Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 107407-80-7, name is Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate. A new synthetic method of this compound is introduced below., Product Details of 107407-80-7

[1120] Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate (4.1 g, 21.2 mmol) is dissolved/suspended in 100 mL concentrated HCl. The mixture is heated under reflux. After 4 h, the reaction is cooled and the solvent is removed in vacuo. Absolute EtOH is added and the solvent is removed (twice) to afford a yellow-green solid. The solid is triturated with Et2O and dried to give 4.28 g (100%) of pyrrolo[1,2-c]pyrimidine-3-carboxylic acid as the hydrochloride salt. The solid can be recrystallized from EtOH. 1H NMR (400 MHz, DMSO) delta 9.24, 8.21, 7.90, 7.06, 6.85.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 107407-80-7, Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate.

Reference:
Patent; Rogers, Bruce N.; Piotrowski, David W.; Walker, Daniel Patrick; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Groppi JR., Vincent E.; US2003/236264; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 767-15-7, name is 2-Amino-4,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Amino-4,6-dimethylpyrimidine

3. The 150 g compound 5, 200g of N – bromosuccinimide added 1 L in acetonitrile, 80 C heated 6 h. Precipitate is filtered, washed with cold acetonitrile, under the condition of vacuum drying, to obtain white solid (compound 6).

With the rapid development of chemical substances, we look forward to future research findings about 767-15-7.

Reference:
Patent; China Agricultural University; Wang Zhanhui; Shen Jianzhong; Wen Kai; Li Chenglong; Ke Yuebin; Zhang Suxia; Shi Weimin; (17 pag.)CN109824604; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Chloropyrimidin-4-amine, blongs to pyrimidines compound. name: 6-Chloropyrimidin-4-amine

6-Chloropyrimidin-4-amine (4.1 g, 31.6 mmo1)was suspended in acetonitrile. DMAP (0.966 g, 7.91 mmo1) anddi-tert-butyl dicarbonate (14.74 g, 67.5 mmo1) were addedand the mixture was stirred at rt for 3 days. The solvent wasevaporated and the residue was purified by silica gel using0-15% ethyl acetate in hexanes to give 6[bis(tert-butoxycarbony1)amino ]-4-ch1oropyrimidine as a white solid (6.27 g,19.01 mmo1,60%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5305-59-9, 6-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 16234-10-9, Thieno[3,2-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 16234-10-9, blongs to pyrimidines compound. Recommanded Product: 16234-10-9

Thieno[3,2-d]pyrimidine-4(3H)-one (4.9 g) was dissolved in acetic acid (20 mL) and then brome (5 mL) was added thereto. In a sealed reactor, the reaction mixture was stirred at 120 C. for 10 hours. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The resulting mixture was added to ice water and the resulting solid was filtered and then dried to obtain the title compound without further purification. 1H NMR (400 MHz, DMSO-d6) delta 12.75 (brs, 1H), 8.36 (s, 1H), 8.24 (s, 1H).

The synthetic route of 16234-10-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HANMI SCIENCE CO., LTD.; CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; Son, Jung Beom; Jung, Seung Hyun; Choi, Wha ll; Jung, Young Hee; Choi, Jae Yul; Song, Ji Yeon; Lee, Kyu Hang; Lee, Jae Chul; Kim, Eun Young; Ahn, Young Gil; Kim, Maeng Sup; Choi, Hwan Geun; Sim, Tae Bo; Ham, Young Jin; Park, Dong-sik; Kim, Hwan; Kim, Dong-Wook; US2013/53370; (2013); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

Aqueous ammonia(8.0ml) and N,N-diisopropylethylamine(13.2ml) were dissolved into 150ml dichloromethane. The mixture was added dropwise to a solution of 2,4-dichloro-5-nitropyrimidine(10.0g) in dichloromethane(30ml) at 0C. After the completion of the dropwise addition, the mixture was kept at the same temperature to react for 1 hour. The precipitate was filtered off. The filter cake was recrystallized to obtain a yellow solid(8.1g) in a yield of 90.1%. 1H NMR(400 MHz, DMSO-d6): delta 9.20(s, 1H), 9.02(s, 1H), 8.60(s, 1H)ppm.

The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1500-85-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Application In Synthesis of 7H-Pyrrolo[2,3-d]pyrimidin-4-amine

500 mg (3.7 mmol) of 7H-pyrrolo[2,3-d]pyrimidin-4-amine were dissolved in 40 mL of dry DMF and 1.03 g (3.7 mmol) of tert-butyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate were added, followed by 3.87 g (3.7 mmol) of caesium carbonate, under argon atmosphere. The mixture was heated in a microwave apparatus at 100 C for 4 hours, then the solvent removed under vacuum.The residue was taken up with dicholomethane and washed with brine. Theorganic layer was dried over Na2S04 and evaporated to give, after trituration with diethyleher, 420 mg of the title compound. (36%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1500-85-2, 7H-Pyrrolo[2,3-d]pyrimidin-4-amine.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; ANGIOLINI, Mauro; BUFFA, Laura; MENICHINCHERI, Maria; MOTTO, Ilaria; POLUCCI, Paolo; TRAQUANDI, Gabriella; ZUCCOTTO, Fabio; WO2014/184069; (2014); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 1780-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. A new synthetic method of this compound is introduced below.

To the stirred solution of 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5- carboxamide 9 (15.0 g, 0.06 mol) and 4,6-dichloro-2-methylpyrimidine (10.9 g, 0.07 mol) in tetrahydrofuran (THF) (150.0 mL) was added a 29% wt.solution of NaOtBu in THF (64.9 g, 0.2 mol) at 10-20C, over 15-20 minutes. The mixture was stirred at room temperature for 1h and cooled to 0-5C. 1N Hydrochloric acid (~90.0 mL) was added slowly to pH 2-3 followedby the added water 90.0 mL) and stirred for 2h at 0-5C, product was filtered and washed the wet cake with water (60.0 mL) followed by acetone (30.0 mL) gave 5 (20.7 g, 94%).UV (Methanol): max, 319.6 & 203.2 nm; IR (KBr, cm-1): 3420.3 (N-H), 3016.6 (Ar C-H), 1638.6 (C=O); 1H NMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 12.23 (s, 1H, thiazole-NH), 10.02 (s, 1H, amide-NH), 8.32 (s,1H, thiazole-H), 7.42-7.40 (m, 1H, Ar-H), 7.31-7.25 (m, 2H, J =7.5, Ar-H), 6.95 (s, 1H, pyrimidine-H), 2.59 (s,3H, Ar-CH3), 2.25 (s, 3H, pyrimidine-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), delta, ppm: 167.4(pyrimidine-C), 161.2 (pyrimidine-C), 159.5 (pyrimidine-C), 158.5 (amide-C), 157.6 (thiazole-C), 140.8 (Ar-C),138.8 (thiazole-C), 133.3 (Ar-C), 132.4 (Ar-C), 129.0 (Ar-C), 128.3 (Ar-C), 127.2 (thiazole-C), 103.4 (pyrimidine-C), 67.0 (pyrimidine-C), 25.2 (Ar-CH3), 18.3 (pyrimidine-CH3); MS (ESI) m/z 391.9 [M – H] – [5].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-26-3, 2-Methyl-4,6-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Suresh, Garbapu; Nadh, Ratnakaram Venkata; Srinivasu, Navuluri; Yennity, Durgaprasad; Synthetic Communications; vol. 47; 17; (2017); p. 1610 – 1621;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 66131-68-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. A new synthetic method of this compound is introduced below.

Potassium t-butoxide (165MG) was added to the product of example 1 step b) (0.2g) and 2-chloro-N-methyl-4-pyrimidinamine (105MG) in NMP (3ML). THE mixture was stirred at 60 C for 20h. The resulting mixture was cooled, acidified with acetic acid (LML) and purified by reverse phase HPLC (Symmetry gradient 90-50% aqueous, ammonium acetate (0.2% aq. ) in acetonitrile) to give the title compound as a solid (40mg). MS (APCI+) 383 [M+H] + H NMR 8 (DMSO 9O O 8.32 (d, lH), 7.82 (d, LH), 7.68 (dd, LH), 6.97 (s, LH), 6.81 (d, lH), 6.08 (d, LH), 5.15 (heptet, 1H), 4.05-3. 97 (m, 2H), 3.51-3. 44 (m, 4H), 3.43-3. 36 (m, 2H), 2.78 (d, 3H), 2.07-2. 00 (m, 2H), 1.87-1. 82 (m, 4H), 1.73-1. 63 (m, 2H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66131-68-8, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2004/74278; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 5767-35-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5767-35-1, name is 4-Chloro-6-hydrazinopyrimidine. A new synthetic method of this compound is introduced below.

A mixture of N-cyano-N’-(4-morpholinopheny)-O-phenylisourea (8.76 g, 27.2 mmol, 4-chloro-6-hydrazino-pyrimidine (4.12 g, 28.5 mmol) and di-iso-propylethylamine (18.9 mL, 109 mmol) in N-methyl-pyrrolidinone (50 mL) was heated in the microwave apparatus at 220C for 5 min, cooled, poured into ice-water, stirred 0.5h and filtered to obtain crude product (9.30 g). Purification by flash chromatography (SiO2) eluted with 2:98 methanol : dichloromethane provided the title compound (3.91 g, 39% yield) as a yellow powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5767-35-1, 4-Chloro-6-hydrazinopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42839-09-8, name is 2-Pyrimidinemethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Pyrimidinemethanol

EXAMPLE 11 5-Butyl-9-[1-(2,4-dimethyl-pyridine-3-carbonyl)-4-methyl-piperidin-4-yl]-3-pyrimidin-2-ylmethyl-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one (IV-5) Pyrimidin-2-ylmethyl methanesulfonate (48)-To a solution of pyrimidin-2-yl-methanol (CASRN 42839-09-8, 2 g, 1.8 mmol) and DCM (1 mL) cooled to 0 C. was added sequentially TEA (0.062 mL) and methanesulfonyl chloride (0.2 mL). The reaction mixture was stirred for 3 h then washed with aqueous NH4Cl. The solvent was removed in vacuo and residue was purified by SiO2 chromatography eluding with MeOH/DCM (1:20) to afford 0.2 g (58%) of 48. The title compound was prepared by the procedure described in steps 10-12 of example 2 except in step 10, 3-methoxy-cyclohexylmethyl tosylate was replaced with 48, and in step 12, 4,6-dimethyl-pyrimidine-5-carboxylic acid was replaced with 2,4-dimethyl-nicotinic acid. The product was purified by preparative HPLC (acetonitrile-0.01M TFA) to afford IV-5 as the trifluoroacetate salt: MS [M+]=549.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42839-09-8, 2-Pyrimidinemethanol.

Reference:
Patent; Rotstein, David Mark; Melville, Chris Richard; US2008/249087; (2008); A1;,
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Pyrimidine – Wikipedia