Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 14331-54-5, 2,4-Dimethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Dimethylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 2,4-Dimethylpyrimidine

2-Chloro-4-methyl-pyrimidine. A mixture of 2,6-dichloropyrimidine (1.5 g, 10.07 mmol), trimethylaluminum (0.87 g, 12.08 mmol), tetrakis(triphenylphosphine)palladium(0) (0.81 g, 0.7 mmol) in THF (30 mL) was heated under reflux for several hours. The reultant mixture was quenched with addition of water. (Note: allowing reaction to go overnight was detrimental). The product mixture was extracted with ethyl acetate three times, dried over sodium sulfate, filtered and concentrated to give a dark yellow oil. The resultant oil was purified by flash chromatography on silica gel (hexane/ethyl acetate) to give title compound as a light yellow solid. 1H NMR (400 MHz, DMSO) delta 8.62-8.61 (d, j=5.1 Hz, 1 H), 7.47-7.46 (d, j=5.1 Hz, 1 H), 2.56 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14331-54-5, 2,4-Dimethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

4-Chloro-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound 4) To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (2.500 g, 15.2444 mmol) in DME (100 ml) and water (20 ml), 2- fluoro-4-(thfluoromethyl)phenylboronic acid (3.1696 g, 15.2444 mmol) and sodium carbonate (4.847 g, 45.7332 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichlohde (0.535 g, 0.7622 mmol) was added and the resulting reaction mixture, heated at 9O0C for 8 hrs, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a dark oily residue (-4.5 g), which was purified by preparative HPLC, to afford 1.21 O g (-26% yield) of the pure title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 767-15-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.767-15-7, name is 2-Amino-4,6-dimethylpyrimidine, molecular formula is C6H9N3, molecular weight is 123.16, as common compound, the synthetic route is as follows.

General procedure: To a stirred mixture of 4-methylbenzaldehyde (1 mmol, 0.120 g) and N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] (0.05 g, 0.09 mmol) or poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide) [PBBS] (0.12 g) at room temperature, was added 2-amino-4,6-dimethylpyrimidin (1 mmol, 0.123 g). Then, indole (1 mmol, 0.12 g) was added to the mixture after 10 min. The progress of the reaction was monitored by TLC (n-hexane/acetone, 17:2). After completion of the reaction, EtOH (5 mL) was added to the reaction mixture and the colorless precipitate was filtered (after evaporation of the ethanol, cool methylene dichloride (2 mL) was added, and the catalyst was recovered), washed with EtOH and dried and purified by recrystallization from ethanol.

Statistics shows that 767-15-7 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4,6-dimethylpyrimidine.

Reference:
Article; Ghorbani-Vaghei, Ramin; Shahbazi, Hajar; Toghraei-Semiromi, Zahra; Comptes Rendus Chimie; vol. 17; 2; (2014); p. 118 – 123;,
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Pyrimidine – Wikipedia

Application of 149849-94-5, Adding some certain compound to certain chemical reactions, such as: 149849-94-5, name is Methyl 2-chloropyrimidine-4-carboxylate,molecular formula is C6H5ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149849-94-5.

To a solution of methyl 2-chloropyrimidine-4-carboxylate (30.00 g, 173.84 mmol) in dioxane (300 mL) was added TEA (26.39 g, 260.77 mmol) and ()-1-phenylethanamine(25.28 g, 208.61 mmol). After addition, it was heated at 50C for 4 h. TLC indicated that the reaction was completed. The solvent was removed by concentration in vacuo and residue was dissolved in ethyl acetate (200 mL), washed by water (100 mL x 2) and brine (100 mL). The separated organic layer was dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluted by DCM : MeOH = 60:1)to give desired product as light yellow solid (38.00 g, yield 85.0%).

According to the analysis of related databases, 149849-94-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHANGHAI METON PHARMACEUTICAL CO., LTD; YANG, Jibin; (67 pag.)WO2018/95344; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2927-71-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, molecular weight is 166.9685, as common compound, the synthetic route is as follows.

A solution of morpholine(870 mg, 10 mmol) in 10 mL EtOH was added slowly to a cooled solution of 18 (1.84g,11 mmol) and K2CO3 (2.76 g, 20 mmol) in EtOH (30 mL), and the mixture wasstirred for about 30 min at 0oC. Stirring was continued for 4h at room temperature andthe reaction was monitored by TLC. The reaction mixture was concertrated, dilutedwith ethyl acetate, washed, intandem, with water and brine. The organic phase wasdried, filtered and concentratedin vacuo to give the title compound (1.87 g) which wasused in the next step without further purification, yield 86%.

The chemical industry reduces the impact on the environment during synthesis 2927-71-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Wu, Xiaoai; Fang, Zhen; Yang, Bo; Zhong, Lei; Yang, Qiuyuan; Zhang, Chunhui; Huang, Shenzhen; Xiang, Rong; Suzuki, Takayoshi; Li, Lin-Li; Yang, Sheng-Yong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 9; (2016); p. 2284 – 2288;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13036-50-5 , The common heterocyclic compound, 13036-50-5, name is 2-Chloro-4-phenylpyrimidine, molecular formula is C10H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Man erhitzte 0, 80 g (4, 20 MMOL) 2-CHLOR-4-PHENYLPYRIMIDIN AUS BEISPIEL 24. 1 in 3, 20 ml konz. HCI 1 Stunde auf 100 C. Anschliessend engte man den Ansatz ein, suspendierte ihn in Methylenchlorid und engte erneut ein. Ausbeute : 0, 83 g. ESI-MS : 174, 3, [M+H+] = 173, 2 ;

The synthetic route of 13036-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT GMBH & CO. KG; WO2004/80981; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.695-86-3, name is 5-Methoxypyrimidin-4-amine, molecular formula is C5H7N3O, molecular weight is 125.13, as common compound, the synthetic route is as follows.SDS of cas: 695-86-3

General procedure: Synthesis of 2-methyl-5-((9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)amino)isoindolin-1-one (4) Procedure A: A mixture of 9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-amine (3, 0.10 g, 0.37 mmol), 5-bromo-2-methylisoindolin-1-one (2, 0.10 g, 0.45 mmol), sodium tert-butoxide (54 mg, 0.56 mmol) and XPhos (5 mg, 0.01 mmol) in toluene (10 mL) was degassed with argon for 30 min. Tris(dibenzylideneacetone)dipalladium(0) (20 mg, 0.022 mmol) was added under argon atmosphere and the reaction mixture was heated at 100 C. for 12 h. After completion of the reaction, the reaction mixture was filtered through celite pad and the filtrate was concentrated. The crude residue was purified by silica gel column chromatography using 0-10% ethyl acetate in hexanes as eluent to afford 2-methyl-5-((9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)amino)isoindolin-1-one (4). Yield: 0.11 g, 71%; MS (ESI) m/z 411 [M+1]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,695-86-3, 5-Methoxypyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; eFFECTOR Therapeutics, Inc.; Sprengeler, Paul A.; Reich, Siegfried H.; Ernst, Justin T.; Webber, Stephen E.; Shaghafi, Mike; Murphy, Douglas; Tran, Chinh; (131 pag.)US10112955; (2018); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

Adding 85 mg (about 0.5 mmol) to a 10 mL microwave reaction tube.7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, 414 mg (about 1.5 mmol) of 1-(4-(trifluoromethyl)benzyl)-1H-indole, 14 mg (about 10 mol%) of the catalyst bistrifluoromethylsulfonimide and 1 mL of the solvent HFIP, and then the microwave reaction tube was sealed.Then, the reactant in the microwave reaction tube was stirred at 100 C for 6 hours, and the solvent was distilled off under reduced pressure.And purified by column chromatography using DCM / MeOH as eluent to afford about 139 mg of pure product e16 as a white solid, yield 68%;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,24415-66-5, 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Yuan Shuo; Wang Shuai; Li Zhonghua; (21 pag.)CN109180684; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55583-59-0, blongs to pyrimidines compound. name: 2,5-Diamino-4,6-dichloropyrimidine

To (1 S,4H)-4-amino-2-cyclopentene-1 -methanol tartrate salt (1 g, 4 mmol) in n- BuOH (10 mL) was added 2,5-diamino-4,6-dichloropyrimidine (DADCP, 0.69 g, 4 mmol) and NaHCOs (1 .12 g, 13 mmol) and the mixture was allowed to stir for 16 hr at 95 C. The mixture was cooled and filtered under vacuum. The resulting solvent from the filtrate was removed in vacuo. The crude product was purified by column chromatography (1 :49 to 1 :24 MeOH-DCM) to yield the title compound (0.52 g, 53%) as a pale brown solid, m.p.: 157-159 C (lit. m.p. 158.5- 160.5 C) (29). 1 H NMR (MeOD): delta 5.87 (ddd, J = 5.5, 2.0, 1 .9 Hz, 1 H), 5.80 (ddd, J = 5.6, 2.0, 2.0 Hz, 1 H), 5.07-5.15 (m, 1 H), 3.47-3.56 (m, 1 H), 3.28 (dt, J = 3.2, 1 .6 Hz, 1 H), 2.79-2.83 (m, 1 H), 2.53 (ddd, J= 13.4, 6.4, 6.4 Hz, 1 H), 1 .36 (ddd, J= 13.4, 6.3, 5.9 Hz, 1 H). 13C NMR (MeOD): delta 158.2, 157.3, 143.2, 135.8, 133.9, 1 14.4, 66.4, 57.8, 57.7, 35.8. m/z (ES+) 256.0955 calculated for CioHi5N5035CI: [M+H]+ 256.0965 and 258.0928 calculated for Ci0Hi5N5O37CI: [M+H]+ 258.0936. IR (cm 1): 3451 (N-H), 3324 (N-H), 3125 (br, O-H), 2931 (C-H), 1570 (C=C aromatic), 1430 (CH2), 690 (C-CI).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55583-59-0, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF LIVERPOOL; O’NEILL, Paul; BERRY, Neil; (52 pag.)WO2017/21716; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 2927-71-1

A mixture of 2,4-dichloro-5-fluoropyrimidine (10.0 g, 0.06 mol), o-phenylenediamine (7.1 g, 0.066 mol) and DIPEA (20.8 mL, 0.12 mol) in n-butanol (80 mL) was stirred at 110 C. for 16 h then concentrated in vacuo and slurried with 0.1 M hydrochloric acid (20 mL). The solid was collected at the pump, washed with water (2¡Á20 mL), n-butanol (30 mL and diethyl ether (2¡Á30 mL), then dried under vacuum to afford N1-(2-chloro-5-fluoropyrimidin-4-yl)benzene-1,2-diamine as a colourless powder (10.8 g, 71%). 1H NMR (d6-DMSO) delta9.31 (br s, 1H), 8.18 (d, 1H), 6.99-7.03 (m, 2H), 6.74-6.76 (m, 1H), 6.54-6.58 (m, 1H), 5.04 (br s, 2H); LCMS method A, (ES+) 239, 241, RT=1.90 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Patent; Harrison, Richard John; Hobson, Andrew; Ramsden, Nigel; US2012/172385; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia