Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 580-17-6, name is 3-Aminoquinoline belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Aminoquinoline

General procedure: To an oven-dried 100 mL three-necked round-bottomed flask equipped with two glass stoppers, a vacuum-jacketed Dean-Stark trap topped with a reflux condenser fitted with a N2 inlet, and a Teflon-coated magnet stirring bar were placed pyridin-3-amine (0.5 g, 5.3 mmol), boric acid (0.1 g, 1.6 mmol), and mesitylene (70 mL). To the stirred reaction mixture were added N,N,N’,N’-tetramethylpropane-1,3-diamine (0.21 g, 1.6 mmol) and 8-methoxy-8-oxooctanoic acid (1.5 g, 8 mmol) in one portion. The stirred reaction mixture was heated at gentle reflux at ca. 164 C for 7 h. TLC analysis (eluent: EtOAc) indicated the complete disappearance of the amine starting material. After cooling to r.t., the mixture was poured into petroleum ether (350 mL) leading to the immediate precipitation of an off-white solid. Stirring was continued for an additional 30 min and the precipitate was then filtered through a sintered glass funnel. The collected solid was thoroughly washed with petroleum ether and H2O, and dried in vacuo at r.t. for 24 h, then purified by flash chromatography to afford methyl 8-oxo-8-(pyridin-3-ylamino)octanoate as an off-white solid; yield: 1.14 g (82%); mp 52.6-53.4 C.

The synthetic route of 580-17-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 580-16-5,Some common heterocyclic compound, 580-16-5, name is 6-Hydroxyquinoline, molecular formula is C9H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Procedure C. The aromatic alcohol (1.2 mmol) and PhOCSCl (1.8 mmol) were dissolved in 10 mL of CH2Cl2 or MeCN. CsF-Celite (2.4 mmol) was then added to form a heterogeneous mixture. The reaction mixture was stirred at room temperature for 2-6 hours and monitored by TLC. Then reaction mixture was diluted with CH2Cl2 and washed with brine. Organic layers were combined and dried with Na2SO4 and solvent was removed under reduced pressure. The crude mixture was purified by column chromatography to afford the corresponding thiocarbonate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Hydroxyquinoline, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 634-47-9 as follows. name: 2-Chloro-4-methylquinoline

The chloroquinoline (100 mg, 0.56 mmol) and piperidine (0.22 ml, 2.25 mmol) were stirred in a microwave reaction vial. The vial was sealed and then irradiated under microwave at 200 ¡ãC with stirring for 15 min. LC/MS indicated reaction completion. The reaction mixture was diluted with MeOH and then concentrated under vacuum. The residue was dissolved in 3percent aqueous HC1 (10 ml) and washed with dichloromethane (2 x 5 ml). The aqueous layer was treated with 2 N NaOH until the pH was 8, resulting in a white slurry. The slurry was extracted with dichloromethane (3 x 20 ml). The combined organic layers were dried over Na2SO4 and concentrated to give 70 mg (55percent) of the product as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 7.75 (d, J = 8.1 Hz, 1H), 7.52-7.45 (m, 2H), 7.21-7.17 (m, 1H), 7.10 (s, 1H), 3.67 (bs, 4H), 2.54 (s, 3H), 1.62-1.55 (m, 6H). LC/MS: RT = 0.65 min, m/z = 227.2 [M + H]+.

According to the analysis of related databases, 634-47-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 881-07-2, name is 2-Methyl-8-nitroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 881-07-2, SDS of cas: 881-07-2

Example 7 Synthesis of 2-methyl-8-aminoquinoleine (Compound Y) Ziessel, R.; Weibel, N.; Charbonniere, L. S. Synthesis 2006, 18, 3128-3133 2.110 g of 8-nitroquinaldine (11.19 mmol) are dissolved in 34 mL HI (57% aq). The reaction mixture is heated to 90 C. for 2 h. At ambient temperature, the reaction medium is neutralized with 150 mL of a NaHCO3 saturated aqueous solution. The aqueous phase is extracted with AcOEt (3*50 mL). The combined organic phases are washed with a Na2S2O3 saturated aqueous solution (2*50 mL), then with brine (2*50 ml). The organic phases are dried on MgSO4, filtered and evaporated under vacuum. The raw product is purified using a flash chromatography column on silica (eluent: CH2Cl2 100%). 1.251 g of a beige solid is obtained. Yield: 89%. deltaH (300 MHz, CD2Cl2) 2.69 (s, 3H), 4.96 (bs, 2H, NH2), 6.88 (dd, 1H, J 7.4 and 1.3 Hz), 7.09 (dd, 1H, J 8.1 and 1.3 Hz), 7.25 (m, 2H), 7.96 (d, 1H, J 8.4 Hz); RMN 13C: deltaC (75 MHz, CD2Cl2) 25.0, 109.8, 115.6, 122.2, 126.4, 127.0, 136.0, 137.8, 143.7, 156.3 ppm; IR: 3467, 3385, 3343, 2365, 3048, 2917, 1616, 1595, 1563, 1507, 1475, 1431, 1373, 1344, 1323, 1284, 1274, 1243, 1137, 1080, 1032, 828, 794, 744, 715, 692 cm-1. SM: El m/z: 158, 131, 103.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 56826-69-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56826-69-8 as follows.

A 150 mL toluene solution of 5,6,7-trihydroquinolin-8-one (0.882 g, 5.99 mmol), 2-benzhydrylnaphthylamine (2.04 g, 6.59 mmol), and a catalytic amount of p-toluenesulfonic acid (0.228 g, 1.20 mmol) was refluxed for 8 h. The solvent was evaporated under reduced pressure, and then the mixture was purified by column chromatography on basic alumina with petroleum ether/ethyl acetate (v/v = 10:1) as eluent to afford the product as a yellow powder in 37% yield. Mp: 165-166 C. 1H NMR (400 MHz, CDCl3, TMS): deltaH 8.80 (d, 1H, 3JHH = 3.2 Hz, Py-H), 7.79 (d, 1H, 3JHH = 8.0 Hz, Py-H), 7.57 (d, 1H, 3JHH = 8.4 Hz, Py-H), 7.50 (d, 2H, 3JHH = 8.4 Hz, Ar-H), 7.41-7.08 (m, 14H, Ar-H), 5.92 (s, 1H, -CHPh2), 2.72-2.64 (m, 1H, -CH2), 2.53-2.46 (m, 1H, -CH2), 1.90-1.83 (m, 1H, -CH2), 1.20-1.13 (m, 1H, -CH2), 0.88-0.77 (m, 2H, -CH2). 13C NMR (100 MHz, CDCl3, TMS): 167.8, 149.8, 148.9, 146.2, 144.5, 142.9, 137.5, 137.2, 132.8, 130.2, 129.7, 128.6, 128.3, 128.1, 127.6, 126.1, 125.5, 125.0, 123.5, 122.5, 51.8, 31.4, 29.2, 21.2. FT-IR (KBr, disk, cm-1): 3054, 3026, 1641 (nuC=N), 1564, 1488, 1450, 1428, 1375, 1315, 1199, 1097, 1028, 790, 745, 701. Anal. Calc.d for C32H26N2 (438.21): C, 87.64; H, 5.98; N, 6.39%; Found: C, 87.48; H, 6.22; N, 6.27%.

According to the analysis of related databases, 56826-69-8, the application of this compound in the production field has become more and more popular.

Related Products of 391-82-2,Some common heterocyclic compound, 391-82-2, name is 4-Chloro-7-fluoroquinoline, molecular formula is C9H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of compound 1VI (0.040 g, 0.22 mmol), m-chloroaniline (0.036 g, 0.31 mmol) and pyridine hydrochloride was heated at reflux for 45 min in isopropanol (6 mL), after the reaction is over by TLC, it was cooled to room temperature and the petroleum ether (4 mL) and NaHCO3 (10 mL) were added into the reaction mixture. The product was filtered and recrystallised from ethanol to give the title compound 1. Compound 2 was prepared in the same manner as 1.

The synthetic route of 391-82-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 580-19-8, name is Quinolin-7-amine, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 580-19-8, Recommanded Product: Quinolin-7-amine

(c) (6-Chloropyrimidin-4-yl)-quinolin-7-yl-amine. A mixture of 4,6-dichloro-pyrimidine (1.04 g, 7.0 mmol, Lancaster), 7-aminoquinoline (1.00 g, 7.0 mmol, SynChem Inc.) and potassium carbonate (1.93 g, 14.0 mmol) in DMF (5.0 mL) was heated at 100¡ã C. with stirring for 24 h. The reaction mixture was allowed to cool to room temperature, diluted with water, and the resulting solid precipitate was filtered. The filter cake was dissolved in a mixture of CH2Cl2 and MeOH (3:1), washed with water and brine, dried over Na2SO4, and filtered. The filtrate was evaporated under reduced pressure, and the brown-yellow solid residue was suspended in CH2Cl2, filtered, and washed with CH2Cl2. The filter cake was dried in vacuo to give the title compound as a light-yellow solid. MS (ESI, pos. ion.) m/z: 257 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Quinolin-7-amine, and friends who are interested can also refer to it.

Electric Literature of 181950-57-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181950-57-2 as follows.

To a 100 ml round bottom flask was added 4-chloro-7-hydroxy quinoline (0.89 g, 5 mmol)Acetone (40 ml) and anhydrousK2C03 (2.0 g) was stirred at room temperature for 15 minutes,Followed by the addition of iodo butane (20 mmol)TLC trace detection.Reaction is completed,The acetone was distilled off under reduced pressure, 150 mL of water was added and the mixture was extracted with ethyl acetate. The combined organic phases were acidified by adding concentrated hydrochloric acid,With water to give a yellow oil, recrystallized from acetone, precipitated white crystals, filtered and basified to give a white solid ( 0.57 g Rate of 47.6%)

According to the analysis of related databases, 181950-57-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 71082-53-6, name is 8-Fluoroquinoline-3-carboxylic acid, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71082-53-6, SDS of cas: 71082-53-6

To a suspension of 8-fluoroquinoline-3-carboxylic acid (3 g, 14.9 mmol) in dichloromethane (37 mL), N,N-dimethylformamide (0.1 mL) was added followed by oxalyl chloride (1 .4 mL, 15.5 mmol) over a period of 30 minutes at room temperature. Vigorous gas evolution was observed. The white suspension was stirred for 4 h until the gas evolution came completely to an end. The pale yellow suspension was checked by LCMS of a small sample (quenched with EtNhb) showing still traces of acid (M+H+=192) and the amide (M+H+=219). Analysis of crude NMR of the acid chloride was performed: 1H NMR (400 MHz, CDCI3) delta ppm 9.50 – 9.63 (m, 1 H), 9.06 – 9.20 (m, 1 H), 7.87 – 7.98 (m, 1 H), 7.75 (s, 1 H), 7.64 – 7.83 (m, 2 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

391-77-5, name is 4-Chloro-6-fluoroquinoline, belongs to quinolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Chloro-6-fluoroquinoline

Nitrogen protection and room temperature conditions, to 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester(22.0 g, 96.8 mmol) in 300 mL of DMSO solution was added portionwise t-BuOK (16.3 g, 145.2 mmol). The reaction system is cooled to 10 to 25 C. Then 4-chloro-6-fluoroquinoline (26.4 g, 145.2 mmol) was added in portions. The control temperature is not higher than 25 C.After the addition, the reaction mixture was stirred at 25 C overnight. TLC showed the reaction was completed. The reaction system was poured into 1000 mL of water and extracted with EA (500 mL x 3). The organic phase is washed with saturated brine. The anhydrous Na2SO4 was sufficiently dried and concentrated under reduced pressure.The residue was purified by column chromatography (PE: EA = 3:1) to afford 25.3 g (yield: 69%) it is a pale yellow solid.

The synthetic route of 391-77-5 has been constantly updated, and we look forward to future research findings.