Tag: M.W:100-200

Synthetic Route of 13223-43-3, Adding some certain compound to certain chemical reactions, such as: 13223-43-3, name is 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine,molecular formula is C7H9N5O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13223-43-3.

General procedure: The compound 4a (6 g, 0.03 mol), catalytic amount of DMSO and3,5-lutidine (9.6 g, 0.09 mol) were dissolved in MeCN (15 mL), and then 7c (10.3 g, 0.03 mol) was addedslowly with stirring at 35 C and keeping for 1 h. The reaction system was heated to 45 C and kept thatuntil the complete conversion monitoring by HPLC. Then the resultant mixture was slowly added into10% sulfuric acid aqueous solution (100 mL). After filtering, the residue was purified by recrystallizingfrom MeCN to afford white solid, yield 13.5 g (89.6%);

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13223-43-3, 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ma, Yi-Chao; Yu, Ying-Hui; Hou, Guang-Feng; Huang, Ji-Han; Gao, Jin-Sheng; Heterocycles; vol. 92; 5; (2016); p. 829 – 843;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 18592-13-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-(Methylsulfonylmethyl)-lH-pyrimidine-2,4-dione6-(Chloromethyl)uracil (10.00 g) was dissolved in DMF (300 mL) and methanesulphinic acid sodium salt (7.64 g) added. The reaction was heated at 1250C for 1 hour. The reaction was allowed to cool, filtered and the filtrate concentrated in vacuo to give the desired material as a yellow solid (12.72 g).NMR Spectrum: 1U NMR (DMSOd6) 53.10 (3H, s), 4.27 (2H, s), 5.63 (IH, s), 10.94 (IH, s), 11.16 (IH, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 18592-13-7, 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7749; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5750-76-5

To a degassed solution of 2,4,5-trichloropyrimidine (15.0 g, 81.8 mmol) in PEG 300 (91 mL) at room temperature under nitrogen atmosphere was added triethylamine (12.0 mL, 85.8 mmol), butyl vinyl ether (13.5 mL, 98.1 mmol) and palladium acetate (0.73 g, 3.3 mmol). The reaction mixture was stirred for 1.5 h at 80 C under nitrogen atmosphere. The reaction was cooled to room temperature, Et20 (250 mL) was added, and the layers were separated. The dark glycol layer was extracted with Et20 (4 x 90 mL). The combined Et20 layers were washed with water (4 x 90 mL), then dried over MgS04, filtered and concentrated to yield an orange oil. The residue was purified by Si02 chromatography (Hex/ Et20 0 to 30% gradient) and afforded the title compound as an orange oil (10.70 g, 43.2 mmol, 53%).

With the rapid development of chemical substances, we look forward to future research findings about 5750-76-5.

Reference:
Patent; SYROS PHARMACEUTICALS, INC.; SPROTT, Kevin; MARINEAU, Jason, J.; SCHMIDT, Darby; BRADLEY, Michael; CIBLAT, Stephane; SIDDIQUI, M., Arshad; KABRO, Anzhelika; LEBLANC, Melissa; LEGER, Serge; ROY, Stephanie; WINTER, Dana, K.; MILLER, Tom; RIPKA, Amy; LI, Dansu; WO2015/154039; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1558-17-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1558-17-4, name is 4,6-Dimethylpyrimidine, molecular formula is C6H8N2, molecular weight is 108.14, as common compound, the synthetic route is as follows.

General procedure: Preparation of 1a’-3f’ and 1g-5g. A mixture of pyrimidines (2.00 mmol) and benzaldehydes (4.00 mmol) in 5 N NaOH solution (20 mL) containing tetrabutylammonium hydrogen sulfate (0.10 g, 0.29 mmol) was refluxed. After cooling, the precipitates were filtered off. The products were purified by recrystallization from EtOAc. Otherwise, the mixture was extracted with CH2Cl2. Then, the organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography to give the products.

Statistics shows that 1558-17-4 is playing an increasingly important role. we look forward to future research findings about 4,6-Dimethylpyrimidine.

Reference:
Article; Lee, Yun Suk; Kim, Hye Yun; Kim, Youngsoo; Seo, Jae Hong; Roh, Eun Joo; Han, Hogyu; Shin, Kye Jung; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 4921 – 4935;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloro-5-fluoropyrimidine

Intermediate 115-Fluoropyrimidine-2-carbonitrile; A 10 ml microwave vial was charged with 2-chloro-5-fluoropyrimidine (2.0 g, 15.09 mmol), Pd2(dba)3 (0.549 g, 0.6 mmol), dppf (0.67 g, 1.21 mmol), zinc cyanide (1.15 g, 9.81 mmol), and zinc dust (0.237 mg, 3.62 mmol). The flask was evacuated and backfilled with N2, and anhydrous DMAc. The vial was mounted onto a Personal Chemistry microwave reactor and heated at 100 ºC for 10 hours. The reaction mixture was diluted with EtOAc and then washed with brine three times. The organic layer was obtained and evaporated to dryness. The dried residue was purified by silica gel chromatography (By ISCO Combiflash with gradient EtOAc and hexanes) to afford the title compound as a creamy solid (1.50 g, 80%). GC-MS: 123 (M); 1H NMR (CDCl3) delta 8.80 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 62802-42-0.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/135785; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 5413-85-4, 5-Amino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5413-85-4, blongs to pyrimidines compound. Recommanded Product: 5413-85-4

General procedure: A solution of 5-amino-4,6-dichloropyrimidine (5, 1.0 mmol),triethylamine (1.0 mmol), ethanol (4.3 mL), and the appropriateamine (2.5 mmol) was heated in a steel vial for the time specifiedfor each compound. After the removal of volatiles in vacuo, thecrude was purified as described for each compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5413-85-4, its application will become more common.

Reference:
Article; Lambertucci, Catia; Marucci, Gabriella; Dal Ben, Diego; Buccioni, Michela; Spinaci, Andrea; Kachler, Sonja; Klotz, Karl-Norbert; Volpini, Rosaria; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 199 – 213;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14001-61-7, name is 2-Methoxy-4,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Methoxy-4,6-dimethylpyrimidine

General procedure: Preparation of 1a’-3f’ and 1g-5g. A mixture of pyrimidines (2.00 mmol) and benzaldehydes (4.00 mmol) in 5 N NaOH solution (20 mL) containing tetrabutylammonium hydrogen sulfate (0.10 g, 0.29 mmol) was refluxed. After cooling, the precipitates were filtered off. The products were purified by recrystallization from EtOAc. Otherwise, the mixture was extracted with CH2Cl2. Then, the organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography to give the products.

With the rapid development of chemical substances, we look forward to future research findings about 14001-61-7.

Reference:
Article; Lee, Yun Suk; Kim, Hye Yun; Kim, Youngsoo; Seo, Jae Hong; Roh, Eun Joo; Han, Hogyu; Shin, Kye Jung; Bioorganic and Medicinal Chemistry; vol. 20; 16; (2012); p. 4921 – 4935;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4HCl2FN2

To a mixture of sodium (450 mg, 19 mmol) in methanol (20 mL) was added a solution of 2,4-dichloro-5-fluoropyrimidine (3.25 g, 19 mmol) in methanol (10ml_). The reaction mixture was stirred at room temperature overnight before being partitioned between water and diethyl ether. The organic phase was separated, washed with brine and evaporated to dryness to give the title compound as an orange oil (80%), which was used in the next step without further purification.1H-NMR delta (400 MHz, CDCI3): 4.1 (s, 3H), 8.2 (s, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine.

Reference:
Patent; ALMIRALL, S.A.; BACH TA?A, Jordi; PAGES SANTACANA, Lluis, Miquel; TALTAVULL MOLL, Joan; EASTWOOD, Paul, Robert; GONZALEZ RODRIGUES, Jacob; GIULIO MATASSA, Victor; WO2011/101161; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 54-20-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54-20-6, name is 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H3F3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-trifluoromethyluracil (48.0 g, 267 mmol) is suspended in 210 mL phosphorus oxychloride (POCI3) while moisture is excluded. Diethylaniline (47.7 g, 320 mmol) is slowly added dropwise to this suspension such that the temperature remains between 250C and 300C. After the addition has ended the mixture is stirred for a further 5 – 10 min in the water bath and the mixture is heated for 5- 6 h with the exclusion of moisture at 80 – 900C. The excess POCI3 is destroyed by stirring into approx. 1200 g of sulphuric acid mixed with ice water and the aqueous phase is immediately extracted 3 x with in each case 500 mL diethyl ether or te/t.-butylmethyl ether. The combined ethereal extracts are washed 2 x with 300 mL sulphuric acid mixed with ice water (approx. 0.1 M) and with cold saline solution and immediately dried on sodium sulphate. The desiccant is filtered off and the solvent is eliminated in vacuo. The residue is distilled in vacuo (10 mbar) through a short column (20 cm) (head temperature: 65 – 700C), to obtain a colourless liquid that is bottled and stored under argon. TLC: Rf = 0.83 (chex:EE = 3:1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54-20-6, 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SAPOUNTZIS, Ioannis; BETZEMEIER, Bodo; STADTMUELLER, Heinz; WO2010/55117; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 90349-23-8 ,Some common heterocyclic compound, 90349-23-8, molecular formula is C9H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step (d) N-((l s,4s)-4-(5-Fluoro-2-(4 ‘-((4-(2-hydroxy ethyl)- 1 ,4-diazepan- l-yl)methyl)-2 ‘- (((SJ-S-methylmorpholinoJmethylJbiphenyl-S-yloxyJnicotinamidoJcyclohexylJ-S^- dimethylpyr azolo [ 1 ,5-a] pyrimidine-2-carboxamideTo a suspension of N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(4′-((4-(2-hydroxyethyl)-l,4- diazepan- 1 -yl)methyl)-2’-(((S)-3 -methylmorpholino)methyl)biphenyl-3 -yloxy Nicotinamide hydrochloride (200 mg, 0.24 mmol) in acetonitrile (2.74 ml) was added 5,7- dimethylpyrazolo[l,5-a]pyrimidine-2-carboxylic acid (48.9 mg, 0.26 mmol) and triethylamine (0.340 ml, 2.44 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.171 ml, 0.27 mmol) was then added and the mixture stirred at RT for 2 hours. The mixture was evaporated to dryness and the residue dissolved in DCM (150 ml) and washed with saturated NaHCC^aq), brine, dried (MgSC^) and evaporated to give a foam. The crude product was purified by preparative HPLC using a 95-5% gradient of aqueous 0.2% ammonia in methanol as eluent to give the title compound as a white solid. Yield: 33 mg 1H NMR (W MHz, CDCl3) delta 8.11 – 8.03 (m, 2H), 7.48 – 7.37 (m, 2H), 7.22 – 7.14 (m, 3H), 7.12 – 7.07 (m, 2H), 6.88 (d, J= 6.9 Hz, 2H), 4.20 – 4.09 (m, IH), 4.06 – 3.96 (m, IH), 3.89 (d, J= 13.1 Hz, IH), 3.63 – 3.54 (m, 4H), 3.52 – 3.31 (m, 9H), 3.31 – 3.26 (m, 2H) 3.09 – 2.96 (m, 2H), 2.81 – 2.70 (m, 4H) 2.69 – 2.59 (m, 4H), 2.53 (s, 3H), 2.44 – 2.36 (m, IH), 2.23 – 2.11 (m, IH), 1.96 – 1.68 (m, 10H), 0.75 (d, J= 6.2 Hz, 3H). MS: [M+H]+=848 (calc=848) (MultiMode+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90349-23-8, 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia