Tag: M.W:100-200

Application of 6320-15-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

Prepared in a similar manner to Example 7 using 6-chloro-2,4-dimethoxypyrimidine to give the title compound (19 mg, 14%). 1H NMR (400 MHz, CDCl3) ? 8.68 (1H, d, J=1.2 Hz), 8.12 (1H, dd, J=8.1, 1.7 Hz), 7.56-7.36 (6H, m), 6.84 (1H, s), 4.11 (3H, s), 4.06 (2H, s), 4.04 (3H, s), 2.73 (3H, s), m/z (ES+) 453 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Boase, Amanda Louise; Ladduwahetty, Tamara; MacLeod, Angus Murray; Merchant, Kevin John; US2004/58970; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Electric Literature of 10320-42-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10320-42-0, name is 2-Chloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 165(5R)-3-(2-chloropyrimidin-5-yl)-5-ethyl-5-methyl-imidazolidine-2,4-dioneTo a solution of triphosgene (1.38 g, 4.65mmol) in Ethyl acetate (20 ml) at 0¡ãC a solution of 2-chloro-5- aminopyrimidine (1 g, 7.75 mmol)/DIPEA (8 ml, 4.65 mmol) in ethyl acetate (40 ml) was slowly added (20 minutes) and the reaction mixture was stirred for 15 minutes at the same temperature. Maintaining the reaction mixture at 0¡ãC, vacuum was applied (10 minutes) for removingthe excess of phosgene. A solution of DMAP (0.945g, 7.75mmol) in ethyl acetate/dichloromethane 1:1 (8 ml) was added and the reaction mixture was stirred for 5 minutes at the same temperature. A solution of methyl (R)-2-amino-2- methyl-butyrate hydrochloride (2.59 g, 15.5 mmol) in ethyl acetate (30 ml) was slowly added (15 minutes) at 0¡ãC and the reaction mixture was stirred for 30 minutes at the same temperature. The reaction was quenched with aqueous buffer (pH3) while the pH was allowed to reach ~5-6 and two phases were separated. The organic layer was washed with aqueous buffer (pH3) (2×20 ml) and then brine (20 ml), dried (Na2S04), filtered and evaporated affording the urea intermediate as orange foam.The urea was dissolved in MeOH (20 ml), NaOMe (0.41 g, 7.75 mmol) was added and the reaction mixture was stirred for 15 minutes at r.t.. The mixture was quenched with an aqueous saturated solution of ammonium chloride (25 ml) and diluted with ethyl acetate (50 ml). Two phases were separated and the organic layer was washed with brine (2×20 ml), dried (Na2S04), filtered and evaporated. The residue was triturated with Et20 (10 ml) and the solid collected affording the title compound (1.22 g) as a beige solid. LC/MS: QC_3_MIN: Rt = 1.341 min; 255 [M+H]+.

According to the analysis of related databases, 10320-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUTIFONY THERAPEUTICS LIMITED; ALVARO, Giuseppe; DAMBRUOSO, Paolo; MARASCO, Agostino; TOMMASI, Simona; DECOR, Anne; LARGE, Charles; WO2012/76877; (2012); A1;,
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Electric Literature of 1005-39-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1005-39-6, name is 2-(Methylthio)pyrimidine-4,6-diamine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1) Synthesis of 4,5,6-triamino-2-methylthiopyrimidine To a solution of 245g of 4,6-diamino-2-methylthiopyrimidine dissolved in 800 ml of acetic acid was added 250 ml of water. The reaction solution was cooled to 10C and thereto was added a solution of 119g of NaNO2 dissolved in 250 ml of water while maintaining the temperature at 10C. The reaction mixture was stirred at room temperature for 2 hours, filtered and dried to obtain 4,6-diamino-5-nitroso-2-methylthiopyrimidine, which was then dissolved in 1l of water.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1005-39-6, 2-(Methylthio)pyrimidine-4,6-diamine.

Reference:
Patent; LUCKY LTD.; EP584797; (1994); A2;,
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Synthetic Route of 4318-56-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

7.71 g of 2-cyanobenzyl bromide (R1 is H and R2 is Br), 6.00 g of 3-methyl-6-chlorouracil and 4.20 g of triethylamine were dissolved in a mixed solution of 78 ml of DMSO and THF, and the temperature was raised The reaction was stirred at 50 C for 1 h, and the reaction was cooled to room temperature. 80 ml of ice water was slowly added dropwise, and the mixture was stirred for 1 h under ice-cooling. The crude product of compound III was 9.15 g. The yield was 88.81%. The crude compound III was rinsed with ethyl acetate at 25 C, filtered, washed and dried to give pure Compound III 8.94. The purification yield was 97.90%. The total yield of compound was 86.77% and the purity was 89.70%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4318-56-3, 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Beijing Wansheng Pharmaceutical Co., Ltd.; Lin Guoliang; Wang Qiang; Jiang Yugang; Wang Yiping; Kang Yi; Lv Xiaona; (10 pag.)CN106608853; (2017); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1450-85-7, name is 2-Mercaptopyrimidine, molecular formula is C4H4N2S, molecular weight is 112.15, as common compound, the synthetic route is as follows.Computed Properties of C4H4N2S

General procedure: To an orange suspension of [Pd2(p-mazb)2Cl2] (0.025 g, 0.035 mmol) in dichloro-methane (5mL), pyridine-2-thione (0.008 g, 0.072 mmol) was added in presence of Et3N base (0.5 mL). The color of the reaction mixture became dark reddish brown and was stirred for 5-6 h. The solution was filtered off and added toluene (1 mL) and left to evaporate slowly. The dark reddish brown crystalline compound was obtained along with the formation of Et3NH+Cl- after a period of 4-5 days. Crystalline compound formed was recrystallized from dichloromethane and methanol. The dark reddish brown crystals were obtained after a period of 4-5 days. (Yield 0.021 g, 68%). .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1450-85-7, 2-Mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Lobana, Tarlok S.; Sandhu, Amanpreet K.; Kaur, Amanpreet; Jasinski, Jerry P.; Journal of Organometallic Chemistry; vol. 751; (2014); p. 519 – 524;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-25-4, name is 4-Chloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-6-methylpyrimidine

To a mixture of (S)-i sopropyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2-methyl-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)-5 -(1,2,3 ,4-tetrahydroi soquinolin-6-yl)pyridin-3 -yl)acetate, 2 HC1 (0.01 g, 0.014 mmol) and 4-chloro-6-methylpyrimidine (0.01 g, 0.078mmol) in dioxane (0.5 mL) was added potassium carbonate (0.02 g, 0.145 mmol) andheated in a seal vial at 100 C for 18 h. Then, filtered off the solid, removed the solvent,and residue was treated with EtOH (1 ml) and sodium hydroxide (0.550 mg, 0.014 mmol)at 85 C for 2 h. Then, cooled and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2- (4-(chroman-6-yl)-2-methyl-5 -(2-(6-methylpyrimidin-4-yl)- 1,2,3 ,4-tetrahydroi soquinolin6-yl)-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)pyridin-3 -yl)acetic acid (0.0027 g, 3.64 tmol, 26.5 % yield) LCMS (M+H) = 705.3.

With the rapid development of chemical substances, we look forward to future research findings about 3435-25-4.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
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Synthetic Route of 32779-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32779-36-5, name is 5-Bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.

In portion wise, Cesium carbonate (6.78 g, 20.6 mmol) was added to a stirred solution of benzyl alcohol (2.25 g, 20.6 mmol) in acetonitrile and dimethylformamide (1:1, 40 mL) under nitrogen atmosphere at room temperature. After 10 min, 5-bromo-2-chloropyrimidine (2.0 g, 10.3 mmol) was added and the mixture was stirred at the same temperature for overnight. The reaction was monitored by TLC; after completion of the reaction, reaction mixture was poured into ice-cold water; the resultant solid was filtered; solid was washed with water (3 x 10 mL) followed by n-pentane (2 x 10 mL) and air dried and recrystallized from benzene gave 3a (2.675 g) as white solid in 97 percentyield, mp 102.9?105.6 ¡ãC, TLC Rf 0.34 (10 percent EtOAc in hexanes as the eluent); 1H NMR (DMSO, 300 MHz); delta 8.78 (s, 2H, Pyrimidine H), 7.34?7.47 (m, 5H, ArH), 5.38 (s, 2H, ArCH2); 13CNMR (DMSO, 100 MHz) delta 163.16,159.83, 136.15, 128.39, 128.02, 127.95, 111.91, 68.95; IR (KBr) 1271(C?O), 1179 (C?N), 525 (C?Br) cm-1; HRMS(ES+) exact mass calculated for [M+H]+ (C11H9BrN2O) requires m/z 264.989, found m/z 265.091, 267.301.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Reddy, Onteddu Surendranatha; Suryanarayana, Ch. Venkata; Narayana; Anuradha; Babu, B. Hari; Medicinal Chemistry Research; vol. 24; 5; (2015); p. 1777 – 1788;,
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Reference of 3177-24-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3177-24-0, name is 2,4-Dichloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION 972-Amino-4-chloropyrimidine-5-carbonitrileTo a solution of 2,4-dichloropyrimidine-5-carbonitrile (600mg, 3.45mmol) in dioxane (20ml) was added a 0.5M solution of NH3 in dioxane (20ml, 10 mmol) and the mixture stirred at room temperature for 4h. A mixture of two isomers were obtained and separated by column chromatography using a mixture of hexane/ethyl acetate (from 0percent to 45percent of ethyl acetate). The title compound (304mg, 56percent yield) was found to be the less polar isomer.LRMS (m/z): 153 (M-1 )\

According to the analysis of related databases, 3177-24-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat; WO2012/146666; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloro-2-(methylthio)pyrimidine

To a stirred solution of 4,6-dichloro-2- (methylthio)pyrimidine (50 g, 0.26 mol) in dichloromethane (1 L) at 00C was added meta-chloroperoxybenzoic acid (143.6 g, 0.64 mol) over a period of 20 minutes. The solution was allowed to warm to room temperature and was stirred for 4 hours. The mixture was diluted with dichloromethane (1.5 L) and then treated sequentially with 50% Na2S2O3 / NaHCO3 solution (2 x 200 ml), sat. NaHCO3 solution (4 x 300 ml), and brine (200 ml) then dried (MgSO4). The solvent was removed in vacuo to afford an off-white solid, which was redissolved in EtOAc (IL) and treated sequentially with sat. NaHCO3 solution (3 x 300 ml), and brine (100 ml) then dried (MgSO4). The solvent was removed EPO in vacuo to afford the title compound (A) as a white solid (55.6 g, 96% yield). 1H NMR CDCl3 delta 3.40 (3H5 s, CH3), 7.75 (IH. s. ArH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/14250; (2007); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, the common compound, a new synthetic route is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 ¡Á 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
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