Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H2BrClN2, blongs to pyrimidines compound. COA of Formula: C4H2BrClN2

5-Bromo-2-phenoxypyrimidine (intermediate AU) A mixture of 5-bromo-2-chloropyrimidine (5.00 g, 0.0259 mol), phenol (3.16 g, 0.0336 mol), dibenzo-18-crown-6 (0.47 g, 0.0013mol) and ground potassium hydroxide (3.51 g, 0.0626 mol) in toluene (75 ml) was heated at reflux for 5 hours with azeotropic removal of water. The mixture was allowed to cool to ambient temperature and the solvent was removed under reduced pressure. The residue was partitioned between water and chloroform. The layers were separated and the aqueous phase was extracted with chloroform three times. The combined organic layers were dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography on silica using n-heptane/ethyl acetate (98:2) as an eluent to give 5-bromo-2-phenoxy-pyrimidine as a white solid (3.55 g, 0.0141 mol): 1H NMR (DMSO-d6, 400 MHz) 8.80 (s, 2H), 7.45 (t, 2H), 7.27 (t, 1H), 7.22 (d 2H); TLC (n-heptane/ethyl acetate=95:5) Rf 0.20

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Abbott Laboratories; US2002/156081; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5767-35-1, name is 4-Chloro-6-hydrazinopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Chloro-6-hydrazinopyrimidine

General procedure: To the suspension of appropriate 1-(6 -chloropyrimidin chloropyrimidin-4-yl) (3) (3.0 mmol) in EtOH (15 mL) was added dropwise with vigorous stirring an aldeldehyde (3.6 mmol, 1.2 equiv) at rt over 0.5-1 h. The progression of the reaction was monitored by TLC. After completion of the reaction, solvent was removed under reduced pressure to afford the crude product. Crystallization from an appropriate solvent or purification by column chromatography on silica gel furnished the pure hydrazones 4.

With the rapid development of chemical substances, we look forward to future research findings about 5767-35-1.

Reference:
Article; Tang, Caifei; Li, Zhiming; Wang, Quanrui; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 2629 – 2634;,
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Adding a certain compound to certain chemical reactions, such as: 5413-85-4, 5-Amino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5413-85-4, blongs to pyrimidines compound. Safety of 5-Amino-4,6-dichloropyrimidine

Step 1: 6-Chloro-4,5-diaminopyrimidine To a cold solution of 5-amino-4,6-dichloropyrimidine (2.0 g, 12.2 mmol) in isopropanol (20 ml) was added liquid ammonia (5 ml), and the mixture was transfered into a sealed tube. The tube was heated at 130 C. for 3 hours and then cooled to room temperature. The product precipitated out was filtered and dried in vacuo. Yield 2.0 g (quantitative).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5413-85-4, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US5102880; (1992); A;,
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Synthetic Route of 14160-93-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14160-93-1, name is 4-Amino-6-chloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide (302.1 mg, 1.15 mmol) and 4-amino-6-chloro-pyrimidine-5-carbaldehyde (157 mg, 1.0 mmol) in DMSO (2 mL) was added DIEA (258.5 mg, 2.0 mmol). The mixture was kept stirring at 100 C. for 2 h and MeONH2.HCl (167 mg, 2.0 mmol) was added. The resulting mixture was heated at 100 C. for 0.5 h. It was diluted with water and extracted with CH2Cl2. The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated under reduced pressure. The crude oil was subjected to flash column chromatography on silica gel (EtOAc as eluent) to yield the title compound (45 mg, 11%). 1H NMR (CDCl3) delta 8.19 (s, 1H), 8.12 (s, 1H), 7.21 (d, J=8.93 Hz, 2H), 6.81 (d, J=8.94 Hz, 2H), 6.45 (br, 1H), 4.46 (m, 1H), 3.96 (s, 3H), 3.58 (m, 4H), 3.42 (m, 4H), 1.30 (d, J=6.06 Hz, 6H); LC/MS (ESI) calcd for C20H28N7O3 (MH)+ 414.2, found 414.4.

According to the analysis of related databases, 14160-93-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Baumann, Christian Andrew; Gaul, Michael David; US2006/281755; (2006); A1;,
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Synthetic Route of 105742-66-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105742-66-3, name is 4,5-Dichloro-2,6-dimethylpyrimidine, molecular formula is C6H6Cl2N2, molecular weight is 177.03, as common compound, the synthetic route is as follows.

General procedure: A mixture of intermediates 8 (5 mmol), (2-phenyloxazol-4-yl)methanamines 4 (5 mmol), and anhydrous potassium carbonate (1.4 g, 10 mmol) were taken in a 1:1 DMF:Water (20 mL) and heated at 80 C for 3-4 h. The progress of reaction was monitored by TLC. After completion of reaction, the reaction mixture was poured into saturated saline and extracted with ethyl acetate (3 x 50 mL). The combined organic layers was dried over Na2SO4 and removed under reducing pressure to give the crude product. The residue was recrystallized from the mixture of petroleum ether (50 mL) and ethyl acetate (10 mL) to give pure target compounds 9 in 79-86% yield.

Statistics shows that 105742-66-3 is playing an increasingly important role. we look forward to future research findings about 4,5-Dichloro-2,6-dimethylpyrimidine.

Reference:
Article; Zhang, Ning; Huang, Ming-Zhi; Liu, Ai-Ping; Liu, Min-Hua; Li, Li-Zhong; Zhou, Chun-Ge; Ren, Ye-Guo; Ou, Xiao-Ming; Long, Chu-Yun; Sun, Jiong; Dang, Ming-Ming; Lan, Zhi-Li; Chemical Papers; vol. 74; 3; (2020); p. 963 – 970;,
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Pyrimidine – Wikipedia

Application of 41103-17-7, Adding some certain compound to certain chemical reactions, such as: 41103-17-7, name is Ethyl 4-chloropyrimidine-5-carboxylate,molecular formula is C7H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41103-17-7.

To a solution of ethyl 4-chloropyrimidine-5-carboxylate (10.5g, 0.056mol) was dissolved in DMF (lOOmL) was added 2-isopropyl-lH-imidazole (6.2g, 0.056mol) and Cs2C03 (27.6g), and then heated to 80C for lhrs, showed reaction completed). After cooled to r.t., water (500 mL) was added, then extracted with EA (200 mL* 2), washed with brine and dried over Na2S04. Then concentrated under reduced pressure and purified by flash chromatography on silica gel column (elution: PE/EA=3/1) to giveExample 43a (9.7 g, yield 66%) as a yellow solid. LCMS [M+1] =261

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 41103-17-7, Ethyl 4-chloropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
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Related Products of 932-52-5 ,Some common heterocyclic compound, 932-52-5, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

15.01g (84.73mmol) 5- amino-uracil was dissolved in 100 mL of 20% hydrochloric acid, stirred for half an hour and then was added 13.5ml (163.62mmol) of freshly distilled crotonaldehyde, the reaction was heated at reflux for 5 hours, the reaction solution was dark brown. The reaction mixture was cooled to room temperature, placed in 4 refrigerator cold storage overnight. The precipitated pale yellow solid was filtered off under reduced pressure using a Buchner funnel, and slowly added dropwise with aqueous ammonia and solid was kept under stirring allowed to become homogeneous slurry, aqueous ammonia was added to stop the detection pH of 7 to 8:00, and again filtered and dried to yield 13.22g of compound 7, an off-white solid, yield 63.2%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing University; Liu, Junyi; Zhou, Shouxin; Zhang, Zhili; (18 pag.)CN102977090; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3073-77-6, name is 2-Amino-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-5-nitropyrimidine

Example 47. 3-(5-Nitropyrimidin-2-vIamino)-N-(2-hvdroxyethyl)-iV- isopropvlbenzamide (33); [0187] A mixture of 5-nitro-pyrimidin-2-ylamine (141 mg, 1.0 mmol), bromide intermediate 32 described in Example 46 (301 mg, 1.1 mmol), Cs2CO3 (1.3 g, 4.0 mmol), Xantphos (117 mg, 0.2 mmol), and Pd2(dba)3 (92 mg, 0.1 mmol) in dioxane (20 mL) was purged with argon for 5 min, and the suspension was heated to reflux for 16 h. under argon. Dioxane was removed in vacuo, and the crude mixture was adsorbed onto silica gel and purified using an Isco flash chromatography system (0% to 30% Methanol with 1% NH4OH in DCM) to afford a tan solid (142 mg, 41%).1H NMR (DMSO-d6) delta 1.11 (bs, 6H), 3.33-3.36 (m, 2H), 3.56 (bs, 2H), 3.87 (bs, IH), 4.76 (bs, IH), 7.08 (d, J= 7.6 Hz, IH), 7.43 (t, J= 7.9 Hz, IH), 7.78 (bs, IH), 7.79 (dd, J = 8.0, 1.5 Hz, IH), 9.25 (s, 2H), 10.94 (s, IH). MS (ES+): m/z = 346 (MH-H)+. LC retention time: 2.21 min.

The synthetic route of 3073-77-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49844-93-1, name is 2-Chloro-4-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-4-(methylthio)pyrimidine

A solution of 2-chloro-4-methylsulfanyl-pyrimidine (1 g, 6.23 mmol), Na2CO3 (9.3 mL of 2 M aq., 18.60 mmol) and 2-[(E)-2-ethoxyvinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.35 g, 6.82 mmol) in 1,2-dimethoxyethane (15 mL) was degassed with nitrogen. Pd(PPh3)4 (600 mg, 0.519 mmol) was added and the mixture again degassed with nitrogen. The mixture was heated under reflux for 2 hours. The reaction mixture was cooled to ambient temperature, partitioned between EtOAc and water and the layers separated. The aqueous layer was extracted with EtOAc and the combined organic extracts washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (silica, EtOAc/petrol gradient) to afford 2-[(E)-2-ethoxyvinyl]-4-methylsulfanyl-pyrimidine (1.10 g, 90%); 1H NMR (500 MHz, Chloroform-d) delta 8.19 (d, 1H), 7.94 (d, 1H), 6.85 (d, 1H), 5.90 (d, 1H), 4.02 (q, 2H), 2.56 (s, 3H), 1.40 (t, 3H); MS m/z 197.1 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 49844-93-1.

Reference:
Patent; MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED; BAYLY, Andrew; BLEICH, Matthew; CHARRIER, Jean-Damien; DODD, James; DURRANT, Steven; ENO, Meredith Suzanne; ETXEBARRIA I JARDI, Gorka; EVERITT, Simon; FRAYSSE, Damien; KELLY, Shazia; KNEGTEL, Ronald; MOCHALKIN, Igor; MORTIMORE, Michael; NORTH, Kiri; PORICHIS, Filippos; PULLIN, Robert; RUTHERFORD, Alistair; STORCK, Pierre-Henri; TWIN, Heather Clare; XIAO, Yufang; (1159 pag.)WO2019/148132; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 22536-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-61-4, name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.

[0613] Synthesis of methyl 5-methylpyrimidine-2-carboxylate: Me [0614] To a stirred solution of 2-chloro-5-methylpyrimidine (200 mg, 1.55 mmol) in MeOH: CH3CN (4: 1, 10 mL) under argon atmosphere were added Pd(dppf)Cl2 (227 mg, 0.31 mmol) and triethyl amine (0.45 mL, 3.11 mmol) at RT; heated to 100 C and stirred for 16 h in steel bomb under CO pressure. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was filtered through celite and the filtrate was concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 60% EtOAc/ Hexanes to afford 5-methylpyrimidine-2-carboxylate (146 mg, 62%) as brick red solid. [0615] 1H-NMR (CDCls, 400 MHz): delta 8.74 (s, 2H), 4.08 (s, 3H), 2.42 (s, 3H); LC-MS: 81.73%; 153 (M++l); (column: X Bridge C-18, 50 3.0 mm, 3.5 mupiiota); RT 2.10 min. 0.05% Aq TFA: ACN; 0.8 mL/min); TLC: 70% EtOAc/ Hexanes (R 0.2)

Statistics shows that 22536-61-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-methylpyrimidine.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia