Tag: M.W=100-150

Sulkowska, A. published the artcilePhysical aspects of the interaction of pyrimidine and purine bases with proteins, COA of Formula: C5H6N2O2, the publication is Spectroscopy (Amsterdam, Netherlands) (2002), 16(3,4), 379-385, database is CAplus.

The study of complexation of purine and pyrimidine derivatives with two kind of serum albumin using ¹H NMR and spectrofluorescence technique are performed in order to obtain model interactions nucleic acid bases-protein. The order of binding strength is as follows: 5mC > 5mU(T) > 3mU > U for pyrimidines and N6mAde > N6Ado > 1mAde > ATP > Ado > Ade for adenine derivatives The effect of temperature on the hydrophobic interaction between the nitrogen bases and protein has been studied. The destabilization of protein structure causes loss of tertiary structural contacts, indicating that protein conformation is crucial for binding.

Spectroscopy (Amsterdam, Netherlands) published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C6H12Br2, COA of Formula: C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sulkowska, Anna published the artcileInteractions between pyrimidine bases derivatives and serum albumin in the presence of urea, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (1999), 158(1-2), 151-156, database is CAplus.

A study of complex formation between pyrimidine base derivatives and serum albumin should allow us to determine the specificity of interactions of the pyrimidine derivatives with proteins. The role of the secondary and tertiary structure of serum albumin on the binding of the protein is also under investigation. The possible importance of the interactions between aliphatic residues of pyrimidine bases derivatives and serum albumin is discussed with respect to the problem of specific protein-nucleic acid interactions. The results suggest a release of ligands from their binding sites on the denatured polypeptide chain. The importance of hydrophobic interactions of the C5 Me group with hydrophobic grooves of protein in the presence of urea is suggested.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C8H6KNO4S, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Wen, Qian published the artcileStudy on the chemical constituents of Crinum latifolium, Product Details of C5H6N2O2, the publication is Yaoxue Shijian Zazhi (2010), 28(3), 225-227, database is CAplus.

The objective of this paper is to investigate the chem. constituents of Crinum latifolium. The chem. constituents of methanol extract of Crinum latifolium were separated by various chromatog. methods. The structures of these chem. constituents were identified by spectral data and physicochem. property. Results show that 15 compounds were resp. identified as: beta-sitosterol (1), daucosterol (2), 5-methyl-2,4(1H,3H)-pyrimidinedione (3), β-purine (4), p-hydroxybenzoic acid (5), Et 4-hydroxybenzoate (6), cinnamyl D-glucopyranoside (7), benzyl D-glucopyranoside (8), adenosine (9), uridine (10), Z-cinnamic acid (11), 5-O-nitrosouridine (12), 3-methyl-1H-pyrimidine-2, 4-dione (13), N-methyl-benzamide (14), and E-cinnamic acid (15). It was concluded that compounds 3-4, 7-10, 12-14 were isolated from Crinum latifolium for the first time.

Yaoxue Shijian Zazhi published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C3H5BN2O2, Product Details of C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Wennerbeck, Ingegerd published the artcileCNDO/2 [complete neglect of differential overlap-new version] calculations of rotational barriers in N,N-dimethylamino azines. Line shape study of the barrier in 3-dimethylamino-1,2,4-triazine, Safety of N,N-Dimethylpyrimidin-4-amine, the publication is Journal of Molecular Structure (1974), 22(1), 1-10, database is CAplus.

Barriers to rotation about exocyclic C-N bonds in dimethylamino derivatives of pyridine, pyrimidine, and 1,2,4- and 1,3,5-triazine were studied using CNDO/2 calculations The results were discussed in terms of calculated total and π-charge densities.

Journal of Molecular Structure published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C25H47NO8, Safety of N,N-Dimethylpyrimidin-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Dolgounitcheva, O. published the artcileIonization Energies and Dyson Orbitals of Thymine and Other Methylated Uracils, Quality Control of 608-34-4, the publication is Journal of Physical Chemistry A (2002), 106(36), 8411-8416, database is CAplus.

Electron propagator methods are applied to the calculation of photoelectron spectra of thymine and other C- and N-methylated uracils. The Partial Third-Order electron propagator method is used. Excellent agreement with existing exptl. spectra is achieved. Relationships between reductions in ionization energies and antibonding contributions from Me groups in corresponding Dyson orbitals are discussed.

Journal of Physical Chemistry A published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Quality Control of 608-34-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Siddiraju, S. published the artcileStability indicating RP-HPLC method development and validation for the simultaneous determination of aminexil and minoxidil in pharmaceutical dosage form, Application of 2,4-Diaminopyrimidine-3-oxide, the publication is Annales Pharmaceutiques Francaises (2015), 73(2), 114-122, database is CAplus and MEDLINE.

The objective of the present work is to develop stability indicating high-performance liquid chromatog. method for the simultaneous determination of aminexil and minoxidil in pharmaceutical dosage form. The chromatog. separation was achieved with BDS Hypersil C₁₈ column (250 mm × 4.6 mm × 5 μ) as stationary phase and phosphate buffer and acetonitrile (78:22) as mobile phase. The method was employed by using a flow rate of 1.1 mL/min kept at 30 °C. The detection wavelength was kept at 238 nm by using photo-diode array detector. The retention times of the aminexil and minoxidil were found to be 2.3 min and 3.9 min, resp. The method developed was validated in accordance with ICH guidelines with respect to the stability indicating capacity of the method including system suitability, accuracy, precision, linearity, range, limit of detection, limit of quantification and robustness. The linearity responses of aminexil and minoxidil were found to be in the concentration ranges of 18.75-112.5 μg/mL and 25-150 μg/mL, resp. The LOD and LOQ values for aminexil were found to be 0.31 and 0.92 μg/mL and minoxidil were found to be 0.03 and 0.10 μg/mL resp. The percentage recoveries for both the drugs were found in the range of 98-101%. This method is accurate, precise and sensitive; hence, it can be employed for routine quality control of aminexil and minoxidil in pharmaceutical industries and drug testing laboratories

Annales Pharmaceutiques Francaises published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C7H7IN2O, Application of 2,4-Diaminopyrimidine-3-oxide.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Zheltovsky, N. V. published the artcileInteractions of methyl and glycosyl derivatives of pyrimidine nucleotide bases with amino acid carboxylic group, Synthetic Route of 608-34-4, the publication is Biopolimery i Kletka (1994), 10(6), 45-51, database is CAplus.

By UV, IR, and NMR interactions of a number of Me and glycosyl derivatives of pyrimidine bases with amino acid carboxylic group in DMSO were studied as a model of probable point contacts in real nucleoprotein complexes. It was found that like the unsubstituted base 1-methylcytosine, 5-methylcytosine, 1,5-dimethylcytosine, cytidine, deoxycytidine, 5-methyldeoxycytidine form complexes with a neutral carboxylic group, and 3-methylcytosine and isocytosine interact with deprotonated carboxylic group (carboxylate ion). Like free thymine and uracil, their derivatives 1-methylthymine, 1-methyluracil, 3-methyluracil, thymidine, uridine, 5-methyluridine, deoxyuridine interact only with carboxylate ion. Anal. of the results obtained and the data of previous works points out the ability of amino acid carboxylic group to differentiate between cytosine and thymine (uracil), and between their nucleosides and derivatives as well.

Biopolimery i Kletka published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C2H3N3, Synthetic Route of 608-34-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Zielenkiewicz, W. published the artcilePartial molar volumes of alkylated uracils- insight into the solvation shell? Part II, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is Journal of Solution Chemistry (1998), 27(6), 543-551, database is CAplus.

The solute-solvent interactions in aqueous solutions of alkylated uracils are discussed. The partial molar volume data are interpreted using a new model of interaction of the solute mol. with the solvent. The model is based on the assumption that the d. of solvent in the hydration shell depends on the structure and polarity of the solute mol. The relation among mol. volume, partial molar volume, and volume of the solvation shell is expressed by α parameter, which is defined as the relative d. of the solvation shell. It is found that in compounds with the same number of CH₂– groups, the α values depend on substitution on the C or N atoms of the uracil skeleton. The α values also depend to some extent, on screening of the oxygen atoms by methylation of the neighboring atoms of the uracil ring. A correlation is presented between the relative d. of solvation shell and polarity (defined as the ratio of the surface of polar groups and atoms exposed to the solvent to the total accessible mol. surface of the mol.) for the compounds studied. It was demonstrated that of the various solute-solvent interactions the dominant role is played by polar interactions.

Journal of Solution Chemistry published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H7BO2S, Application of 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Litonska, Ewa published the artcileConformation of the dimethylamino group in cytosine and in simple model pyrimidines and pyridines. Steric effects of ortho-methyl substitution on infrared spectra and molecular dipole moments, Product Details of C6H9N3, the publication is Acta Biochimica Polonica (1979), 26(1-2), 39-54, database is CAplus.

The IR of NR₂ (R = H, Me) derivatives of 4- or 5-substituted pyrimidines, 4-substituted pyridines, benzenes, or the resp. cytosines were determined in the skeletal ring vibration region. The sensitivity of the ring vibrations, at âˆ?600 cm^-1, to electron donating groups is used to determine the o-Me group as the steric hindrance of NMe₂ conjugation with the ring. The dipole moments of simple pyrimidine and pyridine derivatives were determined in C₆H₆. The vectorial anal. of the dipole moments indicates that the twisting of the Me₂N group in the hindered derivatives decreases in the order: 5-dimethylaminopyrimidine > 4-dimethylaminopyridine > 4-dimethylaminopyrimidine. Sterically crowded I is planar.

Acta Biochimica Polonica published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, Product Details of C6H9N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Qiu, Yan published the artcileDesign and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors, Recommanded Product: 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is RSC Advances (2017), 7(37), 22699-22705, database is CAplus.

Fatty acid amide hydrolase (FAAH) is one of the key enzymes involved in the biol. degradation of endocannabinoids, especially anandamide. Pharmacol. blockage of FAAH restores the levels of endocannabinoids, providing therapeutic benefits in the management of inflammation, depression and multiple sclerosis. In this study, a series of uracil urea derivatives as FAAH inhibitors were designed and synthesized. Structural modifications at the C5 position and side chain of N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide (1a) led to FAAH inhibitors with improved potency and selectivity. Structure-activity relationship (SAR) studies indicated that C5 electron-withdrawing substituents were preferred for optimal potency but not for selectivity, whereas replacement of the alkyl chain with phenylalkyl moieties or biphenyl groups significantly improved both inhibitory potency and selectivity towards FAAH. Two highly potent picomolar FAAH inhibitors (4c, IC₅₀ = 0.3 ± 0.05 nM; 4d, IC₅₀ = 0.8 ± 0.1 nM) were developed. Compound 4c inhibited FAAH in a rapid, selective, noncompetitive, and irreversible pattern. This study provides several highly potent and selective FAAH inhibitors and an optimized chem. scaffold for the development of FAAH inhibitors. We anticipate that these FAAH inhibitors will enable new possibilities in understanding FAAH functions and development of therapeutics for pain and inflammatory diseases.

RSC Advances published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Recommanded Product: 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia