Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4Cl2N2S, blongs to pyrimidines compound. COA of Formula: C5H4Cl2N2S

Example 42a3-[6-chloro-2-(methylthio)pyrimidin-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; A mixture of 4,6-dichloro-2-(methylthio)pyrimidine (0.558 g, 2.86 mmol), Example 1c (1 g, 2.60 mmol), 2M aqueous Cs2CO3 solution (1.30 mL, 2.60 mmol), 1,2-dimethoxyethane/dimethylfomamide (9/l, 12 mL), and tetrakis(triphenylphosphine)palladium (0.120 g, 0.104 mmol) was evacuated and purged with nitrogen. The mixture was heated at 80 C. under nitrogen for 30 minutes, then cooled to room temperature. Solids were collected by filtration, washed with hexanes, and dried under vacuum to give the title compound (606 mg, 56% yield).

The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; US2011/15173; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3435-29-8, Adding some certain compound to certain chemical reactions, such as: 3435-29-8, name is 4-Amino-6-phenylpyrimidine,molecular formula is C10H9N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3435-29-8.

Quinoline-4-carboxylic acid (36.4 mg, 0.226 mmol),3-chloro-5 – (methylthio) benzene amine (50.0 mg, 0.205 mmol) and POCl3 (34.6 mg, 0.226 mmol), pyridine (1 mL) was dissolved in, 80 was stirred for 1 hour dongan. When thin layer chromatography (TLC) check when, a new spot is confirmed, water was added to the reaction mixture, and extracted twice with dichloromethane. And the extracted organic layer was dried using magnesium sulfate, vacuum concentrated and, after the water was removed by filtration of the organic extract over MgSO4 and concentrated by silica gel preparative thin layer chromatography (preparative TLC, ethyl acetate / n- hexane = l / l ) to give to give the title compound (11%) of a white solid.

According to the analysis of related databases, 3435-29-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JUNG, YOUNG SIK; KIM, PIL HO; HAN, SOO BONG; RAGHAVENDRA, ACHARY; KIM, MEE HYEIN; LEE, CHONG KYO; SHIN, JIN SOO; (131 pag.)KR2015/25531; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4270-27-3, Adding some certain compound to certain chemical reactions, such as: 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione,molecular formula is C4H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4270-27-3.

Step – I: Preparation of 2-((6-chloro-2,4-dioxo-3,4-dihydropyrimidin-l(2H)- yl)methyl)benzonitrileTo a 6-chloropyrimidine-2,4(l H,3H)-dione (21 gm) was added N- methylpyrrolidone (80 ml) under stirring and then added diisopropylethylamine (17 ml) slowly for 30 minutes. To the solution was added a solution of 2- (bromomethyl)benzonitrile (20 gm) in toluene (80 ml) slowly for 1 hour and the temperature of the reaction mass was raised to 70 to 80C. The reaction mass was maintained for 4 hours at 70 to 80C and then cooled to 15 to 20C. The reaction mass was quenched with water and maintained for 30 minutes at 15 to 20C. The reaction mass was then cooled to 0 to 5C and stirred for 1 hour. The reaction mass was filtered and washed with water and hexane to obtain a wet solid. To the wet solid thus obtained was added water (200 ml) and pH was adjusted to 9.0 to 10.0 with sodium hydroxide (IN). The reaction mass was stirred for 30 minutes and then added methylene chloride (300 ml) and then the layers were separated. The pH of the aqueous layer was adjusted to 4.0 to 5.0 with hydrochloric acid (IN) and stirred for 30 minutes. The solid obtained was collected by filtration and then dried to obtain 19.3 gm of 2-((6-chloro-2,4-dioxo-3,4- dihydropyrimidin-l(2H)-yl)methyl)benzonitrile.

According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MOHANBABU, Maradolla; VAMSI KRISHNA, Bandi; WO2013/46229; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13036-57-2, 2-Chloro-4-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5ClN2, blongs to pyrimidines compound. COA of Formula: C5H5ClN2

Example 4 [00154] The compound is prepared as follows: [00155] The synthetic route to obtain compound 4 started from a chloration of 4-methyl-2- chloropyrimidine. Compound 1 was obtained in 28% yield after purification. The SNAr reactionwas carried out in 52% yield. The Stille reaction was then realised. The product 3 was obtained in 72% yield. The introduction of piperidine was then carried out under microwave conditions. After purification, the final product was obtained in 19% yield.

The synthetic route of 13036-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOGRA PHARMA LIMITED; HOMMES, Daan; VERHAAR, Auke; VAN DEN BRINK, Gijs; VITI, Francesa; WO2013/178816; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3435-25-4 ,Some common heterocyclic compound, 3435-25-4, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

c) 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxypiperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine dihydrochloride (28 mg, 64.8 mumol) was extracted with dichloromethane/2 M NaOH. The organic layers were washed with brine, dried over sodium sulfate and evaporated. The residue was dissolved in dioxane (0.5 mL) and to this solution 4-chloro-6-methylpyrimidine (9.2 mg, 71.2 mumol) and DIPEA (17.0 muL, 97.2 mumol) were added. Argon was bubbled through the solution for 5 minutes, and then heated in the microwave at 130 C. for 2¡Á30 minutes. After evaporation, purification by chromatography (silica gel, 10 g, 0 to 10% methanol in dichloromethane) afforded the title compound (18 mg, 62%) as an off white foam.MS ISP (m/e): 452.3 [(M+H)+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3435-25-4, 4-Chloro-6-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/201605; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 73418-88-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73418-88-9, name is Methyl 5-aminopyrimidine-2-carboxylate. A new synthetic method of this compound is introduced below.

Methyl 5-aminopyrimidine-2-carboxylate (10.29 mg, 0.067 mmol) and pyridine (0.049 mL, 0.611 mmol) were dissolved in DCM (2 mL) Intermediate 816C (0.030 g, 0.06 1 mmol) was added as a solution in DCM (1 mL). The reaction mixture was allowedto stir for 1 hour. The reaction mixture was concentrated under reduced pressure and purified on ISCO using 24 g column eluting with 0-100% EtOAc over 15 mm to yield Intermediate 816D (24.6 mg, 0.040 mmol, 66.3 % yield) as a pale yellow solid. ?HNIVIR (400MHz, CDC13) 8.47 (d, J=1.8 Hz, 3H), 8.44 (s, 1H), 7.91 (d, J10.3 Hz, 1H), 7.66 (s, 1H), 7.13 (s, 1H), 5.70-5.60 (m, 1H), 5.31 (br. s., 1H), 2.56 (s, 3H), 1.41 (d, J=6.8 Hz,5H), 1.17 (s, 3H), 0.07-0.11 (m, 6H). LC-MS. method H, RT = 1.27 mm, MS (ESI)m/z:608.0 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73418-88-9, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4983-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4983-28-2, name is 2-Chloro-5-hydroxypyrimidine. A new synthetic method of this compound is introduced below.

A stirred mixture of 2-chloro-5-pyrimidinol (107) (1.00 g, 7.66 mmol) and chloromethyl ethyl ether (1.75 mL, 18.9 mmol) in anhydrous DMF (2.5 mL) was treated with K2CO3 (2.15 g, 15.6 mmol). After stirring at room temperature for 16 h, the mixture was added to ice/aqueous NaHCO3 (100 mL) and extracted with 50% Et2O/petroleum ether (5¡Á100 mL). The combined extracts were evaporated to dryness and the residue was chromatographed on silica gel. Elution with 0-1% Et2O/petroleum ether firstly gave foreruns, and then further elution with 1-10% Et2O/petroleum ether gave 2-chloro-5-(ethoxymethoxy)pyrimidine (108) (1.27 g, 88%) as an oil; 1H NMR (CDCl3) delta 8.43 (s, 2H), 5.27 (s, 2H), 3.74 (q, J=7.1 Hz, 2H), 1.23 (t, J=7.1 Hz, 3 H); HRESIMS calcd for C7H10ClN2O2 m/z [M+H]+ 191.0396, 189.0425, found 191.0397, 189.0426.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4983-28-2, its application will become more common.

Reference:
Patent; Global Alliance for TB Drug Development; US2011/28466; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 33034-67-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.

Step 4: The product of Step 3 (460 mg, 1.720 mmol), 2-chloro-4-(trifluoromethyl)pyrimidine (314 mg, 1.638 mmol), Xantphos (284 mg, 0.492 mmol), palladium (II) acetate (73.6 mg, 0.328 mmol), cesium carbonate (1.068 g, 3.28 mmol) and dioxane (12.3 mL) were heated at 90 ¡ãC for 90 minutes. The reaction mixture was diluted with ethyl acetate, washed with water and dried over Na2S04. Filtration and solvent evaporation gave a residue which was further purified by column chromatography on silica gel, eluting with 40percent ethyl acetate in hexane to afford l-[5-(3- cMoro-5-{[4-(trifluoromemyl)pyrimidin-2-yl^ as a brown solid (390 mg, 55.8percent). NM (500 MHz, CDCI3): 5 8.71 (d, J – 4.7 Hz, 1 H); 7.92(s, 1 H); 7.85 (s, 1 H); 7.78 (s, 1 H); 7.69 (s, 1 H); 7.25 (s, 1 H); 7.13 (d, J= 4.8 Hz, 1 H); 3.81 (s, 1 H); 2.73 (s, 2 H); 2.58-2.47 (m, 2 H); 2.13-1.97 (m, 2 H) MS APCI: [M+H]+ m/z 427.1. rhSYK activity = ++

The chemical industry reduces the impact on the environment during synthesis 33034-67-2, I believe this compound will play a more active role in future production and life.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1500-85-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1500-85-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C6H6N4, molecular weight is 134.14, as common compound, the synthetic route is as follows.

To a solution of 200 mg (1.49 mmol) of 7H-pyrrolo[2,3-d]pyrimidin-4-amine in 4 mL of DMF, 235 muL of dimethylformamide dimethyl acetal were added. The mixture was stirred at room temperature overnight. The solvent was then removed in vacuo and the residue taken up with DCM, washed with brine, dried over anhydrous Na2SO4and evaporated to dryness. The crude was triturated with diisopropylether and filtered, to afford 204 mg (73%) of the title compound. 1H NMR (600 MHz, DMSO-cie) delta ppm 3.10 (s, 3 H) 3.16 (s, 3 H) 6.45 (dd, J=3.39, 1.92 Hz, 1 H) 7.21 (dd, J=3.11 , 2.38 Hz, 1 H) 8.28 (s, 1 H) 8.79 (s, 1 H) 11.60 (br. s., 1 H) HRMS (ESI) calcd for C9HnN5 [M+H]+ 190.1087, found 190.1085.

The chemical industry reduces the impact on the environment during synthesis 1500-85-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; ANGIOLINI, Mauro; BUFFA, Laura; MENICHINCHERI, Maria; MOTTO, Ilaria; POLUCCI, Paolo; TRAQUANDI, Gabriella; ZUCCOTTO, Fabio; WO2014/184069; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 24415-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, molecular formula is C6H5ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The preparation method of the compound e10 comprises the steps of: taking about 1 mmol of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine and about 3 mmol.1-benzyl-1H-indole was added to a 10 mL microwave reaction tube,Further, 2 mL of hexafluoroisopropanol solvent and about 0.1 mmol of bistrifluoromethanesulfonimide catalyst were added, sealed and heated to 100 C with stirring and reacted for about 6 h.Then, the reaction system was monitored by TLC, and after the reaction system was cooled to room temperature, it was separated and purified by column chromatography to obtain pure compound e10.The compound e10 is a yellow solid with a yield of 90%.

According to the analysis of related databases, 24415-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Zheng Yichao; Yuan Shuo; Shen Dandan; (27 pag.)CN109020976; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia