Tag: M.W:100-200

Chemistry is an experimental science, Product Details of 3680-71-5, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3680-71-5, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, molecular formula is C6H5N3O, belongs to pyrimidines compound. In a document, author is Prasher, Parteek.

Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review

Development and progression of metastasis comprises synchronized erroneous expressions of several composite pathways, which are difficult to manage simultaneously with the representative anticancer molecules. The emergence of the drug resistance and the complex interplay between these pathways further potentiates cancer related complexities. Barbiturates and their derivatives present a commendable anticancer profile by attenuating the cancer manifesting metabolic and enzymatic pathways including, but not limited to matrix metalloproteinases, xanthine oxidase, amino peptidases, histone deacetylases, and Ras/mitogen-activated protein kinase. The derivatization and conjugation of barbiturates with pharmacophores delivers a suitable hybrid profile in containing the anomalous expression of these pathways. The present report presents a succinct collation of the barbiturates and their derivatives in managing the various cancer causing pathways.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 3680-71-5. Product Details of 3680-71-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Electric Literature of 65-71-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 65-71-4, Name is 5-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C(C)=CN1)=O, belongs to pyrimidines compound. In a article, author is Ding Yuxin, introduce new discover of the category.

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triarylpyrimidines under Solvent-Free and Catalyst-Free Conditions

2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This green methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

Electric Literature of 65-71-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 65-71-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Shen, Jian, once mentioned the application of 4983-28-2, Application In Synthesis of 2-Chloro-5-hydroxypyrimidine, Name is 2-Chloro-5-hydroxypyrimidine, molecular formula is C4H3ClN2O, molecular weight is 130.53, MDL number is MFCD09743796, category is pyrimidines. Now introduce a scientific discovery about this category.

Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors

Our previous discovery of pyrazolo [1,5-a]pyrimidin-7(4H)-one scaffold-based DPP-4 inhibitors yielded two potent compounds b2 (IC50 = 79 nM) and d1 (IC50 = 49 nM) but characterized by cytotoxicity. Herein, with scaffold hopping and fragment-based drug design strategies, highly potent and selective pyrazolo [1,5-a]pyrimidine DPP-4 inhibitors were found featured by reduced or diminished cytotoxicity. Specifically, c24 (IC50 = 2 nM) exhibits a 25 to 40-fold increase of inhibitory activity respect to those of b2 and d1, respectively, 2-fold from Alogliptin (IC50 = 4 nM), and remarkable selectivity over DPP-8 and DPP-9 (>2000 fold). Further docking studies confirmed that the pyrazolo [1,5-a]pyrimidine core interacts with the S1 pocket whereas its substituted aromatic ring interacts with the sub-S1 pocket. The interactive mode in this case resembles that of Alogliptin and Trelagliptin. Further in vivo IPGTT assays in diabetic mice demonstrated that c24 effectively reduces glucose excursion by 48% at the dose of 10 mg/ kg, suggesting that c24 is worthy of further development as a potent anti-diabetes agent. (C) 2020 Elsevier Masson SAS. All rights reserved.

If you are interested in 4983-28-2, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-Chloro-5-hydroxypyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: pyrimidines4270-27-3, Name is 6-Chloropyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C=C(N1)Cl)=O, belongs to pyrimidines compound. In a article, author is Paronikyan, E. G., introduce new discover of the category.

Synthesis and Biological Activity of Partially Hydrogenated 1-Aminopyrimido[4,5-c]isoquinoline Derivatives

A one-pot synthesis of 3-amino-2-aryl-1,2,5,6,7,8-hexahydroisoquinolin-1-ones by the nucleophilic substitution at position 1 of the pyridine ring was developed. The synthesized compounds were used to prepare 1-amino-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinoline derivatives. The biological properties of the products were studied.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4270-27-3. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 1722-12-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 1722-12-9, Name is 2-Chloropyrimidine, SMILES is ClC1=NC=CC=N1, belongs to pyrimidines compound. In a article, author is Pragathi, Y. J., introduce new discover of the category.

Design, Synthesis, and Anticancer Activity of 1,3,4-Oxadiazole Incorporated 5-(Pyrimidin-5-yl)benzo[d]oxazole Derivatives

A novel series of 5-(pyrimidin-5-yl)benzo[d]oxazole derivatives has been synthesized, and the chemical structures of products have been determined by H-1 and C-13 NMR, and mass spectra. The products have been tested for their anticancer activity against a panel of human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer) using MTT assay. Some tested compounds have demonstrated significant anticancer activity higher than that of the reference drug.

Reference of 1722-12-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1722-12-9 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Nainwal, Lalit Mohan, once mentioned the application of 56-06-4, Product Details of 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, molecular formula is C4H6N4O, molecular weight is 126.1166, MDL number is MFCD08528919, category is pyrimidines. Now introduce a scientific discovery about this category.

Synthesis, ADMET prediction and reverse screening study of 3,4,5-trimethoxy phenyl ring pendant sulfur-containing cyanopyrimidine derivatives as promising apoptosis inducing anticancer agents

Cancer remains considered as one of the leading global health problems either due to meagre and suboptimal therapeutic response of chemotherapeutic agents or due to the emergence of spontaneous complex multidrug resistance in cancer cells. This created a persistent need for the development of new anticancer agents. Enthralled by the high success rate for natural product-based drug discovery and current research scenario, we synthesized a new series of 3,4,5-trimethoxy phenyl ring pendant sulfur-containing cyanopyrimidine derivatives clubbed with different amines intending to search an anticancer lead compound. To probe the anti-proliferative spectrum of the synthesized derivatives, an in-vitro evaluation was piloted against a panel of 60 cancer cell lines at the National Cancer Institute (NCI) representing major types of cancer diseases. Most of the derivatives showed good to moderate anti-proliferative activity. The results revealed that compound 4e displayed the most promising broad-spectrum anticancer activity with high growth inhibition of various cell lines representing multiple cancers diseases. Mechanistic investigation of compound 4e in human breast cancer MDA-MB-231 cells showed that compound 4e triggers cell death through the induction of apoptosis. ADMET studies and reverse screening were also performed to identify the potential targets of designed molecules. It was concluded that 3,4,5-trimethoxy phenyl ring pendant sulfur-containing cyanopyrimidine derivative 4e could act as a promising hit molecule for further development of novel anticancer therapeutics.

If you are interested in 56-06-4, you can contact me at any time and look forward to more communication. Product Details of 56-06-4.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 3680-71-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3680-71-5, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, SMILES is O=C1C2=C(NC=C2)NC=N1, belongs to pyrimidines compound. In a article, author is Shi, Meng, introduce new discover of the category.

Alterations and Correlations in Microbial Community and Metabolome Characteristics in Generalized Aggressive Periodontitis

This study aimed to characterize the microbial community and metabolic profiles in generalized aggressive periodontitis (AgP) using 16S ribosomal RNA (rRNA) gene high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS). A total of 146 subgingival plaque samples and 50 gingival crevicular fluid (GCF) samples were collected from 24 patients with AgP and 10 periodontally healthy subjects (PH). Striking differences were observed in subgingival microbiome and GCF metabolomics between patients with AgP and PH, but not between samples with different probing depths (PDs). Metabolomics analysis combined with enrichment analysis showed that periodontitis significantly altered the concentration of compounds associated with biosynthesis of amino acids (e.g., alanine, leucine, isoleucine, and valine), galactose metabolism (e.g., myo-inositol, galactose, glucose, and hexitol), and pyrimidine metabolism (e.g., uracil, uridine, beta alanine, and thymine). Correlation analysis showed that the genera with significant difference between AgP and PH were usually significantly correlated with more metabolites, such as Aggregatibacter, Rothia, Peptostreptococcaceae_[XI][G-5], and Bacteroidaceae_[G-1]. While glucose and oxoproline had the most significant correlations with microorganisms. Our results revealed distinct microbial communities and metabolic profiles between AgP and PH. The significant correlation between microbial taxa and metabolites suggested the possible mechanisms for periodontitis. Our results also provided effective approaches for detecting periodontal disease and managing periodontitis.

Synthetic Route of 3680-71-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 3680-71-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kayamori, Kensuke, once mentioned the application of 22536-61-4, Name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, molecular weight is 128.56, MDL number is MFCD09260903, category is pyrimidines. Now introduce a scientific discovery about this category, Quality Control of 2-Chloro-5-methylpyrimidine.

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

Dihydroorotate dehydrogenase (DHODH) catalyzes a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH inhibition has recently been recognized as a potential new approach for treating acute myeloid leukemia (AML) by inducing differentiation. We investigated the efficacy of PTC299, a novel DHODH inhibitor, for myelodysplastic syndrome (MDS). PTC299 inhibited the proliferation of MDS cell lines, and this was rescued by exogenous uridine, which bypasses de novo pyrimidine synthesis. In contrast to AML cells, PTC299 was inefficient at inhibiting growth and inducing the differentiation of MDS cells, but synergized with hypomethylating agents, such as decitabine, to inhibit the growth of MDS cells. This synergistic effect was confirmed in primary MDS samples. As a single agent, PTC299 prolonged the survival of mice in xenograft models using MDS cell lines, and was more potent in combination with decitabine. Mechanistically, a treatment with PTC299 induced intra-S-phase arrest followed by apoptotic cell death. Of interest, PTC299 enhanced the incorporation of decitabine, an analog of cytidine, into DNA by inhibiting pyrimidine production, thereby enhancing the cytotoxic effects of decitabine. RNA-seq data revealed the marked downregulation of MYC target gene sets with PTC299 exposure. Transfection of MDS cell lines with MYC largely attenuated the growth inhibitory effects of PTC299, suggesting MYC as one of the major targets of PTC299. Our results indicate that the DHODH inhibitor PTC299 suppresses the growth of MDS cells and acts in a synergistic manner with decitabine. This combination therapy may be a new therapeutic option for the treatment of MDS.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 22536-61-4, Quality Control of 2-Chloro-5-methylpyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Polunin, Ruslan A., once mentioned the application of 22536-61-4, Safety of 2-Chloro-5-methylpyrimidine, Name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, molecular weight is 128.56, MDL number is MFCD09260903, category is pyrimidines. Now introduce a scientific discovery about this category.

Versatile Reactivity of Mn-II Complexes in Reactions with N-Donor Heterocycles: Metamorphosis of Labile Homometallic Pivalates vs. Assembling of Endurable Heterometallic Acetates

Reaction of 2,2 ‘-bipyridine (2,2 ‘-bipy) or 1,10-phenantroline (phen) with [Mn(Piv)(2)(EtOH)](n) led to the formation of binuclear complexes [Mn-2(Piv)(4)L-2] (L = 2,2 ‘-bipy (1), phen (2); Piv(-) is the anion of pivalic acid). Oxidation of 1 or 2 by air oxygen resulted in the formation of tetranuclear Mn-II/III complexes [Mn4O2(Piv)(6)L-2] (L = 2,2 ‘-bipy (3), phen (4)). The hexanuclear complex [Mn-6(OH)(2)(Piv)(10)(pym)(4)] (5) was formed in the reaction of [Mn(Piv)(2)(EtOH)](n) with pyrimidine (pym), while oxidation of 5 produced the coordination polymer [Mn6O2(Piv)(10)(pym)(2)](n) (6). Use of pyrazine (pz) instead of pyrimidine led to the 2D-coordination polymer [Mn-4(OH)(Piv)(7)(mu(2)-pz)(2)](n) (7). Interaction of [Mn(Piv)(2)(EtOH)](n) with FeCl3 resulted in the formation of the hexanuclear complex [(Mn4Fe2O2)-Fe-II-O-III(Piv)(10)(MeCN)(2)(HPiv)(2)] (8). The reactions of [MnFe2O(OAc)(6)(H2O)(3)] with 4,4 ‘-bipyridine (4,4 ‘-bipy) or trans-1,2-(4-pyridyl)ethylene (bpe) led to the formation of 1D-polymers [MnFe2O(OAc)(6)L-2](n)center dot 2nDMF, where L = 4,4 ‘-bipy (9Greek ano teleia2DMF), bpe (10Greek ano teleia2DMF) and [MnFe2O(OAc)(6)(bpe)(DMF)](n)center dot 3.5nDMF (11 center dot 3.5DMF). All complexes were characterized by single-crystal X-ray diffraction. Desolvation of 11 center dot 3.5DMF led to a collapse of the porous crystal lattice that was confirmed by PXRD and N-2 sorption measurements, while alcohol adsorption led to porous structure restoration. Weak antiferromagnetic exchange was found in the case of binuclear Mn-II complexes (J(Mn-Mn) = -1.03 cm(-1) for 1 and 2). According to magnetic data analysis (J(Mn-Mn) = -(2.69 divided by 0.42) cm(-1)) and DFT calculations (J(Mn-Mn) = -(6.9 divided by 0.9) cm(-1)) weak antiferromagnetic coupling between Mn-II ions also occurred in the tetranuclear {Mn-4(OH)(Piv)(7)} unit of the 2D polymer 7. In contrast, strong antiferromagnetic coupling was found in oxo-bridged trinuclear fragment {MnFe2O(OAc)(6)} in 11 center dot 3.5DMF (J(Fe-Fe) = -57.8 cm(-1), J(Fe-Mn) = -20.12 cm(-1)).

If you are interested in 22536-61-4, you can contact me at any time and look forward to more communication. Safety of 2-Chloro-5-methylpyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is , belongs to pyrimidines compound. In a document, author is Rupp, Mira T., Safety of 2-bromo-5-fluoropyrimidine.

Substituted 2,4-Di(pyridin-2-yl)pyrimidine-Based Ruthenium Photosensitizers for Hydrogen Photoevolution under Red Light

The photocatalytic reduction of water to form hydrogen gas (H-2) is a promising approach to collect, convert, and store solar energy. Typically, ruthenium tris(bipyridine) and its many derivatives are used as photosensitizers (PSs) in a variety of photocatalytic conditions. The bis(terpyridine) analogues, however, have only recently gained attention for this application because of their poor photophysical properties. Yet, by the introduction of electron-donating or -withdrawing groups on the terpyridine ligands, the photophysical and electrochemical properties can be considerably improved. In this study, we report a series of nonsymmetric 2,6-di(pyridin-2-yl)pyrimidine ligands with peripheral pyridine substituents in different positions and their corresponding ruthenium(II) complexes. The presence of the pyrimidine ring stabilizes the lowest unoccupied molecular orbital, leading to a red-shifted emission and prolonged excited-state lifetimes as well as higher luminescence quantum yields compared to analogous terpyridine complexes. Furthermore, all complexes are easier to reduce than the previously reported bis(terpyridine) complexes used as PSs. Interestingly, the pyridine substituent in the 4-pyrimidine position has a greater impact on both the photophysical and electrochemical properties. This correlation between the substitution pattern and properties of the complexes is further investigated by using time-dependent density functional theory. In hydrogen evolution experiments under blue- and red-light irradiation, all investigated complexes exhibit much higher activity compared to the previously reported ruthenium(II) bis(terpyridine) complexes, but none of the complexes are as stable as the literature compounds, presumably because of an additional decomposition pathway of the reduced PS competing with electron transfer from the reduced PS to the catalyst.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 947533-45-1, in my other articles. Safety of 2-bromo-5-fluoropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia