Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Diaminopyrimidine-5-carboxaldehyde, blongs to pyrimidines compound. Recommanded Product: 2,4-Diaminopyrimidine-5-carboxaldehyde

EXAMPLE 60 6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine To a solution of 0.23 g 60% sodium hydride suspension in 11.0 mL of 2-ethoxyethanol was added 4.18 g of 2,6-dibromophenylacetonitrile and 2.00 g of 2,4-diaminopyrimidine-5-carboxaldehyde. The reaction was refluxed for 4 hours, cooled, and poured into ice water. The residue was washed well with acetonitrile then diethyl ether to give 3.62 g of 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine, CIMS (1% NH3 in CH4): 422=M+ +C2 H5, 396 (Base), 394=M+ +H, 393=M+; mp 284-289 C.

The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Blankley; Clifton John; Doherty; Annette Marian; Hamby; James Marino; Panek; Robert Lee; Schroeder; Mel Conrad; Showalter; Howard Daniel Hollis; Connolly; Cleo; US5733913; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 90349-23-8 ,Some common heterocyclic compound, 90349-23-8, molecular formula is C9H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 5,7-dimethylpyrazolo[l,5-a]pyrimidine-3-carboxylic acid 2 (50 mg, 0.262 mmol), 2,3-dihydro-lH-inden-5-amine (42 mg, 0.314 mmol) and HATU (149 mg, 0.393 mmol) in DMF (1 mL) was added DIPEA (0.1 mL, 0.524 mmol), and the reaction mixture was stirred at room temperature for 16 hours until the reaction was complete. The reaction mixture was purified by reverse phase chromatography (MeCN/10 mM NH4HCO3) to give the title compound (37 mg, 46%) as a white solid.XH NMR (400 MHz, DMSO-i) delta 10.11 (s, 1H), 8.62 (s, 1H), 7.66 (s, 1H), 7.46 (dd, J= 8.0 Hz, 2.0 Hz, 1H), 7.22-7.19 (m, 2H), 2.90- 2.82 (m, 4H), 2.77 (s, 3H), 2.71 (s, 3H), 2.07-1.99 (m, 2H). ES-MS m/z: 307.2 [M+H]+. LC- MS Purity (254 nm): >99%; tR= 1.98 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90349-23-8, 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LYSOSOMAL THERAPEUTICS INC.; SKERLJ, Renato, T.; LANSBURY, Peter, T.; GOOD, Andrew, C.; BOURQUE, Elyse, Marie Josee; (139 pag.)WO2016/73895; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 46155-89-9, name is 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows. name: 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

1,3-Dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione 9 (2 g, 11.2 mmol) was dissolved in DMF (15 mL), K2CO3 (3.1 g, 22.4 mmol) was added and the mixture was stirred at room temperature for 10 min. After cooling at 0 C, a solution of ethyl bromoacetate (2.05 g, 12.32 mmol) in DMF (5 mL) was added dropwise and the reaction was stirred at room temperature for a further 3 h. The solvent was evaporated and the residue partitioned between EtOAc (15 mL) and water (20 mL). The aqueous phase was further extracted with EtOAc (2 × 15 mL) and the organic layers were dried over anhydrous Na2SO4. Evaporation of the solvent gave a solid residue which was filtered after suspension with a 1:1 mixture of Et2O/Petroleum ether (15 mL). White solid; 80% yield; mp 171-172 C; 1H NMR (200 MHz, CDCl3): delta (ppm) 1.29 (t, 3H, J = 7.4), 3.37 (s, 3H), 3.46 (s, 3H), 4.23 (q, 2H, J = 7), 5.10 (s, 2H), 5.99 (d, 1H, J = 3), 6.93 (d, 1H, J = 3). MS (ESI): [MH]+ = 265.3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione.

Reference:
Article; Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1690 – 1698;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 62802-42-0, Adding some certain compound to certain chemical reactions, such as: 62802-42-0, name is 2-Chloro-5-fluoropyrimidine,molecular formula is C4H2ClFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62802-42-0.

Preparation 123 N-[(4aR,7aR)-6-(5-Fluoropyrimidin-2-yl)-7a-(2-thienyl)-4,4-a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide A solution of N-[(4aR,7aR)-7a-(2-thienyl)-4-a,5,6,7-tetrahydro-4H-pyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide (7.7 g, 22.4) and N,N,N’,N’-tetramethylguanidine (3.39 mL, 26.9 mmol) in dimethyl sulfoxide (61 mL) is treated with 5-fluoro-2-chloropyrimidine (2.25 mL, 23.54 mmol) and the resulting solution is heated at 50 C. for 4 hours. The solution is cooled to room temperature and added to water (500 mL). The crude product is purified over silica gel using a 5 to 50% gradient of ethyl acetate/hexanes to give the title compound (7 g, 71%). ES/MS (m/e): 440 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62802-42-0, 2-Chloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eli Lilly and Company; BECK, James Peter; GREEN, Steven James; LOPEZ, Jose Eduardo; MATHES, Brian Michael; MERGOTT, Dustin James; PORTER, Warren Jaye; RANKOVIC, Zoran; SHI, Yuan; WATSON, Brian Morgan; WINNEROSKI, JR, Leonard Larry; US2013/261111; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 49844-90-8

Indole I (400.88g) in 25OmL THF, 2L of IN K1BuO, and 381g pyrimidine II in 35OmL THF were combined with cooling to maintain under 40 0C and allowed to stir at r.t, for 1 hour. The solvent was then removed in vacuo and the solid was suspended in MeOH, filtered, washed with MeOH, water, and again with MeOH, to yield 87.56% III.

The synthetic route of 49844-90-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/138340; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 56843-79-9

General procedure: The synthesis of target compound 2-11 (Scheme 1), commenced from commercially available ethyl-2-amino-3-thiophenecarboxylate (12a, Ri= H) and ethyl-2-amino-4,5-dimethyl-3- thiophenecarboxylate obtained using a reported method. Cyclization of 12a and 12b with HC1 (g) and acetonitrile gave 13a and 13b followed by chlorination with POCl3 afforded 14a and 14b respectively. Treatment with various substituted anilines in dioxane with 2 drops of cone HC1 provided 2-11. (60 -76 % yields).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56843-79-9, 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Reference:
Patent; DUQUESNE UNIVERSITY OF THE HOLY SPIRIT; GANGJEE, Aleem; (140 pag.)WO2017/31176; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 29274-24-6 ,Some common heterocyclic compound, 29274-24-6, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0211] Step 3. Pyrazolo[1,5-alpyrimidine-5-carboxylic acid methyl ester. A mixture of 5- chloro-pyrazolo[1,5-a]pyrimidine (2 g, 13.02 mmol, 1.00 equiv), triethylamine (4 mL), methanol (80 mL), and bis(triphenylphosphine)palladium(II) dichloride (1 g, 1.42 mmol, 0.11 equiv) was stirred in a 100-mL pressure reactor overnight at 100 C under 10 atmospheres of carbon monoxide. The reaction mixture was cooled to rt then concentrated under vacuum.The residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1:5) to yield 1.2 g (52%) of the title compound as a light yellow solid. LC/MS (Method I, ESI): RT= 1.09 mi m/z = 178.0 [M+Hf?.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang; WO2013/130935; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2434-53-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

General procedure: 7 (2.0 mmol, 0.38 g) and the corresponding amine (2.0 mmol) were placed in pressure tube under the flow of dry argon and dissolved in dry DMF (10 mL) containing 1 mL of TMSCl. The mixture was heated at 100 C during 2-12 h (controlled by TLC). Then this solution was evaporated under reduced pressure, treated with water, filtrated and dried on the air and recrystallized from an appropriate solvent, or was subjected to a column chromatography over silica gel.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2434-53-9, 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Gevorgyan, Ashot; Mkrtchyan, Satenik; Arakelyan, Knar; Ostrovskyi, Dmytro; Abbasi, Muhammad S.A.; Supe, Linda; Hakobyan, Ani; Villinger, Alexander; Volochnyuk, Dmitriy M.; Tolmachev, Andrei; Tetrahedron; vol. 69; 3; (2013); p. 1217 – 1228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 22536-61-4 , The common heterocyclic compound, 22536-61-4, name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 50 mL round bottom flask was added 2-chloro-5-methylpyrimidine (0.150 g, 1.167 mmol), clinfloxacin.(0.427 g, 1.167 mmol) and potassium carbonate (0·193 g, 1 · 400 mmol), then 10 mL of acetonitrile, refluxed at 80 C 23 hours. After the reaction,The reaction mixture was concentrated under reduced pressure.Get a crude product,Use it again(methanol / dichloromethane,1/10, V/V) Purified by silica gel column chromatography,get 0.329g Compound III-2, a yellow solid.Yield: 71.8%

The synthetic route of 22536-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southwest University; Zhou Chenghe; Li Di; Chen Jinping; Ba Tini·nasaiya; An Sali·muhanmode·fuade; (19 pag.)CN109942546; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17119-73-2, name is 4-Chloro-6-methyl-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-6-methyl-2-(methylthio)pyrimidine

[00237] To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50 C for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2- (methylthio)pyrimidin-4-amine (20 g, 90% yield).

With the rapid development of chemical substances, we look forward to future research findings about 17119-73-2.

Reference:
Patent; EXELIXIS, INC.; WO2008/127678; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia