Tag: M.W:100-200

Synthetic Route of 56-06-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Mary, Y. Sheena, introduce new discover of the category.

DFT, SERS-concentration and solvent dependent and docking studies of a bioactive benzenesulfonamide derivative

Spectroscopic analysis, DFT studies and surface enhanced Raman scattering (SERS) of antimicrobial bioac- tive 4-[(5-tert-butyl)2-hydroxybenzylidene]amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (THPB) have been studied on different silver sols. Intensity and hence enhancement variations are observed for Raman and SERS bands. Observed changes in the ring modes may be due to surface pi-electron interactions and presence of this indicated that molecule is inclined with respect to the metal surface. Changes in orientation are seen in SERS spectra depending on concentration. The molecular docking results show that binding affinity and interactions with the receptors may be supporting evidence for further studies in design further THPB pharmaceutical applications. Reactivity properties are obtained from DFT analysis. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 56-06-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 56-06-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Ali, T. E., introduce new discover of the category.

Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

The reactions of 6-acetyl- 3-amino-4- imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimi dine with triethyl phosphite and some electrophilic reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and ethyl chloroacetate, were studied. These one-pot three-component reactions regioselectively afforded four new 11-acetyl-2-ethoxy-10-methyl-12- phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5.5]triazaphosphepin-2-ones in 69-73% yields.

Application of 56-06-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: C5H6N2O2626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Huo, Jin-Ling, introduce new discover of the category.

Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents

In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC50 = 0.96 mu M), being around 38-fold selectivity over GES-1. Further underlying mechanism studies indicated that 6i inhibited the colony formation, migration of MGC-803, and exerted anti-proliferative effect by inducing G0/G1 phase arrest in MGC-803 cells. Cell apoptosis was induced by 6i through activating mitochondria-mediated intrinsic pathway and the death receptor-mediated extrinsic pathway. 6i induced cell apoptosis by elevating the level of ROS. Also, 6i up-regulated pro-apoptotic Bax and p53 level, while down-regulating anti-apoptotic Bcl-2 protein expression. Furthermore, acute toxicity experiment indicated 6i exhibited good safety in vivo. Therefore, 6i may be a template for future development of [1,2,4]triazolo [1,5-a]pyrimidine-based anti-cancer agents. (C) 2020 Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 626-48-2. HPLC of Formula: C5H6N2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry, like all the natural sciences, Category: pyrimidines, begins with the direct observation of nature¡ª in this case, of matter.36315-01-2, Name is 2-Amino-4,6-dimethoxypyrimidine, SMILES is C1=C(N=C(N=C1OC)N)OC, belongs to pyrimidines compound. In a document, author is Panigrahi, Girish Ch, introduce the new discover.

Leishmanial aspartyl-tRNA synthetase: Biochemical, biophysical and structural insights

Aminoacyl tRNA synthetases (aaRSs) are integral components of protein biosynthesis along with several non-canonical cellular processes. Inhibition studies of aaRSs presented these enzymes as promising drug targets in many pathogens, however aspartyl tRNA synthetase has not been studied in trypanosomatids despite its essentiality. Hence, full-length ORF of Leishmania donovani aspartyl tRNA synthetase (LdaspRS) was cloned and purified to homogeneity followed by molecular mass determination. The aminoacylation assay established that the purified protein performs its function optimally at physiological pH and temperature. The kinetic parameters of LdaspRS revealed the affinity of L-aspartate towards the enzyme to be very much lower than the cofactor. Our study also highlights the moonlighting function of LdaspRS to stimulate the pro-inflammatory cytokines and nitric oxide generation by host macrophage. Furthermore, CD and intrinsic tryptophan fluorescence measurements showed the changes in structural conformation at varying pH, denaturants and ligands. The modelled LdaspRS structure presented all the specific characteristics of class II aaRSs, while in silico study suggested binding of pyrimidine-derived inhibitors in its cofactor binding site with high affinity followed by validation using MD simulation. Altogether, this study could provide a platform for exploring LdaspRS to develop potential therapeutics against leishmaniasis. (C) 2020 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 36315-01-2. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Yagmur, Hatice Karaer, introduce new discover of the category.

Synthesis, characterization, thermal and electrochemical features of poly (phenoxy-imine)s containing pyridine and pyrimidine units

Poly (4-hydroxybenzaldehyde) was prepared by via the oxidative polymerization process in an aqueous alkaline medium by H2O2 as an oxidant. Then, poly(phenoxy-imine)s were synthesized from the condensation reactions of poly(4-hydroxybenzaldehyde) (P-4HBA) with several amines including pyridine and pyrimidine groups. The structures and characterizations of compounds were made by virtue of FT-IR, NMR, UV-Vis spectroscopy, GPC, TG, DSC, CV, SEM and fluorescence (FL) analyses. The conductivities of poly (phenoxy-imine)s were determined with electrometer by four-point probe technique. The conductivity values of poly (phenoxy-imine)s were increased to be connect with doped factor of iodine. Moreover, the electrical conductivity of the poly (phenoxy-imine)s was also measured and defined which they had semi-conductive features. Fluorescence properties of poly (phenoxy-imine)s and P-4HBA were measured out in DMF solutions to define the optimum concentrations in order to acquire the maximal FL intensities. Average molecular weight of the polymers in number (M-n), and in weight (M-w), and polydispersity index (PDI) values of poly (phenoxy-imine)s and P-4HBA were found from GPC analysis. The M-n, M-w and PDI values of P-4HBA were found to be 9900 Da (M-n), 11,300 Da (M-w) and 1.14, respectively. The electrochemical energy gap (E'(g)) and optical band gap (E-g) values of poly (phenoxy-imine)s were determined from cyclic voltammetry (CV) and UV-Vis measurements, respectively.

Synthetic Route of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 626-48-2 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Kishor, P. B. Kavi, once mentioned the application of 2927-71-1, Name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, molecular weight is 166.9685, MDL number is MFCD00233551, category is pyrimidines. Now introduce a scientific discovery about this category, Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Lysine, Lysine-Rich, Serine, and Serine-Rich Proteins: Link Between Metabolism, Development, and Abiotic Stress Tolerance and the Role of ncRNAs in Their Regulation

Lysine (Lys) is indispensable nutritionally, and its levels in plants are modulated by both transcriptional and post-transcriptional control during plant ontogeny. Animal glutamate receptor homologs have been detected in plants, which may participate in several plant processes through the Lys catabolic products. Interestingly, a connection between Lys and serotonin metabolism has been established recently in rice. 2-Aminoadipate, a catabolic product of Lys appears to play a critical role between serotonin accumulation and the color of rice endosperm/grain. It has also been shown that expression of some lysine-methylated proteins and genes encoding lysine-methyltransferases (KMTs) are regulated by cadmium even as it is known that Lys biosynthesis and its degradation are modulated by novel mechanisms. Three complex pathways co-exist in plants for serine (Ser) biosynthesis, and the relative preponderance of each pathway in relation to plant development or abiotic stress tolerance are being unfolded slowly. But the phosphorylated pathway of L-Ser biosynthesis (PPSB) appears to play critical roles and is essential in plant metabolism and development. Ser, which participates indirectly in purine and pyrimidine biosynthesis and plays a pivotal role in plant metabolism and signaling. Also, L-Ser has been implicated in plant responses to both biotic and abiotic stresses. A large body of information implicates Lys-rich and serine/arginine-rich (SR) proteins in a very wide array of abiotic stresses. Interestingly, a link exists between Lys-rich K-segment and stress tolerance levels. It is of interest to note that abiotic stresses largely influence the expression patterns of SR proteins and also the alternative splicing (AS) patterns. We have checked if any lncRNAs form a cohort of differentially expressed genes from the publicly available PPSB, sequence read archives of NCBI GenBank. Finally, we discuss the link between Lys and Ser synthesis, catabolism, Lys-proteins, and SR proteins during plant development and their myriad roles in response to abiotic stresses.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 2927-71-1, Recommanded Product: 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20980-22-7, Name is 2-(Piperazin-1-yl)pyrimidine, SMILES is C1(N2CCNCC2)=NC=CC=N1, belongs to pyrimidines compound. In a document, author is Mohamadpour, Farzaneh, introduce the new discover, Category: pyrimidines.

Supramolecular beta-cyclodextrin as a Biodegradable and Reusable Catalyst Promoted Environmentally Friendly Synthesis of Pyrano[2,3-d]pyrimidine Scaffolds via Tandem Knoevenagel-Michael-Cyclocondensation Reaction in Aqueous Media

The catalytic activity of supramolecular beta-cyclodextrin as a biodegradable and reusable catalyst was studied for the synthesis of pyrano[2,3-d]pyrimidine scaffolds in aqueous media. This green and eco-safe domino approach revealed simplicity, use of biodegradable and highly efficient catalyst, avoidance of toxic organic solvents, versatility and high stability of the catalyst combined with excellent yields, easy work-up procedures with no necessity of chromatographic purification steps, the reusability of the catalyst and being in agreement with the green chemistry protocols, and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 20980-22-7 is helpful to your research. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Tigreros, Alexis, once mentioned the application of 156-83-2, Category: pyrimidines, Name is 6-Chloropyrimidine-2,4-diamine, molecular formula is C4H5ClN4, molecular weight is 144.56, MDL number is MFCD00006097, category is pyrimidines. Now introduce a scientific discovery about this category.

Photophysical and crystallographic study of three integrated pyrazolo [1,5-a]pyrimidine-triphenylamine systems

Three new intramolecular charge transfer (ICT) fluorophores having triphenylamine and pyrazolo [1,5-a]pyrimidine moieties 4a-c were synthesized, and their structures were solved by X-ray crystallography (XRC). Compounds 4a, 4b and 4c crystallize in the tetragonal P4(2)/n, triclinic P-1 and monoclinic P2(1)/c space groups with calculated CE-B3LYP structural energies of -104.3, -125.6 and -123.8 kJ/mol, respectively. Substituents effect on molecular and photophysical properties of 4a-c was studied in both solution and solid-state through fluorescence, UV-vis, XRC, and computational methods. The 2-phenyl (4b) and 2-anisyl (2c) derivatives showed better absorption coefficient (4b, epsilon = 76400 -> 119600 M-1 cm(-1) and 4c, epsilon = 66200 -> 89200 M-1 cm(-1)) than 4a (2-Me, epsilon = 9933 -> 21667 M-1 cm(-1)), while the relative quantum yield (phi) in solvents of diverse polarity is as high as phi = 0.98 for 4a, phi = 0.86 for 4b and phi = 0.83 for 4c. For these dyes, Lippert-Mataga correlation were used to estimate the difference between the excited and ground state dipole moments (Delta mu), being 4b the one that suffer the bigger changes with a Delta mu of 26.9 D. Probe 4c is found to be useful as a fluorescent indicators for the qualitative sensing of water content in organic solvents. The solid-state emission data reveal that the antiparallel molecular packing of the crystal structure for 4a-c, with energy framework diagrams influenced mainly by dispersion forces, could disturbs the photophysical properties by changing the donor-acceptor intramolecular coupling. Therefore, the combination of these XRC and photophysical results may constitute in a key input for designing applications in material science.

Interested yet? Read on for other articles about 156-83-2, you can contact me at any time and look forward to more communication. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 22536-61-4, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 22536-61-4, Name is 2-Chloro-5-methylpyrimidine, SMILES is CC1=CN=C(Cl)N=C1, belongs to pyrimidines compound. In a article, author is Sacre, Lauralicia, introduce new discover of the category.

Influence of C5-Substituents on Repair of O-4-Methyl Adducts of Pyrimidines by O-6-Alkylguanine DNA Alkyltransferases

The DNA repair protein O-6-alkylguanine-DNA alkyltransferase (AGT), found in numerous organisms, can remove methyl groups from the O-6- and O-4-atoms of 2 ‘-deoxyguanosine and thymidine in DNA. AGT variants demonstrate different repair efficiencies towards these lesions. To understand the influence of C5 nucleobase substituents on O-4-methyl removal by AGTs, DNA duplexes containing 5-chloro-, 5-bromo- 5-iodo- and 5-trifluoromethyl-O-4-methyl-2 ‘-deoxyuridine were studied. UV thermal denaturation revealed a stability reduction of 11 degrees C for the O-4-methyl halogen series and 5-trifluoromethyl analog relative to their controls. For the 5-chloro analog efficient repair was observed by human and E.coli AGTs. For the larger halogens (5-bromo and 5-iodo) and 5-trifluoromethyl analog, human AGT showed moderate repair of the O-4-methyl adduct. E.coli OGT and Ada-C readily repaired most adducts with reduced efficiency for the larger groups, except C5-iodo. These results suggest electronic contributions and favourable interactions of the C5-halogens within the AGT active site contribute to efficient dealkylation.

Synthetic Route of 22536-61-4, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 22536-61-4.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 2927-71-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2927-71-1, Name is 2,4-Dichloro-5-fluoropyrimidine, SMILES is C1=C(C(=NC(=N1)Cl)Cl)F, belongs to pyrimidines compound. In a article, author is Zhang, Q. H., introduce new discover of the category.

Effective corrosion inhibition of mild steel by eco-friendly thiourea functionalized glucosamine derivatives in acidic solution

In the view of environmental protection and sustainable development, the application of green effective inhibitors for metal corrosion in industry field is of great significance. In this work, two thiourea functionalized glucosamine derivatives, 5-hydroxy-1-phenyl-4-(1,2,3,4-tetrahydroxybutyl)imidazolidine-2-thio ne (GA-1) and 1-phenyl-3-(2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)thiourea (GA-2), were synthesized as eco-friendly corrosion inhibitors for mild steel (MS) in 1 M HCl solution, and their inhibition performance were evaluated by electrochemical tests and surface analyses. The electrochemical tests and surface analyses indicate that both GA-1 and GA-2 have high inhibition performance. Especially for GA-2, the inhibition efficiency reaches 97.7% with a concentration of 0.64 mM. Theoretical calculations were also conducted to elucidate the adsorption mechanism of GA-1 and GA-2 on MS surface. (C) 2020 Elsevier Inc. All rights reserved.

Synthetic Route of 2927-71-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2927-71-1.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia