Tag: M.W:100-200

Related Products of 57473-32-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57473-32-2, name is 5,7-Dichloroimidazo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Example 8. General Procedure H A mixture of the desired chloroimidazopyrimidines i-H (1 equiv), desired aminomethyl heterocycle or benzylamine ii-H (1.2 equiv), and triethylamine (NEt3) (1.5-3.5 equiv) in 1,4-dioxane (~0.1 M) was stirred at 70 C until the reaction was complete by LC-MS and/or TLC analysis. The crude reaction mixture was directly purified by silica gel chromatography (typical eluents included, for example, a mixture of hexanes and EtOAc, or a mixture of CH2Cl2 and MeOH, or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-H. The product structures prepared according to General Procedure H were confirmed by 1H NMR and/or by mass analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 57473-32-2, 5,7-Dichloroimidazo[1,2-a]pyrimidine.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 58347-49-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 58347-49-2 as follows.

EXAMPLE 242-rDimethylaminoVl-(4-{7-fluoro-8-methyl-3-r(lS)-l-rpyrazolori.5-alpha1pyrimidin-7- ylamino)ethyl1quinolin-2-vUpiperazin- 1 -vDethanone Intermediate 15 (700 mg, 2.06 mmol), 2-(dimethylamino)-l-(piperazin-l-yl)- ethanone (500 mg), ?-BuOH (10 mL) and DIPEA (2 mL) were combined in a sealed tube and heated to 13O0C for 13 days. The reaction mixture was cooled, concentrated onto silica and purified by column chromatography (SiO2, 0-10% MeOH in EtOAc) to give a white solid. This material, MeOH (8 mL) and 2N HCl in Et2O (4 mL) were combined and stirred at r.t. for 2 days. The reaction mixture was concentrated to give a yellow foam. A portion of this material (50 mg, 0.12 mmol), n-BuOH (6 mL), DIPEA (1 mL) and 7-chloropyrazolo[l,5-alpha]pyrimidine (50 mg, 0.25 mmol) were combined in a sealed tube and heated to 13O0C for 16 h. The reaction mixture was then concentrated to dryness and purified by preparative HPLC to give the title compound (28 mg, 48%) as a tan glass. deltaH (DMSO-Ci6) 8.64 (IH, s), 8.41 (IH, d, J7.80 Hz), 8.13 (2H, m), 7.74 (IH, dd, J8.95, 6.28 Hz), 7.33 (IH, t, J9.13 Hz), 6.44 (IH, d, J2.27 Hz), 6.28 (IH, d, J5.30 Hz), 5.21- 5.13 (IH, m), 4.16-3.73 (4H, m), 3.42-3.17 (6H, m), 2.56 (3H, s), 2.25 (6H, s), 1.89 (3H, d, J 6.71 Hz). LCMS (ES+) 491 (M+H)+, RT 3.23 minutes {Method 1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58347-49-2, its application will become more common.

Reference:
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BROWN, Julien, Alistair; BUeRLI, Roland; HAUGHAN, Alan, Findlay; LANGHAM, Barry, John; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2010/133836; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 67831-83-8 ,Some common heterocyclic compound, 67831-83-8, molecular formula is C7H7N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (35m) (1.0 g, 5.5 mmol) in POCI3 (10 mL) cooled at 5C on an ice bath was added dropwise diethylaniline (1.0 mL, 6.2 mmol). After 2 hours stirring at 80C, the mixture was poured on crushed ice and the resulting precipitate was filtered off and purified by silica gel column chromatography.Yield: 33%.Melting point: 206-208C.H NMR (DMSO -d6) d 2.56 (s, 3H, S CH3), 6.52 (s, 1H, 5 -H), 7.52 (s, 1H, 6 -H), 12.39 (s, 1H, N H). 13C NM R (DMSO -d6) d 13.8 (SCH3), 99.0 (C-5), 113.2 (C-4a), 126.9 (C-6), 150.4-152.7 (C-4/C-7a),162.7 (C-2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67831-83-8, 2-(Methylthio)-7H-pyrrolo[2,3-d]pyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITE DE LIEGE; LANCELLOTTI, Patrizio; OURY, Cecile; PIROTTE, Bernard; (140 pag.)WO2019/158655; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 51674-77-2 ,Some common heterocyclic compound, 51674-77-2, molecular formula is C7H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 5-{3-[(1S)-1-aminoethyl]-5-chloro-2-methoxy-6-methylphenyl}-N,N-dimethylpyridine-2-carboxamide dihydrochloride (17 mg, 0.040 mmol), 4-chloropyrido[3,2-d]pyrimidine (6.7 mg, 0.040 mmol) and N,N-diisopropylethylamine (35 muL, 0.20 mmol) in 1-butanol (0.4 mL) was heated at 120 C. for 2 h. The mixture was purified on prep-LCMS (Sunfire Prep C18 5 mum 30¡Á10 mm column, flow rate 60 mL/min, eluting with a gradient of acetonitrile and water with 0.05% TFA) to afford the title product (2.7 mg, 14%). LCMS calculated for C25H26ClN6O2 (M+H)+: m/z=477.2. found: 477.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51674-77-2, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Combs, Andrew P.; US2015/361094; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 49845-33-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 2,4-dichloro-5-nitropyrimidine (500 mg, 2.5 mmol) dissolved in tetrahydrofuran (10 mL), sodium hydroxide (238 mg, 2.8 mmol) and aqueous ammonia (0.3 mL) was added, and reacted for 2 hrs at 55C. The solvent was removed under reduced pressure, and the residue was separated by flash column chromatography (dichloromethane: methanol=100:1), to obtain Compound w: 2-chloro-5-nitro-4-aminopyrimidine as a white solid (0.47 g, yield 84%). MS(ESI)m/z: [M+H]+=175.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49845-33-2, 2,4-Dichloro-5-nitropyrimidine.

Reference:
Patent; Shanghai Huilun Life Science & Technology Co., Ltd; FAN, Xing; QIN, Jihong; (43 pag.)EP3284743; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4595-61-3, name is Pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Formula: C5H4N2O2

Example 2 1,4,5,6-Tetrahydropyrimidine-5-carboxylic Acid Hydrochloride Pyrimidine-5-carboxylic acid (5.0 g, 40 mmol) was suspended in a mixture of 150 ml water and concentrated hydrochloric acid (4.0 g, 40.5 mmol). The mixture was hydrogenated at 26 psig over 1.0 g Pd-on-carbon 10percent in a Parr hydrogenator for 3 h. The suspension was filtered and the filter rinsed twice with hot water (20 ml). The filtrate was evaporated in vacuo to give 6.11 g yellow oil (92percent). The oil was crystallized from anhydrous methanol/tetrahydrofuran (THF) to give 5.77 g (87percent) white crystals in two crops. 300 MHz nmr indicated product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4595-61-3, Pyrimidine-5-carboxylic acid.

Reference:
Patent; The University of Toledo; US5175166; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4786-52-1 ,Some common heterocyclic compound, 4786-52-1, molecular formula is C7H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Ethyl 4-hydroxypy?miotadiotane-5-carboxylate (380 mg, 2.26 mmol) was dissolved in THF (5 mL) and treated with thionyl chloride (1.65 ml, 22.6 mmol). The solution was heated to reflux for 4 h and then concentrated in vacuo, yielding 417 mg (99%) of the crude product This material was used without purification or characterization

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4786-52-1, its application will become more common.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/49681; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

To 1.9 g of polyphosphoric acid were added 500 mg (3.59 mmol) of 2-aminopyrimidine-5-carboxylic acid portionwise. It was stirred for 5 mm before 327.6 mg (3.59 mmol) of hydrazinecarbothioamide were added portionwise. It was stirred for 1 h at 140 C. It was allowed to cool down and water was added. The pH was adjusted to 12 by adding 25 vol% aqueous ammonia solution. The precipitate wasfiltered off and washed with water. It was dried under vacuum at 50 C to yield 164 mg (23%) of the title compound, containing ca. 25 mol% of the starting material.?H-NMR (300MHz, DMSO-d6): 6 [ppm]= 7.13 (s, 2H), 7.30 (s, 2H), 8.56 (s, 2H).LC-MS (Method 3): R = 0.44 mm; MS (ESIpos): m/z = 195 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

6-hydroxypyrimidine-4-carboxylic acid 1.00 g (7.14 mmol),30 ml of methylene chloride, 3.60 g (28.4 mmol) of oxalyl chloride and 0.05 g (0.68 mmol) of N, N-dimethylformamide were added to 1.00 g (7.14 mmol), and the mixture was heated under reflux for 3 hours. Then, the reaction solution was concentrated under reduced pressure. To the obtained residue was added 30 ml of methylene chloride, 0.70 g (7.18 mmol) of O-ethylhydroxylammonium chloride and 1.45 g (14.3 mmol) of triethylamine were added under ice cooling, and the mixture was stirred at room temperature for 3 hours . Then, the reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography Further purification gave 0.79 g (3.92 mmol, yield 55percent) of 6-chloro-N-ethoxypyridine-4-carboxamide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NIPPON SODA COMPANY LIMITED; ITO, SYUICHI; AMANO, TOMOHIRO; IPPOSHI, JUNJI; KOUBORI, SHINYA; (44 pag.)JP2016/30742; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 696-82-2 ,Some common heterocyclic compound, 696-82-2, molecular formula is C4HF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) adding 100% of a 2,4-diaminobenzenesulfonic acid solution (18.8 g) to 400 mL of water, stirring Add sodium bicarbonate solid, adjust the pH to 4, slowly warm to 20 C after dissolution, add 13.94 g (99%) 2,4,6-trifluoropyrimidine, control the pH at 4, continue the reaction 2 Hours, the end point of the reaction was detected by thin layer chromatography, and the reaction solution was used after the condensation was completed;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,696-82-2, its application will become more common.

Reference:
Patent; Jiangsu Demeike Chemical Co., Ltd.; Wang Siliang; Wang Xiaojun; (16 pag.)CN108129875; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia