Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6N4, blongs to pyrimidines compound. Computed Properties of C6H6N4

7H-pyrrolo[2,3-d]pyrimidin-2-amine (270 mg, 2.01 mmol), 4-bromo-1-fluoro-2-iodobenzene (1.28 g, 4.26mmol), potassium carbonate (840 mg, 6.09) and proline (92 mg, 0.80 mmol) were added to an eggplantflask, dimethyl sulfoxide was added, and the reaction solution was deoxygenated. Copper iodide (114 mg, 0.60mmol) was added and the reaction solution was deoxygenated. Heat to 90 C and stir for 16 hours. After thereaction was completed, it was cooled to room temperature, water and ethyl acetate were added, and the mixturewas filtered over Celite. The target compound was obtained in 240 mg.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Zhiqiang; Yan Ziqin; Li Jia; Zhou Yubo; Su Mingbo; Chen Zheng; (138 pag.)CN109810110; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1004-39-3

28.4 g of 4,6-diamino-2-mercaptopyrimidine (SM) was weighed and dissolved in 100 mL of N,N-dimethylformamide.Then add 82.8 g of potassium carbonate to the system.Trifluoromethyl-iodopropane was added 179.2g,The reaction was carried out for 6 h under the conditions of a 130 C oil bath.The mixture was cooled to room temperature, and the mixture was combined with EtOAc.Recrystallization from methylene chloride gave 38.1 g of a yellow solid 2-[(3,3,3-trifluoropropyl)thio]pyrimidine-4,,6-diamino (intermediate 1),The yield was 80%.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; Changzhi Yuan Yan Pharmaceutical Technology Co., Ltd.; Zhou Jian; Cai Kun; (13 pag.)CN108440627; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2565-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione. This compound has unique chemical properties. The synthetic route is as follows.

(2) In a three-necked reaction flask with a stirrer, add 300 ml of dichlorosulfoxide and 40 g of methyltripyrimidone, and cool to 0 C; Take 7.5ml of water and slowly add it to the mixture; After the dropwise addition was completed, the temperature was raised to 78 C and stirred for 4h until the reaction was completed; The reaction solution was cooled to room temperature, and then added to 1,000 g of ice water, filtered, the filter cake was washed twice with 200 ml of water, dried, 31.6 g of 6-chloro-3-methyluracil was obtained with an LC purity of 98% and a yield of 70%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione.

Reference:
Patent; Suzhou Hande Chuanghong Biochemical Technology Co., Ltd.; Mao Zhongping; Ma Dongxu; Tan Jin; (9 pag.)CN110483416; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H4ClN3, blongs to pyrimidines compound. Computed Properties of C4H4ClN3

To a microwave tube was added 4-bromo-2-(2,6-dichlorophenyl)-lH-imidazo[4,5-c]-pyridine (0.100 g, 0.29 mmol), 2-chloro-6-isopropylpyrimidin-4-amine (0.034 g, 0.26 mmol), Pd2(dba)3 (0.026 g, 0.029 mmol), XantPhos (0.034 g, 0.058 mmol), Cs2C03 (0.189 g, 0.58 mmol) and dioxane (3 niL). The mixture was degassed with N2 for 1 min. The resulting mixture was irradiated in a microwave reactor at 140 C for 1.5 hours and cooled to room temperature. The mixture was filtered and the filtrate was concentrated and purified by column chromatography on silica gel with EtOAc/petroleum ether (1 :1.5) to give the desired product (50 mg, 44% yield). ¾ NMR (MeOH- 4, 500 MHz): delta 8.56 (s, 1H), 8.22 (m, 1H), 7.66 – 7.59 (m, 4H), 7.37 (d, J= 5.0 Hz, 1H). LCMS(ESI) m/z: 391.6 [M+H+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5305-59-9, 6-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk; WO2011/113802; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 33034-67-2 ,Some common heterocyclic compound, 33034-67-2, molecular formula is C5H2ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 5:1′-(Pyridin-3-yl)-1-[4-(trifluoromethyl)pyrimidin-2-yl]-1H,1’H-3,4′-bipyrazoleUnder argon, 1′-(pyridin-3-yl)-1H,1’H-3,4′-bipyrazole (200 mg, 0.94 mmol) was initially charged in dimethylamide.Sodium hydride (56.8 mg, 1.42 mmol, 60percent in paraffin oil) was added, and the mixture was stirred at room temperature for 30 min (slightly exothermic).2-Chloro-4-trifluoromethylpyrimidine (173 mg, 0.94 mmol) was added, and the mixture was stirred at 40 C overnight.The mixture was then concentrated, and the residue was triturated with dichloromethane.Yield: 240 mg (71percent of theory), logP(HCOOH) 2.15, [M++1] 358.11H-NMR (d6-DMSO): 7.00 (m, 1H), 7.56 (m, 1H), 7.90 (d, 1H), 8.31 (m, 2H), 8.56 (m, 1H), 8.73 (m, 1H), 9.10 (s, 1H), 9.17-9.22 (m, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer CropScience AG; US2011/166143; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1193-24-4 , The common heterocyclic compound, 1193-24-4, name is 4,6-Dihydroxypyrimidine, molecular formula is C4H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 31A 5-(4-Ethylphenyl)furo[2,3-d]pyrimidin-4(3H)-one A mixture of 7.50 g (35.44 mmol) of 1-[(Z)-2-chloro-2-nitroethenyl]-4-ethylbenzene and 4.97 g (44.30 mmol) of 4,6-dihydroxypyrimidine in 130 ml of isopropanol is heated at reflux. After 10 min, 13.22 ml (88.59 mmol) of 1,8-diazabicyclo[5.4.0]undecan-7-ene (DBU) are added dropwise, and the resulting reaction mixture is stirred under reflux for 4 h and then, after cooling, concentrated under reduced pressure. The residue is taken up in ethyl acetate and water. The phases are separated and the organic phase is washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:2). This gives 2.8 g (32.9% of theory) of the title compound. HPLC (method 1): Rt=4.14 min. MS (DCI): m/z=241 (M+H)+. 1H-NMR (400 MHz, DMSO-d6): delta=12.68 (s, 1H), 8.19 (s, 1H), 8.17 (d, 1H), 7.88 (d, 2H), 7.28 (d, 2H), 2.63 (q, 2H), 1.22 (t, 3H).

The synthetic route of 1193-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/166163; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H2BrClN2, blongs to pyrimidines compound. Formula: C4H2BrClN2

INTERMEDIATE 6; Ethyl {5-[2-fpiperazin-l-yl)pyrimidin-5-yl]-2//-tetrazol-2-yl}acetate hydrochloride; Step 1 : tert-Butyl 4-(5 -bromopyrimidin-2-yl)piperazine- 1 -carboxylate; Into a 200 mL pressure flask equipped with a magnetic stir bar was added tert- butyl piperazine-1 -carboxylate (4.8 g, 25.8 mmol), 5-bromo-2-chloropyrimidine (5.0 g, 25.8 mmol) and 2-propanol (50 mL). DIPEA (5.0 mL, 28.4 mmol) was added, the vial was sealed and the reaction mixture heated to 120 °C for 1 h. The cooled reaction mixture was poured into a 250 mL separatory funnel containing water (125 mL) and extracted with EtOAc (3 x 75 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Recrystallization from EtOAc (about 40 mL) and hexanes (about 150 mL) at -78 0C afforded crystals which were collected by filtration through filter paper on a Hirsch funnel under vacuum.

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK FROSST CANADA LTD.; ISABEL, Elise; LACHANCE, Nicolas; LECLERC, Jean-Philippe; LEGER, Serge; OBALLA, Renata, M.; POWELL, David; RAMTOHUL, Yeeman, K.; ROY, Patrick; TRANMER, Geoffrey, K.; ASPIOTIS, Renee; LI, Lianhai; MARTINS, Evelyn; WO2010/94126; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 18592-13-7 ,Some common heterocyclic compound, 18592-13-7, molecular formula is C5H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 20 L reaction flask, compound SM1 (1000.0 g, 6.23 mol) was added to 5000 mL of acetic acid. Mechanical stirring was started and an ice bath was added. Sulfonyl chloride (1000 mL, 12.37 mol) was added dropwise keeping the temperature of the addition below 30 C. Canada completed at room temperature (20 ) reaction 6h, a large number of white solid precipitation. TLC trace compound SM1 point reaction disappeared (dichloromethane: methanol = 10: 1), the reaction was completed. The reaction mixture was suction filtered, and the resulting solid was air-dried for 12 hours at 60 C to give 5-chloro-6-chloromethyluracil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18592-13-7, its application will become more common.

Reference:
Patent; Sinopharm Wholeheartedly Pharmaceutical Co., Ltd.; Wang Shujuan; Xu Hao; Kang Wei; (15 pag.)CN106892902; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 171178-47-5 ,Some common heterocyclic compound, 171178-47-5, molecular formula is C7H4ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of K2CO3 (267mg, 1.94mmol) and 1 (250mg, 0.969mmol) in anhydrous DMF (5.0mL) was stirred at room temperature for 30min. To this white suspension was added 2a (392mg, 1.94mmol), and the resulting reaction mixture was stirred at room temperature for 2h. The resulting mixture was quenched with water, and the aqueous solution was extracted with EtOAc (3×10.0mL). The combined organic layers were washed with brine (3×10.0mL), dried with anhydrous Na2SO4, filtered, and concentrated under vacuum to give the crude product. The crude product was purified by flash silica gel column chromatography (hexane/CH2Cl2=1/2) to afford 3a as white crystals (276mg, 75%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 171178-47-5, 6-Chloropyrido[3,4-d]pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Guo, Junsong; Chen, Bingyi; Yu, Ying; Cheng, Bao; Cheng, Yanfang; Ju, Yingchen; Gu, Qiong; Xu, Jun; Zhou, Huihao; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-17-6, name is 4,6-Dihydroxy-2-mercaptopyrimidine, molecular formula is C4H4N2O2S, molecular weight is 144.1518, as common compound, the synthetic route is as follows.name: 4,6-Dihydroxy-2-mercaptopyrimidine

General procedure: A mixture of aldehyde (1 mmol), malanonitrile (1 mmol), barbituricor thiobarbituric acid (1 mmol), and DES (0.1 g, 36 mol%)was stirred in refluxing water (2 mL) for an appropriate period oftime. The reaction progress was followed by TLC (eluent: EtOAc: nhexane).After completion of the reaction, the mixture was dilutedwith water (4 mL) and filtered off. Finally, the solid product wasrecrystallized from warm ethanol if necessary.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Biglari, Mohammad; Shirini, Farhad; Mahmoodi, Nosrat O.; Zabihzadeh, Mehdi; Mashhadinezhad, Maryam; Journal of Molecular Structure; vol. 1205; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia