Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Derivatives of pyridine and quinoline. LII. Synthesis of 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (4-desoxyadermine)》. Authors are van Wagtendonk, H. M.; Wibaut, J. P..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

cf. C. A. 35, 5112.3. NCCH2CONH2 and CH2Ac2 with piperidine in EtOH at 80° give 87% of 4,6-dimethyl-3-cyano-2-pyridone (I), m. 293° (corrected); with HNO3 (d. 1.52) in Ac2O at 5°, I gives a crude yield of 40-6% of the 5-NO2 derivative which with PCl5 in PhCl gives 24-8% of 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine (II), yellow, m. 114-15°. Catalytic reduction of II with Pd-C in 96% EtOH gives 81.4% of 2,4-dimethyl-3-amino-5-cyano-6-chloropyridine, m. 149-9.2° (corrected); further reduction with Pd-C catalyst in AcOH-AcONa at room temperature gives 2,4-dimethyl-3-amino-5-(aminomethyl)pyridine, characterized as the dipicrate, m. 244° (decomposition), and the di-HCl salt (III), with 1 mol. H2O, does not m. 300°. Reaction of III in 2 N H2SO4 with NaNO2 at 80° gives 2,4-dimethyl-3-hydroxy-5-(hydroxymethyl)pyridine (4-desoxyadermine), isolated as the HCl salt, m. 257°.

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Name: Piperidin-4-amine dihydrochloride. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Piperidin-4-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 35621-01-3, about Efficient and Scalable Method for the Selective Alkylation and Acylation of Secondary Amines in the Presence of Primary Amines. Author is Laduron, Frederic; Tamborowski, Vanessa; Moens, Luc; Horvath, Andras; De Smaele, Dirk; Leurs, Stef.

Selective substitution of secondary amines in the presence of primary amines is performed by using the reaction solvent, Me isobutylketone (MIBK), as a temporary protecting group for the primary amine. After acylation or alkylation of the secondary amine, the resulting imine intermediate is smoothly hydrolyzed, leading to the free primary amine in high yield and purity. This procedure represents a cheap and scalable alternative to multistep methods requiring several protections and deprotections.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ) is researched.Product Details of 18436-73-2.Calligaris, Mario; Illuminati, Gabriello; Marino, Gianlorenzo published the article 《Nucleophilic heteroaromatic substitution. XXVII. Piperidino dechlorination and methoxy dechlorination of 6- and 8-alkyl-4-chloroquinolines. Steric hindrance to specific solvation》 about this compound( cas:18436-73-2 ) in Journal of the American Chemical Society. Keywords: KINETICS PIPERIDINO DECHLORINATION; METHOXY DECHLORINATION; PIPERIDINO DECHLORINATION KINETICS; DECHLORINATION PIPERIDINO KINETICS; SOLVATION. Let’s learn more about this compound (cas:18436-73-2).

Kinetic data for the reaction of 6- and 8-alkyl-substituted 4-chloroquinolines with piperidine in four different solvents and with NaOMe in MeOH were obtained and compared. The tert-butyl group located at the position peri to the aza group is found to cause rate-depressing effects and significant increases in the energy and entropy of activation when the solvent is hydroxylic (methanol) whereas only minor changes are observed in aprotic or poor proton-donor solvents (toluene, HCONMe2, and piperidine). The results are interpreted in terms of steric inhibition of specific solvation (H bonding). 15 references.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Preparation of 3-hydroxy-5-hydroxymethyl-2,4-dimethylpyridine (4-deoxyadermine)》. Authors are Wibaut, J. P.; Uhlenbroek, J. H.; Kooijman, E. C.; Kettenes, D. K..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Electric Literature of C8H12ClNO2. Through the article, more information about this compound (cas:148-51-6) is conveyed.

The preparation of 4-deoxyadermine (I) as described earlier (CA 38, 32849) was improved to give a total yield 15%. Ac2CH2 (25 g.) was slowly added to a refluxing solution of 21 g. NCCH2CONH2 in 150 ml. EtOH and 3 ml. piperidine to give 97% 2-hydroxy-3-cyano-4,6-dimethylpyridine (II), m. 294°, which on nitration with HNO3 (d. 1.52) in Ac2O at 45-50° gave a 5-nitro derivative (III) m. 268° in 70% yield. A mixture of 50 g. dry III and 65 g. PCl5 was treated with 30 ml. POCl3 and heated to 130°, to yield 71% 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine, m. 112-13° (EtOH), which was reduced by Pd-C in MeOH and aqueous HCl to give 70-5% 2,4-dimethyl-3-amino 5-aminomethylpyridine di-HCl salt monohydrate (IV), m. 310° (decomposition). The reaction of IV with Ba(NO2)2 and H2SO4 at 0°, and subsequent heating to 90° afforded 45% I, m. 264°.

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COA of Formula: C10H8ClN. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors. Author is Berg, Maya; Bal, Gunther; Goeminne, Annelies; Van der Veken, Pieter; Versees, Wim; Steyaert, Jan; Haemers, Achiel; Augustyns, Koen.

The purine metabolism of Trypanosoma and Leishmania spp. provides a good target in the search for new selective drugs. Bicyclic N-arylmethyl-substituted iminoribitols were developed as inhibitors of T. vivax nucleoside hydrolase, a key enzyme of the purine salvage pathway. The obtained results and structure-activity data confirmed our model for inhibitor binding with a hydrogen bond between a nitrogen atom of the nucleobase mimetic and the protonated Asp40 from the enzyme. This interaction depends on an optimal pKa value, which can be influenced by the electronic properties of the substituents. These compounds are potent, selective inhibitors of nucleoside hydrolase and are inactive toward human nucleoside phosphorylase.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Compounds affecting fertility in adult houseflies》. Authors are LaBrecque, G. C.; Gouck, H. K..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Of 1100 compounds that were tested, 20 caused sterility in adult Musca domestica when given in the food. P,P-Bis(1-aziridinyl)-N-(p-methoxyphenyl)phosphinic amide, 5-fluoroorotic acid, and 1,4-piperazinediylbis[bis(1-aziridinyl)phosphinic oxide] induced sterility without apparent toxic effect over the broadest range of concentrations, from 5% to 0.1% or 0.25%.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal fuer Praktische Chemie (Leipzig) called Synthetic and natural phellandrene., Author is Kondakow, J.; Schindelmeiser, J., which mentions a compound: 148-51-6, SMILESS is OC1=C(C)C(CO)=CN=C1C.[H]Cl, Molecular C8H12ClNO2, Safety of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

[Machine Translation of Descriptors]. Carvomenthene, from carvomenthylchloride represented, became after REYCHLER into tertiary carvomenthol and over with 12 mm and 83.5-84.5° boiling. Chloride, D204; 0.932, into tertiary carvomenthene, C10H18, transferred. Boiling point 174-176°; D204; 0.811; nD = 1.45709, molecular refraction 46.23. Dibromide, under strong cooling in petroleum-ether prepared, Kp11; 130-144°. D204; 1.208, optical-inactively, separates no HBr, however alcoholic KOH supplies a hydrocarbon, from the main quantity with 175-180° with boiling D204; 0.825, nD = 1.46693, the smaller part with 180-185°. D204; 0.828, nD = 1.4673; molecular refraction 45.56. Both optical-inactive fractions color intensively raspberry red in a solution of acetic anhydride by H2SO4 and are undoubtedly different from the output hydrocarbon. Under consideration of the formation of the new hydrocarbon from carvomenthol author writes it from SEMMLER, (Ber. German Chem. Society 36. 1779; C. 1903. II. 116) for the phellandrene determined constitution without being able to prove the identity. Phellandrene from phellandrum aquaticum, boiling point 165-168°, D204; 0.844, nD = 1.47575, [α] D20 = 8° 37′. Molecular refraction a mixture of monochloride and dichloride gives 45.28, which probably contains an optical-inactive isomer, with HCl in glacial acetic acid. Monochloride, C10H17Cl, Kp11; 86°, melting point about 110° in the melted out tube, optically dextrorotatory. Dichloride, C10H18Cl2, Kp16; 122.5-125°, D204, 1.006, nD20 = 1.48516.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Nucleophilic heteroaromatic substitution. XXVII. Piperidino dechlorination and methoxy dechlorination of 6- and 8-alkyl-4-chloroquinolines. Steric hindrance to specific solvation》. Authors are Calligaris, Mario; Illuminati, Gabriello; Marino, Gianlorenzo.The article about the compound:4-Chloro-8-methylquinolinecas:18436-73-2,SMILESS:CC1=C2N=CC=C(Cl)C2=CC=C1).Reference of 4-Chloro-8-methylquinoline. Through the article, more information about this compound (cas:18436-73-2) is conveyed.

Kinetic data for the reaction of 6- and 8-alkyl-substituted 4-chloroquinolines with piperidine in four different solvents and with NaOMe in MeOH were obtained and compared. The tert-butyl group located at the position peri to the aza group is found to cause rate-depressing effects and significant increases in the energy and entropy of activation when the solvent is hydroxylic (methanol) whereas only minor changes are observed in aprotic or poor proton-donor solvents (toluene, HCONMe2, and piperidine). The results are interpreted in terms of steric inhibition of specific solvation (H bonding). 15 references.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 148-51-6, is researched, SMILESS is OC1=C(C)C(CO)=CN=C1C.[H]Cl, Molecular C8H12ClNO2Journal, Article, Brain Research called Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatta), Author is Meldrum, B. S.; Horton, R. W., the main research direction is pyridoxine antagonist convulsant; bicuculline convulsant; aminobutyrate neurotransmitter epilepsy.Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.

4-Deoxypyridoxine HCl (I) [148-51-6] administered i.v. at 40-100 mg/kg enhanced the natural syndrome of photosynthetic epilepsy in baboons and increased the severity of photically-induced myoclonus so that it progressed to a tonic-clonic seizure. In subconvulsive doses I provoked epileptic afterdischarges in the occipital cortex of monkeys exposed to photic stimulation. In both species I at 100-150 mg/kg induced spontaneous seizures which originated unilaterally in the occipital cortex and began with a horizontal nystagmus. When the occipital discharges no longer generalized, the animals had a normal electroencephalogram. A 4:1 excess of pyridoxine [65-23-6] in baboons blocked the increase in photically-induced responses and drug-induced seizures. Bicuculline (II) [485-49-4] administered i.v. at 0.1-0.4 mg/kg induced generalized seizures in both species, and at 0.3-0.6 mg/kg induced prolonged (150-300 min) seizures characterized by sustained myoclonic activity and relative absence of episodes of postictal silence in baboons. At 0.1-0.3 mg/kg II sometimes caused a brief myoclonic jerk associated with frontorolandic spikes and waves. There seem to be 2 inhibitory systems which differ in their pharmacol. responsiveness but both probably involve γ-aminobutyric acid [56-12-2] as the neurotransmitter. One system seems to be intracortical and its functional failure causes occipital discharges and spontaneous seizures after administration of the pyridoxine antagonists. The other is probably a collateral inhibitory system within the pathways afferent to the somatomotor cortex.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The relation between iodine-131 metabolism, tumor growth, and regression》. Authors are Scott, Kenneth G.; Daniels, Marie B..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Product Details of 148-51-6. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Ability of tumors to alter the normal metabolic pathway of I131 and compounds labeled with it (iodide-trapping syndrome) (I) is characterized by higher than normal retention of I131 by skin, muscle, gastrointestinal tract, and plasma, and a lower than normal thyroid uptake and urinary excretion of I131. I was elicited in rats by isografts and homografts of a transmissible fibrosarcoma, but not by homoiografts (which regressed after 5-7 days of growth). The data suggest that local and systemic I parallels progressive tumor growth and is absent in tumor implants destined to regress.

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