Tag: M.W:100-200

Electric Literature of 62802-42-0, Adding some certain compound to certain chemical reactions, such as: 62802-42-0, name is 2-Chloro-5-fluoropyrimidine,molecular formula is C4H2ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62802-42-0.

Preparation 152 N-[(4aR,7aR)-6-(5-Fluoropyrimidin-2-yl)-7a-isothiazol-5-yl-4,4-a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 5-Fluoro-2-chloropyrimidine (58 mL, 608.3 mol), and diisopropylethylamine (227 mL 1.30 mol, 227.3 mL) is added to N-[(4aR,7aR)-7a-isothiazol-5-yl-4-a,5,6,7-tetrahydro-4H-pyrrolo[3,4-d][1,3]thiazin-6-ium-2-yl]benzamide chloride (174.2 g, 434.5 mol), in N-methylpyrrolidone (1.4 L) at 22 C. and stirred. The reaction is heated at 100 C. for 4 hours and then cooled to room temperature. The crude mixture is added to water (14 L) and then stirred 1 hour. A white solid is collected by filtration and dried under vacuum to constant weight. The crude product is purified by silica gel chromatography, eluting with ethyl acetate: methylene chloride (3/1) to give the title compound (139 g, 72%). ES/MS (m/e): 441.0 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62802-42-0, 2-Chloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eli Lilly and Company; BECK, James Peter; GREEN, Steven James; LOPEZ, Jose Eduardo; MATHES, Brian Michael; MERGOTT, Dustin James; PORTER, Warren Jaye; RANKOVIC, Zoran; SHI, Yuan; WATSON, Brian Morgan; WINNEROSKI, JR, Leonard Larry; US2013/261111; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4,6-Diaminopyrimidine-2-thiol

Potassium hydroxide (88.8 g, 1.58 mol) and 4,6-diamino-2-mercaptopyrimidine (45.0 g, 316 mmol) were sequentially added to 230 ml of water and heated at 85 C. for 2 h.Add 220 ml of methanol, 1-bromo-3,3,3-trifluoropropane (280 g, 1.58 mol) and KI(2.63 g, 15.8 mmol), continued stirring at 60 C for 24 h. The reaction solution was concentrated under reduced pressure.After cooling to room temperature, the filter cake was dried to obtain 71.6 g of a yellow solid with a yield of 95%.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Lu Kuanying; Ma Zhilong; Jin Xunqi; Zhou Chao; (21 pag.)CN107973832; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 58347-49-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58347-49-2, name is 7-Chloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1 Preparation of 7-(3,5-di-t-butyl-4-hydroxyphenyl)-aminopyrazolo[1,5-a]pyrimidine: A suspension of 7-chloropyrazolo[1,5-a]pyrimidine (1.0 g), 3,5-di-t-butyl-4-hydroxyaniline hydrochloride (1.8 g) and diethylaniline (2.3 ml) in toluene (50 ml) is heated at 120 C. for 30 minutes. After cooling, the solvent is distilled off, and the residue is purified by silica gel column chromatography (solvent; CHCl3) to give 7-(3,5-di-t-butyl-4-hydroxyphenyl)aminopyrazolo[1,5-a]pyrimidine (890 mg) as colorless crystal. M.p. 264-266 C. (decomposed) 1 H-NMR (CDCl3): delta 1.48 (s, 18H), 5.63 (s, 1H), 5.92 (s, 1H), 6.55 (d, J=2.3 Hz, 1H), 7.47 (s, 2H), 8.14 (d, J=2.3 Hz, 1H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58347-49-2, 7-Chloropyrazolo[1,5-a]pyrimidine.

Reference:
Patent; Otsuka Pharmaceutical Factory, Inc.; US5688949; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6328-58-1, Adding some certain compound to certain chemical reactions, such as: 6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one,molecular formula is C6H8N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6328-58-1.

Propargyl bromide (2) (1.2 mmol, 0.10 mL) was added slowlyto a stirred mixture of 6-methyl-2-(methylthio)pyrimidine-4(3H)-one (1) (1.0 mmol, 0.15 g) and K2CO3 (2.0 mmol,0.27 g) in dry DMF (4 mL) at room temperature, and the mixturewas stirred at room temperature for 10 h. Upon completionof the reaction, the solvent was evaporated under vacuum,and the resulting residue was washed with water. The residuewas finally purified by flash column chromatography (hexane/ethyl acetate = 10:1) to give the titles compounds. Compound (3): TLC (hexane/ethyl acetate = 10:1)Rf = 0.7; yield 70%; white powder; m.p. 80-82 C; 1H NMR(300 MHz, CDCl3): delta 2.38 (s, 3H, CH3), 2.51 (t, J = 2.4 Hz,1H, CH), 2.56 (s, 3H, CH3), 5.00 (d, J = 2.4 Hz, 2H, CH2),6.30 (s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 14.0,23.8, 53.6, 74.9, 78.1, 102.0, 167.9, 168.1, 171.3; IR (KBr):3167, 2925, 2116, 1581, 1404, 1339, 1041 cm-1. Anal.calcd for C9H10N2OS: C, 55.65; H, 5.19; N, 14.42; found:C, 55.82; H, 5.28; N, 14.58%.Compound (4): TLC (hexane/ethyl acetate = 10:1) Rf = 0.52;yield 30%; white powder; m.p. 122-124 C; 1H NMR(300 MHz, CDCl3): delta 2.15 (s, 3H, CH3), 2.20 (t, J = 2.4 Hz, 1H,CH), 2.53 (s, 3H, CH3), 4.76 (d, J = 2.4 Hz, 2H, CH2), 6.00(s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 15.1, 23.8, 32.6,72.3, 107.6, 161.1, 161.3, 162.7; IR (KBr): 3124, 3001, 1645,1581, 1543, 1461 cm-1. Anal. calcd for C9H10N2OS: C, 55.65;H, 5.19; N, 14.42; found: C, 55.79; H, 5.11; N, 14.28%.

According to the analysis of related databases, 6328-58-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 431 – 436;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 767-15-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 767-15-7, name is 2-Amino-4,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.

2-Amino-5-bromo-4,6-dimethylpyrimidine (3):; To a stirred solution containing 4.3 lg (34.75 mmol) of 2-amino-4,6-dimethylpyrimidine (2) in 150 mL of acetonitrile were added 6.15g (52.12 mmol) of N-bromosuccinimide. The reaction mixture was stirred at room temperature under argon atmosphere for 3 h. The formed precipitate was filtered and dried to afford the expected product as a white solid: yield 5.93g (83%).1H-NMR(CDC13) delta 5.19 (br, 2H), 2.44 (s, 6H);13C-NMR (CDC13) delta 166.28, 160.73, 109.60, 24.70.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,767-15-7, 2-Amino-4,6-dimethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ARIZONA BOARD OF REGENTS; HECHT, Sidney; ARMSTRONG, Jeffrey; KHDOUR, Omar; LU, Jun; ARCE, Pablo; WO2011/103536; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1193-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-24-4, name is 4,6-Dihydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

With a reflux condenser, thermometer,In the device of the agitator and the constant pressure dropping funnel,Add 4,6-dihydroxypyrimidine (114.3 g, content 98%, 1 mol), phosphorus oxychloride (1140 g, 99%) and mix well.The temperature was raised to 95-100 C, and phosgene (220 g, 99%, 2.2 mol) was slowly added to carry out the reaction, and the sample was taken after 8 hours.HPLC analysis of 4,6-dihydroxypyrimidine content of 0.9%,The content of 4,6-dichloropyrimidine was 98.3%, and the reaction was over.Vacuum distillation reaction mixture (oil bath temperature 95 C,Vacuum degree -0.095MPa),Obtained 1082 g of phosphorus oxychloride (content 99%); 142.8 g of 4,6-dichloropyrimidine (content 99.0%),Yield 94.9% (based on 4,6-dihydroxypyrimidine), wherein W (DCP) refers to the mass of DCP, and W (DHP) refers to the mass of DHP.The content refers to the mass content of DCP, and 112 is the molecular weight of DHP.149 is the molecular weight of DCP.

According to the analysis of related databases, 1193-24-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lianyungang Guosheng Chemical Co., Ltd.; Xu Chen; Zhu Guoqing; Zhang Xin; Zhou Tulin; (6 pag.)CN108178749; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30129-53-4, name is 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.SDS of cas: 30129-53-4

General procedure: To a solution of 7a (50.0 mg, 0.32 mmol) and aminomethyl-benzoic acids 8a (40.6 mg, 0.27 mmol) in triethylamine (66.8 mkL,0.48 mmol), anhydrous DMF (1.5 mL) was added and the reaction mixture was stirred at 80 C for 4 h. The reaction mixture was diluted with ethyl acetate (8 mL) and was washed with water (3×4 mL). The ethyl acetate layer was then dried with anhydrous Na2SO4, and concentrated to give a residue that was subjected to purification through the column chromatography on silica gel with DCM and MeOH (10:1) as eluent to afford the titled compounds 1a (31.1 mg, 43%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Qian, Shan; He, Tao; Wang, Wei; He, Yanying; Zhang, Man; Yang, Lingling; Li, Guobo; Wang, Zhouyu; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6194 – 6205;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Hydroxypyrimidine-4-carboxylic acid

The 6-chloropyrimidine-4-carbonyl chloride used as a starting material was prepared as follows: Phosphorus oxychloride (10 ml) was added carefully to a stirred sample of 6-hydroxypyrimidine-4-carboxylic acid (1 g) and the mixture was heated to reflux for 16 hours. Phosphorus pentachloride (5.8 g) was added and the resultant mixture was heated to reflux for a further 16 hours. The excess of phosphorus oxychloride was evaporated under reduced pressure and the residue was distilled. A solid formed in the cooling condenser. There was thus obtained 6-chloropyrimidine-4-carboxylic acid (0.5 g); NMR (DMSOd6) 8.07 (s, 1H), 9.2 (s, 1H), 14.0-14.3 (br s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid.

Reference:
Patent; Astra Zeneca AB; US6455520; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5466-43-3, name is 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, molecular formula is C7H6Cl2N2, molecular weight is 189.04, as common compound, the synthetic route is as follows.Computed Properties of C7H6Cl2N2

A mixture of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[if|pyrimidine (0.250 g, 1.32 mmol) and sodium thiomethoxide (0.093 g, 1.32 mmol) in THF (10 mL) was stirred at rt for 6 h. After this time, the mixture was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated. The residue was purified by column chromatography (silica, hexanes/ethyl acetate) to afford the title compound (0.210 g, 84%) as an off-white solid. MW = 200.69. NMR (DMSO- , 300 MHz) delta 2.90 (t, / = 7.6 Hz, 2H), 2.71 (t, / = 7.6 Hz, 2H), 2.56 (s, 3H), 2.10 (quin, / = 7.6 Hz, 2H); APCI MS mJz 201 [M + H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5466-43-3, 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei; WO2014/66659; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 51-20-7, 5-Bromouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 51-20-7, blongs to pyrimidines compound. HPLC of Formula: C4H3BrN2O2

To 5-bromouracil (50 G) were sequentially added N, N-diethylaniline (60 mL) and phosphoryl chloride (120 mL), and the mixture was refluxed for 5 h. The volatiles were removed by distillation, the residue poured into ice water and the mixture extracted with methyl tert-butyl ether. The combined extracts were washed with brine, dried (NA2SO4) and filtered through Celite. Distillation of the crude product gave the title compound (63.4 g). IH NMR (300 MHz, CDCl3) : O/PPM = 8.69 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51-20-7, its application will become more common.

Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/48343; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia