Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 3934-20-1, 2,4-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3934-20-1, blongs to pyrimidines compound. HPLC of Formula: C4H2Cl2N2

To a solution of 2,4-dichloropyrimidine (149 mg, 1 mmol) in THF (5 mL), tetrakis (triphenylphosphine) palladium (23 mg, 2 mol%) and 0.5M solution of phenylzinc bromide (2.1 mL, 1.05 mmol) in THF were added. The reaction mixture was stirred at50 C for overnight. Then it was added saturated ammonium chloride solution and extracted with EtOAc twice. The organic layers were combined, washed with water and dried(MgS04). Evaporation of solvent gave a yellow residue which was purified by Prep. HPLC to afford a yellowish oil as 2-chloro-4-phenyl- pyrimidine to carry on. To a solution of intermediate 2 (20 mg, 0.039 mmol) in DMF (3 mL), NaH (3.9 mg of 60% dispersion in mineral oil, 0.0975 mmol) was added at0 C. The reaction mixture was then warmed to rt. and stirred for 1 hr. Then 2-chloro-4-phenyl- pyrimidine prepared above (18 mg as crude) was added. The reaction mixture was stirred at rt. for overnight. It was then quenched with water and extracted with EtOAc. The organic layer was separated, washed with brine and dried(MgS04). Evaporation of solvent gave yellowish oil which was then purified by Prep. HPLC to give a thick colorless oil as final product (Compound 335) as TFA salt. (5.5 mg, 18% yield) ‘H NMR (CD30D, 300 MHz) 0.92-1. 12 (m, 11 H). 1.25 (m, 2 H), 1.44 (dd, J=9. 2, 5.5 Hz,1 H), 1.89 (dd, J=8. 1,5. 5 Hz, 1H), 2.17-2. 37 (m, 2 H), 2.57 (m, 1 H), 2.95 (m,1 H), 3.52 (s, 3 H), 4.14 (m,1 H), 4.24-4. 38 (m, 2 H), 4.51 (m,1 H), 5.13 (d, J=10. 2 Hz,1 H), 5.31 (d, J=17. 2 Hz,1 H), 5.77 (m,1 H), 5.86 (s,1 H), 7.48-7. 60 (m,3 H), 7.66 (d, J=5.3 Hz, 1 H), 8.18 (m,2 H), 8.60 (d, J=5.1 Hz, 1 H). LC-MS (retention time: 1.947 min. ), MS m/z 669(MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3934-20-1, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 16234-10-9, Thieno[3,2-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16234-10-9, blongs to pyrimidines compound. Safety of Thieno[3,2-d]pyrimidin-4(3H)-one

Thieno[3,2-d]pyrimidin-4(3H)-one (12.5 g) was dissolved in acetic acid (52 mL), and bromine (13 mL) was added thereto. The reaction mixture was stirred at 120 C. for 12 hours in a hermetically sealed reactor. The reaction mixture was cooled to room temperature and distilled under reduced pressure to remove acetic acid. The reaction mixture was placed in ice water, and the solid thus obtained was filtered and washed with ether, and dried to obtain the title compound (7.8 g). [0172] 1H NMR (300 MHz, DMSO-d6): delta 12.75 (brs, 1H), 8.36 (s, 1H), 8.24 (s, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16234-10-9, its application will become more common.

Reference:
Patent; HANMI PHARM. CO., LTD; Son, Jung Beom; Kim, Nam Du; Chang, Young Kil; Kim, Hee Cheol; Kim, Ji Sook; Jung, Young Hee; US2013/274268; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7752-82-1, name is 5-Bromopyrimidin-2-amine, molecular formula is C4H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5-Bromopyrimidin-2-amine

Example 9; 211 212 213Part A:To compound 211 (1.00 g, 5.74 mmol) in ethanol (100 ml_) was added chloroacetaldehyde (50 wt% solution in water, 7.34 ml_, 57.5 mmol) at room temperature. The reaction mixture was heated at reflux for 16 hours at which time LC- MS analysis indicated that the reaction was complete. The reaction mixture was concentrated under vacuum. The residue was taken back up in ethyl acetate and saturated sodium bicarbonate. The organic and aqueous layers were separated. The organic layer was washed with brine, dried over anh. sodium sulfate and concentrated to afford compound 212 as a beige solid. 1H NMR (400 MHz, DMSO-d6) delta 9.32 (d, 1 H), 8.56 (d, 1 H), 7.85 (d, 1 H), 7.74 (d, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 7752-82-1.

Reference:
Patent; SCHERING CORPORATION; WO2008/82487; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 769-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 1.1 mmol aromatic aldehyde, 0.144 g 2 (1 mmol), 0.156 g 3 (1 mmol), and 0.01 g ZnO NPs (10 mol%) in a round bottom flask was heated in an oil bath at 110 C for 20-35 min. During the reflux the reaction was monitored by TLC (eluent: n-hexane: ethyl acetate, 1:1). After completion of the reaction the mixture was cooled to room temperature, then the reaction mixture was dissolved in dichloromethane and stirred for 5 min. The suspended solution was filtered and then heterogeneous nanocatalyst was recovered. Then solvent was evaporated and the solid was recrystallized from methanol to afford the pure product 4.

According to the analysis of related databases, 769-42-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mohaqeq, Mahboubeh; Safaei-Ghomi, Javad; Monatshefte fur Chemie; vol. 146; 9; (2015); p. 1581 – 1586;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 16019-33-3, Adding some certain compound to certain chemical reactions, such as: 16019-33-3, name is 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde,molecular formula is C6H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16019-33-3.

A mixture of compound 7 (20.0 g, 0.1 mol), triethyl orthoformate (18.6 g, 0.12 mol), and TsOH (1.0 g, 5.8 mmol) in EtOH (100 ml) was stirred at 40C for 2 h. After completion of the reaction, aqueous Na2CO3 was added to the mixture to adjust pH to 8. The solvent was removed under reduced pressure and the residue extracted with EtOAc (300 ml), washed with water (100 ml). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the residue that was purified by column chromatography on silica gel (eluent petroleumether – EtOAc, 5:1). Yield 25.0 g (90%), colorless oil. IR spectrum, nu, cm-1: 2987, 1546, 1518, 1123, 1068, 785. 1H NMR spectrum (CDCl3), delta, ppm (J, Hz): 8.62 (1H, s,H-2); 4.80 (1H, t, J = 5.8, CH); 3.74-3.66 (2H, m,CH2CH3); 3.48-3.41 (2H, m, CH2CH3); 3.25 (2H, d, J = 5.7,CH2); 1.13 (6H, t, J = 7.0, CH2CH3). 13C NMR spectrum (CDCl3), delta, ppm: 162.7; 155.8; 132.5; 129.2; 100.9; 62.9;35.4; 15.2. Found, m/z: 287.0323 [M(35Cl)+Na]+.C10H14Cl2N2NaO2. Calculated, m/z: 287.0325. Found, m/z:289.0295 [M(35Cl,37Cl)+Na]+. Calculated, m/z: 289.0296.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16019-33-3, 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Yu-Liu; Xu, Cheng-Tao; Liu, Ting; Zhu, Yong; Luo, Yu; Chemistry of Heterocyclic Compounds; vol. 54; 6; (2018); p. 638 – 642; Khim. Geterotsikl. Soedin.; vol. 54; 6; (2018); p. 638 – 642,5;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C4HCl3N2

After 2,4,6-nichluropyiimidin 25g(l 362mm 1), phenylbu x n c acid 36.5g(299.3mmol), and tetrakis(triphenyLphosp}tine)palladium (1.118 Q96mmoL) were dissolved in toluene (408mL), 2.OM Na,CA, aqueous solution (204 mL) and ethanol (204mL) were added thereto. The mixture was stored under influx for 2 hours at 120C. Upon completion of the reaction, extraction with EA and purification by column chromatography gave a compound 1-2 (25g, 93.7mmol, 69%).

With the rapid development of chemical substances, we look forward to future research findings about 3764-01-0.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; LEE, Hyo Jung; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; WO2011/71255; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17321-97-0, name is 2-Amino-4-methylpyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N4

To a stirred solution of intermediate 41B (500 g, 3730 mmol) in TI-IF (75 mL) andDMF (15 rnL) was added copper (II) bromide (16.65 g, 74.50 rnmol) and Isoamyl nitrite (7.53ml, 55,9 mmol) and the reaction was refluxed for I h. The reaction mixture was cooled to ambient temperature, concentrated to dryness, diluted with the DCM (200 mL), filtered, and washed with THF (200 ml.). The combined organic extracts were washed with 10 % Nai-1C03 (150 mL). Then brine (50 mL), dried over anhydrous sodium sulfate and evaporated underreduced pressure. The residue was puiified by column chromatography (Redisep.-120 g, 0-15 % EtOAc/n.-I-Iexane) to obtain intermediate 41C (0.75 g, 10.00%). ?H NMR (400 MHz, DMSO d6) S ppm 2.65 (s. 3 1-1), 908 (s, 1 H). LCMS MethodL); retention time 0.92 mm, [M±2H1199.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17321-97-0, 2-Amino-4-methylpyrimidine-5-carbonitrile.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 271-70-5, Adding some certain compound to certain chemical reactions, such as: 271-70-5, name is 7H-Pyrrolo[2,3-d]pyrimidine,molecular formula is C6H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 271-70-5.

7H-Pyrrolo[2,3-d]pyrimidine (6, 0.450 g, 3.78 mmol), (5-formyl-pyridin-2-yl)-(6-methoxy-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester (71, 1.43 g, 4.16 mmol), potassium hydroxide (0.689 g, 12.3 mmol) and 6.6 mL methanol were combined in a reaction vessel. The reaction mixture was allowed to stir at room temperature for 36 hours, then concentrated under vacuum to provide a thick brown slurry, which was combined with ethyl acetate and aqueous saturated sodium bicarbonate. The organic layer was dried with sodium sulfate, filtered and the filtrate adsorbed onto silica. This was purified by silica gel column chromatography, eluting with a gradient of 1-10% methanol in dichloromethane over 30 minutes. Appropriate fractions were combined and the solvents removed under vacuum to provide the desired compound (72, 380 mg). 1H NMR was consistent with the compound structure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-70-5, 7H-Pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ibrahim, Prabha N.; Bremer, Ryan; Zhang, Jiazhong; Nespi, Marika; Cho, Hanna; US2009/286782; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-24-4, name is 4,6-Dihydroxypyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dihydroxypyrimidine

General procedure: According to the conventional manufacturing method of the present inventors [16], under the condition containing two equivalents of triethylamine in dichloromethane at 25 , 4,6- dihydroxy-pyrimidine with 2 equivalents of Compound 2 by acylating a new and compounds 4, 6-pyrimidyl di (2-halo-benzoate) (compound 3) is prepared. After evaporation of dichloromethane, the mixture is dissolved in anhydrous THF, to remove the triethylamine hydrochloride by filtration. The concentrated residue was purified by short length silica gel (Davisil, pH = 7) was purified by column chromatography, or the Compound 3 is prepared by purification was recrystallized with 75% EtOAc / n- hexane

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-24-4, 4,6-Dihydroxypyrimidine.

Reference:
Patent; Duksung Women’s University Academic Cooperation; Lee, Jae In; Song, Yun jU; Choe, Jin Son; (12 pag.)KR2015/106483; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 33034-67-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.

Step 3 : A solution of 2-chloro-4-(trifluoromethyl)pyrimidine (0.297 g, 1.626 mmol) in dioxane (4 ml) was added to 3-Bromo-5-(difluoromethyl)aniline (0.314 g, 1.414 mmol) followed by methanesulfonic acid (0.1 1 ml, 1.694 mmol) and the resulting solution was heated overnight to 100 °C. The reaction was diluted with water and extracted with EtOAc. The organic phase was washed with saturated sodium bicarbonate, water, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel (EtOAc/hexane=2/8) to afford N- [3-bromo-5-(difluoromethyl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine. MS ESI calc’d. for Ci2H7BrF5N3 [M + H]+ 368, 370, found 368, 370. lH NMR (500 MHz, CDCI3) delta 8.65 (d, J= 4.9, IH), 8.09 (s, IH), 7.97 (s, IH), 7.73 (s, IH), 7.27 (s, IH), 7.07 (d, J= 4.9, IH), 6.56 (t, J= 56.2, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; ELLIS, John Michael; FISCHER, Christian; GRIMM, Jonathan; HAIDLE, Andrew, M.; KATTAR, Solomon, D.; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETROCCHI, Alessia; SCHELL, Adam, J.; ZHOU, Hua; WO2012/154519; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia