Tag: M.W:100-200

Application of 155-10-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-fluorobenzyl alcohol (2.56 g, 20.3 mmol) in 1,4-dioxane (20 mL) was added 60% NaH (0.813 g, 20.3 mmol) in several portions over a period of 10 min. To the magnetically stirred solution was added 2-Chloro-5-fluoropyrimidin-4-amine* (2.00 g, 13.6 mmol) and the mixture was stirred at room temperature until gas evolution subsided. The reaction mixture was then heated in a CEM Discover microwave reactor at 120 C. for 90 min. The cooled reaction mixture was partitioned between ethyl acetate and water, the organic phase was concentrated, and the product was purified by column chromatography (hexane/ethyl acetate gradient) to yield 5-fluoro-2-(4-fluorobenzyloxy)pyrimidin-4-amine (1.66 g, 52% yield) as a white solid: mp 129-131 C.; 1H NMR (300 MHz, CDCl3) delta 7.91 (d, J=2.6 Hz, 1H), 7.42 (m, 2H), 7.03 (m, 2H), 5.27 (s, 2H), 5.05 (br s, 2H); MS (ESI) m/z 238 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 155-10-2, 4-Amino-2-chloro-5-fluoropyrimidine.

Reference:
Patent; DOW AGROSCIENCES LLC; US2009/203647; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 55583-59-0 ,Some common heterocyclic compound, 55583-59-0, molecular formula is C4H4Cl2N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of compound 42 (1.29 g, 7.21 mmol) and 3,4-dimethoxyaniline 9 (919 mg, 6 mmol) in n-BuOH (30 mL) in an Ace Tube was added DIPEA (3.2 mL) and the reaction mixture was stirred at 125 C for 3 days. The mixture was allowed to cool to rt and subsequently concentrated in vacuo. The residue was purified by silica gel column chromatography (toluene:EtOAc 2:3 ? EtOAc) affording compound 43 (1.241 g, 65%) as an off-white solid. 1H NMR (d6-DMSO, 499.95 MHz): delta = 3.72 (s, 3 H, 4-OCH3), 3.77 (s, 3 H, 3-OCH3), 4.20 (bs, 2 H, 5-NH2), 5.84 (bs, 2 H, 2-NH2), 6.98 (d, 1 H, J5, 6 = 8.7, H-5), 7.23 (dd, 1 H, J6, 5 = 8.7, J6, 2 = 2.5, H-6), 7.44 (d, 1 H, J2, 6= 2.5, H-2), 8.20 (bs, 1 H, NH). 13C NMR (d6-DMSO, 150.92 MHz): delta = 55.62 (3-OCH3), 56.00 (4-OCH3), 106.03 (C-2), 112.18 (C-5), 112.36 (C-6), 114.07 (C-5), 133.89 (C-1), 142.82 (C-6), 144.45 (C-4), 148.66 (C-3), 152.65 (C-4), 155.54 (C-2). HRMS calcd for C12H15N5O2Cl m/z: 296.09088 (M+H)+, found 296.09094.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55583-59-0, its application will become more common.

Reference:
Article; ?ala, Michal; Koegler, Martin; Pla?kova, Pavla; Mejdrova, Ivana; H?ebabecky, Hubert; Prochazkova, Eli?ka; Strunin, Dmytro; Lee, Gary; Birkus, Gabriel; Weber, Jan; Mertlikova-Kaiserova, Helena; Nencka, Radim; Bioorganic and Medicinal Chemistry Letters; vol. 26; 11; (2016); p. 2706 – 2712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14394-70-8, name is 2-Chloro-5-methylpyrimidin-4-amine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-5-methylpyrimidin-4-amine

[0228] A mixture of 2-chloro-5-memyl-pyrimidin-4-ylamine (0.30 g, 2.1 mmol), A- bromo-l-chloro-2-trifluoromethyl-benzene (0.40 mL, 2.7 mmol), Pd2(dba)3 (0.10 g, 0.11 mmol), Xantphos (0.13 g, 0.22 mmol) and cesium carbonate (1.5 g, 4.6 mmol) in. dioxane/DMF (6/1, 7 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 C for 15 min. After cooling to room temperature, the cap was removed and the resulting mixture filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (hexanes to 50% EtOAc/hexanes) to afford the title compound (0.65 g, 96%) as a white solid. MS (ES+): m/z 322 (MH-H)+.

The synthetic route of 14394-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 696-82-2, Adding some certain compound to certain chemical reactions, such as: 696-82-2, name is 2,4,6-Trifluoropyrimidine,molecular formula is C4HF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 696-82-2.

23.9 parts of J acid was dissolved in 200 parts of water, 10% sodium carbonate solution was adjusted to pH 6, fully dissolved, and then added13.5 parts of trifluoroxrimidine at 10 , pH 9 under the conditions of condensation reaction 6h, without J acid is the end point, the preparation of condensation products

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 696-82-2, 2,4,6-Trifluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Dimei Chemical Co., Ltd.; Wang, Xiaojun; (7 pag.)CN106398302; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2435-50-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2435-50-9, name is Pyrimidine-4-carbaldehyde, molecular formula is C5H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: SI, Figure 4. General procedure of the reductive amination reactions: synthesis of AA9-AA24 compounds (Tables 1 and 2). The ethyl 3-amino-4-(cyclohexylamino)benzoate (AA1) and derivatives (1 equiv.)and benzaldehyde (1 equiv) were heated in DCE for 1h at 80 oC in the presence of molecular sieves (4 A), then the mixture was cooled down to room temperature before addition of the NaBH(OAc)3 (1.6 equiv.) in small portions over 3h. The reaction mixture was stirred at room temperature under a nitrogen atmosphere for 17h. The reaction mixture was quenched with aqueous saturated NaHCO3, and the product was extracted with EtOAc. The EtOAc extract was dried (MgSO4), and the solvent was evaporated. The residue was purified by flash-column chromatography on silica gel, using a mixture of solvent of DCM: MeOH (50:1), to provide the desired AA9-AA24 compounds (Tables 1-2).

According to the analysis of related databases, 2435-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Iniguez, Eva A.; Perez, Andrea; Maldonado, Rosa A.; Skouta, Rachid; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5315 – 5320;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, molecular weight is 155.16, as common compound, the synthetic route is as follows.Computed Properties of C6H9N3O2

To 50 ml pear-shaped flask add 155 mg (1 mmol) of 2 – amino – 4, 6 – dimethoxy pyrimidine solid and 8 ml of dried DMF, stirring to dissolve adding 2 g water-free K2CO3, Stirring under the room temperature condition 0.5 h, then to slow added in the reaction system of 270 mg (1 mmol) of 5 – bromo valeric acid O-methyl ester, stir at room temperature overnight TLC monitoring to the reaction is complete. After the reaction is finished adding 40 ml of water, then 2 × 50 ml ethyl acetate, the combined organic phase sequentially for 2 × 50 ml of 1 N HCl solution, 2 × 50 ml of saturated sodium chloride solution. The organic phase after drying over anhydrous sodium sulfate the solvent is removed by reduced pressure distillation after purification on silica gel, ethyl acetate/petroleum ether (v/v, 4/1) elution, to obtain light yellow oily liquid, yield 72%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Northwest A&F University; Ji Zhiqin; Wei Shaopeng; (12 pag.)CN107857735; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 3680-69-1

38.4 g (250.4 mmol, 1.0 eq.) with stirring in an ice bath. 4-chloro-7H-pyrrole [2,3-d]pyrimidine is dissolved in 200 mL of dry DMF solution.13 g (305 mmol, 1.2 eq) of 57% NaH was added. The reaction was stirred at room temperature for 1 hour, then 50.9 g of SEMCl (305 mmol, 1.2 eq.).After the addition, the reaction was stirred in an ice bath for 1 hour. quenched with water, extracted with ethyl acetate. the title compound (71 g, yield = 100%) was obtained.

With the rapid development of chemical substances, we look forward to future research findings about 3680-69-1.

Reference:
Patent; Beijing Puqi Pharmaceutical Technology Co., Ltd.; Zhu Li; Hu Wei; Wang Jin; (32 pag.)CN109867675; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 56-06-4 ,Some common heterocyclic compound, 56-06-4, molecular formula is C4H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound (37)Intermediate AA (0.5g, 3.96 mmol) was added to a solution of NaOAc (0.647g, 4.76 mmol, 1.2 eq.) in H20 (15 mL). The reaction was heated to 60 C for ~15 minutes, and a solution of 50% aqueous ClCH2CHO (0.5 mL) was then added. The reaction stirred for 2 hours at 60 C. The reaction mixture was filtered to remove undissolved material, and the filtrate stored at 0 C overnight. The resulting precipitated solid was collected by filtration, washed with cold H20, and dried to obtain Compound (37) (120mg, 20%) as a pink solid. Rf = 0.7 (30%MeOH/CHCl3/0.2 mL of aqueous NH3). 1H-NMR (400MHz, DMSO-_¾ delta 10.95 (br. s, exchanged with D20, 1H), 10.20 (s, exchanged with D20, 1H), 6.60 (dd, J = 3.2, 2.0Hz, 1H), 6.18 (dd, J = 3.2, 2.0Hz, 1H), 6.03 (br. s, exchanged with D20, 2H). Mass (m/z): 150.8 (M++l). LCMS: (Column: Zodiacsil 120-5-C-18-Aq (4.6 * 50 mm), Mobile phase: A: 0.01M HCOONH4 (Aq); B: MeOH, T/%B: 0/5, 10/90, 10.1/5, Flow: 1.0 mL/min, Diluent: MeOH), Rt=2.599 min, 99.16 (214 nm), 99.10 (254 nm).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-06-4, 2,6-Diaminopyrimidin-4(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian; WO2011/35009; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.

Example 145 Synthesis of 2-(4-{6-[7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-2-methyl-pyrimidin-4-yl}-piperazin-1-yl)-ethanol To synthesize the title compound (CLXIX), two intermediate compounds 62 (2-[4-(6-chloro-2-methyl-pyrimidin-4-yl)-piperazin-1-yl]-ethanol) and 63 (7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamine) shown below were used. To synthesize compound 62, to a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2-piperazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DIPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The reaulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford compound 62 as a brown liquid (2.1 g, 39%). MS (ESI+): m/z 257.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TargeGen, Inc.; US2005/245524; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6328-58-1, blongs to pyrimidines compound. Recommanded Product: 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one

A mixture of 0.01 mol of 6-methyl-2-(methylsulfanyl)-pyrimidin-4(3H)-one and 0.02 mol of pyrrolidine in 20 mL of butan-1-ol was heated for 15 h at 130140C. The solvent was distilled off, the residue was treated with diethyl ether, and the precipitate was ltered off and dried. Yield 72%, mp 240242C. IR spectrum: nu 1646 cm -1 (C=O). 1 H NMR spectrum, delta, ppm: 1.921.99 m (4H, CH 2 CH 2 ), 2.04 s (3H, CH 3 ), 3.433.51 m (4H, CH 2 NCH 2 ), 5.32 s (1H, 5-H), 10.84 br.s (1H, OH). 13 C NMR spectrum, delta C , ppm: 23.7, 24.7, 46.1, 98.8, 152.2, 163.7, 165.1. Found, %: C 60.21; H 7.26; N 23.20. C 9 H 13 N 3 O. Calculated, %: C 60.32; H 7.31; N 23.45.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6328-58-1, its application will become more common.

Reference:
Article; Pivazyan; Ghazaryan; Azaryan, Zh. A.; Yengoyan; Russian Journal of General Chemistry; vol. 89; 10; (2019); p. 2010 – 2017; Zh. Obshch. Khim.; vol. 89; 10; (2019); p. 1511 – 1519,9;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia