Tag: M.W:100-200

Reference of 372118-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tosyl chloride (254 mg, 1.33 mmol), K2CO3 (538 mg, 3.9 mmol) and 22 (436 mg, 1.33 mmol) were added to acetonitrile (10 mL) and stirred at room temperature overnight. Compound 23 (194 mg, 1.33 mmol) was added to the prepared mixed solution of the mixed anhydride, and the mixture was stirred at room temperature for 20 minutes. After completion of the reaction by TLC, the starting material was reacted. The mixture was diluted with water and washed with ethyl acetate. The aqueous phase was extracted twice more with ethyl acetate. The combined organic phases were dried over anhydrous sodium sulfate and concentrated to give compound 25 (588 mg, yield 93%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 372118-67-7, Pyrimidin-2-ylmethanamine hydrochloride.

Reference:
Patent; Anrun Pharmaceutical (Suzhou) Co., Ltd.; Hong Jian; Xu Xin; Liu Guobin; Liu Huahui; (14 pag.)CN104710411; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 874-14-6 ,Some common heterocyclic compound, 874-14-6, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 1,3-dimethyluracil 1a (0.20 mmol) in 2,2,2-trifluoroethanol (TFE) (3 mL),(4-chlorophenyl)(hydroxy)iodonium tosylate 2f (0.20 mmol) was added and it was stirred at room temperature. After completion of the reaction, the solvent was removed under vacuum. The product wasthen precipitated by the addition of Et2O with stirring. The precipitate was filtered to giveuracil-iodonium(III) salt 3f as white powder.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,874-14-6, its application will become more common.

Reference:
Article; Takenaga, Naoko; Ueda, Shohei; Hayashi, Takumi; Dohi, Toshifumi; Kitagaki, Shinji; Heterocycles; vol. 97; 2; (2018); p. 1248 – 1256;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2927-71-1, Adding some certain compound to certain chemical reactions, such as: 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2927-71-1.

title compound (81%) as an orange solid, which was used without further purification.LRMS (m/z): 163 (M+1)+.1H-NMR delta (CDCl3): 4.11 (s, 3H), 8.20 (d, 1 H)

According to the analysis of related databases, 2927-71-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Almirall, S.A.; Eastwood, Paul Robert; Gonzalez Rodriguez, Jacob; Bach Tana, Jordi; Pages Santacana, Lluis Miquel; Taltavull Moll, Joan; Caturla Javaloyes, Juan Francisco; EP2338888; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.

16.2 g (100 mmol) of 4,6-dichloro-2-methylpyrimidine was added to a solution of 21 g (300 mmol) of hydroxylamine hydrochloride in ethanol (100 ml), and then 30.6 g of triethylamine was added, and the mixture was refluxed at 110 C for 1.5 h. Cool to room temperature, concentrate, wash with water, filter,Drying to obtain 14.3 g of N-(6-chloro-2-methylpyrimidin-4-yl)hydroxylamine (Compound 3),The yield was 90% and the HPLC purity was 99.61%.

According to the analysis of related databases, 1780-26-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANQING QICHUANG PHARMACEUTICAL CO LTD; Anqing Qichuang Pharmaceutical Co., Ltd.; WU XUEPING; Wu Xueping; SHI ZHUYONG; Shi Zhuyong; (10 pag.)CN108299417; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, molecular weight is 174.59, as common compound, the synthetic route is as follows.Formula: C6H7ClN2O2

Methyl 2-hydroxy isobutyrate 0.52g (0.005 mol) and 2-chloro-4,6-dimethoxy-pyrimidine 0.88g (0.005 mol) were dissolved in DMF 20 ml, K2CO3 0.52g (0.75 eq) was added thereto, and sodium methane sulfate 0.1g was added thereto, followed by stirring at 120C for 5 hours. The reacted solution was cooled to room temperature, and distilled under reduced pressure to obtain residue. The residue was extracted with cold water and ethylacetate three times, and washed with brine twice, the organic layer was dried with MgSO4, and the solvent was removed under reduced-pressure. Through purification with silica gel column chromatography, a target material 0.14g (12%) was obtained.: 1H NMR (300MHz, CDCl3) delta: 1.72(s, 6H), 3.66(s, 3H), 3.93(s, 6H), 5.7(s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13223-25-1, 2-Chloro-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SNU R&DB Foundation; Korea Research Institute Of Chemical Technology; EP2497768; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 17119-73-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17119-73-2, name is 4-Chloro-6-methyl-2-(methylthio)pyrimidine, molecular formula is C6H7ClN2S, molecular weight is 174.6512, as common compound, the synthetic route is as follows.

EXAMPLE 10 STR124 1.9 l of sodium hypochlorite (about 150 g of active chlorine per liter) were added slowly to a solution of 175 g (1 mole) of 2-methylmercapto-4-methyl-6-chloropyrimidine in 375 ml of concentrated hydrochloric acid and 375 ml of water at 5 C. The product which had precipitated was then filtered off and rinsed with water. This gave 170 g (82% of theory) of 2-methylsulfonyl-4-methyl-6-chloropyrimidine in the formn of colorless crystals of melting point 72 C. STR125

The chemical industry reduces the impact on the environment during synthesis 17119-73-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer Aktiengesellschaft; US4113860; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4558-59-2, name is 4,6-Dimethoxypyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4558-59-2

l. 2,6-dimethyl-4-(4′,6′-dimethoxy-5′-pyrimidyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diallyl ester, m.p. 174; from 4,6-dimethoxypyrimidine-5-aldehyde, acetoacetic acid ethyl ester and ammonia.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4558-59-2, 4,6-Dimethoxypyrimidine-5-carbaldehyde.

Reference:
Patent; Bayer Aktiengesellschaft; US4048171; (1977); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, the common compound, a new synthetic route is introduced below. Quality Control of 2,5-Diamino-4,6-dichloropyrimidine

Amino derivative 30 (1.05 g, 5.24 mmol), 2,5-diamino-4,6-dichloropyrimidine 17 (1.03 g, 5.76 mmol), and triethylamine (3.1 ml, 22.53 mmol) were suspended in n-butanol (55 ml) and heated to 140 C in a pressure vessel over 48 h. After the reaction was completed, the solvent was evaporated and the residue chromatographed on a silica gel using a linear gradient of ethyl acetate in toluene. The product was obtained in a 56% yield (1.00 g, 2.92 mmol) as a dark orange foam.numax (KBr) 3493 (s), 3405 (s), 3213 (m), 2975 (m), 2934 (m), 2858 (w), 1688 (s), 1617 (s), 1571 (vs), 1502 (m), 1467 (s), 1430 (s), 1442 (s), 1392 (m), 1366 (m), 1308 (w), 1265 (m), 1242 (m), 1174 (m), 1153 (s), 860 (w), 773 (w); deltaH (DMSO, 499.8 MHz, 80 C) 6.06 (1H, br d, JNH-3 7.4 Hz, NH), 3.92 (1H, m, H-3), 5.35 (2H, br s, NH2), 3.82 (1H, m, H-2eq), 3.77 (2H, br s, NH2), 3.63 (1H, m, H-6eq), 2.94-3.01 (2H, m, H-2ax, H-6ax), 1.94 (1H, m, H-4eq), 1.75 (1H, m, H-5eq), 1.51 (1H, m, H-4ax), 1.42 (1H, m, H-5ax), 1.38 (9H, s, (CH3)3); deltaC (DMSO, 125.7 MHz, 80 C) 78.4 (C(CH3)3), 47.7 (C-2), 46.2 (C-3), 43.2 (C-6), 29.6 (C-4), 27.8 (C(CH3)3), 22.9 (C-5); HRMS (ESI) C14H24O2N6Cl (M+H)+ calcd 343.1644, found 343.1645.

The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kova?kova, So?a; Dra?insky, Martin; Rejman, Dominik; Tetrahedron; vol. 67; 7; (2011); p. 1485 – 1500;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 35808-68-5, 4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 35808-68-5, blongs to pyrimidines compound. Application In Synthesis of 4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

Step 4. To the solution of 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (1.0 g, 5.97 mmol,1.0 eq) and (S)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (1.32 g, 6.57 mmol,1.1 eq) and PPh3 (3.03 g, 11.94 mmol, 2.0 eq) in THF (50 mL), DIEA (2.08 g, 11.94 mmol,2.0 eq) was added at 00 C. The resulted mixture was stirred and warmed to RT for 12 h.Solvent was removed and purified by column chromatography (eluting with 10 % EtOAc in PE) to afford (S)-tert-butyl 2-((4-chloro-6-methyl-7H-pyrrolo [2,3-d]pyrimidin-7-yl)methyl)pyrrolidine-1-carboxylate as a white solid (2.08 g, 100 % in yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35808-68-5, its application will become more common.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BABLER, Martin; GERRITSEN, Mary E.; WO2014/22569; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 63200-54-4 ,Some common heterocyclic compound, 63200-54-4, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 2,4-dichloro-1H-pyrrolo[3,2-d]pyridine (5) was dissolved in a solution of 1:1 THF:DMF underN2. Sodium hydride (60% suspension in oil) was added directly, and the mixture was stirredat room temperature for 1 h. Appropriate halogenated reagent (methanesulfonyl chloride (6),2-nitrobenzenesulfonyl chloride (7), 2,4,6-Triisopropylbenzenesulfonyl chloride (8), benzyl bromide(9), 2,4-dichlorobenzyl bromide (10), 4-methoxybenzyl chloride (11), acetyl chloride (12), isobutyrylchloride (13), diphenylcarbamyl chloride (14), iodoethane (15)) was added and the mixture was stirredat r.t. for 18 h. The solvent was removed and residue dissolved in EtOAc and washed with waterand brine, then dried over MgSO4. Organics were loaded onto Celite and product purified usingsilica column chromatography eluting with 4:1 hexanes:EtOAc or 9:1 DCM:MeOH to obtain product,generally as a white to o-white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63200-54-4, its application will become more common.

Reference:
Article; Cawrse, Brian M.; Robinson, Nia’mani M.; Lee, Nina C.; Wilson, Gerald M.; Seley-Radtke, Katherine L.; Molecules; vol. 24; 14; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia