Tag: M.W:100-200

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2,4-Dichloro-5-fluoropyrimidine

[0639] Synthesis of 2-chloro-5-fluoropyrimidine: [0640] To a stirred solution of 2, 4-dichloro-5-fluoropyrimidine (1 g, 5.98 mmol) in THF (10 mL) under argon atmosphere was added zinc (1.13 g, 17.96 mmol) at room temperature, heated to 70 C; then added acetic acid (0.36 mL, 5.98 mmol) and stirred for 6 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 10% EtOAc/ Hexanes to afford 2-chloro-5-fluoropyrimidine (280 mg, 35%) as colorless liquid. [0641] 1H-NMR (CDCls, 400 MHz): delta 8.52 (s, 2H); LC-MS: 90.01%; 133.1 (M++l); (column: X-Bridge C-18, 50 3.0 mm, 3.5 mupiiota); RT 1.29 min. 0.05% TFA (aq.): ACN; 0.8 mL/min); TLC: 10% EtOAc/ Hexanes (R/. 0.5).

With the rapid development of chemical substances, we look forward to future research findings about 2927-71-1.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

With the rapid development of chemical substances, we look forward to future research findings about 1004-38-2.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 89793-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.6, as common compound, the synthetic route is as follows.

Ethyl 2-chloropyrimidine-5-carboxylate (7.0 Kgs),ethanol (60 Kgs), 2-Chloroaniline (9.5 Kgs, 2 eq) and acetic acid (3.7 Kgs, 1.6 eq) were charged to a reactor under inert atmosphere. The mixture was heated to reflux. After at least 5 hours the reaction was sampled for HPLC analysis (method TM-113.1016). When analysis indicated reaction completion, the mixture was cooled to 70 ± 5 °C and N,N10 Diisopropylethylamine (DIPEA) was added. The reaction was then cooled to 20 ± 5°C andthe mixture was stirred for an additional 2-6 hours. The resulting precipitate is filtered and washed with ethanol (2 x 6 Kgs) and heptane (24 Kgs). The cake is dried under reduced pressure at 50 ± 5 °C to a constant weight to produce 8.4 Kgs compound 11(81percent yield and 99.9percent purity.

Statistics shows that 89793-12-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; VAN DUZER, John, H.; SEYEDI, Farzaneh; LIU, Gui; (100 pag.)WO2016/200919; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 4,6-Dichloro-5-methylpyrimidine

Tert-butyl 4-hydroxypiperidine-1-carboxylate (2.47 g, 12.3 mmol) and potassium tert-butoxide (1.42 g, 12.7 mmol) were added to a THF (20 mL) solution of 2,4-dichloro-3-methylpyrimidine (1.60 g, 9.82 mmol), and the mixture was stirred for 2 hours. To the reaction solution, water was added, followed by extraction with ethyl acetate three times. The obtained organic layer was washed with saturated saline and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=80:20-60:40, V/V) to obtain the title compound as colorless oil (3.07 g, yield: 95%). 1H-NMR (400 MHz, CDCl3) delta ppm: 8.39 (1H, s), 5.36-5.31 (1H, m), 3.75-3.69 (2H, m), 3.75-3.69 (2H, m), 3.39-3.33 (2H, m), 2.23 (3H, s), 2.02-1.95 (2H, m), 1.80-1.72 (2H, m), 1.48 (9H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4316-97-6, 4,6-Dichloro-5-methylpyrimidine.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP2210886; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 42754-96-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C5H2Cl2N4, molecular weight is 189, as common compound, the synthetic route is as follows.

To a solution of 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine (1 g, 5.29 mmol) in MeOH (15 mL) was added a solution of methylamine 33% in MeOH (0.55 mL, 5.89 mmol). The mixture was heated to 70 C for 1 hour followed by cooling to room temperature. The resulting precipitate was filtered, washed with ice-cold MeOH and dried to afford the title compound (874 mg, 90% yield) as a white solid. MS m/z 184.73 [M+1].

The chemical industry reduces the impact on the environment during synthesis 42754-96-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael, S.; HATCHER, John; CHOI, Hwan, Geun; (198 pag.)WO2016/130920; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 63200-54-4, Adding some certain compound to certain chemical reactions, such as: 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63200-54-4.

Step 1: preparation of 2,4-dichloro-5-(3-methoxylpropyl)-5H-pyrrolo[3,2-d]pyrimidine 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (188 mg, 1.0 mmol) and sodium hydride (45 mg, 1.5 mmol) were dissolved in N,N-dimethylformamide (5 mL). The reaction mixture was stirred at room temperature for 1 hour, followed by adding 1-bromo-3-methoxypropane (184 mg, 1.2 mmol). The solution was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with brine. The organic phase was dried over anhydrous sodium sulfate and separated by flash column chromatography (eluent: n-hexane: ethyl acetate = 2: 1) to give 200 mg of a white solid. Yield: 77%. MS (ESI, m/z): [M+H]+: 260.1.

According to the analysis of related databases, 63200-54-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Hanmi Pharmaceutical Co., Ltd.; XUE, Baoyu; ZHENG, Runa; CHA, Mi Young; KIM, Maengsup; (71 pag.)EP3336091; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 13036-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0622] Synthesis of methyl 4-methylpyrimidine-2-carboxylate: [0623] To a stirred solution of 2-chloro-4-methylpyrimidine (370 mg, 2.87 mmol) in MeOH: CH3CN (4: 1, 20 mL) under argon atmosphere were added Pd(dppf)Cl2 (420 mg, 0.57 mmol) and triethyl amine (0.8 mL, 5.75 mmol) at RT; heated to 100 C and stirred for 16 h in steel bomb under CO pressure. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 40% EtOAc/ Hexanes to afford methyl 4-methylpyrimidine-2-carboxylate (330 mg, 75%) as an off-white solid. [0624] 1H-NMR (CDC13, 400 MHz): delta 8.78 (d, 1H), 7.31 (d, 1H), 4.01 (s, 3H), 2.68 (s, 3H); LC-MS: 97.40%; 153.2 (M++l); (column: X Bridge C-18, 50 3.0 mm, 3.5 muiotaeta); RT 0.68 min. 5 mM NH4OAc: ACN; 0.8 mL/min); TLC: 50% EtOAc/ Hexanes (R 0.2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13036-57-2, 2-Chloro-4-methylpyrimidine.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 20090-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20090-69-1, name is 2-Chloro-4-methylpyrimidin-5-amine, molecular formula is C5H6ClN3, molecular weight is 143.57, as common compound, the synthetic route is as follows.

To a solution of 2-chloro-4-methylpyrimidin-5-amine (300 mg 2.090 mmol) in THF (20 mL) was added triphosgene (620 mg 2.090 mmol) in one portion. The mixture was stirred at 60 for 20 min. LCMS analysis showed the starting material had disappeared ES-LCMS m/z 202.1 (M+MeOH)

Statistics shows that 20090-69-1 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidin-5-amine.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, molecular weight is 192.0028, as common compound, the synthetic route is as follows.HPLC of Formula: C5H3Cl2N3O

A solution of lambda/-methylpiperazine (0.624ml), 2-amino-4,6-dichloro-5- formylpyrimidine (1.0Og) and DIPEA (0.936ml) in NMP (120ml) is stirred at room temperature for 18 hours. After addition of MTBE (400ml) the mixture is washed with a saturated solution of NaHCtheta3 (2 x 120ml) and brine (1 x 50ml), dried (MgStheta4) and concentrated to give the title compound as a colourless oil (509mg, 38%). LCMS 255/257 [M+H]+ (pH5.8), RT 1.67 mins. 1H NMR 300 MHz (d6-DMSO) (delta ppm): 10.07 (1H, s), 5.32 (2H1 bs), 3.66 – 3.58 (4H, m), 2.57 – 2.46 (4H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; UCB PHARMA, S.A.; WO2008/74445; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 115617-41-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

5-Chloro-6-ethyl-4-(1,4-dioxaspiro[4,5]dec-8-yloxy)pyrimidine STR27 5 g (0.16 mol) of 80% sodium hydride are added to a solution of 19 g (0.12 mol) of 4-hydroxycyclohexanone ethylene acetal in 200 ml of absolute THF and the mixture is refluxed for 1 hour. The reaction solution is then cooled to room temperature and 21.2 g (0.12 mol) of 4,5-dichloro-6-ethylpyrimidine are added dropwise. The reaction mixture is refluxed for a further 2 hours. To destroy excess sodium hydride, 20 ml of isopropanol are slowly added dropwise, and the reaction mixture, which is still warm, is stirred for a further 30 minutes. 100 ml of aqueous ammonium chloride solution are subsequently added, the aqueous phase is extracted using ether, and the combined organic phases are dried over magnesium sulfate. The solvent is concentrated in vacuo to dryness. This gives 35.0 g (93%) of a yellow oil. The crude product can be reacted further without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115617-41-9, 4,5-Dichloro-6-ethylpyrimidine.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5691321; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia