Tag: M.W:100-200

Application of 16462-28-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16462-28-5, name is 4-Amino-2-hydroxypyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.

After the reaction in step (2), the intermediate II obtained is added with 2.5-3.0mol / L of dilute hydrochloric acid 30-150mL, and then the microwave reaction temperature is 80-100 CThe power is 500W, radiate for 30 to 50 minutes under normal pressure, cool, and filter to get:The urea 1-300 mmol and malononitrile 1-300 mmol are carried out in an amount of equal substances and an excess of 10-80 mL of triethyl orthoformate,The microwave temperature does not exceed 80 degrees at 500W power, otherwise it will affect product purity and color.In order to get good products,The intermediate II in the second step is decolorized with 0.1-0.5 g of activated carbon and acidified with 5-30 mL of glacial acetic acid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16462-28-5, 4-Amino-2-hydroxypyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Zunyi Medical College; Yuan Zeli; He Shunli; Song Wenting; Yu Guangqin; (6 pag.)CN104356073; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4595-61-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4595-61-3 as follows.

Pyrimidine-5-carbonyl chloride hydrochloride 7.50 g (60 mmol) pyrimidine-5-carboxylic acid are stirred in 50 ml of thionyl chloride and 0.5 ml dimethylformamide for 4 hours at 70° C. The reaction mixture is evaporated to dryness and re-evaporated several times with toluene. Yield: 7.80 g (72percent of theoretical)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4595-61-3, its application will become more common.

Reference:
Patent; Maier, Udo; Grauert, Matthias; Hoffmann, Matthias; Hoenke, Christoph; Joergensen, Anne T.; Pautsch, Alexander; Brandl, Trixi; Breitfelder, Steffen; Scheuerer, Stefan; Erb, Klaus; Pieper, Michael; Pragst, Ingo; US2007/259855; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1074-41-5 ,Some common heterocyclic compound, 1074-41-5, molecular formula is C5H7N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An intimate mixture containing equimolar quantities of6-amino-2-(methylsulfanyl)pyrimidin-4(3H)-one, naphthalene-1,2,4(3H)-trione and 4-methoxybenzaldehyde was subjectedto microwave irradiation for 5 min at 300 W maximumpower and 473 K in a CEM Discover microwave oven. Upon completion of the reaction, as monitored by thin-layer chromatography,the reaction mixture was cooled to ambient temperature. Recrystallization from ethanol, at ambient temperature and in air, provided yellow crystals suitable forsingle-crystal X-ray diffraction [yield 80%, m.p. > 573 K(decomposition)]. MS: (70 eV) m/z = 431 (61, M+), 325 (19),324 (100), 276 (18), 248 (12).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1074-41-5, 6-Amino-2-(methylthio)pyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Castillo, Yelder A.; Zapata, Luis F.; Trilleras, Jorge; Cobo, Justo; Glidewell, Christopher; Acta Crystallographica Section C: Structural Chemistry; vol. 70; 1; (2014); p. 50 – 54;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 24415-66-5, Adding some certain compound to certain chemical reactions, such as: 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine,molecular formula is C6H5ClN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24415-66-5.

A mixture of appropriate compound 8 (10 mmol), piperazine, (10 mmol) and K2CO3 (12 mmol) in 1,4-dioxane was reflux at 100 C for 3 h. The reaction mixture was cooled down to room temperature. The reaction mixture was filter and washed with 1,4-dioxane. The filtrate was concentrated and dried by vacuum. 4.1.5.1. 5-methyl-7-(piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine (9). Yellowish (Yield 70%). 1H NMR (400 MHz, CDCl3) delta 8.23 (s, 1H, Triazolopyrimidine-Hb), 6.09 (s, 1H, Triazolopyrimidine-Ha), 3.73 (4H, Piperazine), 3.63 (s, 1H, -NH), 3.05 (4H, Piperazine), 2.51 (s, 3H, Triazolopyrimidine-CH3).; 13C NMR (101 MHz, CDCl3) delta 164.7, 157.2, 153.9, 150.7, 94.5, 49.2, 45.8, 25.2.

According to the analysis of related databases, 24415-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kumar, Jitendra; Meena, Poonam; Singh, Anju; Jameel, Ehtesham; Maqbool, Mudasir; Mobashir, Mohammad; Shandilya, Ashutosh; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 260 – 277;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2380-63-4, blongs to pyrimidines compound. COA of Formula: C5H5N5

Synthesis of tert-butyl 3-(4-amino-lH-pyrazolo[3,4-d]pyrimidin-l-yl)piperidine-1-carboxylate: To a solution of lH-pyrazolo[3,4-J]pyrimidin-4-amine (675 mg, 5 mmol) in DMF (12 mL) was added NaH (60%wt in mineral oil, 240 mg, 6.0 mmol, 1.2 eq) and the mixture was stirred at rt for 0.5 h. The tert-butyl 3-((methylsulfonyl)oxy)piperidine-l-carboxylate (1.67 g, 6 mmol, 1.2 eq) was added and the mixture was heated to 100 C for 16 h. The solution was cooled to rt and the reaction was quenched with brine (50 mL) and extracted with EtOAc (80 mL x 4). The organic layers were dried over Na2S04i concentrated in vacuo to afford a residue which was purified by column chromatography (silica gel, pure EtOAc) to give the title product (700 n yield: 50%) as a light yellow solid. lH NMR (400 MHz, DMSO-d6) delta: 9.24 (br s, IH), 8.72 (br IH), 8.41 (s, IH), 8.33 (s, IH), 4.67-4.62 (m, IH), 4.05-3.58 (m, 3H), 3.40-3.33 (m, IH), 2.9 2.95 (m 1 H), 2.16-2.04 (m, IH), 1.61-1.24 (m, 11H). ESI-MS (M+H+): 319.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2380-63-4, its application will become more common.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art; WO2012/58645; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H7ClN4

Example 2583-[2-am ino-6-(methylamino)pyrimidin-4-yl]-2-methylbenzonitrile.A mixture of 6-chloro-4-N-methylpyrimidine-2,4-diamine (24 mg, 0.15 mmol), (3-cyano-2-methylphenyl)boronic acid (29 mg, 0.18 mmol), potassium carbonate (41mg, 0.30 mmol) and palladium tetrakis(triphenylphosphine)palladium (0) (9 mg,0.008 mmol) in 1 ,4-dioxane (3 mL) and water (1 mL) was heated in a sealed tube at 900C overnight. The reaction mixture was concentrated and purified by preparative H PLC. LCMS [M+H] 240.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1005-37-4, 6-Chloro-N4-methylpyrimidine-2,4-diamine.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; HELLEDAY, Thomas; KOOLMEISTER, Tobias; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; WO2014/84778; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7752-82-1, name is 5-Bromopyrimidin-2-amine. A new synthetic method of this compound is introduced below., Product Details of 7752-82-1

The compound 5-bromopyrimidin-2-amine 89a (2.6 g, 15 mmol) was dissolved in anhydrous tetrahydrofuran (50 mL), and after cooling to 0 C, sodium hydride (purity 60%, 1.32 g, 33 mmol) was added.After stirring at this temperature for 30 minutes, p-methoxybenzyl chloride (5.17 g, 33 mmol) was added and gradually warmed to room temperature.After stirring for 15 hours,The reaction was quenched with water (2 mL), the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 2/1),The target product 5-bromo-N, N-bis (4-methoxybenzyl) pyrimidin-2-amine 89b (5.5 g, pale yellow solid) was obtained, yield: 89%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7752-82-1, 5-Bromopyrimidin-2-amine.

Reference:
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2244-11-3, Adding some certain compound to certain chemical reactions, such as: 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate,molecular formula is C4H4N2O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2244-11-3.

General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.9 5-[2-(4′-Acetylbiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (15) 55% Yield, mp > 250 C (decomp. 235 C). 1H NMR delta 11.45 (s, 2H, NH), 8.05-8.08 (m, 4H), 7.90-7.93 (m, 4H), 7.31 (s, 1H, OH), 3.94 (s, 2H), 2.61 (s, 3H). Anal. % (C20H16N2O6) calculated: C 63.16, H 4.24, N 7.37; found C 63.30, H 4.43, N 7.44.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4983-28-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4983-28-2 as follows.

Compound 3-(dimethylamino)propan-1-ol (825.28 mg, 8 mmol) and triphenylphosphine (2.517 g, 9.6mmol) were added successively to a suspension of 19 (1.044 g, 8 mmol) in THF (15 mL) under nitrogen.A solution of DIAD (1.67 g, 9.6 mmol) in THF (2 mL) was then slowly added dropwise with ice cooling.The resultant solution was stirred at room temperature for 12 hours. The aqueous phase wasextracted with dichloromethane (40 mL 3). The combined organic layer was washed with H2O (40 mL)and brine (20 mL), and then dried over anhydrous Na2SO4, filtered and evaporated in vacuo. Theresidue was purified by flash chromatography over silica gel (DCM/MeOH = 40:110:1) to give 20a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4983-28-2, its application will become more common.

Reference:
Article; Zhang, Niu-niu; An, Bai-jiao; Zhou, Yan; Li, Xing-shu; Yan, Ming; Molecules; vol. 24; 6; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1005-38-5 , The common heterocyclic compound, 1005-38-5, name is 4-Amino-6-chloro-2-(methylthio)pyrimidine, molecular formula is C5H6ClN3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 36 Using the method of Example 35, thiomorpholine was reacted with 4-amino-6-chloro-2-methylthiopyrimidine to provide 4-amino-2-methylthio-6-(4-thiomorpholino)pyrimidine as a yellow solid, m.p. 144-145 C. The structural assignment was supported by nuclear magnetic resonance spectral analysis.

The synthetic route of 1005-38-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Riker Laboratories, Inc.; US4503050; (1985); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia