Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 13754-19-3, Pyrimidine-4,5-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 13754-19-3, blongs to pyrimidines compound. Recommanded Product: 13754-19-3

PREPARATION 48 2-Hydromethyl-3H-imidazo[5,4-d]pyrimidine 8.58 g of ethyl glycolate were added to 2.27 g of 4,5-diaminopyrimidine, and the resulting mixture was stirred at 140 C. for 2 hours. At the end of this time, the reaction mixture was freed from ethyl glycolate by distillation under reduced pressure. The residue thus obtained was decolorized by activated charcoal and crystallized by trituration with ethanol, to give 1.81 g of the title compound having Rf=0.27 (on silica gel thin layer chromatography using a 10:1 by volume mixture of ethyl acetate and methanol as the developing solvent).

The synthetic route of 13754-19-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sankyo Company, Limited; US5624935; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

A tube containing a solution of 2-chloropyrimidine-4-carboxamide (0.24 g, 1 eq) and potassium (S)-trifluoro(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3yl)ethynyl)phenyl)borate (1 eq) in Ethanol (0.25 M) was purged with nitrogen before addition of Pd(OAc)2 (0.06 eq), RuPhos (0.12 eq), and Sodium Carbonate (2 eq). The tube was sealed and stirred at 85 C. for 18 hours. The reaction mixture was cooled to room temperature and extracted with dichloromethane and saturated ammonium chloride then dried with Magnesium sulfate, filtered and concentrated to dryness. The crude material subjected to reverse phase purification to afford 53 mg of the title compound (10%). M+H=337.0; 1H NMR (400 MHz, DMSO-d6) delta 9.16-9.11 (m, 1H), 8.70-8.60 (m, 3H), 7.98 (s, 1H), 7.94 (d, J=5.0 Hz, 1H), 7.64-7.54 (m, 2H), 6.47 (s, 1H), 3.40-3.35 (m, 2H), 2.81 (s, 3H), 2.48-2.43 (m, 1H), 2.25-2.17 (m, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 22536-66-9, 2-Chloropyrimidine-4-carboxamide.

Reference:
Patent; Genentech, Inc.; Blaquiere, Nicole; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Staben, Steven; Yuen, Po-wai; Wu, Guosheng; Lin, Xingyu; Burch, Jason; US2015/57260; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26452-81-3, name is 4-Chloro-6-methoxypyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C5H5ClN2O

To a solution of (S)isopropyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2,6-dimethyl-5-( 1,2,3,4- tetrahydroisoquinolin-6-yl)pyridin-3-yl)acetate, 2 HC1 (0.0 15 g, 0.024 mmol) and 4- chloro-6-methoxypyrimidine (0.01 g, 0.069 mmol) in ACN (0.5 mL) was addedpotassium carbonate (0.02 g, 0.145 mmol) and heated at 100 °C for 18 h in a sealed vial. Then, cooled, filtered off the solid, removed the solvent and treated with EtOH (1 ml)sodium hydroxide (0.975 mg, 0.024 mmol). The resulting mixture was heated at 85for 3 h and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2-(4-(chroman-6-yl)-5-(2- (2-methoxypyrimidin-4-yl)- 1,2,3 ,4-tetrahydroi soquinolin-6-yl)-2,6-dimethylpyridin-3yl)acetic acid (0.0077 g, 0.013 mmol, 51.4 percent yield). LCMS (M+H) = 609.4.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26452-81-3, 4-Chloro-6-methoxypyrimidine.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1004-39-3

PREPARATION 6: Synthesis of 4,6-diaminopyrimidine 167.78g of 2-mercapto-4,6-diaminopyrimidine was dissolved in 1007ml of 1.5N-aqueous sodium hydroxide solution, and the reaction solution was cooled down to 0 to 4C. To this reaction solution was slowly added dropwise 267.55g of 30% aqueous hydrogen peroxide solution. After the addition is completed, 170ml of acetic acid was slowly added dropwise to the reaction solution to precipitate the solid product which was then filtered, washed successively with 200ml of distilled water, 200ml of methanol and 400ml of diethylether and dried to obtain 185.56g of the solid product as a white powder. The solid product thus obtained was slowly added to 1L concentrated hydrochloric acid which was cooled to 0C to 4C. The reaction solution was stirred for one hour at the same temperature, warmed to room temperature and then stirred for further 8 hours. The solid product produced during the reaction was filtered, washed with 1L of acetone and 1L of diethylether and then dried to obtain 109.13g of the title compound in the form of hydrochloride salt. 109.13g of the solid thus obtained was suspended in 400ml of distilled water, and 200ml of 15% aqueous sodium hydroxide solution was then added thereto. The mixture was stirred at room temperature for one hour and filtered. The filtered solid product was washed with 400ml of ethanol and then dried to obtain 100.7g of the title compound as a white powder.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; LUCKY LTD.; EP643061; (1995); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below., SDS of cas: 62802-42-0

Part 1: Preparation of 5-fluoropyrimidin-2-amine 2-Chloro-5-fluoropyrimidine (1.34 g, 10 mmol) was stirred with ammonium hydroxide (30%, 15 mL) at 100 C. in a sealed tube overnight. The mixture was cooled to room temperature and filtered. The solid was washed with water and dried to give the title compound (0.95 g, 80%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62802-42-0, 2-Chloro-5-fluoropyrimidine.

Reference:
Patent; PTC Therapeutics, Inc.; F. Hoffmann-La Roche AG; Woll, Matthew G.; Chen, Guangming; Choi, Soongyu; Dakka, Amal; Huang, Song; Karp, Gary Mitchell; Lee, Chang-Sun; Li, Chunshi; Narasimhan, Jana; Naryshkin, Nikolai; Paushkin, Sergey; Qi, Hongyan; Turpoff, Anthony A.; Weetall, Marla L.; Welch, Ellen; Yang, Tianle; Zhang, Nanjing; Zhang, Xiaoyan; Zhao, Xin; Pinard, Emmanuel; Ratni, Hasane; (317 pag.)US9617268; (2017); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1004-39-3, 4,6-Diaminopyrimidine-2-thiol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-39-3, blongs to pyrimidines compound. SDS of cas: 1004-39-3

(R)-N-(2-(5-(4-(1-((4,6-diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methanesulfonamide (10R) and (S)-N-(2-(5-(4-(1-((4,6- diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methane-sulfonamide (10S)A mixture of crude chloride F from previous step and 4,6-diamino-2-mercaptopyrimidine (112 mg, 0.86 mmol) in DMF (5 mL) was stirred at 80 C for 1 h. The solution was cooled, concentrated in vacuo and purified by flash column chromatography over silica gel (25: 1 dichloromethane: methanol) to give the couple of enantiomers 10R and 10S (178 mg, 0.35 mmol, ee 40% of 10R, 61% total yield in two steps) as a white solid. Recrystallization of the enantiomers with MeOHacetone solvent system gave the 10R with >93% ee. NMR (500 MHz, Acetone-d6) delta 7.55 (d, J= 2.0 Hz, 1H), 7.48 (dd, J= 8.5, 2.0 Hz, 1H), 7.06 (d, J= 8.5 Hz, 1H), 6.26 (br s, 1H), 5.60 – 5.55 (m, 4H), 5.37 (s, 1H), 5.30 (q, J= 7.0 Hz, 1H), 4.23 (t, J= 5.5 Hz, 2 H), 3.89 (s, 3H), 3.58 (dt, J= 5.5, 5.5 Hz, 2H), 3.05 (s, 3H), 2.52 (s, 3H), 1.74 (d, J= 7.0 Hz, 3H); 13C NMR (125 MHz, DMSO-d6) delta 168.0, 163.5 (2), 162.9, 153.6, 150.6, 147.8, 126.6, 126.2, 119.5, 1 12.3, 110.4, 79.0, 67.9, 55.7, 41.9, 36.1, 30.7, 22.2, 11.2; HRMS-ESI (m/z) [M+H]+ calcd for C20H26N6O4S3 H, 511.1256; found 51 1.1259; 10R [a]19D = +340.0 (c = 0.12 acetone) (ee = 93%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; RADU, Caius G.; LI, Zheng; GIPSON, Raymond M.; WANG, Jue; SATYAMURTHY, Nagichettiar; LAVIE, Arnon; MURPHY, Jennifer M.; NATHANSON, David A.; JUNG, Michael E.; WO2015/23776; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 26305-13-5, Adding some certain compound to certain chemical reactions, such as: 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine,molecular formula is C6H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26305-13-5.

Step 1 5,6-Dimethyl-2,4-dichloropyrimidine A mixture solution of 5,6-dimethyl-2,4-dihydroxypyrimidine(72 g, 0.51 mol), phosphorous oxychloride(250 ml) and N,N-dimethylaniline(41 ml) was heated to reflux for 3 hours and cooled to room temperature. The reaction mixture was added to ice water and the resulting solid was filtered and recrystallized from dichloromethane to give 58.5 g of the titled compound. (Yield: 64.7%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yuhan Corporation; US5750531; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

METHOD L 7-Benzyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (250 mg/1.63 mmol) in 12 mL of DMF was added 676 mg (4.89 mmol) of potassium carbonate and the resulting mixture stirred at room temperature for 20 min. Benzylchloride (310 mg/2.45 mmol) was added and the new mixture stirred at room temperature for 24 h then filtered, concentrated and the residue purified by silica gel chromatography (3:1 hexanes/ethyl acetate) affording 318 mg (80%) of the title compound. LRMS: 244.1 (M+1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Blumenkopf, Todd A.; Flanagan, Mark E.; Brown, Matthew F.; Changelian, Paul S.; US2002/19526; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 120747-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.

To a mixture of 166 mg (1.35 mmol) of aminopyrimidine 67, 17 mg (0.14 mmol) of DMAP and 418 muL (3.00 mmol) OfEt3N in 10 mL of THF was added 589 mg (2.7 mmol) of (BOC)2O. The mixture was stirred at room temperature for 5 h, concentrated-dry loaded on silica gel and flash chromatographed (1-3% acetone/ CH2Cl2) to produce 117 mg (0.36 mmol; 27%) of 68 as a clear oil.

The chemical industry reduces the impact on the environment during synthesis 120747-84-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; WO2008/108957; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 84905-80-6, Adding some certain compound to certain chemical reactions, such as: 84905-80-6, name is 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84905-80-6.

Example 67 Production of N-[4-(benzyloxy)-3-methoxyphenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine A mixture of 4-chloro-5H-pyrrolo[3,2-d]pyrimidine (200 mg), 4-(benzyloxy)-3-methoxyaniline (298 mg) and 1-methyl-2-pyrrolidone (5 mL) was stirred at 80C for 4 hrs. Methanol and activated carbon were added to the reaction mixture and the mixture was stirred. The activated carbon was filtered off, aqueous sodium hydrogen carbonate solution was added and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (eluent, methanol:ethyl acetate=10:80 ? 20:80) and recrystallized from methanol-ethyl acetate to give the title compound (269 mg) as a pale-gray powder. 1H-NMR (DMSO-d6) delta: 3.82 (3H, s), 5.06 (2H, s), 6.45 (1H, m), 7.03 (1H, d, J= 8.9 Hz), 7.30-7.49 (6H, m), 7.51 (1H, d, J= 2.5 Hz), 7.63 (1H, t, J= 2.9 Hz), 8.30 (1H, s), 9.07 (1H, s), 11.06 (1H, s).

According to the analysis of related databases, 84905-80-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1752457; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia