag.)CN103755705; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 932-52-5, Adding some certain compound to certain chemical reactions, such as: 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione,molecular formula is C4H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 932-52-5.

General procedure: A suspension of 5-aminouracil 1 (1 mmol) in dry pyridine (7.5 mL) was cooled to 0 C and the appropriate sulfonyl chloride (1 mmol) was added. The reaction mixture was stirred at room temperature until the TLC showed the reaction was completed (1.5-20 h). The solvent was removed under reduced pressure and the crude product was recrystallized from methanol or aqueous methanol to afford the product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ismaili, Hamit; Ban, ?eljka; Mati?, Josipa; Safti?, Dijana; Juki?, Marijana; Glava?-Obrovac, Ljubica; ?ini?, Biserka; Croatica Chemica Acta; vol. 92; 2; (2019); p. 269 – 277;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C4H2ClFN2

2-Chloro- 5-fluoro-pyrimidine (14.45 mL, 117 mmol), potassium (Z)-but-2-en-2-yltrifluoroborate (24.63 g, 152 mmol), tricyclohexylphosphine (6.56 g, 23.39 mmol), and Pd2(dba)3 (10.71 g, 11.70 mmol) were added to a vial which was then degassed and backfilled with nitrogen. 1,4-Dioxane (195 mL) and aqueous potassium phosphate tribasic (29.0 mL, 351 mmol) were then added by syringe. The resulting reaction was heated at 100 C for 16 h. The reaction was then cooled to RT. The organics were concentrated in vacuo. The residue was filtered through a plug of silica gel and then loaded onto a silica gel column (0-20% EtOAc in hexanes) to afford Example 56.1 (14.24 g, 94 mmol, 80 % yield). LCMS-ESI (pos.) m/a: 153.1 (M+H)t

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62802-42-0, 2-Chloro-5-fluoropyrimidine.

Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 25193-95-7 ,Some common heterocyclic compound, 25193-95-7, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of pyrimidin-5-ylmethanol (5.00 g, 45.4 mmol) in dichloromethane (125 mL) was added thionyl chloride (9.88 mL, 136 mmol) drop wise at 0 C, and allowed to stirred at room temperature for 2 h. The reaction mixture was analyzed by TLC (50% EtOAc/hexanes) and it showed no starting material. The reaction mixture was concentrated under reduced pressure to afford title compound (4.2 g, 69.3%) as a light brown solid. NMR (400 MHz, DMSO-c/6): delta 9.17 (s, 1 H), 8.91 (s, 2H), 4.85 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; STOLLER, Andre; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; GAGNEPAIN, Julien, Daniel, Henri; RENDINE, Stefano; (155 pag.)WO2019/86474; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4316-97-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.

4,6-dichloro-5-methylpyrimidine (0.60g, 3.68mmol) and (3R, 4R) -1- benzyl -N, 4- dimethyl-piperidin-3-amine (0.80g, 3.68 mmol) were dissolved DMF (5mL), was added potassium carbonate (1.02g, 7.36mmol), 70 reaction was stirred overnight under nitrogen.Water was added (100 mL) to quench the reaction, extracted with ethyl acetate (70mL ¡Á 3), the organic phase water (50mL) washed with saturated aqueous sodium chloride solution (50 mL), dried the organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure, performed column chromatography (eluent: PE / EtOAc (v / v) = 1/1), to give the product 1.08g, yield: 85.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4316-97-6, 4,6-Dichloro-5-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Huang, Jiuzhong; Ren, Xingye; Li, Zhi; Zhang, Yingjun; Zhang, Changchun; (55 pag.)CN105566321; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 60025-09-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60025-09-4 as follows.

To a stirred solution of 1-(3-(pyridin-2-yl)-1,6-naphthyridin-2-yl)ethanamine (15 mg, 0.060 mmol) in butanol (1.5 mL) was added 4-amino-6-chloropyrimidine-5-carbonitrile (9.26 mg, 0.060 mmol) and N-ethyl-N-isopropylpropan-2-amine (20.93 muL, 0.120 mmol). The reaction was heated at 120 C. for 2 h. After this time the reaction was cooled to rt. The resulting precipitate was filtered and washed with hexanes to give racemic 4-amino-6-(((1S,1R)-1-(3-(2-pyridinyl)-1,6-naphthyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile. 1H NMR (400 MHz, chloroform-d) delta ppm 9.33 (1H, s), 8.83 (2H, d, J=5.9 Hz), 8.33 (1H, s), 8.14 (1H, s), 8.02 (1H, d, J=5.9 Hz), 7.93 (1H, td, J=7.7, 1.8 Hz), 7.64 (2H, d, J=7.8 Hz), 7.44 (1H, ddd, J=7.6, 4.9, 1.0 Hz), 6.15 (1H, m), 5.28 (2H, bs), 1.38-1.43 (3H, m). Mass Spectrum (ESI) m/e=251.0. Mass Spectrum (ESI) m/e=369.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60025-09-4, its application will become more common.

Reference:
Patent; AMGEN INC.; US2010/331306; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 611-08-5, name is 5-Nitrouracil. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 611-08-5

Preparation of 2,4-dichloro-5-nitropyrimidine. 5-Nitrouracil, was treated with phosphorous oxychloride and N, N- [DIMETHYLANILINE,] according to the procedure of Whittaker (J. Chem. Soc. 1951,1565), to give the title compound, which is also available from City Chemical (West Haven, CT).

With the rapid development of chemical substances, we look forward to future research findings about 611-08-5.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/99231; (2003); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6840-45-5, 3-Bromoimidazo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6840-45-5, blongs to pyrimidines compound. Product Details of 6840-45-5

A mixture of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine (1.0g, 4.54mmol), 3-bromoimidazo[1 ,2-a]pyrimidine (899mg, 4.54mmol) and Na2C03 (963mg, 9.09mmol) in DMF:H20 (3: 1 , 20ml_) was degassed with N2 for 15 min at rt. Pd(PPh3)4 (525mg, 0.45mmol) was added to this degassed mixture at rt. The reaction mixture was again purged with N2 for 5 min. The reaction vessel was sealed and stirred at 90 C for 16h. The TLC showed reaction to be complete. The reaction mixture was allowed to cool to rt and concentrated under reduced pressure. The crude residue was triturated with MeOH (25ml_) and the precipitated solid was filtered through the sintered funnel. The filtrate was concentrated under reduced pressure. The residue was purified by combiflash chromatography using 12g silica column, eluting with 10% MeOH in DCM to afford 4-(imidazo[1 ,2-a]pyrimidin-3- yl)pyridin-2-amine as a brown solid. Yield: 500mg (51 %); MS (ESI+) for CHNOS m/z 212.0[M+H]+; 1 H NMR (400 MHz, DMSO-d6): <5 8.96-9.05 (m, 1 H), 8.55-8.61 (m, 1 H), 8.40 (s, 1 H), 7.94-8.01 (m, 1 H), 6.98-7.15 (m, 3H), 6.05-6.15 (bs, 2H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6840-45-5, its application will become more common. Reference:
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia