Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4316-93-2

Sodium methoxide (2.70 g, 50.0 mmol) was added portionwise over 10 min to a 0C suspension OF 4, 6-DICHLORO-5-NITROPYRIMIDINE (4.85 g, 25.0 mmol) in methanol (90 ml). On complete addition the mixture was stirred at 0C for 2 h. The precipitate was filtered and the filtrate evaporated. The residue was suspended in isohexane and filtered. The filtrate was evaporated and the residue purified by flash column chromatography on silica, eluting with 5% ethyl acetate in isohexane. Collecting appropriate fractions gave 4-chloro-6-methoxy-5- nitropyrimidine (3.50 g, 74%) as a white solid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4316-93-2, 4,6-Dichloro-5-nitropyrimidine.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 155-90-8, name is 2-Amino-4-methoxypyrimidine, molecular formula is C5H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 155-90-8

Method 14; Synthesis of 5-bromo-4-methoxypyrimidine-2-ylamine; [0255] To a solution of 4-methoxypyrimidine-2-ylamine (1.84 g, 14.7 mmol) in chloroform (600 mL) was added N-bromosuccinimide (2.62 g, 14.7 mmol). After stirring in the dark for 5 hours, the solution was added to CH2Cl2 (200 mL) and IN NaOH(10O mL). Upon mixing, the layers were separated and the organic layer was washed with NaCl(sat) (10O mL), dried over Na2SO4, filtered and concentrated yielding 2.88 g(96%) of 5-bromo-4-methoxypyrimidine-2-ylamine. LCMS (m/z): 204/206 (MH+). 1H NMR (CDCl3): delta 8.10 (s, IH), 4.93 (bs, 2H), 3.96 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 155-90-8.

Reference:
Patent; NOVARTIS VACCINES AND DIAGNOSTICS, INC.; WO2008/98058; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H4N2O2S, blongs to pyrimidines compound. Computed Properties of C4H4N2O2S

General procedure: To a mixture of ethyl acetoacetate (1 mmol, 0.13 g) and hydrazine hydrate (1 mmol, 0.05 g) in magnetized water was added an aldehyde (1 mmol) and thiobarbituric acid (1mmol, 0.144 g). The reaction mixture was stirred at 50 C,and the reaction progress was monitored by TLC using chloroform as the eluent. After completion of the reaction, the precipitate formed was filtered and purified by recrystallization from ethanol to afford the desired product

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Bakherad, Mohammad; Doosti, Rahele; Keivanloo, Ali; Gholizadeh, Mostafa; Amin, Amir H.; Letters in Organic Chemistry; vol. 14; 7; (2017); p. 510 – 516;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 105806-13-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 105806-13-1, name is 4,6-Dichloro-5-fluoro-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Part C: A mixture of 4,6-dichloro-5-fluoro-2-methylpyrimidine (1.55 g, 8.56 mmol), ammonium hydroxide (35%, 10.0 mL, 257 mmol), and MeOH (1.00 mL) was heated, in a sealed tube, at 70 C. for 2 h. The reaction mixture was cooled to RT, and a precipitate was formed. The reaction mixture was diluted with water (ca. 10 mL) and was stirred 30 min. The solids were collected by suction filtration, washed with water and air-dried to give 4-amino-6-chloro-5-fluoro-2-methylpyrimidine (845 mg, 61%) as a tan solid. LCMS (m/z): 162,164 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 105806-13-1, 4,6-Dichloro-5-fluoro-2-methylpyrimidine.

Reference:
Patent; ICAGEN, INC.; US2007/197523; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Ethynylpyrimidine

To a solution of 235(100mg, 0.272rnrnoi) and 4(56.6mg, 0543mmo1) in 2OrnL of Et3N was added Pd(PPh3)2C12 (9.53mg, 0.0 i4mmol) and Cui (5.17mg, 0.O27mmol). The mixture was protected with N2 atmosphere, then was heated at 70¡ãC for 4 hours. TLC analysis showedcomplete conversion of starting material to major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 133(24mg, yield: 25.7percent).LCMS: m/z 345 (M+HY;111 NMR (400 MHz, CDCI3): oe 8.76 (d, J= 4.0 Hz, 2H), 754 . 7.52. (m, 211), 7.35 7.32 (m,211), 7 25 (t J 4 6 Hz 1TI) 6 52 (d, / 0 4 lTz 111), 2 P (d, 1 0 4 Hz, 311)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37972-24-0, 2-Ethynylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 335654-06-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 335654-06-3 as follows.

2-chloro-7H-pyrrolo[2,3-T]pyrimidine (330 mg; 2.15 mmol) and JV-iodosuccinimide (580 mg; 2.58 mmol) are taken up in 3.3 mL DMF and stirred for 1 h at 200C. The reaction mixture is extracted with sodium thiosulphate solution and ethyl acetate. The combined organic phases are dried, the solvent is eliminated in vacuo and A.21 (EtaPLC- MS: tRet. = 1.60 min; MS(M+Eta)+ = 280; method FEC3) is obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,335654-06-3, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 306960-77-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 306960-77-0, name is 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid, molecular formula is C6H3F3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-(Trifluoromethyl)pyrimidine-5-carboxylic acid (44.39 g, 231 .1 mmol),methoxymethanine hydrochloride (33.8 g, 346.6 mmol) and DIPEA (119.5 mL, 924.3 mmol) were combined in DCM (750 mL) then HATU (105.4 g, 277.3 mmol) was added and the mixture stirred at RT for 2 h. The reaction mixture was washed with water (3 x 300 mL), the organic phase collected, dried (over Mg504), filtered andconcentrated in vacuo to give a viscous yellow oil. The crude material was purified by dry flash chromatography (eluting with 0 – 40 % EtOAc in heptane) to give 54.2 g (95% yield) of the title compound as a free flowing pale yellow oil.1H NMR (500 MHz, Chloroform-d): 6 [ppm] 9.22 (5, 2H), 3.61 (5, 3H), 3.43 (5, 3H). LCMS (Analytical Method A) Rt = 1 .03 mm, MS (ESipos): m/z = 235.9 (M+H).

According to the analysis of related databases, 306960-77-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 13036-57-2 , The common heterocyclic compound, 13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of ethyl 3-{[(2,6-diotafluorophenyl)sulfonyl]amiotano}-4-fluorobenzoate (5 0 g, 13 9 mmol) in THF (100 mL) was added 1 0 M LHMDS in THF (34 8 mL, 34 8 mmol) A solution of 2-chloro-4-methylpyriotamiotadiotane (2 7 g, 20 9 mmol) in THF (100 mL) was added dropwise over 30 mm, and the reaction was stirred overnight at rt The reaction was quenched with 10 mL of MeOH and concentrated, and the residue was partitioned between EtOAc and saturated aqueous sodium bicarbonate The aqueous layer was extracted with 2×50 mL EtOAc, and the combined organic layers were passed through a pad of silica gel, concentrated, and adsorbed onto silica gel The crude product was purified via flash chromatography with 0-100% EtOAc/DCM to generate 3 07 g (50% yield) of the product of Step B as a white powder ES- LCMS m/z 443 (M+H)

The synthetic route of 13036-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory; WO2010/104899; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 37131-89-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37131-89-8, name is 2,4-Dichloropyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.

To a 50 ml three-necked flask was added successively the crude product (0.6 g, 3.1 mmol) in the previous step,Thionyl chloride (10 ml) and heated to 80 C for 4 hours.Concentrated to dryness under reduced pressure to give 0.6 g of 2,4-dichloro-5-pyrimidinecarboxylic acid chloride in a yield of 90%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37131-89-8, 2,4-Dichloropyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 56621-89-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56621-89-7, name is 5-Amino-2-methoxypyrimidine, molecular formula is C5H7N3O, molecular weight is 125.1286, as common compound, the synthetic route is as follows.

Step 1. l-(4-Bromophenyl)-N-(2-methoxypyrimidin-5-yl)cyclobutane-l- carboxamide: Into a 200 mL round bottom flask equipped with a magnetic stir bar and under N2 was added 2-methoxypyrimidin-5-amine (1.23 g, 9.80 mmol) and l-(4-bromophenyl)cyclo- butanecarboxylic acid (2 g, 7.84 mmol). The solids were dissolved in EtOAc (20 mL) and treated with pyridine (1.24 g, 15.68 mmol, 1.27 mL) followed by propylphosphonic anhydride (7.48 g, 1 1.76 mmol, 6.99 mL, 50% purity) in EtOAc. The yellow-orange solution was stirred at 24 C for 5 hr, the reaction was worked up by adding HC1 ( 1M, 20 mL). The EtOAc layer was concentrated and purified by column chromatography eluting with 10% to 100 % (0296) EtOAc/hexanes gradient over 10 min. The desired fractions were combined, concentrated and further dried under high vacuum O/N, yielding a white solid (2 g). LCMS (ESI+) m/z = 362,364 (M+l, M+3).

The chemical industry reduces the impact on the environment during synthesis 56621-89-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TEMPEST THERAPEUTICS, INC.; POWELL, David Andrew; ROPPE, Jeffrey Roger; SEIDERS, Thomas Jon; DING, Jinyue; SHENG, Tao; JACINTHO, Jason Duarte; (65 pag.)WO2019/79614; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia