Tag: M.W:100-200

Synthetic Route of 49844-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, molecular formula is C5H5ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-chloro-2-(methylthio)-pyrimidine (21,9.90 g, 61.6 mmol) in MeOH (28 mL) and MeCN (20 mL)mixed solution, NBS (13.16 g, 73.9 mmol) was added(2 ¡Á 6.58 g). After the additions, the reaction mixture wasstirred at room temperature. After quenching with saturatedNa2SO3solution, the solution was extracted with DCMand saturated NaHCO3solution three times. The combinedorganic phases were dried over MgSO4,filtered, and concentrated in vacuo. The residue was purified by passingthe organic extract through a silica gel column using PE/EA(25:1) to give the product 22 (Elliott 1981). White solid;yield 73%; m.p. 48.5-50.1 C; 1H NMR (300 MHz, CDCl3)delta 8.54 (s, 1H), 2.55 (s, 3H); 13C NMR (75 MHz, CDCl3)delta172.1, 159.5, 114.1, 14.7; HRMS ([M + H]+): m/z calcd for[(C5H4BrClN2S) + H]+: 240.90254, found: 240.90203.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine.

Reference:
Article; Li, Shu-ting; Chen, Jun-qing; Feng, Cheng-liang; Yang, Wan-feng; Ji, Min; Chemical Papers; vol. 73; 12; (2019); p. 3043 – 3051;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 767-15-7, name is 2-Amino-4,6-dimethylpyrimidine, molecular formula is C6H9N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Amino-4,6-dimethylpyrimidine

General procedure: For the synthesis of 2, the solution of sulfurisocyanatidic chloride (7.2mmol) in 20mL toluene was added to the solution of 1 (6.0mmol) in 20mL toluene dropwise at room temperature. The reactant was heated to 140C and then the reaction proceeded for 18h under reflux. Subsequently, the mixture was cooled down to room temperature and remaining sulfurisocyanatidic chloride was removed under reduced pressure, together with the solvent. Without further purification, the resulting yellow oil 2 was dissolved in 10mL anhydrous acetonitrile and after that it was added slowly to 5mmol of 3, which was also dissolved in 10mL anhydrous acetonitrile beforehead in ice bath. After stirring for 24hat room temperature, acetonitrile was removed under reduced pressure and saturated sodium bicarbonate was added to product 4. Product 5 precipitated easily and it was further purified by recrystallization from petroleum ether/acetone in 1:1 ratio in high yields. 15% hydrochloric acid was added to aqueous solution of 5 under stirring and corresponding acidified product 4 precipitated out easily in high yields.

With the rapid development of chemical substances, we look forward to future research findings about 767-15-7.

Reference:
Article; Wu, Ren-Jun; Ren, Tongtong; Gao, Jie-Yu; Wang, Li; Yu, Qilin; Yao, Zheng; Song, Guo-Qing; Ruan, Wei-Bin; Niu, Cong-Wei; Song, Fu-Hang; Zhang, Li-Xin; Li, Mingchun; Wang, Jian-Guo; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 348 – 363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Adding some certain compound to certain chemical reactions, such as: 626-48-2, name is 6-Methylpyrimidine-2,4(1H,3H)-dione,molecular formula is C5H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-48-2.

To a stirred mixture of 96% H2S04(15 mL) and of 70% HN03(15 mL) was added 6- methyl pyrimidine-2,4-(lH,3H)-dione (2.5 g,19.8 mmol). The solution was kept at 50 C for lOh. The mixture was cooled to room temperature and poured into a large volume of ice water. The solid was collected and dried in vacuo. Recrystallization with MeOH gave the final compound (2.7g,16.2 mmol) as yellows solid.1H NMR (200 MHz,DMSO) delta 2.31 (s,3H), 11.82 (s,1H), 11.85 (s,1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-48-2, 6-Methylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TES PHARMA S.R.L.; PELLICCIARI, Roberto; (253 pag.)WO2018/69532; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5750-76-5, name is 2,4,5-Trichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 5750-76-5

2,5-dichloro-N-[2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (0440) To a solution of 1-Amino-2-(isopropylsulphonyl)benzene (0.955 g, 4.80 mmol) in 2 mL of DMF at 0 C. was added NaH (60% in oil, 0.349 g, 8.72 mmol) in one portion. After stirring fro 20 min, 2,4,5-trichloropyrimidine was added. The mixture was stirred at 0 C. for 30 minutes, and then at room temperature for 2 h. After quenching with saturated ammonium chloride solution, the mixture was poured in water and ethyl acetate mixture. Yellow suspension was filtered as final product (0.3 g, 20% yield). MS/ES+: m/z=346.

With the rapid development of chemical substances, we look forward to future research findings about 5750-76-5.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; Wang, Yihan; Huang, Wei-Sheng; Liu, Shuangying; Shakespeare, William C.; Thomas, Ranny M.; Qi, Jiwei; Li, Feng; Zhu, Xiaotian; Kohlmann, Anna; Dalgarno, David C.; Romero, Jan Antoinette C.; Zou, Dong; US2015/225436; (2015); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 89793-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.6, as common compound, the synthetic route is as follows.

0126] A mixture of aniline (3.7 g, 40 mmol), ethyl 2-chloropyrimidine-5-carboxylate 1 (7.5 g, 40 mmol), K2CO3 (11 g, 80 mmol) in DMF (100 mL) was degassed and stirred at 120C under N2 overnight. The reaction mixture was cooled to it and diluted with EtOAc (200 mL), then washed with saturated brine (200 mL x 3). The organic layer was separated and dried over Na2SO4, evaporated to dryness and purified by silica gel chromatography (petroleum ethers EtOAc=101) to give the desired product as a white solid (6.2 g, 64%).

The chemical industry reduces the impact on the environment during synthesis 89793-12-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; Golonzhka, Olga; Jarpe, Matthew B.; (30 pag.)US2017/114023; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 2434-56-2, Adding some certain compound to certain chemical reactions, such as: 2434-56-2, name is 4,6-Diaminopyrimidine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2434-56-2.

The hydrochloric acid reaction solution was diluted to 1.5 mol / L,Cooled to -10 C,Add 82g in batchesSodium nitrite,After stirring for 1.5 h, sodium carbonate was added and the reaction solution was neutralized to pH neutral,Filtered to give a damp 4,6-diamino-5-nitrosylpyrimidine cake.The yield was 85%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2434-56-2, 4,6-Diaminopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang University of Technology; Li, Yongshu; Yan, Yiyi; Chen, Liqi; Mao, Liping; Wang, Yunlong; (17 pag.)CN103709164; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 25193-95-7, Adding some certain compound to certain chemical reactions, such as: 25193-95-7, name is 5-(Hydroxymethyl)pyrimidine,molecular formula is C5H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25193-95-7.

To a solution of pyrimidin-5-yl-methanol (100 mg, 0.91 mmol, 1.0 equiv; [CASRN 25193-95-7])in anhydrous THF (6 mL) and NEt3 (97 mg, 0.13 mL, 0.95 mmol, 1.05equiv) at 0C was added slowly a solution of methanesulfonyl chloride (104 mg,0.071 mL, 0.91 mmol, 1.0 equiv) dissolved in THF (1 mL). After 30 min, sodiumiodide (136 mg, 0.91 mmol, 1.0 equiv) was added and stirring at 0C continuedfor another 30 min, then the cooling bath was removed and the reaction allowedto reach rt. After 1 h, the reaction was again cooled down to 0C and asolution of 3-(4-trifluoromethyl-phenyl)-prop-2-yn-1-ol (182 mg, 0.91 mmol, 1.0equiv; [CAS RN 173546-21-9]) in THF (3 mL) was added, followed bytreatment with potassium tert-butoxide(239 mg, 2.09 mmol, 2.3 equiv). After 1 h, the reaction mixture was allowed toreach rt and stirring continued for 18 h. The reaction was quenched by addition of a 10%solution of KH2PO4 (50 mL) and the crude product extracted with diethylether (3x 50 mL). The combined organic layers were dried over MgSO4,concentrated under reduced pressure and the product purified by MPLC elutingwith a gradient of heptane / ethyl acetate. The title compound was isolated aslight yellow solid (56 mg, 21%). 1H NMR (600 MHz, [D6]DMSO): d = 4.56 (s, 2H), 4.70 (s, 2H), 7.66 – 7.72 (m, 2H), 7.74 – 7.78 (m, 2H),8.84 (s, 2H), 9.15 (s, 1H). 13C NMR (150 MHz, [D6]DMSO): d = 58.6, 66.6, 84.9, 88.5, 123.9 (q, JCF = 274.9 Hz), 125.6 (q, JCF = 3.8 Hz), 126.0, 128.8 (q, JCF = 32.0 Hz), 131.3, 132.2, 156.5, 157.9.19F NMR (375 MHz, [D6]DMSO): d = -61.4. HRMS (ESI+): m/z [M]+calcd for C15H11F3N2O: 292.0824,found: 292.0827.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Martin, Rainer E.; Lenz, Mario; Alzieu, Thibaut; Aebi, Johannes D.; Forzy, Liliane; Tetrahedron Letters; vol. 54; 49; (2013); p. 6703 – 6707;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H4Cl2N4

In the reaction vessel, 4,6-dichloropyrimidine-2,5-diamine(501 mg, 2.79 mmol),Benzofuran-2-boronic acid (1.05 g, 6.46 mmol),Sodium carbonate (1.48 g, 14.0 mmol),And tetrakis (triphenylphosphine) palladium (0)To a solution of (161 mg, 0.140 mmol) in toluene (28 mL), ethanol (7 mL) and distilled water (7 mL) are added at room temperature, and the reaction solution is stirred under an argon atmosphere for 20 hours under heat reflux Was cooled to room temperature. Add distilled water (8 mL) and stir,The separated aqueous layer was extracted three times with ethyl acetate (12 mL).Thereafter, the whole organic layer is combined, saturated aqueous sodium chloride solution (12 mL) is added thereto, the mixture is stirred and washed, anhydrous sodium sulfate is added to the separated organic layer for dehydration, and the filtrate after filtration is concentrated under reduced pressure. Flash column chromatography of the obtained concentratePurified with (silica gel, n-hexane / ethyl acetate),4,6-Di (benzofuran-2-yl) pyrimidine-2, 5-diamine(0.748 g, 78% yield)

The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4270-27-3, Adding some certain compound to certain chemical reactions, such as: 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione,molecular formula is C4H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4270-27-3.

6-chloro-uracil (7 g, 1 eq.), methyl iodide (8.9 ml, 3 eq.) and anhydrous potassium carbonate (3.36 g, 0.5 eq.) were stirred in 30 ml of dimethylsulfoxide at room temperature for 3 h, then 38 ml of water was added and stirred in ice bath for 2 h. A white solid precipitated and the precipitate was collected by filtration and dried to give 5.12 g of a solid. MS (ESI): 161(M+H)

According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Institute Of Materia Medica Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; CHEN, Xinde; XU, Wenwei; WANG, Kai; (84 pag.)EP3239135; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42839-09-8, name is 2-Pyrimidinemethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Pyrimidinemethanol

Also, reacting 2-hydroxymethylpyrimidine with 3-mercaptopropylamine by the procedure of Example 1 and then reacting the resulting 2-[(3-aminopropyl)thiomethyl]-pyrimidine with dimethyl-N-cyanoimidodithiocarbonate and methylamine by the procedure of Example 3(d) gives N-cyano-N’-methyl-N”-[3-(2-pyrimidylmethylthio)propyl]guanidine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42839-09-8, 2-Pyrimidinemethanol.

Reference:
Patent; Smith Kline & French Laboratories Limited; US3950333; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia