Tag: M.W:100-200

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 156-83-2, Name is 6-Chloropyrimidine-2,4-diamine. In a document, author is Basu, Kallol, introducing its new discovery. Name: 6-Chloropyrimidine-2,4-diamine.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation-Cyclization Sequence to the Diaminopyrimidine Core

The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic understanding of the cyclization step in the presence of guanidine was established by performing isotopic labeling experiments and identification of impurities. Guided by the mechanistic understanding, further attempts to modify the cyclization reaction by employing additives to reduce the triazine (9) formation and guanidine loading will also be presented. This newly developed method delivered compound 1 in 88-94% yield on a commercial scale and addressed the shortcomings of the early synthetic route including high PMI, low atom economy, long cycle-time, and multiple purifications to achieve the desired quality.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 156-83-2 help many people in the next few years. Name: 6-Chloropyrimidine-2,4-diamine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Massari, Serena, once mentioned the application of 156-83-2, Recommanded Product: 6-Chloropyrimidine-2,4-diamine, Name is 6-Chloropyrimidine-2,4-diamine, molecular formula is C4H5ClN4, molecular weight is 144.56, MDL number is MFCD00006097, category is pyrimidines. Now introduce a scientific discovery about this category.

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, which can dramatically increase during severe pandemic outbreaks. Antiviral drugs are an indispensable weapon to treat infected people and reduce the impact on human health, nevertheless anti-Flu armamentarium still remains inadequate. In search for new anti-Flu drugs, our group has focused on viral RNA-dependent RNA polymerase (RdRP) developing disruptors of PA-PB1 subunits interface with the best compounds characterized by cycloheptathiophene-3-carboxamide and 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide scaffolds. By merging these moieties, two very interesting hybrid compounds were recently identified, starting from which, in this paper, a series of analogues were designed and synthesized. In particular, a thorough exploration of the cycloheptathiophene-3-carboxamide moiety led to acquire important SAR insight and identify new active compounds showing both the ability to inhibit PA-PB1 interaction and viral replication in the micromolar range and at non-toxic concentrations. For few compounds, the ability to efficiently inhibit PA-PB1 subunits interaction did not translate into anti-Flu activity. Chemical/physical properties were investigated for a couple of compounds suggesting that the low solubility of compound 14, due to a strong crystal lattice, may have impaired its antiviral activity. Finally, computational studies performed on compound 23, in which the phenyl ring suitably replaced the cycloheptathiophene, suggested that, in addition to hydrophobic interactions, H-bonds enhanced its binding within the PAC cavity. (c) 2020 Elsevier Masson SAS. All rights reserved.

If you are interested in 156-83-2, you can contact me at any time and look forward to more communication. Recommanded Product: 6-Chloropyrimidine-2,4-diamine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Zhang, Ning, once mentioned the application of 3680-71-5, Name: 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, molecular formula is C6H5N3O, molecular weight is 135.1234, MDL number is MFCD01686814, category is pyrimidines. Now introduce a scientific discovery about this category.

Improving the efficiency of exciplex based OLEDs by controlling the different configurations of the donor

Two D-A-D type donor materials, 10,10 ‘-(pyridine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Pra-2DMAC) with vertical molecular conformation and 10,10 ‘-(pyrimidine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Prm-2DMAC) with near-planar molecular conformation, were designed and synthesized in order to develop the performance of exciplex based OLEDs. Pra-2DMAC shows a better performance than Prm-2DMAC, due to its vertical configuration, which has a beneficial effect on exciplex emission because the separated HOMO and LUMO in donor facilitates the intramolecular charge transfer (ICT) and reverse intersystem crossing (RISC) process at the excited state. An exciplex device with a simple structure based on Pra-2DMAC shows a high maximum external quantum efficiency (EQE) of 15.0% (13.9% at 1000 cd m(-2)), low turn-on voltage of 2.4 V, and stable electroluminescence spectrum of nearly constant CIE coordinate. The better performance of Pra-2DMAC demonstrates the superiority of the donor with vertical configurations in an exciplex system. To our knowledge, this is the first work to study exciplex based OLEDs using dual configuration donor materials.

If you are interested in 3680-71-5, you can contact me at any time and look forward to more communication. Name: 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 3993-78-0, Name is 2-Amino-4-chloropyrimidine, SMILES is C1=CN=C(N=C1Cl)N, in an article , author is Serevicius, Tomas, once mentioned of 3993-78-0, COA of Formula: C4H4ClN3.

Single-exponential solid-state delayed fluorescence decay in TADF compounds with minimized conformational disorder

Thermally activated delayed fluorescence (TADF) compounds with rapid triplet upconversion in solutions frequently yield drastically lowered upconversion rates in solid hosts due to the conformational disorder, resulting in prolonged multiexponential TADF decay profiles. The dispersion of singlet-triplet gaps was shown to be the nature of this unwanted effect, minimized in compounds with more sterically confined molecular structure, though the observation of low solid-state disorder still is scarce. Therefore, here we present the unambiguous realization of rapid single-exponential solid-state TADF decay in the optimized acridine-pyrimidine TADF compound ACRPyr. The compound was designed to have a rigid molecular structure with negligible conformational disorder along with small singlet-triplet energy gaps, leading to rapid solid-state TADF with a lifetime of about 1.76 mu s, a fluorescence quantum yield of about 0.67 and an exceptional rISC rate of 5.7 x 10(6) s(-1). Furthermore, the ACRPyr based sky-blue OLED device showed a peak EQE of 14.3% with minor roll-off.

Interested yet? Read on for other articles about 3993-78-0, you can contact me at any time and look forward to more communication. COA of Formula: C4H4ClN3.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 4318-56-3, Name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, formurla is C5H5ClN2O2. In a document, author is Xu, Xu, introducing its new discovery. Recommanded Product: 4318-56-3.

Ruthenium-Catalyzed Meta-Selective C-H Difluoromethylation of Phenol Derivatives

With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4318-56-3 help many people in the next few years. Recommanded Product: 4318-56-3.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

2927-71-1, Name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, belongs to pyrimidines compound, is a common compound. In a patnet, author is K. Bains, Amreen, once mentioned the new application about 2927-71-1, HPLC of Formula: C4HCl2FN2.

Bioinspired Radical-Mediated Transition-Metal-Free Synthesis of N-Heterocycles under Visible Light

A redox-active iminoquinone motif connected with pi-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the molecule was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcohols happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcohols under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinoline and pyrimidine. This organocatalytic approach is very mild (70 degrees C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

If you¡¯re interested in learning more about 2927-71-1. The above is the message from the blog manager. HPLC of Formula: C4HCl2FN2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 2-bromo-5-fluoropyrimidine, Especially from a beginner¡¯s point of view. Like 947533-45-1, Name is 2-bromo-5-fluoropyrimidine, molecular formula is C8H12N4, belongs to pyrimidines compound. In a document, author is Shafikov, Marsel Z., introducing its new discovery.

Extended ligand conjugation and dinuclearity as a route to efficient platinum-based near-infrared (NIR) triplet emitters and solution-processed NIR-OLEDs

Near infrared (NIR) emission from molecular materials is typically targeted by using more extended conjugated systems compared to visible-emitting materials. But efficiencies usually fall off due to the combined effects of increasing non-radiative and lower oscillator strengths as the energy of emissive excited states decreases. Efficient NIR-emitting organic light emitting diodes (OLEDs) are rare compared to the huge progress that has been made for visible-light devices. For organometallic emitters that contain a heavy metal ion to promote phosphorescence through the effect of enhanced spin-orbit coupling (SOC), the problem is typically exacerbated by decreased metal character in the S-n and T-1 excited states as the conjugation in a bound ligand increases. Here we show how the use of a dinuclear metal complex with an extended conjugated ligand allows such effects to be mitigated compared to analogous structures with just one metal centre. The complex Pt-2(bis-dthpym)(dpm)(2) (complex 5) is readily prepared by a double N<^>C cyclometallation of 4,6-bis(dithienyl)-pyrimidine (H(2)bis-dthpym), with the coordination sphere of each Pt centre being completed by O<^>O-coordinating dipivaloylmethane (dpm). This new complex displays intense NIR emission in solution, lambda(max) = 725 nm, with essentially no contamination by visible light <700 nm. The photoluminescence quantum yield of 0.17 in toluene at 300 K is vastly superior to that of the analogous mononuclear complex, where reduced SOC leads primarily to ligand-based fluorescence and only very weak phosphorescence. Computational results indicate that a key reason for the superior performance of the dinuclear system is a doubling of the number of higher-lying excited singlet states with which the T-1 state may couple, to promote the formally forbidden phosphorescence process. Complex 5 has been evaluated as an NIR emitter in solution-processed OLEDs. An external quantum efficiency (EQE) of 3.6% is attained using 5 doped into TBP:PBD at 5% w/w, with a turn-on voltage of 5.6 V (at 0.01 mW cm(-2)). The maximum radiosity of 2.7 mW cm(-2) for this device is particularly high compared to most reported NIR-emitting phosphorescent OLEDs. If you are hungry for even more, make sure to check my other article about 947533-45-1, Recommanded Product: 2-bromo-5-fluoropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

4318-56-3, Name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, Application In Synthesis of 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, belongs to pyrimidines compound, is a common compound. In a patnet, author is Lee, Won Dong, once mentioned the new application about 4318-56-3.

Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered the sole contributor of folate-mediated 1C units in proliferating cancer cells. Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed. Tumor-specific reliance on cytosolic 1C flux is associated with poor capacity to retain intracellular folates, which is determined by the expression of SLC19A1, which encodes the reduced folate carrier (RFC). We show that silencing SHMT1 in cells with low RFC expression impairs pyrimidine biosynthesis and tumor growth in vivo. Overall, our findings reveal major diversity in cancer cell utilization of the cytosolic versus mitochondrial folate cycle across tumors and SLC19A1 expression as a marker for increased reliance on SHMT1.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4318-56-3 help many people in the next few years. Application In Synthesis of 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 4270-27-3, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 4270-27-3, Name is 6-Chloropyrimidine-2,4(1H,3H)-dione, SMILES is O=C1NC(C=C(N1)Cl)=O, belongs to pyrimidines compound. In a article, author is Yin, Jiechen, introduce new discover of the category.

Non-targeted metabolomic profiling of atrazine in Caenorhabditis elegans using UHPLC-QE Orbitrap/MS

The widespread use of the herbicides Atrazine (ATR) has been raised attention due to its ubiquitous occurrence in the environment. As an endocrine disruptor, ATR causes reproductive, immune, nervous system toxicity in biota. In this study, we aimed to investigate metabolic profile characteristics and potential metabolic biomarker that reflects specific damage in toxic effect after ATR exposure. Hence, a metabolomics study was performed to determine the significantly affected metabolites and the reproduction and locomotion of C. elegans were investigated. Mediation analysis was used to evaluate the mediating effect of metabolites on association between ATR exposure and toxic effect. ATR (>= 0.04 mg/L) caused the significant dose dependent reduction of brood size and locomotion behavior, however, the body length and width were significantly decreased only in 40 mg/L group. These results suggesting that brood size, head thrashes and body bends are more sensitive indictor to assessment ATR toxicity in C. elegans. Meanwhile, metabolomics analysis revealed that ATR exposure can induce metabolic profiles significant alterations in C. elegans. We found that 9 metabolites significantly increased and 18 metabolites significantly decreased, such as phosphatidylcholine, GMP, CDP-choline, neopterin etc. Those alteration of metabolites were mainly involved in the pathways: glycerophospholipid metabolism, glycolysis/gluconeogenesis, folate biosynthesis, glycine, serine and threoninemetabolism, pyrimidine and purine metabolism. Overall, these changes are signs of possible oxidative stress and ATP synthesis disruption modification. Mediation analysis showed a significant indirect effect of ATR exposure on brood size, via 7,8-dihydroneopterin 2′,3′-cyclic-p, and phosphatidylcholine might mediate association between ATR exposure and body bends, suggesting that 7,8-dihydroneopterin 2′,3′-cyclic-p and phosphatidylcholine might be potentially specificity marker for brood size and body bend respectively. This preliminary analysis investigates metabolic characteristics in C. elegans after ATR exposure, helping to understand the pathways involved in the response to ATR exposure and provide potential biomarkers for the safety evaluation of ATR.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 3680-71-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 3680-71-5, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, SMILES is O=C1C2=C(NC=C2)NC=N1, belongs to pyrimidines compound. In a article, author is Puusepp, Sanna, introduce new discover of the category.

Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

The PRPS1 gene, located on Xq22.3, encodes phosphoribosyl-pyrophosphate synthetase (PRPS), a key enzyme in de novo purine synthesis. Three clinical phenotypes are associated with loss-of-function PRPS1 variants and decreased PRPS activity: Arts syndrome (OMIM: 301835), Charcot-Marie-Tooth disease type 5 (CMTX5, OMIM: 311070), and nonsyndromic X-linked deafness (DFN2, OMIM: 304500). Hearing loss is present in all cases. CMTX5 patients also show peripheral neuropathy and optic atrophy. Arts syndrome includes developmental delay, intellectual disability, ataxia, and susceptibility to infections, in addition to the above three features. Gainof-function PRPS1 variants result in PRPS superactivity (OMIM: 300661) with hyperuricemia and gout. We report a 6-year-old boy who presented with marked generalized muscular hypotonia, global developmental delay, lack of speech, trunk instability, exercise intolerance, hypomimic face with open mouth, oropharyngeal dysphagia, dysarthria, and frequent upper respiratory tract infections. However, his nerve conduction velocity, audiologic, and funduscopic investigations were normal. A novel hemizygous variant, c.130A > G p.(Ile44Val), was found in the PRPS1 gene by panel sequencing. PRPS activity in erythrocytes was markedly reduced, confirming the pathogenicity of the variant. Serum uric acid and urinary purine and pyrimidine metabolite levels were normal. In conclusion, we present a novel PRPS1 loss-of-function variant in a patient with some clinical features of Arts syndrome, but lacking a major attribute, hearing loss, which is congenital/early-onset in all other reported Arts syndrome patients. In addition, it is important to acknowledge that normal levels of serum and urinary purine and pyrimidine metabolites do not exclude PRPS1-related disorders.

Application of 3680-71-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 3680-71-5.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia