Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 49845-33-2

[00510] To a solution of 2,4-dichloro-5-nitropyrimidine (582 mg, 3 mmol) in THF (5 mL) wasadded DIEA (775 mg, 6 mmol) and tert-butyl3-aminophenylcarbamate (625 mg, 3 mmol, in 2mL THF) at -78 °C underN2 atmosphere. After stirring at -78 °C for 30 min, the reaction waswarmed up tor. t. and stirred overnight. The reaction was quenched with water (10 mL) andextracted with IPA/DCM (15:85) (5 mL X 3). The combined organic layer was washed withbrine, and dried over Na2S04. The solvents were removed under vacuum and the residue waspurified by flash chromatography (silica gel, 0 to 5percent ethyl acetate in PE/DCM (Ill) with 0.5percentTEA) to provide tert-butyl 3-(2-chloro-5-nitropyrimidin-4-ylamino )phenylcarbamate (1)(1.087g, 99percent) as an orange solid. LC-MS (ESI) m/z (M/M+2) 366.2/368.2.

The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACYCLICS, INC.; CHEN, Wei; YAN, Shunqi; LOURY, David, J.; FRYE, Leah, Lynn; GREENWOOD, Jeremy, Robert; SHELLEY, Mee, Yoo; WANG, Longcheng; WO2014/130693; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1820-81-1, 5-Chlorouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1820-81-1, blongs to pyrimidines compound. category: pyrimidines

Method 19 2,4,5-Trichloropyrimidine 5-Chlorouracil (10.0 g, 68.5 mmol) was dissolved in phosphorus oxychloride (60 ml) and phosphorus pentachloride (16.0 g, 77 mmol) was added. The reaction mixture was then stirred at reflux (110 C.) for 16 hrs then allowed to cool to 20 C. The reaction mixture was then poured slowly and carefully into water (200 ml) at 25 C. with vigorous stirring. Then stirred well for 90 minutes before addition of EtOAc (250 ml). Organic layer separated off and aqueous layer re-extracted into EtOAc (250 ml). The organic layers were then combined and washed with sodium bicarbonate (200 ml aqueous solution), brine (200 ml) and then evaporated to a yellow liquid. The crude material was purified by column chromatography eluding with dichloromethane to afford the product as a yellow liquid (6.37 g, 51%). NMR (CDCl3): 8.62 (s, 1H); MS (M+): 182, 184,186.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1820-81-1, its application will become more common.

Reference:
Patent; Pease, Elizabeth Janet; Breault, Gloria Anne; Morris, Jeffrey James; US2003/149064; (2003); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine. A new synthetic method of this compound is introduced below., Computed Properties of C5H7ClN4

General procedure: General Procedure 5: To a mixture of a suitable chloropyrimidine derivative (1 equiv.) in DMF/water (9: 1) is added the appropriate boronic acid (or boronic ester) derivative (1.1 equiv.), Na2C03 (2 equiv.) and Pd(PPh3)4 (0.1 equiv.). The mixture is heated at 120 C overnight or in the microwave until the reaction is complete as shown by LCMS. The crude mixture is then purified by preparative HPLC to afford the desired product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1005-37-4, 6-Chloro-N4-methylpyrimidine-2,4-diamine.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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Reference of 7752-82-1 ,Some common heterocyclic compound, 7752-82-1, molecular formula is C4H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A sealed tube is charged with [5-[[[8-(1-methylindol-6-yl)quinoxalin-6- yl]amino]methyl]-3-pyridyl]boronic acid (Intermediate 25) (130.00 mg; 0.20 mmol; 1.00 eqf.), 5-bromopyrimidin-2-ylamine (37.70 mg; 0.22 mmol; 1.10 eqf.), solution of 2M Na2C03 (0.30 mL; 0.59 mmol; 3.00 eqf.), EtOH (2.00 mL) and toluene (2.00 mL). RM is purged with argon and then Pd(PPh3)4 (22.76 mg; 0.02 mmol; 0.10 eqf.) is added. The resulting mixture is heated at 120C for 24 h. After this time, the mixture is diluted with EtOAc. The organic layer is washed with water, brine, dried over MgSO4 and evaporated. The residue is purified by FCC (EtOAc/MeOH; gradient). N-{[5-(2-Aminopyrimidin-5- yl)pyridin-3-yl]methyl}-8-(1 -methyl- 1 H-indol-6-yl)quinoxalin-6-amine (64.00 mg; yield 65.1 %; 92 % by HPLC) is obtained as a yellow powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7752-82-1, 5-Bromopyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 504-17-6, 4,6-Dihydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 504-17-6, blongs to pyrimidines compound. Product Details of 504-17-6

General procedure: A mixture of aldehyde (0.25 mmol), 2-thiobarbituric acid(0.5 mmol), ammonium acetate (0.3 mmol) and CuFe2O4 (10 mol%)in distilled H2O was stirred for an appropriate time. After completionof the reaction (monitored by TLC), the resulted precipitatewasfiltered and dissolved in hot methanol and the catalyst was separatedand collected by an external magnetic and washed withacetone and EtOH several times and dried in an oven at 70 C toreuse in next reactions. The pure solid product was obtained viaevaporation the 2/3 of methanol and filtration. The solid productwas recrystallized from water/ethanol as solvent to afford the pureproducts. All of the products were identified by physical andspectroscopic data. Yellow powder; M.P: 242 C decompose. IR (KBr) n (cm1): 3591,3447 (NH), 3166 (CeH, sp2 stretch), 2922 (CeH, sp3), 1632 (C]O),1437, 1536 (C]C, Ar). 1H NMR (DMSO-d6, 400 MHz) d (ppm): 3.63(s, 3H), 5.91e5.97 (s, 1H), 6.49e6.52 (s, 1H), 6.56e6.57 (m, 1H),6.62e6.64 (m, 1H), 6.93 (s, 1H), 7.06 (s, 2H), 7.19e7.23 (s, 1H), 11.56e11.73 (m, 4H). 13C NMR (DMSO-d6, 100 MHz) d (ppm): 30.89,55.24, 96.21, 109.8, 113.61, 119.62, 129.09, 145.24, 159.42, 173.22.Anal. Calcd for C16H15N5O3S2: C, 49.34; H, 3.88; N, 17.98, %; Found C,49.38; H, 3.90; N, 18.02%.

The synthetic route of 504-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Naeimi, Hossein; Didar, Asieh; Journal of Molecular Structure; vol. 1137; (2017); p. 626 – 633;,
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Reference of 3524-87-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-87-6, name is 6-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 70 g (0.64 mol) A-l in acetic acid is added 127 g (0.56 mol) NIS portion wise at RT within 15 min. The reaction is stirred at RT until all starting material is consumed (30 h). The reaction mixture is diluted with water and the solid product is filtered off, washed with an aqueous sodium thiosulfate solution to remove excess iodine and dried in vacuo. Yield: 90 g (60 %).

According to the analysis of related databases, 3524-87-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver; WO2012/101186; (2012); A1;,
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Application of 1780-31-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-31-0, name is 2,4-Dichloro-5-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2,4-dichloro-5-methylpyrimidine (50 g, 0.31 mol), water (500 mL) and zinc dust (50 g, 0.94 mol) was heated at reflux overnight. The reaction mixture was filtered and the filtrate was extracted with dichloromethane (3*500 mL). The organic layer was washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was recrystallized from petroleum ether to afford compound C60 as a white solid. Yield: 27.9 g, 0.22 mol, 75%. LCMS m/z 129.3 (M+1). 1H NMR (400 MHz, CDCl3) delta 2.25 (s, 3H), 8.40 (5, 2H).

According to the analysis of related databases, 1780-31-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US2010/190771; (2010); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1193-24-4, name is 4,6-Dihydroxypyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C4H4N2O2

(Ref: A. Gomtsyan, S. Didomenico, C-H. Lee, M. A. Matulenko, K. Kim, E. A. Kowaluk, C. T. Wismer, J. Mikusa, H. Yu, K. Kohlhass, M. F. Jarvis, S. S. Bhagwat; J. Med. Chem., 2002, 45, 3639-3648.) A mixture of DMF (32 mL) and POCl3 (100 mL) at 0 C. was stirred for 1 hour, treated with 4,6-dihydroxypyrimidine (25.0 g, 223 mmol), and stirred for 0.5 hour at room temperature. The heterogeneous mixture was then heated to refluxed and stirred for 3 hours. The reaction was cooled to room temperature and the resulting viscous, black liquid was poured onto ice water and extracted with diethyl ether (6×100 mL). The organic phase was subsequently washed with NaHCO3, and water, dried over MgSO4, and concentrated to give 25 as a yellow solid (20.0 g, 57% yield). 1H NMR (CDCl3) delta 10.41 (s, 1H), 8.85 (s, 1H).

The synthetic route of 1193-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation; US2007/72864; (2007); A1;,
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Pyrimidine – Wikipedia

Electric Literature of 4316-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: A solution of dibenzylamine (10.2 g) in dichloromethane (30 mL) is dripped into a solution of 4,6-dichloro-5-nitropyrimidine (10 g) in dichloromethane (70 mL) on an ice bath. Then triethylamine (14.4 mL) is added, and the mixture is stirred for 1 hour. Water is added to the reaction mixture, the organic layer is washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent is concentrated under reduced pressure to obtain N,N-dibenzyl-6-chloro-5 -nitropyrimidine-4-amine (19.2 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4316-93-2, 4,6-Dichloro-5-nitropyrimidine.

Reference:
Patent; ACERTA PHARMA B.V.; IZUMI, Raquel; SALVA, Francisco; HAMDY, Ahmed; WO2015/181633; (2015); A2;,
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Reference of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

Intermediate 216 2-(4-methylchroman-5-yl)oxy-5-nitro-pyrimidine [1137] [1138] 4-methyl-3,4-dihydro-2Hchromen-5-ol (Intermediate 211, 111 mg, 0.676 mmol) was dissolved in 5.0 mL of DMF. K2CO3 (140 mg, 1.01 mmol) and 2-chloro-5-nitropyrimidine (162 mg, 1.01 mmol) were added and the reaction mixture was stirred for 1 hour at room temperature. DMF was then evaporated under high vacuum and the residue was purified by flash chromatography on silica gel using cyclohexane/ethyl acetate from 1:0 to 7:3 as eluents affording the title compound (192 mg). [1139] 1H NMR (400 MHz, CDCl3) delta ppm 9.36 (2H, s), 7.21 (1H, t), 6.85 (1H, d), 6.68 (1H, d), 4.15-4.35 (2H, m), 2.90-3.02 (1H, m), 2.08-2.20 (1H, m), 1.65-1.75 (1H, m), 1.29 (3H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common.

Reference:
Patent; AUTIFONY THERAPEUTICS LIMITED; Alvaro, Giuseppe; Dambruoso, Paolo; Tommasi, Simona; Decor, Anne; Large, Charles; US2013/267510; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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