Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 99586-66-0, 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile, blongs to pyrimidines compound. Recommanded Product: 2-Amino-4-chloro-6-methylpyrimidine-5-carbonitrile

The procedure mentioned in Scheme 6 was used with (S)-methyl 6-((2-(1- ((tert-butoxycarbonyl)amino)propyl)-4-oxo-3 -phenyl-3 ,4-dihydroquinazolin-5- yl)amino)hexanoate 1.3b (110.0 mg, 0.21 mmol) and trifluoroacetic acid (480.0 mg, 4.21 mmol, 0.32 ml) in dichioromethane (2.1 ml). The resulting mixture was stirred at room temperature for 3 hours and worked-up (Method A) to form (S)-methyl 6-((2-(1- aminopropyl)-4-oxo-3 -phenyl-3 ,4-dihydroquinazolin-5-yl)amino)hexanoate 6.11. This free amine 6.11 was used with 2-amino-4-chloro-6-methylpyrimidine-5-carbonitrile (53.0 mg, 0.32 mmol) and diisopropylethylaime (81.0 mg, 0.63 mmol, 110.0 pi) in n-butanol (0.5 ml) and heated at 130 C for 2 hours. The remaining residue was purified by flash chromatography on silica gel using 0-100% EtOAc/Hexanes to afford the product methyl (5)- 6-((2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-phenyl-3,4- dihydroquinazolin-5-yl)amino)hexanoate 6.2q (97.0 mg, 0.174 mmol) in 83% yield. LC-MS (method 1): tR = 3.25 mi mlz (M + H)+ = 555.3.

The synthetic route of 99586-66-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; GREWAL, Gurmit; THAKUR, Ashish; TAWA, Gregory James; FERRER, Marc; SIMEONOV, Anton M.; (191 pag.)WO2018/237007; (2018); A1;,
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Pyrimidine – Wikipedia

Related Products of 3680-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.

To a suspension of commercial 4-chloro-7H-pyrrolo[2,3-d]pyrimidine 10.75 g (70.00 mmol) in 150mL DCM, and added 1-bromopyrrolidine-2,5-dione (18.69 g, 105.00 mmol) at ambient temperature overnight. Upon the reaction completion, large amounts of precipitates formed. The precipitates were collected by filtration, and the filtrate was removed under reduced pressure to get the solid, washed with DCM, to yield of the title compound as yellow solid (15.00 g, 92% yield). 1H NMR (400 MHz, DMSO) delta 12.97(s, 1H), 8.63 (s, 1H), 7.95 (d, J 2.6 Hz, 1H).

Statistics shows that 3680-69-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Article; Zhang, Chufeng; Pei, Heying; He, Jun; Zhu, Jiali; Li, Weimin; Niu, Ting; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 169; (2019); p. 121 – 143;,
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Pyrimidine – Wikipedia

Related Products of 10070-92-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10070-92-5, name is Pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of pyrimidine-5-carbaldehyde (500 mg, 4.6 mmol) in MeOH (10 mL) at 0, was added NaBH4 (262 mg, 6.9 mmol) in one portion. The mixture was stirred at RT for 4 h. It was then washed with brine and extracted with EA. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated to give pyrimidin-5- ylmethanol as a white solid (456 mg, 89%). LC-MS (ESI): m/z (M+H) =111.13

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10070-92-5, Pyrimidine-5-carbaldehyde.

Reference:
Patent; REMEDY PLAN, INC.; CRIMMINS, Gregory, Thomas; DE JESUS DIAZ, Dennise, Alexandra; BHURRUTH-ALCOR, Yushma; (483 pag.)WO2019/213570; (2019); A1;,
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Pyrimidine – Wikipedia

Electric Literature of 91717-22-5 ,Some common heterocyclic compound, 91717-22-5, molecular formula is C10H16N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100 mL jar, 2-amino-4-piperidinyl-6-methylpyrimidine (0.001 mol) was added,Furfural (0.001 mol), dimethyl malonate (0.0015 mol), and p-xylene (30 mL) as the solvent,The reaction was terminated after 50 minutes in a microwave at 100C, and paraxylene was recovered under reduced pressure.Column chromatography (petroleum ether:ethyl acetate=4:1 V/V) gave the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 91717-22-5, 2-Amino-4-piperidino-6-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guizhou Institute Of Technology; Bai Song; Zhu Yunying; Wei Xian; Wu Qin; Zou Shuliang; Tang Qin; Gong Zhihai; Zhou Han; Zhou Hang; (14 pag.)CN108101855; (2018); A;,
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Pyrimidine – Wikipedia

Reference of 49845-33-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.

[00235] Example 5.1 Synthesis of 4-({8-[(2,6-Difluorophenyl)amino]-9- cvclopentylpurin-2-yl) amino) frvms-cyclohexan-l-ol; [00236] 1. (2-Chloro-5-nitropyrimidin-4-yl’)cvclopentylamine; [00237] 2,4-Dichloro-5-nitropyrimidine (10.31 mmol, 2 g) and cyclopentylamine(10.31 mmol, 1.02 mL) were dissolved in THF (60 mL) and cooled to -78C. N5N- diisopropylethylamine (10.31 mmol, 1.8 mL) was added dropwise. The reaction mixture was stirred at -78C for about 45 minutes. The cooling bath was removed and the reaction mixture was stirred at room temperature for about 16 hours. After removal of the solvent the residue was redissolved in EtOAc and washed with water and brine. The organic phase was dried over MgSO4 and the solvent evaporated. The residue was purified using column chromatography (SiO2, 9:1 n-hexanes/ ethyl acetate) to give the desired product (2.11 g, 84% yield). ES-MS: 242 (M+l). When the hydrochloride salt of an amine is used in place of the cyclopentylamine described above, 2 to 3 equivalents of N,N-diisopropylethylamine and dichloromethane are used as solvent.

Statistics shows that 49845-33-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-nitropyrimidine.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2006/76595; (2006); A1;,
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Pyrimidine – Wikipedia

Reference of 16019-33-3, Adding some certain compound to certain chemical reactions, such as: 16019-33-3, name is 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde,molecular formula is C6H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16019-33-3.

2-(4,6-dichloropyrimidin-5-yl)acetaldehyde was dissolved in ethanol (0.55M). Triethylamine was then added to the reaction mixture (2 equiv) and stirred for ten minutes at room temperature. Tert-butylamine was then added (2 equiv) to the reaction mixture and heated (reflux, 90 C) overnight. The reaction mixture was then evaporated in vacuo. The crude mixture was then dissolved in 1 : 1 deionized water ethyl acetate and the organic layer was collected and concentrated. The organic extract was then purified using FCC (gradient of hexanes:ethyl acetate (95:5 to 80:20) to yield a yellow oil in 59.5% Yield. NMR matched literature (Andrews et al, Patent WO2012137089 Al, Prep 5). NMR (400 MHz, CDCh) delta 8.57 (s, 1H), 7.35 (d, J= 3.7 Hz, 1H), 6.49 (d, J= 3.7 Hz, 1H), 1.75 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16019-33-3, 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION; GUSTAFSON, Jeffrey L.; TOENJES, Sean Thomas; MADDOX, Sean M.; (69 pag.)WO2018/237134; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 698-29-3, 4-Amino-2-methylpyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 698-29-3, blongs to pyrimidines compound. SDS of cas: 698-29-3

A solution of 4-amino-2-methylpyrimidine-5-carbonitrile 1a (3.04g, 30mmol) and raney nickel (3.0g) in formic acid (20mL) was stirred at 80C for 4h. After this, the reaction mixture was filtered and washed with 10mL formic acid. The filtrate and washings were collected together and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel and eluted with ethyl acetate/petroleum ether (1:1, v/v) to give white solid 2a, which was used directly for the next step. Under this same condition, the intermediate compounds 2a and 2c were also prepared.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,698-29-3, its application will become more common.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
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Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 46155-89-9, blongs to pyrimidines compound. Recommanded Product: 46155-89-9

A solution of 1 g (5.58 mmol)of compound 1a in 5 mL of concentrated sulfuric acid was cooled to 2-5C, and a mixture of 0.37 mL(5.58 mmol) of nitric acid (d = 1.41 g/cm3) and 2 mL of concentrated sulfuric acid was added dropwise with vigorous stirring and cooling. The mixture was stirred for 1 h and poured onto 20 g of ice. After 30 min, the precipitate was filtered off and washed with 10 mL of water. Yield 0.77 g (62%, assuming formation of mononitro derivatives). According to the 1H NMR data, the product was a mixture of 6- and 7-nitro derivatives ata ratio of 7 : 93. It was recrystallized from 55 mL of ethanol to isolate 0.47 g (38%) of 7-nitro isomer 2a,mp 272-273C. IR spectrum, nu, cm-1: 3150 m (NH),1710 s, 1680 s (C=O), 1575 s, 1390 s (NO2). 1H NMRspectrum (DMSO-d6), delta, ppm: 3.25 s (3H, 1-CH3),3.58 s (3H, 3-CH3), 8.27 d (1H, 6-H, J = 3.47 Hz),13.55 br.s (1H, NH). Found, %: C 42.73; H 3.70;N 24.88. C8H8N4O4. Calculated, %: C 42.86; H 3.60;N 24.99.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Tkachenko, Yu. N.; Popov; Pozharskii; Borodkin; Levchenkov; Russian Journal of Organic Chemistry; vol. 53; 10; (2017); p. 1564 – 1572; Zh. Org. Khim.; vol. 53; 10; (2017); p. 1536 – 1543,8;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 705263-10-1, Adding some certain compound to certain chemical reactions, such as: 705263-10-1, name is 6-Bromopyrazolo[1,5-a]pyrimidine,molecular formula is C6H4BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 705263-10-1.

The intermediate of formula VI (30 mmOl, 5.9 g)And the substance of formula VII (30 mmol, 4.6 g)Was placed in a 250 ml round bottom flask equipped with a reflux condenser, potassium carbonate (90 mmol, 12.4 g) and Pd (PPh3) 4 (3 mmol, 3.3 g) were added, dioxane (90 ml) and water (30 ml ), Stirred under nitrogen for three times, heated under nitrogen to 110 C, stirred for 4 h,After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed under reduced pressure. The mixture was extracted with 100 ml of water and 100 ml of dichloromethane. The organic phase was separated and the aqueous phase was extracted with dichloromethane 50 ml chi 3 for 3 times. Dried over sodium sulfate, the solvent was removed by suction filtration, and the residue was purified by column chromatography with ethyl acetate / petroleum ether to give 5.5 g of a pale yellow product.The pale yellow product is an intermediate of formula III-1,The yield of the intermediate of formula III-1 was calculated to be 82%.

According to the analysis of related databases, 705263-10-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chengdu Zhipulai Bio-pharmaceutical Technology Co., Ltd.; Chen Wei; Zhao Gang; Pu Lin; Liu Jifeng; (13 pag.)CN105130991; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4765-77-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4765-77-9, name is 6-Chloropyrimidin-4(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 6-chloropyrimidin-4(3H)-one (5 g), methyliodide (2.6 mL) and K2CO3 (10.6 g) in acetone (100 mL) is stirred at room temperature over night. The mixture is partitioned between water and ethyl acetate. The organic phase is washed with brine, dried (MgSO4) and concentrated. The residue is triturated with diisopropylether to give the title compound. Yield: 5.1 g; LC (method 1 1 ): tR = 0.25 min; Mass spectrum (ESI+): m/z = 145 [M+H]+.

According to the analysis of related databases, 4765-77-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144097; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia