Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 956034-07-4, 2,4-Dichlorofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 956034-07-4, blongs to pyrimidines compound. Quality Control of 2,4-Dichlorofuro[3,2-d]pyrimidine

[0174] To a reaction flask were added compound 31-c (0.088 mmol), compound 31-b (according to the synthesisprocedure in the patent: WO 2011/079230 A2) (15 mg, 0.080 mmol), PdCl2(dppf) (3 mg, 0.004 mmol), 2 N aqueoussodium carbonate solution (0.12 mL, 0.24 mmol) and 1,4-dioxane (3 mL). Under nitrogen, the mixture was stirredovernight at 80C. After the reaction mixture was concentrated, the residue was diluted with water (15 mL), and theaqueous phase was extracted with dichloromethane (15 mL 3 2). The organic layers were combined and washedsuccessively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to givecrude product 31-a (35 mg) which was used directly in the next reaction without further purification. LC-MS (ESI): m/z=248.1 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,956034-07-4, its application will become more common.

Reference:
Patent; Shanghai Yingli Science and Technology Co., Ltd; Shanghai Chemexplorer Co., Ltd.; XU, Zusheng; EP2860181; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5750-76-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Id) 2-Amino-N-methyl-benzamide (1.5g, 10 mmol) and 2,4,5-Trichloro-pyrimidine (1.31 ew) were combined in DMF (30 mL). Potassium carbonate (1.3 eq) was added the mixture heated to 750C for 4.5 h and stirred at room temperature overnight. The mixture was poured into water and the white precipitate that ensued was filtered and dried to give 2- (2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-benzamide (2.7 g, 92%): 1H NMR (400 MHz, DMSOd6) I’ 12.19 (s, IH), 8.86 (s, IH), 8.54 – 8.48 (m, 2H), 7.81 (d, J =7.9 Hz, IH), 7.61 (t, J = 8.7 Hz, I H), 7.23 (t, J = 8.9 Hz, IH), 2.50 (d, J = 1.5 Hz, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5750-76-5, 2,4,5-Trichloropyrimidine.

Reference:
Patent; CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2008/51547; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 62802-42-0, 2-Chloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62802-42-0, blongs to pyrimidines compound. Product Details of 62802-42-0

To a 5- (0934) L autoclave was added 2-chloro-5-fluoropyrimidine (150.0 g, 1132 mmol), potassium- (E)-propenyl trifluoroborate (251.0 g, 1698 mmol), potassium carbonate (235.0 g, 1698 mmol), 1,4-dioxane (1.5 L, 10.0 mL/g), and water (300.0 mL, 2.0 mL/g) at RT. The reaction mixture was degassed with nitrogen for 15 minutes. PdCi2(dppf) (16.56 g, 22.64 mmol,) was added, and the resulting reaction mixture was again degassed with nitrogen for 5 minutes and then heated to 70 C for 16 h. The reaction mass was cooled to RT and filtered through a pad of Celite brand filter aid. The Celite brand filter aid pad was washed with diethyl ether (1.0 L). The filtrate was partitioned between diethyl ether (8.0 L) and water (6.0 L). The organic layer was washed with brine (2.5 L) and dried over sodium sulfate, filtered and concentrated in vacuo (bath temperature; 30 – 35 C) to obtain the initial material which was purified by column chromatography (silica gel 60-120 mesh, mobile phase: 0-5% EtOAc in hexane) to give Example 138.11 (140.0 g, 1013 mmol, 90% yield) as a yellow oil. NMR (400 MHz, DMSO-Patent; AMGEN INC.; DRANSFIELD, Paul John; HARVEY, James S.; MA, Zhihua; SHARMA, Ankit; (281 pag.)WO2019/89335; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 871254-61-4, name is 2,4-Dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 871254-61-4

To a solution of 2,4-dichloropyrimidine-5-carbaldehyde (20.2 g, 114 mmol) in THF (530 mL) at 0 C was added a chilled solution of hydrazine hydrate (11.5 g, 2 eq) in THF (230 mL) over 5 minutes. The reaction mixture was stirred 10 minutes at 0 C and 1 hour at room temperature. It was then diluted with EtOAc and H20 and the layers were separated. The aqueous layer was extracted with EtOAc then the combined organic phase was dried over Na2S04, filtered, and concentrated. The crude product was purified by normal-phase column chromatography on silica gel (50% EtO Ac/hexanes) to afford 6-chloro-lH- pyrazolo[3,4-d]pyrimidine as a light-yellow solid (8.8 g, 50% yield). 1HNMR (400 MHz, CD3OD) d (ppm): 9.17 (s, 1H), 8.30 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 871254-61-4, 2,4-Dichloropyrimidine-5-carbaldehyde.

Reference:
Patent; RAPT THERAPEUTICS, INC.; BUI, Minna, H.T.; DUKES, Adrian, O.; HAN, Xinping; HU, Dennis, X.; JACKSON, Jeffrey, J.; KO, Yoo, Min; LEGER, Paul, R.; MA, Anqi; MAUNG, Jack; NG, Andrew, A.; OKANO, Akinori; ROBLES, Omar; SHIBUYA, Grant; SHUNATONA, Hunter, P.; SCHWARZ, Jacob, B.; SHAKHMIN, Anton, A.; WUSTROW, David, J.; ZIBINSKY, Mikhail; (0 pag.)WO2019/236631; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (8 g, 52.3 mmol) in CH2Cl2 (200 ml) was added NIS (14 g, 62.5 ml). The mixture was stirred at rt for 5 h. LC- MS indicated complete reaction. The mixture was filtered and the filtered solid was washed with CH2Cl2 (50 ml), followed by hot water (500 ml). The solid was then dried in vacuum oven at 40 C for 2 days to give 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, MM as a gray solid (13.6 g, 93%). 1H NMR (DMSO-d6) delta 12.97 (br s, 1H), 8.60 (s, 1H), 7.95 (s, 1H). LC/MS m/z 279.9 (M+H).

According to the analysis of related databases, 3680-69-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHIMERIX, INC.; ALMOND, Merrick; LANIER, Ernest, Randall; MUSSO, David, Lee; WARE, Roy; WO2010/135520; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 26452-81-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26452-81-3, name is 4-Chloro-6-methoxypyrimidine. A new synthetic method of this compound is introduced below.

A RM of methyl 3-ethoxy-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate (10520 mg, 30 mmol), 4-chloro-6-methoxypyrimidine (4645 mg, 31.5 mmol), dichloro(1 ,1′-bis(diphenylphosphino) ferrocene) palladium (II) dichloromethane adduct) (2449 mg, 3 mmol) and potassium phosphate tribasic monohydrate (20719 mg, 90 mmol) in water (4 mL) and DMF (150 mL) is degassed for 20 min under a nitrogen stream, then stirred at RT for 1 hi 5. The RM is filtered through celite, the filtrate is concentrated under vacuum, the residue is partitioned between water and EtOAc. The organic layer is further washed with brine, dried over MgS04, filtered and concentrated. Purification by FC (heptane/EtOAc, from 1 :0 to 0:1 ) affords the title compound as a yellow solid (7.87 g, 89percent ). LC-MS B: tR = 0.93 min; [M+H]+ = 295.18.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26452-81-3, its application will become more common.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; BOSS, Christoph; CORMINBOEUF, Olivier; FRETZ, Heinz; LYOTHIER, Isabelle; POZZI, Davide; RICHARD-BILDSTEIN, Sylvia; SIENDT, Herve; SIFFERLEN, Thierry; (160 pag.)WO2018/210992; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5305-59-9, Adding some certain compound to certain chemical reactions, such as: 5305-59-9, name is 6-Chloropyrimidin-4-amine,molecular formula is C4H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5305-59-9.

A microwave vial was charged with 4-amino-6-chloropyrimidine (1.0 g, 7.72 mmol), and pyrrolidine (10 mL) was added. The vial was sealed, and heated in the microwave at 180 C for 1 h. After cooling, the reaction was diluted with methanol (30 mL), and silica (15.0 g) was added. All solvents were removed in vacuo, and the remaining silica slurry loaded on a 40.0 g silica column. Elution with a 0% to 10% methanol in dichloromethane gradient yielded 6-(pyrrolidin-1-yl)pyrimidin-4-amine (1.22 g, 96% yield). MS (ESI) calcd for C8H14N4: 164.11

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5305-59-9, 6-Chloropyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; WO2013/59587; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3435-29-8, name is 4-Amino-6-phenylpyrimidine, the common compound, a new synthetic route is introduced below. Formula: C10H9N3

General procedure: Quinoline-4-carboxylic acid (36.4 mg, 0.226 mmol),3-chloro-5 – (methylthio) benzene amine (50.0 mg, 0.205 mmol) and POCl3 (34.6 mg, 0.226 mmol), pyridine (1 mL) was dissolved in, 80 was stirred for 1 hour dongan. When thin layer chromatography (TLC) check when, a new spot is confirmed, water was added to the reaction mixture, and extracted twice with dichloromethane. And the extracted organic layer was dried using magnesium sulfate, vacuum concentrated and, after the water was removed by filtration of the organic extract over MgSO4 and concentrated by silica gel preparative thin layer chromatography (preparative TLC, ethyl acetate / n- hexane = l / l ) to give to give the title compound (11%) of a white solid.

The synthetic route of 3435-29-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JUNG, YOUNG SIK; KIM, PIL HO; HAN, SOO BONG; RAGHAVENDRA, ACHARY; KIM, MEE HYEIN; LEE, CHONG KYO; SHIN, JIN SOO; (131 pag.)KR2015/25531; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

Example 7 Synthesis of 5-amino-2-chloropyrimidine Compound 40 Referring to the reaction scheme of , to 140 g (0.88 mol) of 2-chloro-5-nitropyrimidine (39) dissolved in 700 mL of EtOH was added a mixture of 1400 mL of acetic acid, 700 mL water and 197 g of iron powder (70 m mesh, <212 mum). The mixture was heated overnight at 70 C. and then cooled to r.t. and then filtered. EtOH was removed from the filtrate in vacuo, and the pH was adjusted to 8 with 12 N NaOH and the product was extracted overnight with continuous liquid-liquid extraction with EtOAc. The resulting filter cake was washed with EtOAc, and the combined EtOAc layers were washed with water, then brine, dried over magnesium sulfate, and filtered. After removal of the solvent in vacuo and recrystallization with EtOH, 97.2 g (85%) of pale brown solid product 39 was obtained. 1H NMR (DMSO-d6) delta 8.94 (s, 2H), 5.77 (brs, 2H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common. Reference:
Patent; KADOR, PETER F.; US2014/235858; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H6Cl2N2

5-Chloro-4-(3,3-diethyl-1,5-dioxaspiro[5.5]undec-9-yloxy)-6-ethylpyrimidine 2.0 g (8.8 mmol) of 3,3-diethyl-1,5-dioxaspiro[5.5]-undecan-9-ol were added to a suspension of 0.80 g (13.2 mmol) of sodium hydride (80%) in 20 ml of dry THF under a nitrogen atmosphere and the mixture was refluxed for 2 hours until deprotonation was complete. The reaction solution was then allowed to cool to approximately 35 C., and 1.60 g (8.9 mmol) of 4,5-dichloro-6-ethylpyrimidine dissolved in 3 ml of dry THF were added rapidly, and the reaction mixture was refluxed until the reaction was complete (approximately 2 hours, TLC check). After the reaction mixture had cooled to room temperature, 3 ml of isopropanol were added to destroy excess sodium hydride, the mixture was stirred for a further 15 minutes and poured into a mixture of in each case 100 ml of ether and saturated aqueous ammonium chloride solution. The aqueous phase was extracted thoroughly using ether, and the combined organic phases were dried over magnesium sulfate and subsequently concentrated in vacuo. Silica gel chromatography (petroleum ether/ethyl acetate 3:2) gave 2.0 g (60.3% of theory) of a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 115617-41-9.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5859009; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia