Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62802-38-4, name is 5-Bromo-2-fluoropyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 62802-38-4

To a solution of 5-bromo-2-fluoro-pyrimidine (1.0 g, 4.93 mmol) and 6,7- dihydro-5H-pyrrolo[l,2-a]imidazol-2-amine (0.87 g, 4.93 mmol) in DMSO (20 mL) was added DIEA (1.27 g, 9.86 mmol), and the mixture was stirred at 100 C for 2 h under 2 before it was allowed to cool to rt. The mixture was purified by reverse phase column chromatography (Welch Ultimate XB-C18, 40-70 muiotaeta) eluting with a gradient of 20-95% acetonitrile in water to afford N-(5-bromopyrimidin-2-yl)-6,7-dihydro-5H-pyrrolo[l,2- ]imidazol-2-amine.

The synthetic route of 62802-38-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PLEXXIKON INC.; HOLLADAY, Mark W.; LIU, Gang; (267 pag.)WO2017/19804; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 99420-75-4 ,Some common heterocyclic compound, 99420-75-4, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-methylpyrimidine-2-carboxylic acid (1 g, 7.24 mmol) in DMF (72.4 ml) was added 5-methylpyrimidine-2-carboxylic acid (1 g, 7.24mmol), and N,0- dimethylhydroxylamine hydrochloride (0.777 g, 7.96 mmol). The mixture was cooled to 0 C and 1-propanephosphonic acid cyclic anhydride, 50 wt. % solution in EtOAc (9.21 ml, 14.48 mmol) was added droppwise. The mixture was allowed to warm to RT overnight. LCMS indicated complete conversion to product. The mixture was diluted with water, extracted with CHC13:IPA (3: 1) and washed with brine and NaHC03. The mixture was dried over Na2S04, concentrated in vacuo and purified by silica gel chromatography (0-100% heptane s:EtO Ac) to yield N-methoxy-N,5-dimethylpyrimidine- 2-carboxamide (0.7 g, 3.86 mmol, 53.4 % yield). NMR (500 MHz, CDC13) delta 8.61 – 8.69 (m, 2 H) 3.61 – 3.79 (m, 3 H) 3.27 – 3.47 (m, 3 H) 2.34 – 2.45 (m, 3 H). LCMS-ESI (pos.) m +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,99420-75-4, its application will become more common.

Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DEBENEDETTO, Mikkel V.; DRANSFIELD, Paul John; HARVEY, James S.; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; SHARMA, Ankit; (321 pag.)WO2018/93576; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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Reference of 1004-40-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, molecular formula is C4H5N3OS, molecular weight is 143.167, as common compound, the synthetic route is as follows.

General procedure: A mixture of 0.174 g of 3-methyl-1-phenyl-2-pyrazoline-5-one (1, 1.0 mmol), 0.150 g of 4-chlorobenzaldehyde (2,1 mmol), 0.160 g of 6-amino-2-thiouracil (3, 1 mmol) and 9.8 mm3 of piperidine as a catalyst (10%) in 8 cm3 of ethanol in a 100-cm3 round-bottomed flask fitted with areflux condenser was heated with stirring in an oil bath maintained at 80 C. After the complete appearance of the white solid and monitored by TLC, the reaction mixture was cooled to room temperature and resulting solid product was filtered, washed with ethanol to give products 4a-4r.

The chemical industry reduces the impact on the environment during synthesis 1004-40-6, I believe this compound will play a more active role in future production and life.

Reference:
Article; Bayat, Mohammad; Nasri, Shima; Mohammadali, Mohammad Reza; Monatshefte fur Chemie; vol. 148; 10; (2017); p. 1833 – 1842;,
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Adding a certain compound to certain chemical reactions, such as: 108-52-1, 4-Methylpyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-52-1, blongs to pyrimidines compound. SDS of cas: 108-52-1

Step 44a: 5-Bromo-4-methylpyrimidin-2-amine (Compound 0601-125)[0378]A mixture of 2-amino-4-methylpyrimidine (4.0 g, 36.7 mmol), NBS (7.18 g, 40.3 mmol) in chloroform (100 mL) was stirred for 2 h at room temperature, then the solvent was removed in vacuum. Water (100 mL) was added and stirred for 30 min at room temperature, filtered. The solid was washed with water and dried to get compound 0601-125 (6.3 g, 91percent) as a white solid. LCMS: 188 [M+1]+, 1H NMR (400 MHz, DMSO-d6) delta 2.32 (s, 3H), 6.79 (s, 2H), 8.21 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-52-1, its application will become more common.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 87362-32-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87362-32-1, name is 5-Methoxypyrimidine-2-carbonitrile. A new synthetic method of this compound is introduced below.

A mixture of 5-methoxypyrimidine-2-carbonitrile (100 mg, 0.74 mmol) and B C O (194 mg, 0.89 mmol) and MeOH (5 mL) was added to Raney-Ni (30 mg, 10%), the reaction mixture was stirred at room temperature for 2 hours under a H atmosphere (45 psi). The reaction mixture was filtered to remove the catalyst and the filter cake was washed with MeOH (10 mL c 3), and the filtrate was concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (0~10% ethyl acetate in petroleum ether) to give ferf-butyl ((5-methoxypyrimidin-2- yl)methyl)carbamate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,87362-32-1, 5-Methoxypyrimidine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (275 pag.)WO2019/115566; (2019); A1;,
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Related Products of 14394-70-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14394-70-8, name is 2-Chloro-5-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

[0426] A mixture of 2-chloro-5-methyl-pyrimidin-4-ylamine (0.71 g, 4.9 nimol), intermediate 74 (1.25 g, 5.9 mmol), Pd2(dba)3 (0.45 g, 0.49 mmol), Xantphos (0.57 g, 0.98 mmol) and cesium carbonate (4.8 g, 14.7 mmol) were suspended in dioxane (40 mL) refluxed for 18 h. The reaction mixture was then cooled to room temperature, filtered and solvents evaporated. Resulting residue was purified by flash chromatography on silica gel to afford title compound as white solids (0.44, 32%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14394-70-8, 2-Chloro-5-methylpyrimidin-4-amine.

Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 16234-10-9 , The common heterocyclic compound, 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of H2SO4 (20 mL) and HNO3 (15 mL) was added compound 3 (9.7 g, 0.064 mol) slowly under ice-bath condition. Then, the reaction mixture was heated to room temperature. When the staring material was consumed, the mixture was poured into the ice-water carefully, and the yellow solid was formed, followed by filtration. The cakewas washed with water for three times, dried to afford the desired compound 4, 10.8 g as yellow solid in 86% yield. 1H NMR (400 MHz, DMSO-d6) delta 13.00 (s, 1H), 9.33 (s, 1H), 8.35 (s, 1H); MS (ESI) m/z 195.9 [M+H]+.

The synthetic route of 16234-10-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Jiang; Su, Mingbo; Li, Tingting; Gao, Anhui; Yang, Wei; Sheng, Li; Zang, Yi; Li, Jia; Liu, Hong; European Journal of Medicinal Chemistry; vol. 128; (2017); p. 293 – 299;,
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Pyrimidine – Wikipedia

Reference of 13223-25-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 3 Synthesis of 2-(4,6-dimethoxypyrimidin-2-yloxy)benzaldehyde di-n-octylacetal (Compound No. 7) To a mixed solvent of 40 ml of n-octanol and 15 ml of benzene, 1 g of salicylaldehyde was added. The mixture was poured into an eggplant-type flask equipped with a SHEALAM cap, followed by purging with nitrogen. After the addition of 0.04 g of dichlorotris(triphenylphosphine)ruthenium, the mixture was reacted under heating at 100 C. for 20 hours. After the completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue thus obtained (0.9 g) was dissolved in 10 ml of DMF, followed by the addition of 0.5 g of 2-chloro-4,6-dimethoxypyrimidine and 0.2 g of potassium carbonate. The resulting mixture was reacted under heating at 110 C. for 3 hours. After the completion of the reaction, the reaction mixture was poured into 100 ml of water, followed by extraction three times, with 50 ml each of ethyl acetate. The organic layer was washed, dried and concentrated under reduced pressure. The residue was subjected to chromatography on a silica gel column and then eluated with a 7:3 mixed solvent of n-hexane and ethyl acetate to purify the same, whereby 0.7 g of the target compound, 2-(4,6-dimethoxypyrimidin-2-yloxy)benzaldehyde di-n-octylacetal, was obtained (yield 17%).

According to the analysis of related databases, 13223-25-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsui Toatsu Chemicals, Inc.; US5178662; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 26305-13-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 5,6-dimethylpyrimidine-2,4(l f,3H)-dione (10.3 g, 0.07 mol, Step B) in phosphorus(V) oxychloride (150 mL) was added dimethylformamide (0.2 ml). The resulting mixture was refluxed overnight under argon and cooled down to ambient temperature. The resulting mixture was evaporated. Toluene (200 mL) was added to the residue. The resulting mixture was concentrated. Cold water with ice (400 mL) was added to the residue, and the mixture was extracted with chloroform (3 x 150 mL). The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel, eluting with ethyl acetate/hexane mixture (1 :2-l : 1) to yield 9.5 g (73%) of the titled compound. H NMR (400 MHz, CDC13) delta ppm 2.35 (s, 3H) 2.55 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine.

Reference:
Patent; ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail; WO2013/123401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 84905-80-6 , The common heterocyclic compound, 84905-80-6, name is 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 1-chloroisoquinoline 1a (2g, 12.225 mmol) in ethanol was added 4-fluorobenzenethiol 2a (1.436 mL, 13.447 mmol). The reaction was stirred at roomtemperature for 16h. The mixture was concentrated in vacuo. The crude waspurified by silica gel column chromatography using ethyl acetate/hexane to yieldpure compound (686 mg, 22%);

The synthetic route of 84905-80-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ahn, Jin Hee; Ahn, Se Hwan; Bae, Eun Jung; Bae, Myung Ae; Choi, Byeong Wook; Hwang, Kyu-Seok; Kim, Seong Soon; Lee, Byung Hoi; Shin, Dae-Seop; Yang, Jung Yoon; Bioorganic and medicinal chemistry letters; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia