Tag: M.W:100-200

Synthetic Route of 3680-69-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

Dissolve 4-chloro-pyrrolo[2,3-d]pyrimidine (20 mmol) in DMF (6 mL), add NBS or NCS (21 mmol) in portions on ice bath, react at room temperature for 12 h, and pour the reaction mixture into 80 mL of ice. In the water, a large number of off-white solids precipitated and were filtered. The filter cake was washed with 15 mL of water and dried to give Intermediate 2. 4-Chloro-5-bromo-pyrrolo[2,3-d]pyrimidine (2b) Off-white solid, yield 95%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong University; Zhao Guisen; Yang Dezhi; Liu Meixia; Zhang Zhen; Zhang Qian; Yang Qingtao; (36 pag.)CN107556318; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4983-28-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4983-28-2, name is 2-Chloro-5-hydroxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-[l-(5-chloropyrimidin-2-yl)piperidin-4-yl]propan-l-ol (Preparation 22, 766mg, 3.0mmol) in DCM (25mL) was added triethylamine (0.5OmL, 3.6mmol) and the mixture was cooled to 00C. Methanesulfonyl chloride (0.23mL, 3.0mmol) was added and the reaction warmed to r.t. over 15 min. IM HCl was added and the resulting mixture poured into EtOAc. The organic layer was separated, washed with IM HCl, brine, dried (MgSO4), and the solvent removed in vacuo. To a solution of the material in DMF (1OmL) was added 2-chloro-5- hydroxypyrimidine (390mg, 3.0mmol) and potassium carbonate (828mg, .Ommol), and the mixture was heated to 800C for 16h. DMF was removed in vacuo and the residue was re- dissolved in EtOAc. The organic solution was washed with brine (x 2), dried (MgSO4), and solvent removed in vacuo. Recrystalisation from the minimal volume of MeOH afforded the title compound: RT = 4.53 min mlz (ES+) = 368.1 [M + H]+.

According to the analysis of related databases, 4983-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; DUPREE, Tom, Banksia; FRY, Peter, Timothy; FYFE, Matthew, Colin, Thor; JEEVARATNAM, Revathy, Perpetua; KRULLE, Thomas, Martin; SCHOFIELD, Karen, Lesley; SMYTH, Donald; STAROSKE, Thomas; STEWART, Alan, John, William; STONEHOUSE, David, French; SWAIN, Simon, Andrew; WITHALL, David, Matthew; WO2010/103334; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 23906-13-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23906-13-0, name is 2-Hydrazinyl-4,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

1.0 mM of 4-diethylamino salicylaldehyde was dissolved inmethanol (5 mL) and a hot solution of 1.0 mM 3, 5-dimethyl2-hydrazino pyrimidine in 2 mL methanol was added drop wise toit. After stirring overnight and then reducing the volume to3 mL,deep yellow crystals were obtained. It was washed with coldmethanol and dried in vacuum overnight. Yield: 68%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 23906-13-0, 2-Hydrazinyl-4,6-dimethylpyrimidine.

Reference:
Article; Makhal, Subhash Chandra; Bhattacharyya, Arghyadeep; Ghosh, Soumen; Guchhait, Nikhil; Journal of Photochemistry and Photobiology A: Chemistry; vol. 358; (2018); p. 138 – 146;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 123240-66-4, N-(4,6-Dichloropyrimidin-5-yl)formamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 123240-66-4, blongs to pyrimidines compound. Product Details of 123240-66-4

a 4-Chloro-6-[[4-(diethoxyphosphoryl)butoxy]amino]-5-formamidopyrimidine 4,6-Dichloro-5-formamidopyrimidine (0.441 g, 2.3 mmol), diethyl 4-(aminooxy)butylphosphonate (0.4 g, 1.77 mmol) and N,N-diisopropylethylamine (0.8 ml, 4.6 mmol) in diglyme (15 ml) were stirred at 100 C. for 2.5 hr. The reaction mixture was then allowed to cool, the hydrochloride of N,N-diisopropylethylamine was filtered off and the filtrate was diluted with chloroform (150 ml). The resulting solution was washed with 4% aq. NaHCO3 (1*20 ml) and water (1*20 ml). The combined aqueous layers were extracted with chloroform (6*20 ml) and the combined chloroform solutions were concentrated to an oil. The residue was chromatographed on silica gel (eluted with chloroform: ethanol, 96:4) to yield the title compound (0.520 g, 77%). 1 H NMR: deltaH [(CD3)2 SO] 1.22 (6H, t, J=7Hz, (OCH2 CH3)2), 1.68 (6H, m, CH2 CH 2 CH2 P), 3.9 (2H, m, NOCH2), 3.97 (4H, m, (OCH2 CH3)2), 8.14 (1H, s, H-2), 9.5 (1H, br.s, NHOCH2, D2 O exchangeable), 11.0 (1H, NHCHO, D2 O exchangeable).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,123240-66-4, N-(4,6-Dichloropyrimidin-5-yl)formamide, and friends who are interested can also refer to it.

Reference:
Patent; Beecham p.l.c.; US5166198; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 314021-93-7, name is 1-Methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1-Methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol

Compound 9: To a solution of 8 (0.835 g, 5.5 mmol) in 10 mL thionyl chloride was added 0.5 mL DMF. The resulting mixture was heated to 90 C. under nitrogen for 1 hour. After cooling to room temperature, the solvents were removed under reduced pressure. Water was added to the resulting residue and the mixture was extracted with dichloromethane (×3). The combined organics were dried (MgSO4) and concentrated under reduced pressure to afford 9 (0.94 g, 100%), ES (+) MS m/e=169 (M+1).

With the rapid development of chemical substances, we look forward to future research findings about 314021-93-7.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2007/27166; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 42754-96-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4,6-dichloro-lH-pyrazolo[3,4-d]pyrimidine (1.0 g, 5.29 mmol), TsOH (91 mg, 0.53 mmol) and dihydropyran (1.33 g, 15.87 mol) in THF (20 mL) was heated to reflux and stirred overnight. After cooling, the mixture was concentrated to give 4,6- dichloro-l-(tetrahydro-2H-pyran-2-yl)-lH-pyrazolo[3,4-d]pyrimidine (1.2 g) which was used without further purification

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42754-96-1, 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; LIU, Xuedong; ZHANG, Gan; CHAN, Daniel, Chuen-Fong; PISCOPIO, Anthony, D.; (117 pag.)WO2015/175813; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine, molecular formula is C5H4Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C5H4Cl2N2

Methylbenzylzinc chloride (25 ml of 0.5 M THF solution, 12 mmol) was added to a solution of 4,6-dichloro-5-methylpyrimidine (2.0 g, 12 mmol) and bis(triphenylphosphine) palladium(II) chloride (0.4 g. 0.6 mmol) in THF (20 mL). The reaction mixture was heated to reflux for 2 hours, cooled to room temperature, and then poured onto water (10 mL). The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated. The residue was purified by silica gel flash column chromatography (1:10 Et2O/Hexane) to yield the product (1.0 g, 35%) as a white solid. 1H NMR (CDCl3, 400 MHz) delta 8.75 (s, IH), 7.09-7.22 (m, 4H), 6.84 (d, J = 7.81 Hz, IH), 4.15 (s, IH), 2.38 (s, 3H), 2.32 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 4316-97-6.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; WO2007/146824; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2,4-Diaminopyrimidine-5-carboxaldehyde

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 945950-37-8, Adding some certain compound to certain chemical reactions, such as: 945950-37-8, name is 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C7H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 945950-37-8.

General procedure: To a mixture of appropriate 3a-e (1.5 mmol), 1 (1.57 mmol) and Ph3P (3.75 mmol) in THF was added DIAD (3.75 mmol) dropwise at 0 C under nitrogen and stirring continued at rt. Completion of reaction was analyzed by TLC, solvent evaporated under reduced pressure and crude was purified by column chromatography on silica gel by eluting up to 30 % ethyl acetate in hexane to give couple products in more than 80 % yield. The deprotection was carried out by heating at 60 C in 10 % HCl in MeOH. After completion (monitored by TLC), the reaction mixture was neutralized by NaHCO3 and purified by silica gel chromatography (10% methanol in DCM) to get 6a-e in 70-85% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 945950-37-8, 4-Methyl-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Thiyagarajan, Anandarajan; Salim, Mohammed T.A.; Balaraju, Tuniki; Bal, Chandralata; Baba, Masanori; Sharon, Ashoke; Bioorganic and Medicinal Chemistry Letters; vol. 22; 24; (2012); p. 7742 – 7747;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 5604-46-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

Step 1 ; 1- (2-Amino-4, 6-dichloro-pyrimidin-5-yl) -ethanol A fine suspension OF 2-AMINO-4, 6-DICHLORO-PYRIMIDINE-5-CARBALDEHYDE (3.0 g, 15 mmol); (Seela, F.; Stecker, H. Helv. Chim. Acta 1986, 69, 1602) in THF was cooled to- 78 C. A 3M solution of MeMgBr in THF (25 mL, 75 mmol, 5 equiv. ) was added over 3 h, keeping the internal temperature AT-78 C. The mixture was stirred for a further 0.5 h, quenched with 100 ml H20, and neutralized with aw. HC1. Extraction (EtOAc) gave 1- (2-AMINO-4, 6-dichloro-pyrimidin-5-yl) -ethanol as a pale yellow solid (2.5 g, 76%) which was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; CONFORMA THERAPEUTICS CORPORATION; WO2005/28434; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia