Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 2434-56-2, 4,6-Diaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2434-56-2, blongs to pyrimidines compound. Computed Properties of C4H6N4

To a stirred suspension of pyrimidine-4,6- diamine (500 mg, 4.55 mmol) in dioxane (20 mL) was added acetic anhydride (465 mg, 4.55 mmol) and the resulting mixture was heated under reflux for 15 hours. The reaction was cooled to room temperature and the resulting preceipitate was collected by filtration. The filtercake was dissolved in IN HC1 and the pH of the aqueous phase adjusted to 7 by the addition of IN NaOH. The resulting white precipitate was collected by filtration and dried to afford the desired product as a white solid (420 mg, 61% yield). LCMS (ESI) m/z: 152.0 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2434-56-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution of Intermediate 2 (1 g, 4.2 mmcl) in dry DMF (10 mL), Et3N (2.3 mL, 16.8 mmcl) and 2-chloro-5-nitropyrimidine (0.74 g, 4.6 mmcl) were added at rt and the resulting mixture was stirred at 120 °C for 20 h. It was diluted with water andextracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and concentrated under vacuum. The resulting crude product was purified by flash chromatography to give the title compound (yellow solid). 1H NMR (400 MHz, DMSOd 6): 6 9.08 (s, 2H), 6.92 (s, I H), 6.85-6.83 (m, I H), 6.77 (s, I H), 5.98 (m, 2H), 3.89 (s, 4H), 3.50 (s, I H), 2.45-2.44 (m, 4H), 1.30 (br s, 3H). LCMS: (Method A) 358.0 (M+H), Rt. 3.00 mm, 94.23percent (Max).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; TORONTO, Dawn, V.; CROWE, David, Malcolm; (150 pag.)WO2017/144637; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3073-77-6, Adding some certain compound to certain chemical reactions, such as: 3073-77-6, name is 2-Amino-5-nitropyrimidine,molecular formula is C4H4N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3073-77-6.

Synthesis of I-5 Into a 1-L round-bottom flask, was placed 5-nitropyrimidin-2-amine (30 g, 214.13 mmol, 1.00 equiv), methanol (400 mL), Palladium carbon (12 g). The resulting solution was stirred overnight at room temperature in a hydrogen bath. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 20 g (85%) of pyrimidine-2,5-diamine as a light brown solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3073-77-6, 2-Amino-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; IRM LLC; LIANG, Fang; MISHRA, Pranab Kumar; MOLTENI, Valentina; NAGLE, Advait Suresh; SUPEK, Frantisek; TAN, Liying Jocelyn; VIDAL, Agnes; US2014/275119; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 7461-50-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7461-50-9, name is 2-Chloropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of (6-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)pyridin-3-yl)boronic acid (240.0 mg, 1.0 mmol)2-chloropyrimidin-4-amine (129.0 mg, 1.0 mmol) in 1,4-dioxane (5 mL) and H2O (1 mL) was added potassium carbonate (276.4 mg, 2.0 mmol). After the mixture was degassed with N2 for 3 times, Pd(PPh3)4 (57.8 mg, 0.05mmol) was added under N2 and the mixture was stirred at 90 oC for 3 hrs. The reaction mixture was cooled down and poured into EA. The organic phase was separated, washed with water and brine, dried over Na2SO4 and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by chromatography (eluted with PE : EA = 1: 1) to afford the title product (140 mg, 58.1 % yield) as a white solid. Retention time (LC-MS): 0.365 min. MH+ 290.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7461-50-9, 2-Chloropyrimidin-4-amine.

Reference:
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertand, L.; WU, Xinyuan; (351 pag.)WO2016/44792; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 306960-77-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 306960-77-0, name is 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Example 340 W-{[1 -ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1 H- pyrazolo[3,4-b]pyridin-5-yl]methyl}-2-(trifluoromethyl)-5-pyrimidine carboxamideEthyl 2-(trifluoromethyl)-5-pyrimidinecarboxylate [e.g. available from J. Med. Chem., (2000), 43 (21), 3995 (49mg) in ethanol (0.63ml) was treated with 2N sodium hydroxide (0.443ml) and the solution stirred at room temperature for 24h. 2M Hydrochloric acid (0.31ml) was added and the mixture blown down to dryness. The residue was suspended in dry dichloromethane (0.5ml) and treated at room temperature with oxalyl chloride (0.019ml) and DMF (1 drop). The mixture was stirred at room temperature for 30mins and then added dropwise to a solution of Intermediate 15 (53mg) in acetonitrile (1ml). DIPEA (0.039ml) was added and the mixture was stirred at room temperature for 18h. The mixture was blown down to dryness and the residue was purified by mass directed autoprep HPLC followed by SPE cartridge (1g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 340 as a beige solid (9mg). LCMS showed MH+ = 464; TRET = 2.42min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 306960-77-0, 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H7ClN2O2

4-(furan-2-yl)-2,6-dimethoxypyrimidine According to the general procedure, a mixture of 6-chloro-2,4-dimethoxypyrimidine (175 mg, 1 .00 mmol), 2-furanboronic acid (168 mg, 1 .50 mmol), (7i-crotyl)Pd(XPhos)CI (14 mg, 0.02 mmol), 2 mL THF, and 4 mL of 0.5 M aqueous K3P04 are stirred at room temperature for 1 hour. The crude material is chromatographed on silica gel with a gradient of 0 – 10 % EtOAc/hexanes as the eluent to give 194 mg (0.94 mmol, 94 %) of 4-(furan-2-yl)-2,6-dimethoxypyrimidine as a colorless solid. H NMR (400 MHz, CDCI3, delta): 7.53 (dd, J = 0.9 Hz, 1 .9 Hz, 1 H), 7.19 (dd, J = 0.7 Hz, 3.5 Hz, 1 H), 6.69 (s, 1 H), 6.53 (dd, J = 1 .7 Hz, 3.4 Hz, 1 H) 4.02 (s, 3H), 3.99 (s, 3H). l3C NMR (100 MHz, CDCI3, delta): 172.6, 165.6, 157.4, 152.2, 144.6, 1 12.3, 1 1 1 .9, 95.0, 54.8, 54.0. Anal. Calcd. for C10H10N2O3: C, 58.25; H, 4.89; N, 13.59. Found: C, 58.19; H, 4.72; N, 13.42

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H5N3O2

To a solution of 2-aminopyrimidine-4,6-diol (1.0 eq) in POCl3 (1M) was stirred at 100 C. for 4 h. The reaction mixture was allowed to cool to rt and the mixture was poured into ice-water. The precipitated solid was collected by filtration. The solid was washed with water and dried in vacuum to give the title compound as a yellow solid.

With the rapid development of chemical substances, we look forward to future research findings about 56-09-7.

Reference:
Patent; Apros Therapeutics, Inc.; WU, Tom Yao-Hsiang; (209 pag.)US2018/155298; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20781-06-0, blongs to pyrimidines compound. HPLC of Formula: C5H6N4O

General procedure: Appropriate substituted benzoyl hydrazine 4 (1 equiv) was added to a solution of intermediate 2 (1mmol) in ethanol (10mL). The reaction mixture was stirred for 3h at reflux under the condition of the presence of acetic acid as catalyzer, then poured into cold water and the resulting solid was collected by filtrated, washed with EtOH (10mL), and dried in the atmospheric pressure to give the desired title compounds A, B, and C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20781-06-0, its application will become more common.

Reference:
Article; He, Haifeng; Xia, Hongying; Xia, Qin; Ren, Yanliang; He, Hongwu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5652 – 5661;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H7ClN2O2

Step 2: 6-(hydroxyamino)-l,3-dimethylpyrimidine-2,4(lH,3H)-dione: A solution of Step 1 intermediate (10 g, 57.261 mmol), hydroxylamine hydrochloride (12.15 g, 176.361 mmol) and sodium acetate (33.81 g, 412.28 mmol) in isopropyl alcohol (280 ml) were refluxed for 4 h. The reaction mixture was concentrated under reduced pressure, diluted with water and stirred for 1 h. The precipitated solid was collected by filtration, washed with water (25 ml) and dried to obtain 9.56 g of the product as a pale brown solid; NMR (300 MHz, DMSO-i/6) delta 3.07 (s, 3H), 3.16 (s, 3H), 3.67 (s, 2H), 10.45 (br s, lH).

With the rapid development of chemical substances, we look forward to future research findings about 6972-27-6.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil; WO2011/114184; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 96548-91-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96548-91-3, name is 2-Fluoropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2-fluoropyrimidin-4-amine (1.94 g, 17.1 mmol), ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate (3.0 g, 11.4 mmol) and cesium carbonate (5.57 g, 17.1 mmol, Aldrich) was heated to 85 C. for 18 h. The mixture was cooled to RT, diluted with H2O and extracted with CH2Cl2 (2*) and CHCl3 (2*). The combined organics were dried over Na2SO4, Filtered and concentrated. Purifications by flash chromatography (0?15?50% EtOAc/Hexanes) afforded the title product. MS m/z 340 (MH)+.

According to the analysis of related databases, 96548-91-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Andersen, Denise Lyn; Chang, Catherine H.; Falsey, James R.; Frohn, Michael J.; Hong, Fang-Tsao; Liao, Hongyu; Liu, Longbin; Lopez, Patricia; Retz, Daniel Martin; Rishton, Gilbert M.; Rzasa, Robert M.; Siegmund, Aaron; Tadesse, Seifu; Tamayo, Nuria; Tegley, Christopher M.; US2006/69110; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia