Tag: M.W:100-200

Application of 14394-56-0, Adding some certain compound to certain chemical reactions, such as: 14394-56-0, name is 4-Amino-6-chloro-5-methylpyrimidine,molecular formula is C5H6ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14394-56-0.

The compound 6-chloro-5-methylpyrimidin-4-amine 48a (100 mg, 0.700 mmol), cyclopropylcarbonyl chloride (87 mg,0.839 mmol), pyridine (3 mL) and tetrahydrofuran (3 mL) were combined.The mixture was heated to 60 C and stirred for 16 hours.This mixture was diluted with 20 ml of water and extracted with ethyl acetate (20 mL¡Á2).The combined organic phases were washed with brine (20 mL¡Á2).The organic phase is dried over anhydrous sodium sulfate, and the desiccant is removed by filtration.Decompressing under reduced pressure to obtain a crude product,The residue was purified by preparative silica gel ( petroleum ether / ethyl acetate = 4:1).The target product N-(6-chloro-5-methylpyrimidin-4-yl)cyclopropanecarboxamide 48b (40 mg,0.190 mmol, white solid). Yield: 27%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14394-56-0, 4-Amino-6-chloro-5-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3680-69-1, Adding some certain compound to certain chemical reactions, such as: 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3680-69-1.

4-chloro-7H-pyrrolo[2,3-d]pyrimidine (8.0 g, 52.32 mmol, 1.0 eq) was dissolved in DMF (40 mL), NIS (15.7 g, 57.55 mmol, 1.1 eq) was added at 0C, stirred overnight at room temperature, 200 mL of saturated Na2S2O3 solution was added, filtered, washed with water three times, and dried in vacuum to obtain 14.6 g (100%) of products. 1H NMR (400 MHz, d6-DMSO): delta 12.94 (s, 1H), 8.59 (s, 1H), 7.93 (d, J = 2.4 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jinan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; DING, Ke; GENG, Meiyu; TAN, Li; DING, Jian; ZHANG, Zhang; AI, Jing; REN, Xiaomei; GAO, Donglin; TU, Zhengchao; LU, Xiaoyun; ZHANG, Dongmei; (88 pag.)EP3339294; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 56181-39-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56181-39-6, name is 5-Bromo-4-chloropyrimidine, molecular formula is C4H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound (III-11) (120 mg, 0.620 mmol) and compound (IIb-2) (150 mg, 0.931 mmol) were dissolved in NMP(2.0 mL), p-toluenesulfonic acid monohydrate (118 mg, 0.620 mmol) was added and the mixture was stirred at 60C for2 hr. The reaction mixture was allowed to cool, water was added, and the mixture was extracted with ethyl acetate. Theorganic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was evaporated under reduced pressure,and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate) to give compound (IV-122)(yield 100 mg, 51%)

According to the analysis of related databases, 56181-39-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6299-87-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: 6-chloropyrimidine-4-carboxylic acid chloride 50.0 g (0.35 mol) 6-hydroxypyrimidine-4-carboxylic acid were taken and 500 mL phosphorus oxychloride were added. Then 150 g (0.72 mol) phosphorus pentachloride were added batchwise with stirring. The reaction mixture was refluxed for 5 h. The phosphorus oxychloride was distilled off and the residue was purified by vacuum distillation through a column. Yield: 51.9 g (83% of th.) MS: m/z=176/178/180 (M)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/21500; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H2BrClN2

To a solution of 5-bromo-2-chloropyrimidine (1) (0.01 mol) in methanol (100 mL), added hydrazine hydrate (80%, 0.03 mol) drop wise with external cooling. The reaction mixture was stirred at room temperature. Completion of the reaction was confirmed by thin layer chromatography (TLC). The solid separated was filtered, washed well with water, dried and recrystallized from ethyl acetate [35].

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Adhikari, Adithya; Kalluraya, Balakrishna; Sujith, Kizhakke Veedu; Gouthamchandra, Kuluvar; Jairam, Ravikumar; Mahmood, Riaz; Sankolli, Ravish; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 467 – 474;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride, molecular formula is C5H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 936643-80-0

A solution of 1 -(5-(4,4,5, 5-tetramethyl- 1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine (1 .0 g, 3.5 mmol), 2-(chloromethyl)pyrimidine hydrochloride (0.68 g, 4.1 mmol), and Cs2CO3 (2.8 g, 8.6 mmol) in DMF (6 mL) was stirred overnight at ambient temperature, and then at 50 C until LCMS indicated reaction completion. After cooling to ambient temperature, the reaction mixture was diluted with MTBE (20 mL), and extracted sequentially with 1:1 water: saturated NaHCO3(aq) (5 mL) and brine (3 x 5 mL). The organic extracts were dried over anhydrous Mg504, filtered, and concentrated in vacuo. The residue obtained was purified by silica chromatography (1-25% DCM-MeOH as the gradient eluent) to afford the title compound (500 mg, 38% yield). ?H NMR (400 IVIFIz, CDC13) 8.76-8.75 (d, 2H), 8.54-8.53 (d, 1H), 7.82-7.79 (dd, 1H), 7.22-7.20 (t, 1H), 6.59-6.57 (d, 1H), 3.88 (s, 2H), 3.71-3.68 (m, 4H), 2.70-2.68 (m, 4H), 1.31 (s, 12H).

With the rapid development of chemical substances, we look forward to future research findings about 936643-80-0.

Reference:
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 13418-77-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13418-77-4, name is 2-Amino-5-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

5-Methoxypyrimidin-2-amine (12.3 g, 98.3 mmol) was dissolved in pyridine (123 mL), the solution was added with hexanoyl chloride (14.5 g, 108 mmol) on an ice bath, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was added with 1 M aqueous glycine (98.3 mL) at 0 C., and the mixture was stirred for 1 hour, and then extracted with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, and the resulting residue was azeotroped with toluene. The resulting residue was recrystallized from chloroform-hexane to obtain N-(5-methoxypyrimidin-2-yl)hexanamide (18.4 g, 84%) as colorless solid. 1H-NMR (CDCl3) delta: 0.91 (3H, t, J=7.1 Hz), 1.30-1.40 (4H, m), 1.70-1.78 (2H, m), 2.50-2.70 (2H, m), 3.89 (3H, s), 8.10 (1H, br), 8.28 (2H, s).

According to the analysis of related databases, 13418-77-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KOWA COMPANY, LTD.; US2009/62306; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5751-20-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one, molecular formula is C5H6N2OS, molecular weight is 142.18, as common compound, the synthetic route is as follows.

To a mixture of HOAc (500 mL) and Ac2O (10 mL) was added compound 2- (methylthio)pyrimidin-4(3H)-one (40 g, 0.28 mol). The resulting mixture was heated at 80 ¡ãC for 30 min to remove any moisture. Then NCS (49 g, 0.37 mol) was added at 50-60 ¡ãC. The resulting mixture was stirred at 50-60 ¡ãC for 24 h. The mixture was then cooled to room temperature and was poured into ice-water (500 mL). The solid formed was collected and was treated with MeOH (100 mL) at reflux. Then the solid was filtered and dried on vacuum to give title compound (24 g, 48percent) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 5751-20-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; NAIR, Sajiv, Krishnan; PLANKEN, Simon, Paul; WO2012/52948; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 5018-38-2, 4,6-Dichloro-5-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5018-38-2, blongs to pyrimidines compound. Formula: C5H4Cl2N2O

1-(5-Methoxy-4-pyrimidinyl)piperazine Piperazine (20 g) was dissolved in water (100 mL) in a Parr bottle and then solid 4,6-dichloro-5-methoxypyrimidine (5.00 g, 27.9 mmole) was added. The mixture was vigorously stirred for 2 h at room temperature during which the 4,6-dichloro-5-methoxypyrimidine dissolved. The stirring bar was removed, catalyst (10% Pd/C, 1.0 g) was added to the turbid solution, and the mixture was then hydrogenated (60 psi, 3 h) at room temperature. The catalyst was filtered off and the filtrate extracted 3 times with CH2Cl2. The CH2Cl2 extracts were dried over Na2SO4 and concentrated in vacuo to give a clear oil which solidified upon standing (3.34 g, 61.7%). This crude product was Kugelrohr distilled (yield 3.24 g), dissolved in acetonitrile, and concentrated HCl was added to precipitate the product as a white powder which was dried in vacuo (4.32 g, 94.0% from crude product, m.p. 2190-221.5 C.).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5018-38-2, its application will become more common.

Reference:
Patent; Fabre-Kramer Pharmaceuticals, Inc.; US2009/281114; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 347418-42-2, 4-Chloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 347418-42-2, blongs to pyrimidines compound. Recommanded Product: 347418-42-2

Pd(Ph3P)4 (43.6 mg, 0.038 mmol) and 1,1,1,2,2,2-hexamethyldistannane (124 mg, 0.377 mmol) were successively added to a mixture of 4-chloro-5-fluoropyrimidine (50 g, 0.377 mmol) in 1,4-dioxane (1886 mE) under a nitrogen atmosphere. The reaction mixture was then stirred at reflux overnight, cooled to r.t, and filtered. The filtrate was used in next step without further purification.

The synthetic route of 347418-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INCYTE CORPORATION; WANG, Xiaozhao; GAN, Pei; HAN, Heeoon; HUANG, Taisheng; MCCAMMANT, Matthew S.; QI, Chao; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHANG, Fenglei; (284 pag.)WO2019/168847; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia