Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5305-40-8, name is 4,6-Dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 5305-40-8

The compound 4,6-dichloropyrimidine-5-carbaldehyde (5 g, 28.25 mmol) was suspended in dry MeOH (100 mL)After K2CO3 (7.8 g, 56.5 mmol) was added thereto, the reaction mixture was stirred at 90 C for 1 hour and then concentrated under reduced pressure to giveThe residue was dissolved in a mixed solvent of water (100 mL) and DCM (100 mL), separated on a liquid phase, the aqueous phase was extracted with DCM (50 mL ¡Á 3)The combined organic phases were concentrated under reduced pressure, the residue was diluted in DCM / PE (1 mL / 20 mL) and the resulting mixture stirred at room temperatureThe mixture was stirred for 3 hours and then filtered off with suction to give a yellow solid which was purified by silica gel column chromatography (PE / EtOAc (v / v) = 5/1)Purification gave the title compound as a white solid (2.2 g, 46.3%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5305-40-8, 4,6-Dichloropyrimidine-5-carbaldehyde.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wu Zuping; Feng Xuejin; Wu Yanjun; (154 pag.)CN104513235; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
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Related Products of 4316-93-2 ,Some common heterocyclic compound, 4316-93-2, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 2′,3′-O-Isopropylidene-beta-D-ribofuranosylamine p-toluenesulfonate salt (2.65 g, 7.34 mmol) in 30 mL of N,N-dimethylformamide at room temperature was treated first with triethylamine (2.3 mL, 16.7 mmol) followed by the slow addition of 4,6-dichloro-5-nitropyrimidine (1.30 g, 6.68 mmol). After stirring for 3 h, the yellow solution was diluted with ethyl acetate (50 mL) and washed with water (50 mL). The aqueous phase was further extracted with 2*20 mL of ethyl acetate and the combined organic extracts were washed with 2*50 mL of brine, dried over MgSO4, filtered and concentrated in vacuo. The resulting crude product was purified by silica gel chromatography (3:1 hexane/ethyl acetate) to afford 6-chloro-5-nitro-4-(2,3-O-isopropylidene-beta-D-ribofuranosylamino)pyrimidine (1.37 g, 59%) as a white powder (m.p. 117-119 C.). TLC Rf 0.3 (3:1 hexane/ethyl acetate). 1H NMR (CDCl3, 300 MHz): delta 8.71 (1H, d, J=8.7 Hz), 8.43 (1H, s), 6.35 (1H, d, J=8.7 Hz), 4.93 (1H, J=6.0 Hz), 4.69 (1H, d, J=6.0 Hz), 4.44 (1H, s), 3.88 (2H, dd, J=3.6 Hz, 1.8 Hz), 2.81 (1H, dd, J=2.4 Hz, 2.1 Hz), 1.57 (3H, s), 1.36 (3H, s). MS (ES+): 347.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4316-93-2, 4,6-Dichloro-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wilde, Richard G.; Almstead, Neil G.; Welch, Ellen M.; Beckmann, Holger; US2006/166926; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.Product Details of 4316-93-2

General procedure: To a stirred solution of 4,6-dichloro-5-nitropyrimidine (1.5mmol), amine (0.5mmol), Pd2(dba)3 (0.01mmol), R-BINAP (0.03mmol) and potassium carbonate (0.7mmol) in toluene (5mL) at room temperature and the mixture was under an argon atmosphere for 3.5h. The resulting reaction mixture was filtered and evaporated. The residue was purified by column chromatography on silica gel.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4316-93-2, 4,6-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Liu, Meng-Meng; Mei, Qiong; Zhang, Yi-Xiao; Bai, Peng; Guo, Xiang-Hai; Chinese Chemical Letters; vol. 28; 3; (2017); p. 583 – 587;,
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Related Products of 1780-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-36-5, name is 2,4,6-Trichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.

(c) Production of 4-amino-2,6-dichloro-5-methylpyrimidine 39.5 g (0.2 mol) of 5-methyl-2,4,6-trichloropyrimidine are dissolved in 250 ml of dimethoxyethane, and ammonia gas is then introduced at room temperature until the solution is saturated. A white suspension is formed, which is stirred for 12 hours at room temperature; it is subsequently concentrated in a rotary evaporator, and 200 ml of water are added to the residue. The formed suspension is filtered and the precipitate is dried. The mother liquor is concentrated to half the volume, filtered, and the precipitate is dried. There are thus obtained 26.4 g of crude product, which is recrystallized from acetonitrile/water (5:1); m.p. 193-194 C. (yield=75% of theory). Analysis: calculated: C 33.74%, H 2.83%, N 23.61%, Cl 39.83%, found: C 33.80%, H 2.87%, N 23.44%, Cl 39.51%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-36-5, 2,4,6-Trichloro-5-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Ciba-Geigy Corporation; US4741760; (1988); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 91717-22-5 , The common heterocyclic compound, 91717-22-5, name is 2-Amino-4-piperidino-6-methylpyrimidine, molecular formula is C10H16N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Briefly, 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine 1 (0.30 mmol), benzaldehyde 2a (0.30 mmol), 10 equiv of dimethyl malonate 3a (3 mmol), and chiral catalyst Q4(10 mol%) were added to capped vials at 60C and stirred for 36 h. After completion of the reaction, as observed by TLC, the mixture was directly purified by column chromatography on silica gel (EtOAc/hexane=8:1), affording the product (R)-4a. However, the product (S)-4a was obtained using the Q5 catalyst. Enantiomeric excess of the product was determined by HPLC analysis using a Chiralpak IA column.

The synthetic route of 91717-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bai, Song; Liu, Shan; Zhu, Yunying; Zhao, Kunhong; Wu, Qin; Synlett; vol. 29; 14; (2018); p. 1921 – 1925;,
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Pyrimidine – Wikipedia

Related Products of 10070-92-5 , The common heterocyclic compound, 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of equimolar pyrimidine-5-carbaldehyde and 3-acetylindole in ethanol (50 mL) was refluxed for 3 h following up the drop by drop addition of 20% sodium hydroxide solution yielded(2E)-1-(1H-indol-3-yl)-3-(pyrimidine-5-yl)prop-2-en-1-one (1). On completion of the reaction, the product was achieved by pouring the reaction mixture on to the ice cooled water to yield the precipitate [53]. Yield 81%; yellow-colored crystals; m. p: 125-127 C; Anal. calc. for C15H11N3O:C 72.28%,H 4.45%, N 16.86%; found: C 72.32%, H 4.40%, N 16.91%;IR numax(cm-1): 1535 (C=N), 1610 (C=N), 1734 (C=O), 3190(NH), 2985 (CH-Ar); 1H NMR (CDCl3)delta(ppm): 7.083 (s, 1H,Ar-H), 7.142 (s, 1H, Ar-H), 7.310 (s, 1H, Ar-H), 7.371 (s,1H, Ar-H), 7.410-7.489 (d, 1H, -HC=CH-), 8.198-8.257(m, 4H, Ar-H), 8.294-8.310 (d, 1H, -HC=CH-), 10.805 (s,1H, NH); 13C NMR (CDCl3)deltappm: 121.41, 121.89, 122.33,123.10, 124.21, 124.93, 125.09, 125.48, 125.88, 126.22,126.95, 127.37, 131.47, 132.51, 174.29 (C=O); ESI-MS(m/z): [M++1] 250.25 (250.09).

The synthetic route of 10070-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arshad, Mohammad; Journal of the Iranian Chemical Society; vol. 17; 6; (2020); p. 1305 – 1315;,
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Pyrimidine – Wikipedia

Reference of 4425-56-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4425-56-3 as follows.

EXAMPLE 78 In 400 ml. of acetic acid is suspended 2.05 g. of 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile and, with vigorous stirring a mixed gas of fluorine and nitrogen (15:85 (V/V)) is introduced. When about 1.5 molar equivalents to fluorine to the substrate has been introduced, the reaction mixture is evapolated to dryness. Ethanol (70 ml.) is added to the residue and the mixture is heated under reflux for 2 hours and, then, evapolated to dryness again. The resultant syrup is subjected to column chromatography on silica gel (solvent:benzene-acetone=4:1(V/V)) to recover 1.54 g. of 5-fluoro-6-ethoxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carbonitrile as white crystals. Melting Point: 195-196 C. NMR spectrum (DMSO-d6) delta: 1.07(3H, t, J=7HZ), 3.64(2H, q*d, J=7HZ and J=2HZ), 5.42(1H, d*d, J=4HZ and J=2HZ), 9.38(1H, broad), 11.59(1H, broad). Elemental analysis, for C7 H8 FN3 O3: Calcd.: C, 41.80; H, 4.01; N, 20.89. Found: C, 41.44; H, 3.95; N, 20.70.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4425-56-3, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4329460; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine. A new synthetic method of this compound is introduced below., Safety of 2,4-Dichloro-5-methoxypyrimidine

Production Example 1Synthesis of 2-methoxy-4-methylpyrimidin-5-ol (Prep 1-5)(1) 2-Chloro-5-methoxy-4-methylpyrimidine (Prep 1-1)2,4-Dichloro-5-methoxypyrimidine (10 g) was dissolved in THF (100 ml), and while cooling, iron(III) acetylacetone (1.97 g), methyl magnesium chloride (3.0 M: 22.4 ml) were then added to the solution. The obtained mixture was stirred at room temperature overnight. Thereafter, iron(III) acetylacetone (1.97 g), and methyl magnesium chloride (3.0 M: 22.4 ml) were added to the reaction solution further twice. Thereafter, a 1 N hydrochloric acid aqueous solution was added to the reaction mixture, and diethyl ether was then added to the reaction solution to carry out liquid separation and extraction. The organic layer was dried over magnesium sulfate, and the solvent was then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate), so as to obtain the title compound (6.6 g).1H-NMR (400 MHz, CDCl3) 5 (ppm): 2.46 (s, 3H), 3.92 (s, 3H), 8.06 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19646-07-2, 2,4-Dichloro-5-methoxypyrimidine.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; US2012/95031; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

4-Chloro-6-(4-methoxy-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound6}To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (6.000 g, 33.7038 mmol) in DME (50 ml) and water (10 ml), 4- methoxy phenyl boronic acid (5.122 g, 33.7038 mmol) and sodium carbonate (7.144 g, 67.4076 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichloride (1.183 g, 1.6852 mmol) was added and the resulting reaction mixture, heated at 9O0C for 3 hours, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a residue (-6 g), which eluted through silica gel with 4% AcOEt in hexane gave 4.503 g (-75% yield) of the pure title compound as a yellow solid.

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
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Electric Literature of 4994-86-9, Adding some certain compound to certain chemical reactions, such as: 4994-86-9, name is 4-Chloro-2-methylpyrimidine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4994-86-9.

To a mixture of 4-chloro-2-methyl-pyrimidine (10.0 g, 7.8 mmol) and AIBN (5.1 g, 31.1 mmol) in CCl4 (100 mL) was added NBS (16.6 g, 93.3 mmol) at 25 C. and the mixture was stirred at 80 C. for 16 hrs. LCMS showed the reaction was completed. The reaction mixture was cooled down to room temperature, poured into H2O (150 mL) and extracted with DCM (80 mL¡Á2). The organic layers were combined and washed with brine (80 mL¡Á2), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-(bromomethyl)-4-chloropyrimidine (1.7 g, yield 10.5%) as yellow oil. 1H NMR (400 MHz, CDCl3) delta=8.64 (d, J=5.6 Hz, 1H), 7.29 (d, J=5.2 Hz, 1H), 4.56 (s, 2H).

According to the analysis of related databases, 4994-86-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ESSA Pharma, Inc.; Zhou, Han-Jie; Virsik, Peter; (216 pag.)US2020/123117; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia