Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 504-17-6, blongs to pyrimidines compound. Product Details of 504-17-6

General procedure: A mixture of aldehyde (0.25 mmol), 2-thiobarbituric acid(0.5 mmol), ammonium acetate (0.3 mmol) and CuFe2O4 (10 mol%)in distilled H2O was stirred for an appropriate time. After completionof the reaction (monitored by TLC), the resulted precipitatewasfiltered and dissolved in hot methanol and the catalyst was separatedand collected by an external magnetic and washed withacetone and EtOH several times and dried in an oven at 70 C toreuse in next reactions. The pure solid product was obtained viaevaporation the 2/3 of methanol and filtration. The solid productwas recrystallized from water/ethanol as solvent to afford the pureproducts. All of the products were identified by physical andspectroscopic data. Cream powder; M.P: 211 C Lit. [51] (M.Prep: 238 C, decompose).IR (KBr) n (cm1): 3452 (NH), 3054 (CeH, sp2 stretch), 2898(CeH, sp3), 1637 (C]O), 1440, 1559 (C]C, Ar). 1H NMR (DMSO-d6,400 MHz) d (ppm): 5.93 (s, 1H), 6.95e6.99 (d, 2H, J 6.0 Hz), 7.05 (s,1H), 7.15 (s, 2H), 7.60 (s, 1H), 7.91 (s, 1H), 11.33e12.00 (s, 3H).

The synthetic route of 504-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Naeimi, Hossein; Didar, Asieh; Journal of Molecular Structure; vol. 1137; (2017); p. 626 – 633;,
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Related Products of 51674-77-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 51674-77-2, name is 4-Chloropyrido[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.

To a solution of Intermediate 9 (500 mg, 1.48 mmol) in NMP (6 mL) were added (cyclopropyl)(piperazin-l-yl)methanone (455 mg, 2.95 mmol) and DIPEA (1.3 mL), and the mixture was heated at 140C for 16 h. The reaction mixture was taken up in EtOAc^ (150 mL) and water (50 mL) and the organic layer was washed with water (2 x 50 mL) and brine (50 mL). The organic layer was separated and dried (phase separation cartridge), and the solvent was removed in vacuo. Purification by columnchromatography (Si02, 10-20% EtOAc in isohexane) gave a beige solid (390 mg, 57%). To a solution of this material (390 mg, 0.85 mmol) in DCM (6 mL) was added TFA (3 mL) and the resulting solution was stirred at r.t. for 15 minutes. The solvents were30removed in vacuo. The residue was dissolved in MeOH (5 mL), then placed on an SCX cartridge, washed (MeOH), eluted (7M ammonia in MeOH) and concentrated in vacuo to afford a white solid (304 mg, 100%). To a portion of this material (60 mg, 0.17 mmol) in NMP (1.2 mL) were added DIPEA (0.14 mL) and 4-chloropyrido[3,2-c/]pyrimidine (33 – – mg, 0.2 mmol). The resulting solution was heated under microwave irradiation at 150C for 1 h. Purification by preparative HPLC afforded the title compound (51 mg, 61%) as a beige solid. deltaEta (DMSO-ifc) 8.93-8.88 (2H, m), 8.54 (2H, d, J 11.51 Hz), 8.17 (IH, dd, J 8.46, 1.58 Hz), 7.90 (IH, dd, J 8.46, 4.25 Hz), 7.74 (IH, dd, J 8.94, 6.26 Hz), 7.33 (IH, t, J9.12 Hz), 5.91 (IH, m), 4.05-3.13 (8H, s), 2.58 (3H, m), 2.12-2.07 (IH, m), 1.67 (3H, d, J 6.71 Hz), 0.90-0.73 (4H, m). LCMS (ES+) 486 (M+H)+, RT 2.78 minutes (Method 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51674-77-2, its application will become more common.

Reference:
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2011/58108; (2011); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4-(trifluoromethyl)pyrimidine

2-Chloro-4-(trifluoromethyl)pyrimidine (20 mmol), 2,4-difluorophenylboronic acid (30 mmol), Na2CO3 (36 mmol) andPd(PPh3)4 (0.20 mmol) were dissolved in toluene: ethanol: water(30 mL, 2: 1: 2, v/v). The mixture was refluxed for 24 h andextracted twice with CH2Cl2 at room temperature. The mixedorganic solutionwas washed with brine and the solid obtained waspurified with column chromatography on SiO2 using ethyl acetateand petroleumether (v : v 10 : 1) as eluant to afford white solid 2-(2,4-difluorophenyl)-4-(trifluoromethyl)pyrimidine (dfptfmpm,yield: 75percent). 1H NMR (400 MHz, CDCl3) delta 9.01 (d, J 5.0 Hz, 1H), 8.14(td, J=8.7, 6.6 Hz, 1H), 7.48 (d, J=5.0 Hz, 1H), 6.98-6.83 (m, 2H). 19FNMR (376 MHz, CDCl3) delta 70.12 (s, 3F), 105.06 (d, J=11.0 Hz,1F), 108.14 (d, J=11.0 Hz, 1F). MS (ESI) m/z calcd for C11H5F5N2H[M+H]: 261.05, found: 260.95.

With the rapid development of chemical substances, we look forward to future research findings about 33034-67-2.

Reference:
Article; Zhou, Yong-Hui; Xu, Jing; Wu, Zheng-Guang; Zheng, You-Xuan; Journal of Organometallic Chemistry; vol. 848; (2017); p. 226 – 231;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4HCl2N3O2

Compound (1a), 2,4-dichloro-5-nitropyrimidine, (100 g, 0.52 mol) is dissolved in 1.0 L cyclohexane and potassium carbonate (83 g, 0.60 mol) is added. The resulting suspension is stirred at a temperature between 5 and 15 C. and compound (2a), isopropylamine, (44.2 ml, 0.52 mol) is slowly added. After complete addition stirring is continued under warm up of the reaction mixture to room temperature. Water (400 mL) is added (caution: exothermic reaction). The reaction mixture is filtered. Ethyl acetate (400 mL) is added to the filtrate. The organic phase is separated, dried and evaporated.Yield: 90.9 g (81% of theory) of compound (3a) as a brown crystalline solid. 1H-NMR confirmed the structure of compound (3a).

With the rapid development of chemical substances, we look forward to future research findings about 49845-33-2.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/329803; (2012); A1;,
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Electric Literature of 41103-17-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41103-17-7, name is Ethyl 4-chloropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below.

2.1 g of the compound obtained in step 2) above and 2.64 g of 3-chloro-4- (pyridin-2-ylmethoxy)benzenamine were dissolved in 20 mL of 2-propanol, and the mixture was stirred for 3 hours. After the reaction was completed, the resulting solution was cooled to room temperature and distilled under a reduced pressure. The resulting residue was subjected to column chromatography (ethyl acetate : dichloromethane: methanol = 7 : 7 : 1) to obtain the title compound (2.0 g).1H-NMR (300MHz, CDC13) delta 10.32 (s, 1H), 9.01 (s, 1H), 8.79 (s, 1H), 8.60 (d, 1H), 7.82 (d, 1H), 7.75 (t, 1H), 7.73 {d, 1H), 7.43 (dd, 1H), 7.01 (dd, 1H), 5.29 (s, 2H), 4.34 (m, 2H), 1.26 (t, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41103-17-7, its application will become more common.

Reference:
Patent; HANMI HOLDINGS CO., LTD.; CHA, Mi Young; KIM, Mi Ra; KANG, Seok Jong; KIM, Se Young; JUNG, Young Hee; LEE, Kwang Ok; SONG, Ji Yeon; KIM, Young Hoon; KIM, Eun Young; KIM, Maeng Sup; WO2011/99764; (2011); A2;,
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Adding a certain compound to certain chemical reactions, such as: 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 2-chloropyrimidine-5-carboxylate, blongs to pyrimidines compound. name: Methyl 2-chloropyrimidine-5-carboxylate

A solution of methyl 2-chloropyrimidine-5-carboxylate (200 mg, 1.16 mmol) in dichloromethane (4.00 mL) was added to a stirred solution of 1-cyclopropyl-1,4-diazepane (247 mg, 1.16 mmol) and N-ethyl-N-propan-2-ylpropan-2-amine (0.902 mL, 5.22 mmol) in dichloromethane (4.00 mL) at 25 C. The resulting solution was stirred at ambient temperature for 18 h. The reaction mixture was evaporated to dryness and redissolved in MeOH (20 mL) and the crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH and evaporated to dryness to afford methyl 2-(4-cyclopropyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate (312 mg, 97%) as a cream solid. This was used directly with no further purification. 1H NMR (399.9 MHz, DMSO-d6) delta 0.28-0.31 (2H, m), 0.40-0.45 (2H, m), 1.80-1.84 (2H, m), 1.85-1.89 (1H, m), 2.71 (2H,m), 2.85-2.88 (2H, m), 3.81 (3H, s), 3.82-3.88 (4H, m), 8.79 (2H, s). MS: m/z 277 (MH+)

The synthetic route of 287714-35-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
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Related Products of 116247-92-8 ,Some common heterocyclic compound, 116247-92-8, molecular formula is C9H11N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 3-amino-5- (5-methyl-lH-pyrazol-4- yl) thiophene-2-carboxamide (111 mg, 0.50 mmol) , l-(2- pyrimidinyl) -piperidin-4-one (266 mg, 1.50 mmol), CSA (11.6 mg, 0.05 mmol), MgSO4 (120 mg, 1.00 mmol) and DMA (4 mL) was stirred at 1000C for 1 h. The mixture was poured into saturated aqueous NaHCO3 and extracted with 3:1 EtOAc/THF, and the extract was dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Purif, silica gel, EtOAc to 80:20 EtOAc/MeOH) . The obtained yellow solid was triturated with MeOH/EtOAc and collected by filtration to afford the title compound (141 mg, 74%) as a pale yellow solid: 1H NMR (300 MHz, DMSO-d6) 6 1.74-1.98 (4H, m) , 2.34-2.40 (3H, m) , 3.55-3.64 (2H, m) , 4.12-4.20 (2H, m) , 6.60-6.63 (2H, m) , 7.24 (IH, br s) , 7.52 (IH, br s) , 7.71 (0.67H, br s) , 8.08 (0.33H, br s) , 8.35-8.37 (2H, m) , 12.79 (0.33H, br s) , 12.87 (0.67H, br s) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116247-92-8, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; OGURO, Yuya; KURASAWA, Osamu; WO2010/101302; (2010); A1;,
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Related Products of 5750-76-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-76-5, name is 2,4,5-Trichloropyrimidine. A new synthetic method of this compound is introduced below.

Potassium carbonate (2.26 g, 16.4 mmol) and 2,4,5-trichloropyrimidine (1.5 g, 8.19 mmol) were added to a solution of 3-nitrophenol (1.2 g, 8.19 mmol) in N,N-dimethylformamide (20 mL). The reaction mixture was heated to 60 C. for 2 hours and after cooling was filtered and the filtrate was dilute with ethyl acetate (3*500 mL) and washed with water (20 mL) three times. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo to afford 2.0 g (yield 87%) of a light yellow solid. 1H NMR 400 MHz (DMSO-d6) delta 8.88 (s, 1H), 8.30 (d, J=2 Hz, 1H), 8.29-8.21 (m, 1H), 7.85-7.81 (m, 2H); LCMS m/e: 286 [M]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5750-76-5, its application will become more common.

Reference:
Patent; Sabila Biosciences LLC; MANSOUR, Tarek Suhayl; (66 pag.)US2018/208564; (2018); A1;,
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Electric Literature of 1193-24-4 , The common heterocyclic compound, 1193-24-4, name is 4,6-Dihydroxypyrimidine, molecular formula is C4H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: According to the conventional manufacturing method of the present inventors [16], under the condition containing two equivalents of triethylamine in dichloromethane at 25 , 4,6- dihydroxy-pyrimidine with 2 equivalents of Compound 2 by acylating a new and compounds 4, 6-pyrimidyl di (2-halo-benzoate) (compound 3) is prepared. After evaporation of dichloromethane, the mixture is dissolved in anhydrous THF, to remove the triethylamine hydrochloride by filtration. The concentrated residue was purified by short length silica gel (Davisil, pH = 7) was purified by column chromatography, or the Compound 3 is prepared by purification was recrystallized with 75% EtOAc / n- hexane

The synthetic route of 1193-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksung Women’s University Academic Cooperation; Lee, Jae In; Song, Yun jU; Choe, Jin Son; (12 pag.)KR2015/106483; (2015); A;,
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Electric Literature of 3435-25-4 ,Some common heterocyclic compound, 3435-25-4, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 4-chloro-6-methylpyrimidine (1 g, 7.77 mmol) in 1, 4- dioxane (30 mL) under argon atmosphere were added diisopropyl ethyl amine (1.35 g, 10.50 mmol) and tert-butyl piperidin-4-ylcarbamate (1.7 g, 8.55 mmol) at RT. The reaction mixture was stirred at 150 C for 3 h. After consumption of the starting material (monitored by TLC), the reaction was diluted with water (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified through silica gel column chromatography using 5% MeOH:DCM to afford tert-butyl (1 -(6-methylpyrimidin-4-yl) piperidin-4-yl) carbamate (1.75 g, 77%) as an off-white solid. ?H-NMR (DMSO-d6, 400 MHz): oe 8.34 (s, 1H), 6.69 (s, 1H),4.28-4.24 (m, 2H), 3.54-3.52 (m, 1H), 3.00-2.93 (m, 2H), 2.23 (s, 3H), 1.77-1.75 (m, 2H),1.38 (s, 9H), 1.30-1.22 (m, 3H); LC-MS: 293.3 (M+1); (column; X-Bridge C-18 (50 x 3.0 mm, 3.5 .im); RT 3.32 mm. 5 mM NH4OAc: ACN; 0.80 mL/min); TLC: 50% EtOAc:hexanes (R1: 0.2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3435-25-4, its application will become more common.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66696; (2015); A1;,
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