Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile

Step 3. Preparation of 4-Amino-5-cyano-6-(((8-chloro-2-phenyl-1,4-dihydroquinolin-3-yl) methyl) amino) pyrimidine 3-Aminomethyl-2-phenylquinolin-4(1H)-one (1.25g, 0.005mol) and 50ml of isopropanol were added to a 100ml three-necked flask and stirred to be dissolved. 4-amino-5-cyano-6-chloropyrimidine (0.93g, 0.006mol) and potassium carbonate (2.1g, 0.015mol) were then added; the temperature was raised to 80C and reaction was carried out under reflux for 5h with stirring. TLC tracking was performed until the completion of the reaction. The reaction was stopped and suction filtration was performed. The filter cake was washed with a large amount of ethyl acetate; solvent was removed under reduced pressure; and methanol and silica gel were added to the residue for preparing a mixture for chromatography. After column chromatography separation, 1.37g of a white solid was obtained with a yield of 68.1 %. 1H NMR (500MHz, DMSO-d6) delta: 10.80(s, 1H), 8.18?8.17(d, 1H, J=5.0Hz), 7.88?7.87(d, 1H, J=5.0Hz), 7.56?7.54(m, 5H), 7.36?7.39(t, 1H, J=7.5Hz), 6.4 3(s, 3H), 6.10(s, 2H), 4.23(s, 2H). ES: m/z 368.9[M+H]+.

The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; LIU, Xiaorong; HUANG, Dandan; ZHANG, Yan; KAI, Yumei; (47 pag.)EP3266774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 4270-27-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione, molecular formula is C4H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of 6-chlorouracil (17.58 g, 120 mmol) in DMF (60 mL) were added DIPEA (27.2 mL, 156 mmol) and 1-bromo-2-butyne (12 mL, 132 mmol). The reaction mixture was stirred overnight at r.t. Water was added. The precipitate was collected by filtration, washed with water and EtOH, and dried to give 5b as a light yellow solid (21 g, 88%).

According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lai, Zeng-Wei; Li, Chunhong; Liu, Jun; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 547 – 560;,
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Electric Literature of 36315-01-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: For the synthesis of 2, the solution of sulfurisocyanatidic chloride (7.2mmol) in 20mL toluene was added to the solution of 1 (6.0mmol) in 20mL toluene dropwise at room temperature. The reactant was heated to 140C and then the reaction proceeded for 18h under reflux. Subsequently, the mixture was cooled down to room temperature and remaining sulfurisocyanatidic chloride was removed under reduced pressure, together with the solvent. Without further purification, the resulting yellow oil 2 was dissolved in 10mL anhydrous acetonitrile and after that it was added slowly to 5mmol of 3, which was also dissolved in 10mL anhydrous acetonitrile beforehead in ice bath. After stirring for 24hat room temperature, acetonitrile was removed under reduced pressure and saturated sodium bicarbonate was added to product 4. Product 5 precipitated easily and it was further purified by recrystallization from petroleum ether/acetone in 1:1 ratio in high yields. 15% hydrochloric acid was added to aqueous solution of 5 under stirring and corresponding acidified product 4 precipitated out easily in high yields.

According to the analysis of related databases, 36315-01-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wu, Ren-Jun; Ren, Tongtong; Gao, Jie-Yu; Wang, Li; Yu, Qilin; Yao, Zheng; Song, Guo-Qing; Ruan, Wei-Bin; Niu, Cong-Wei; Song, Fu-Hang; Zhang, Li-Xin; Li, Mingchun; Wang, Jian-Guo; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 348 – 363;,
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Synthetic Route of 34289-60-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 34289-60-6 as follows.

In a 25 ml round bottom flask with stirring bar was combined 2-hydroxy-4,6- dimethylpyrimidine hydrochloride, 2.05 g, cesium carbonate, 5.5g, and dimethyl formamide, 8.5 ml. The mix was stirred 30 minutes, then intermediate 1 c, 1.3g, was added. The resulting mix was heated at 80 0C overnight. TLC with 1 : 1 ethyl acetate/hexanes on silica showed complete conversion to new lower RF spot. The reaction was diluted with water, and extracted with ethyl acetate. The organic layer was washed twice with water. The combined aqueous layers were back extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and then concentrated in vacuo to provide methyl 9-{3-[(4,6-dimethylpyrimidin-2-yl)oxy]propyl}- 2,3,4,9-tetrahydro-lH-carbazole-6-carboxylate as an orange oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34289-60-6, its application will become more common.

Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
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Related Products of 13418-77-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13418-77-4, name is 2-Amino-5-methoxypyrimidine. A new synthetic method of this compound is introduced below.

b) 2-ri-(4-Fluorophenyl)-3-r2-(4-methoxyphenyl)ethyll-5-oxo-2- sulfanylideneimidazolidin-4-yll-N-(5-methoxypyrimidin-2-yl)acetamide (example 84). Oxalyl chloride (130 mu; 1.49 mmol; 3 eq) and anhydrous dimethylformamide (catalytic amount) were added dropwise to a solution of 2-[l-(4-fluorophenyl)-3-[2- (4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl] acetic acid (1-21) (200 mg; 0.50 mmol; 1 eq) in anhydrous dichloromethane (8 mL). The reaction mixture was stirred at room temperature for 2 hours. 5-Methoxypyrimidin-2-amine (1-22) (124 mg; 0.99 mmol; 2 eq) and pyridine (93mu; 1.49 mmol; 3 eq) were added and the reaction mixture was stirred at room temperature for 2 hours and 30 minutes. Water (20 mL) and saturated ammonium chloride (15 mL) were added and the aqueous layer was extracted with ethyl acetate (3 x 40 mL). The combined organic layers were washed with saturated sodium chloride (30 mL), dried over sodium sulfate, filtered and concentrated to dryness. The crude was purified on silica gel using dichloromethane/ethyl acetate (90/10) as an eluent. After trituration in ethanol/diethyl ether, the title compound 2-[l-(4-fluorophenyl)-3-[2-(4- methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(5- methoxypyrimidin-2-yl)acetamide was obtained in 7% yield (23 mg) as an orange solid. 1H-NMR (Acetone-d6): delta (ppm) 2.93 (m, 1H), 3.1 (m, 1H), 3.43 (m, 1H), 3.72 (s, 3H), 3.81 (m, 2H), 3.95 (s, 3H) , 4.27 (m, 1H), 4.65 (s, 1H), 6.85 (d, 2H), 7.25 (m, 4H), 7.45 (m, 2H), 8.36 (s, 2H) , 9.58 (s, 1H); MS (ESI+): m/z = 509.9 [M+H]+ .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13418-77-4, its application will become more common.

Reference:
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
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Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28485-17-8, name is 5-Carbethoxyuracil, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H8N2O4

EXAMPLE 5 In 200 ml. of water is suspended 920 mg. of ethyl 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carboxylate and, while the suspension is stirred vigorously at room temperature, a gaseous mixture of fluorine (25 V/V%) and nitrogen is introduced. In the course, the starting material dissolves to yield a homogeneous solution. When 2.6 mole equivalents of said gaseous mixture has been introduced, the ultraviolet absorption spectrum of the reaction mixture is measured. When the absence of unreacted starting compounds is confirmed by the spectrum, the reaction is stopped. Following addition of 1.10 g. of calcium carbonate, the reaction mixture is stirred for a while, after which the insolubles are filtered off. The filtrate is concentrated to dryness under reduced pressure, whereupon a white solid is obtained. This product is suspended in 50 ml. of acetone and the insolubles are filtered off. The acetone-solubles are subjected to column chromatography on silica gel (solvent: chloroform containing 1.5 V/V% of methanol), followed by concentration of the fraction containing the desired compound under reduced pressure to recover a white solid product. Recrystallization from methanol-chloroformhexane yields 561 mg. of colorless prisms of ethyl 5-fluoro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate. melting point: 163-165 C. NMR spectrum (DMSO-d6) delta: 1.22(3H,t, J=7HZ), 4.28(2H, q, J=7HZ), 4.93(1H, d*d, JHF =3HZ, J=5HZ; after addition of deuterium oxide, d, JHF =3HZ), 6.3(1H, broad), 8.48(1H, broad), 10.80(1H, broad). Elemental analysis, for C7 H9 FN2 O5: Calcd.: C, 38.19; H, 4.12; N, 12.73. Found: C, 37.90; H, 3.94; N, 12.87.

With the rapid development of chemical substances, we look forward to future research findings about 28485-17-8.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4329460; (1982); A;,
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Pyrimidine – Wikipedia

Synthetic Route of 104408-29-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104408-29-9, name is 4-Hydrazinyl-2-(methylthio)pyrimidine, molecular formula is C5H8N4S, molecular weight is 156.2088, as common compound, the synthetic route is as follows.

Step 3: 4-(3-isopropyl-5-(3-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)-2-(methylthio)pyrimidine, 36 is prepared as follows: 4-methyl-1-(3-(trifluoromethyl)phenyl)pentane-1,3-dione, 34 (1.65 g) and 4-hydrazinyl-2-(methylthio)pyrimidine, 35 (1.00 g) are dissolved in acetic acid (15 mL) and the mixture heated to 90 C. for 2 h. On cooling, the mixture is partitioned between dichloromethane and aqueous sodium hydrogen carbonate and the aqueous layer washed with two further portions of dichloromethane. The combined organics are washed with brine, dried over magnesium sulfate, filtered and concentrated. Purification by flash chromatography affords the title compound (1.29 g). The compound obtained in this step shows the following mass spectral data: LC/MS: C18H17F3N4S requires 378.1; observed M/Z 379.0 [M+H]+. RT 7.43 min.

Statistics shows that 104408-29-9 is playing an increasingly important role. we look forward to future research findings about 4-Hydrazinyl-2-(methylthio)pyrimidine.

Reference:
Patent; Griffin, John; Lanza, Guido; Yu, Jessen; US2005/261354; (2005); A1;,
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Pyrimidine – Wikipedia

Reference of 3764-01-0, Adding some certain compound to certain chemical reactions, such as: 3764-01-0, name is 2,4,6-Trichloropyrimidine,molecular formula is C4HCl3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3764-01-0.

[00299] To a solution of 2,4,6-trichloropyrimidine (0.29 mL, 2.5 mmol) in tetrahydrofuran (5 mL) were added palladium acetate (8 mg, 0.035 mmol), triphenylphosphine (18 mg, 0.065 mmol), phenylboronic acid (0.20 g, 1.6 mmol) and aqueous sodium carboante solution (1 M, 3.3 mL, 3.3 mmol). The mixture was stirred at 60 C for 6 h, then cooled to rt and concentrated to remove the organic solvent. To the residue was added H20 (10 mL), and the mixture was extracted with EtOAc (10 mL x 3). The combined organic layers were washed with saturated brine (30 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to dry and the residue was purified by silica gel column chromatography (PE) to give the title compound as a white solid (0.225 g, 6 1%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3764-01-0, 2,4,6-Trichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 1004-40-6, Adding some certain compound to certain chemical reactions, such as: 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine,molecular formula is C4H5N3OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-40-6.

Ethyl iodide (12 mmol) was added dropwise into a solutionof6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(6mmol)in KOH (6.2 mmol) and then the reaction mixture was stirred atroom temperature overnight. The obtained solid was collectedby filtration, washed with petroleum ether, and then dried. The solid product was sufficiently pure to be used in the subsequentreactions without further purification. Yield: 85 %, white crys-tals (EtOH), mp 220-222 8 C (Lit.[41]218-219 8 C). n max /cm 13465 (NH), 3275-3260 (NH 2 ), 2926 (C-H aliphatic), 1659(C=O), 1571 (C=N stretching), 1453 (C=C stretching). dH(90 MHz, DMSO-d 6 ) 11.80 (s, 1H, NH(3)), 6.45 (s, 2H, NH 2 ),5.00 (s, 1H), 3.10 (q, J 18.0, 2H), 1.30 (t, J 18.0, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; El-Mahdy, Ahmed F. M.; El-Sherief, Hassan A. H.; Hozien, Zainab A.; Australian Journal of Chemistry; vol. 72; 7; (2019); p. 542 – 554;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4595-60-2 ,Some common heterocyclic compound, 4595-60-2, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The 1,10-phenanthroline 2,2,3,3-tetrafluoropropyl ether copper (I) prepared in Example 2,In a nitrogen atmosphere, a polytetrafluoroethylene magnet was placed in the reactor,Was added 0.36 mmol of 1,1,10-phenanthroline 2,2,3,3-tetrafluoropropyl ether copper (I) (phen) 2Cu (OCH2CF2CF2H)0.3 mmol of 2-bromopyrimidine,0.3 mmol of sodium tert-butoxide and 3 mL of N, N-dimethylformamide solvent,And stirred in a closed system at 80 C for 12 h, cooled to room temperature, extracted with 3 x 10 mL of ether,The extracts were combined and concentrated, and the resulting residue was subjected to silica gel column chromatography,With ether: n-pentane = 1: 1 as eluent,To give 2- (2,2,3,3-tetrafluoropropoxy) pyrimidine, yield = 94%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4595-60-2, its application will become more common.

Reference:
Patent; Fuzhou University; Weng, Zhi Qiang; Huang, yangjie; Huang, ronglu; Ding, jianping; (9 pag.)CN104557924; (2016); B;,
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