Tag: M.W:100-200

Related Products of 671-35-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 671-35-2, Name is 5-Fluoro-4-hydroxypyrimidine, SMILES is O=C1NC=NC=C1F, belongs to pyrimidines compound. In a article, author is Tan, Yao, introduce new discover of the category.

Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice

S Hyperuricemia is a well-known key risk factor for gout and can cause a variety of metabolic diseases. Several studies have shown that dioscin could improve metabolic symptoms and reduce the uric acid level in blood. However, there is no comprehensive metabolomic study on the anti-hyperuricemia effects of dioscin. A total of 29 adult male Kunming mice were divided into three groups: Normal (blank), PO (potassium oxonate-administrated, 200 mg/kg/day), and Dioscin (potassium oxonate + dioscin, potassium oxonate 200 mg/kg/day, dioscin 50 mg/kg/day). All mice were treated for 42 days via oral gavage. This paper implemented an untargeted metabolomics study based on H-1 NMR and LC-MS to discover the comprehensive mechanism of dioscin. Furthermore, a targeted lipidomics was fulfilled to further analyze the lipid metabolism disorder. Finally, the metabolic pathway mediated by dioscin was verified at the gene level by means of transcriptomics. The results show 53 different metabolites were closely related to the improvement of dioscin in PO-induced hyperuricemia, and 19 of them were lipids. These metabolites are mainly involved in the tricarboxylic acid cycle, lipid metabolism, amino acid metabolism, and pyrimidine metabolism. According to the transcriptomics study, the levels of 89 genes were significantly changed in the PO group compared to the normal control. Among them, six gene levels were restored by the treatment of dioscin. The six changed genes (tx1b, Tsku, Tmem163, Psmc3ip, Tcap, Tbx15) are mainly involved in the cell cycle and energy metabolism. These metabolites and genes might provide useful information for further study of the therapeutic mechanism of dioscin.

Related Products of 671-35-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 671-35-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 65-71-4, Name is 5-Methylpyrimidine-2,4(1H,3H)-dione, formurla is C5H6N2O2. In a document, author is Naikoo, Rayees Ahmad, introducing its new discovery. Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione.

7-Endo-trig Pictet-Spengler type cyclization of 5-alkylidene/arylidene-amino-3H-pyrimidin-4-ones: An efficient and diastereoselective synthesis of pyrimido[4,5-b] [1,4]benzodiazepines

The manuscript describes an efficient, atom economical synthesis of pyrimido[4,5-b][1,4]benzodiazepin-4-ones by relatively unexplored 7-endo-trig Pictet-Spengler type cyclisations. The synthetic methdodlogy involves the synthesis of different variants of 5-arylidene-amino-3H-pyrimidines and their p-toluene sulfonic acid mediated 7-endo-trig Pictet-Spengler type cyclisations to afford biologically relavent functionalized benzodiazepine condensed pyrimidinones such as pyrimido[4,5-b][1,4]benzodiazepines in good to excellent yields (82-94%).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 65-71-4 help many people in the next few years. Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2927-71-1, Name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is , belongs to pyrimidines compound. In a document, author is Zhang, Duoteng, Product Details of 2927-71-1.

Two-photon small molecular fluorogenic probe visualizing biothiols and sulfides in living cells, mice brain slices and zebrafish

Biothiols and sulfides, especially glutathione (GSH), cysteine (Cys), homocysteine (Hcy) and hydrogen sulfide (H2S) play important roles in an extensive range of biological processes and functions. Due to their reductivity, they are deemed as second messengers of oxidative stress, and the imbalance of these biothiols are closely associated to a variety of diseases. Herein, we report a two-photon (TP) turn-on probe DT-01 that can detect biothiols and sulfides both in vitro and in vivo. The probe was synthesized by nitrobenzoxadiazole (NBD) derivative (NBD-Cl) and pyrimidine-based TP fluorophore (FL-01), the fluorescence of DT-01 is quenched due to the photoinduced charge transfer (PET) from FL-01 moiety to NBD moiety. Upon substitution reaction by nucleophilic biothiols, TP fluorophore released and exhibited turn-on fluorescence at 550 nm. We further demonstrated that DT-01 can detect biothiols and H2S in living cells, mice brain slices and zebrafish. More importantly, by real-time detecting the total content of biothiols and H2S, we have successively measured the changes of oxidative stress levels in HeLa cells.

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Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 947533-45-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a article, author is Balasubramaniam, Arun, introduce new discover of the category.

Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B

Repurposing existing compounds for new indications may facilitate the discovery of skin prebiotics which have not been well defined. Four compounds that have been registered by the International Nomenclature of Cosmetic Ingredients (INCI) were included to study their abilities to induce the fermentation of Staphylococcusepidermidis (S. epidermidis), a bacterial species abundant in the human skin. Liquid coco-caprylate/caprate (LCC), originally used as an emollient, effectively initiated the fermentation of S. epidermidis ATCC 12228, produced short-chain fatty acids (SCFAs), and provoked robust electricity. Application of LCC plus electrogenic S. epidermidis ATCC 12228 on mouse skin significantly reduced ultraviolet B (UV-B)-induced injuries which were evaluated by the formation of 4-hydroxynonenal (4-HNE), cyclobutane pyrimidine dimers (CPD), and skin lesions. A S. epidermidis S2 isolate with low expressions of genes encoding pyruvate dehydrogenase (pdh), and phosphate acetyltransferase (pta) was found to be poorly electrogenic. The protective action of electrogenic S. epidermidis against UV-B-induced skin injuries was considerably suppressed when mouse skin was applied with LCC in combination with a poorly electrogenic S. epidermidis S2 isolate. Exploring new indication of LCC for promoting S. epidermidis against UV-B provided an example of repurposing INCI-registered compounds as skin prebiotics.

Application of 947533-45-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 947533-45-1 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Fang, Hui-Lin, once mentioned the application of 873-83-6, COA of Formula: C4H5N3O2, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category.

Domino beta-C-H Functionalization and [3+2] Cycloaddition for Efficient Synthesis of Diverse Spiro and Polycyclic Compounds

The acetic acid catalyzed three-component reaction of pyrrolidine, aromatic aldehydes and 4-arylidene-5-methyl-2-phenylpyrazol-3-one in refluxing toluene gave functionalized 7 ‘-(E)-benzylidenespiro[pyrazole-4,1 ‘-pyrrolizines] in good yields and with high diastereoselectivity. The similar reaction with 2-arylidene-N,N’-dimethylbarbiturates resulted in mixture of Z/E-isomers of 7 ‘- arylidenespiro[pyrimidine-5,1 ‘-pyrrolizines] in good yields. However, the three-component with N-phenylmaleimides and sequential oxidation with DDQ reaction gave 8-(E)-arylidenedihydropyrrolo[3,4-a]pyrrolizines in satisfactory yields. The reaction mechanism included sequential beta-C-H functionalization of pyrrolidine, generation of conjugated azomethine ylides, and sequential [3+2] cycloaddition with active alkenes.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is an experimental science, Application In Synthesis of 2-Chloro-5-hydroxypyrimidine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4983-28-2, Name is 2-Chloro-5-hydroxypyrimidine, molecular formula is C4H3ClN2O, belongs to pyrimidines compound. In a document, author is Behera, Prafulla Kumar.

Gold(I) and gold(III) complexes supported by a pyrazine/pyrimidine wingtip N-heterocyclic carbene: Synthesis, structure and DFT studies

Starting from pyrazine and pyrimidine functionalized N-heterocyclic carbene (NHC) proligand 1-(2-Pyrazinyl)-3(methyl) imidazolium chloride (1.HCl), 1-(2-Pyrimidyl)-3(methyl) imidazolium chloride (2.HCl), four novel gold complexes [Au(1)Cl], (1a); [Au(1)Cl-3], (1b), [Au(2)Cl], (2a) and [Au(2)Cl-3] (2b) were synthesized and characterized using NMR spectroscopic techniques and elemental analysis. Additionally, the solid state structures of 1a & 2b were elucidated using single crystal X-ray diffraction analysis, which revealed that in 1a, the carbene nucleus and the chloride ion bound to Au(I) nearly linear having C-Au-Cl bond angle 178.84 degrees. Where as in 2b, the carbene nucleus and the chloride ion bound to the Au(III) adopts the square planar geometry surrounding Au(III). A series of DFT calculations were also performed to gain further insight into the respective structures of the complexes to relate the crystallographic parameters and electronic distribution. (C) 2020 Published by Elsevier B.V.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4983-28-2. Application In Synthesis of 2-Chloro-5-hydroxypyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4270-27-3, Name is 6-Chloropyrimidine-2,4(1H,3H)-dione, molecular formula is C4H3ClN2O2, belongs to pyrimidines compound, is a common compound. In a patnet, author is Kirsch, Volker C., once mentioned the new application about 4270-27-3, COA of Formula: C4H3ClN2O2.

Global Inventory of ClpP- and ClpX-Regulated Proteins in Staphylococcus aureus

Staphylococcus aureus represents an opportunistic pathogen, which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. While detailed transcriptome data for S. aureus ClpP and ClpX knockout mutants is available, corresponding studies on the proteome and secretome level are largely lacking. To globally decipher the functional roles of ClpP and ClpX, we utilized S. aureus genomic deletion mutants of the corresponding genes for in-depth proteomic liquid chromatographymass spectrometry (LC-MS)/MS analysis. These studies were complemented by an inactive ClpP active-site mutant strain to monitor changes solely depending on the activity and not the presence of the protein. A comparison of these strains with the wildtype revealed, e.g., downregulation of virulence, purine/pyrimidine biosynthesis, iron uptake, and stress response. Correspondingly, the integration of metabolomics data showed a reduction in the subset of purine and pyrimidine metabolite levels. Interestingly, a comparison between the ClpP knockout and ClpP S98A active-site mutant strains revealed characteristic differences. These results are not only of fundamental importance to understand the cellular role of ClpXP but also have implications for the development of novel virulence inhibitor classes.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4270-27-3. The above is the message from the blog manager. COA of Formula: C4H3ClN2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Motloch, Petr, once mentioned the application of 1722-12-9, Name is 2-Chloropyrimidine, molecular formula is C4H3ClN2, molecular weight is 114.53, MDL number is MFCD00006060, category is pyrimidines. Now introduce a scientific discovery about this category, Product Details of 1722-12-9.

Cooperative assembly of H-bonded rosettes inside a porphyrin nanoring

The melamine center dot barbiturate H-bonded rosette motif is of comparable dimensions and symmetry to the cavity of a butadiyne-linked 6-porphyrin nanoring. Functionalisation of each of the barbiturate components and the pyrimidine components of a H-bonded rosette with a pyridine ligand leads to a self-assembled hexapyridine ligand, which binds cooperatively to the zinc porphyrin nanoring. UV-vis-NIR and H-1 NMR experiments show that the 7-component assembly forms at concentrations at which neither the H-bonding interactions nor the zinc porphyrin-pyridine interactions are formed in the absence of one of the three components. The mean effective molarities of these rosette complexes are around 200 mM in chloroform at 298 K.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 1722-12-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1722-12-9, Name is 2-Chloropyrimidine, SMILES is ClC1=NC=CC=N1, belongs to pyrimidines compound. In a article, author is Yang, Feng, introduce new discover of the category.

A novel LC-MS/MS method for quantification of unstable endogenous 3,4-dihydroxyphenylacetaldehyde in rat brain after chemical derivatization

3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic intermediary metabolite of dopamine (DA), causes catecholaminergic neurodegeneration via covalent binding with functional proteins or other biomolecules. Accurate quantification of DOPAL is essential to investigate the etiological factors associated with DOPAL and the pathogenetic role of DOPAL in Parkinson’s disease (PD). However, no validated quantitative methods are available. Quantification of DOPAL in biosample is challenging since it is a reactive endogenous aldehyde with poor ionization efficiency and chromatographic behavior in the LC-MS system. Here, a sensitive, simple, and robust UPLC-MS/MS method has been established and validated for the determination of DOPAL in rat brain tissue specimens. DOPAL was found to be unstable in biosample due to reactive aldehyde whereas it was stable in acidic condition. The analyte was stabilized by pH and temperature control during the sample preparation and derivatization. Then, a chemical derivatization method that can be readily performed in acidic conditions and at low temperature was employed using 2-hydrazino-4-(trifluoromethyl)-pyrimidine (HTP) to block the reactive aldehyde and improve the detection sensitivity (about 100-fold increase) and chromatographic retention. Bovine serum albumin was used as a surrogate matrix, which was validated by the parallelism assay and post-column infusion experiment. This method was fully validated and the lower limit of quantification (LLOQ) was 0.5 ng/mL. With the method, a significant increase of DOPAL level was found in striatum region of rats received 6-hydroxydopamine (6-OHDA) injection for 12 h, indicating DOPAL may play a pathogenic role in 6-OHDA-induced PD model. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 1722-12-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1722-12-9.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 947533-45-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, SMILES is FC1=CN=C(Br)N=C1, belongs to pyrimidines compound. In a article, author is Lakomska, Iwona, introduce new discover of the category.

Platinum(II) Complexes with Bulky Disubstitute Triazolopyrimidines as Promising Materials for Anticancer Agents

Herein, we present dicarboxylate platinum(II) complexes of the general formula [Pt(mal)(DMSO)(L)] and [Pt(CBDC)(DMSO)(L)], where L is dbtp 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine) or ibmtp (7-isobutyl-5-methyl-1,2,4- triazolo[1,5-a]pyrimidine), as prospective prodrugs. The platinum(II) complexes were synthesized in a one-pot reaction between cis-[PtCl2(DMSO)(2)], silver malonate or silver cyclobutane-1,1-dicarboxylate and triazolopyrimidines. All platinum(II) compounds were characterized by FT-IR, and H-1, C-13, N-15 and Pt-195 NMR; and their square planar geometries with one monodentate N(3)-bonded 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine, one S-bonded molecule of dimethyl sulfoxide and one O,O-chelating malonato (1, 2) or O,O-chelating cyclobutane-1,1-dicarboxylato (3, 4) was determined. Additionally, [Pt(CBDC)(dbtp)(DMSO)] (3) exhibited (i) substantial in vitro cytotoxicity against the lung adenocarcinoma epithelial cell line (A549) (IC50 = 5.00 mu M) and the cisplatin-resistant human ductal breast epithelial tumor cell line (T47D) (IC50 = 6.60 mu M); and (ii) definitely exhibited low toxicity against normal murine embryonic fibroblast cells (BALB/3T3).

Reference of 947533-45-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 947533-45-1.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia