Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31058-83-0, name is 6-Chloro-N,N-dimethylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 31058-83-0

Example 33: N.N-Dimethyl-e-KIS.eRVe-tP-iS-methyl-l ^^-oxadiazol-S- l)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidin-4-amine.A mixture of Intermediate 12 (50 mg, 0.17 mmol), 2-chloro-4,6- dimethylpyrimidine (24 mg, 0.17 mmol) and DIPEA (0.87 mL, 0.5 mmol) in ACN (1 mL) was heated in the microwave at 200 C for 2 h. The mixture was concentrated in vacuo and chromatography (Hex to 100% EtOAc/Hex) to afford the desired product as a pale yellow foam (39 mg, 55%). MS (ESI) mass calculated for C22H25N7O2, 419.2; m/z found, 420.2. 1 H NMR (500 MHz, CDCI3): 8.15 (s, 1 H), 8.12 – 8.04 (m, 1 H), 7.59 – 7.50 (m, 2H), 7.25 – 7.17 (m, 1 H), 5.22 (s, 1 H), 4.44 – 4.33 (m, 2H), 4.1 1 – 3.99 (m, 1 H), 3.94 – 3.73 (m, 2H), 3.68 – 3.60 (m, 1 H), 3.1 1 – 3.05 (m, 6H), 3.02 – 2.86 (m, 2H), 2.45 – 2.42 (m, 3H), 2.22 – 1 .97 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31058-83-0, 6-Chloro-N,N-dimethylpyrimidin-4-amine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; WO2011/50202; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 99586-66-0, Adding some certain compound to certain chemical reactions, such as: 99586-66-0, name is 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile,molecular formula is C6H5ClN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 99586-66-0.

General procedure: To a solution of 7a (80mg, 0.18mmol, 1 equiv), 4-amino-6-chloropyrimidine-5-carbonitrile (31mg, 0.2mmol, 1.1 equiv) in BuOH was added DIPEA (0.06mL, 0.36mmol, 2 equiv). The mixture was reacted under microwave at 130C for 20min. After completion, the solvent was removed under reduced pressure. The residue was redissolved in CH2Cl2. The crude was further purified via silica gel chromatography to give compound 8a as white solid (81mg, 80%).

According to the analysis of related databases, 99586-66-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wei, Manman; Zhang, Xi; Wang, Xiang; Song, Zilan; Ding, Jian; Meng, Ling-Hua; Zhang, Ao; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1156 – 1171;,
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Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H4Cl2N2

[0059] Synthesis ofS5: ethyl 2-aminothiazole-5-carboxylate (1.0 g, 5.8 mmol) and 4,6- dichloro-2-methylpyrimidine (0.95 g, 5.8 mmol) were added to an oven dried flask. (0113) Dimethylformamide (20 mL) was then added. The reaction mixture was then cooled to 0 C, and sodium hydride (0.510 g, 12.8 mmol) was added. The reaction was allowed to warm to room temperature and stirred for an additional 3 hours. Excess base was quenched using ammonium chloride. The reaction was then suspended in water and filtered. After drying, the S5 was obtained as a white solid (1.4g, 81% yield). Spectral data: 1H NMR (400 MHz, DMSO-d6) delta 12.30 (s, 1H), 8.07 (s, 1H), 6.88 (s, 1H), 4.24 (q, J = 7.1 Hz, 2H), 2.54 (s, 3H), 1.26 (t, J = 7.1 Hz, 3H); 13C NMR (126 MHz, dmso) delta 167.85, 162.83, 161.96, 159.07, 157.88, 145.84, 122.02, 104.11, 61.22, 25.61,14.70; HRMS-ESI (m/z): [M + H]+ calcd for CnHnClN402S, 299.0364; found 299.0371.

With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; SOELLNER, Matthew, B.; PHADKE, Sameer; MERAJVER, Sofia, D.; (60 pag.)WO2017/87818; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 156-81-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.156-81-0, name is Pyrimidine-2,4-diamine, molecular formula is C4H6N4, molecular weight is 110.1172, as common compound, the synthetic route is as follows.

To a mixture of 2,4-diaminopyrimidine (5.5 g, 0.05 mol, 1.0 eq.) and THF (200 ml) was added pyridinium tribromide (17.5 g, 0.055 mol, 1.1 eq) at 0 C. in three portions. The resulting mixture was stirred at about 0 C. for two hours, filtered and washed with THF (20 ml). The yellow solid was mixed with water (100 ml) and the resulting mixture was neutralized with 10% NaOH solution to a pH of about 7. Stirring was continued at room temperature for 30 minutes, after which the mixture was filtered, washed with water (2¡Á20 ml) and dried under vacuum at 50 C. to give 8.2 g (87%) of 2,4-diamino-5-bromo-pyrimidine as a white solid. 1H NMR, HPLC and LCMS analyses of this product are identical to the product described in Step 1 of Example 1.

The chemical industry reduces the impact on the environment during synthesis 156-81-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Anadys Pharmaceuticals, Inc.; US2007/117979; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 31462-59-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31462-59-6, name is Pyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure 8 Thionyl chloride (3.55 mL, 48.4 mmol, 3 eq) was added drop-wise to a solution of pyrimidine-4-carboxylic acid (2 g, 16.1 mmol) in EtOH (15 mL) and the resulting mixture was heated to reflux for 14 h. The mixture was then cooled to RT and made alkaline with saturated aqueous NaHCO3 to pH 8. The basic solution was then extracted with EtOAc (450 mL). The combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford Intermediate 23 (1.7g, 77%). 1H NMR: (DMSO-d6) delta 9.40 (d, J=1.0 Hz, 1H), 9.10 (d,J=5.1Hz, 1H), 8.05 (dd, J=5.1, 1.3 Hz, 1H), 4.39 (q, J=7.1Hz, 2H), 1.35 (t, J=7.1Hz, 3H); MS: 153 [M+H]+; TLC: 40% hexane in EtOAc: Rf: 0.40.

According to the analysis of related databases, 31462-59-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERSEON CORPORATION; Short, Kevin Michael; Pham, Son Minh; Williams, David Charles; Datta, Somalee; (82 pag.)US2017/326125; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 108831-66-9, 6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H6N2OS, blongs to pyrimidines compound. HPLC of Formula: C7H6N2OS

General procedure: A mixture of thienopyrimidinone (0.01 mol), POCl3 (11 mL) and PCl5 (1.5 g) was quickly heated to 105 C and boiled for 5-6 h. The solvent was evaporated. Dry product was dissolved in methylene chloride (12 mL) and neutralized by cold solution of NaOH (0.5 N). The organic phase was separated and dried over Na2SO4, filtered, and then solvent was evaporated in vacuum. The residue was crystallized from isopropyl alcohol. Yield 80%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,108831-66-9, 6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Article; Ostrynska, Olga V.; Balanda, Anatoliy O.; Bdzhola, Volodymyr G.; Golub, Andriy G.; Kotey, Igor M.; Kukharenko, Olexander P.; Gryshchenko, Andrii A.; Briukhovetska, Nadiia V.; Yarmoluk, Sergiy M.; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 148 – 160;,
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Pyrimidine – Wikipedia

Related Products of 54326-16-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54326-16-8, name is 5-Chloropyrimidin-2(1H)-one, molecular formula is C4H3ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

I. N-(5-tert-butyl-isoxazol-3-yl)-N’-{4-[6-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea hydrochloride [Compound B12] was also prepared by first preparing the benzothiazole starting material, 5 methoxy-benzothiazol-2-yl-amine: To prepare the 5-methoxy-benzothiazol-2-ylamine starting material: To a suspension of (3-methoxy-phenyl)-thiourea (1.822 g, 10 mmol) in CH2Cl2 (20 mL) at 0 C. was added dropwise a solution of bromine (1.76 g, 11 mmol) in 10 ml of trichloromethane over a period of thirty minutes. The reaction was stirred for 3 hours at room temperature then heated to 3 hours to reflux for one hour. The precipitate was filtered and washed with dichloromethane. The solid was suspended in saturated NaHCO3 and extracted with CH2Cl2. The extract was dried over MgSO4 and concentrated to give a white solid (1.716 g, 95%). To prepare the 2-amino-benzothiazol-5-ol: To a suspension of 5-methoxy-benzothiazol-2-ylamine in 16 mL of 48% HBr/H2O was heated to 105 C. in an oil bath for 10 hours. After the reaction was cooled to room temperature, the precipitate was collected by filtration and washed with acetone. The filtrate was suspended in saturated NaHCO3 and extracted with CH2Cl2. The extract was dried over MgSO4 and concentrated to give a white solid (0.986 g, 63%). N-(5-tert-butyl-isoxazol-3-yl)-N’-{4-[6-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea hydrochloride 2-amino-benzothiazol-5-ol from the previous step and following the method described in 1H NMR (DMSO-d6) ? 11.1 (br, 1H), 9.69 (br, 1H), 9.28 (br, 1H), 8.71 (s, 1H), 7.97 (d, 1H), 7.79 (d and s, 3H), 7.56 (d, 2H), 7.13 (dd, 1H), 6.53 (s, 1H), 4.56 (t, 2H), 3.98 (m, 2H), 3.82 (t, 2H), 3.65 (m, 2H), 3.55 (m, 2H), 3.25 (m, 2H), 1.31 (s, 9H); LC-MS: ESI 561 (M+H)+. [Compound B12]

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54326-16-8, 5-Chloropyrimidin-2(1H)-one.

Reference:
Patent; Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.; US2007/232604; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1749-68-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1749-68-4, name is 6-Chloro-2-methylpyrimidin-4-amine, molecular formula is C5H6ClN3, molecular weight is 143.57, as common compound, the synthetic route is as follows.

The 6-amino-4-(1-indolinyl)-2-methylpyrimidine was obtained as a solid, m.p. 209-210 C., in a similar number to that described for the analogous intermediate in Example 51 by reaction of 6-amino-4-chloro-2-methylpyrimidine with indoline.

The chemical industry reduces the impact on the environment during synthesis 1749-68-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Imperial Chemical Industries Plc; US5223505; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22536-63-6, name is 2-Chloro-4-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-4-methoxypyrimidine

Reference Example 24 N-(4-Iodophenyl)-4-methoxy-N-methylpyrimidin-2-amine [Show Image] (1) Under an argon atmosphere, sodium hydride (100 mg) was added to a solution of 4-iodoaniline (220 mg) and 2-chloro-4-methoxypyrimidine (145 mg) in anhydrous DMF (10 ml), and the resulting mixture was stirred at 125C for 21 hours. The reaction solution was cooled to room temperature and water was added thereto, followed by extracting the resulting mixture with ethyl acetate. Organic layer was washed twice with water and once with saturated brine, and dried over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was purified by column chromatography (silica gel, eluent: hexane/ethyl acetate = 10/1) to obtain N-(4-iodophenyl)-4-methoxypyrimidin-2-amine (46 mg).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 22536-63-6, 2-Chloro-4-methoxypyrimidine.

Reference:
Patent; Toray Industries, Inc.; EP2042171; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Safety of 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione

Mixture of 6-amino-1-methyl-pyrimidine -2,4 (1H, 3H) – dione(5.46g, 40.0mmol) and bromo succinimide (7.56g, 42.0mmol) in acetonitrile (100 mL) solution was heated to reflux under nitrogen protection for 1.5 hours. The reaction was cooled to room temperature, filtered, (20 mL) and washed to remove the solvent, the resulting solid was washed with water, and dried to give 6-amino-5-bromo-1-methyl-pyrimidine -2,4 (1H, 3H)-dione (8.6g, white solid), yield: 98%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Sichuan Gooddoctor Pharmaceutical Group Co., Ltd.; Wu, Lingyun; Zhang, Peng; Zhang, Li; Li, Jian; Chen, Shuhui; Geng, Funeng; Chen, Yongmei; Liu, Bin; Ma, Xiuying; (109 pag.)CN105566324; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia