Tag: M.W=100-150

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Safety of 2-Chloropyrimidine.

Huang, Chia-Yu;Li, Jianbin;Li, Chao-Jun research published ã€?A cross-dehydrogenative C(sp³)-H heteroarylation via photo-induced catalytic chlorine radical generationã€? the research content is summarized as follows. Here, a photo-induced and chem. oxidant-free cross-dehydrogenative coupling (CDC) between alkanes and heteroarenes using catalytic chloride and cobalt catalyst were reported. Couplings of strong C(sp³)-H bond-containing substrates and complex heteroarenes was achieved with satisfactory yields. This dual catalytic platform features the in-situ engendered chlorine radical for alkyl radical generation and exploited the cobaloxime catalyst to enable the hydrogen evolution for catalytic turnover. The practical value of this protocol was demonstrated by the gram-scale synthesis of alkylated heteroarene with merely 3 equivalent alkane loading.

Safety of 2-Chloropyrimidine, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 554-01-8, formula is C5H7N3O, Name is 4-Amino-5-methylpyrimidin-2(1H)-one. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Related Products of 554-01-8.

Huang, Jiliang;Ru, Gaizhen;Sun, Jiajia;Sun, Luying;Li, Zhiling research published ã€?Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese miceã€? the research content is summarized as follows. Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood. We established an obesity model in female mice by high-fat diet (HFD) feeding. The effects of the HFD on the developmental potential of oocytes and embryos, the metabolic phenotype, and epigenetic modifications were investigated. The efficacy of metformin administration was assessed. Finally, the regulatory pathway of epigenetic remodeling during zygotic genome activation (ZGA) was explored. Maternal HFD consumption significantly impaired glucose tolerance and increased the risk of metabolic disorders in F0 and F1 mice. Maternal HFD consumption also decreased embryonic developmental potential, increased reactive oxygen species (ROS) and γH2AX levels, and reduced the mitochondrial membrane potential (MMP) within oocytes, causing high levels of oxidative stress damage and DNA damage. Starting with this clue, we observed significantly increased RIF1 levels and shortened telomeres in obese mice. Moreover, significant abnormal DNA methylation and histone modification remodeling were observed during ZGA in obese mice, which may be coregulated by RIF1 and the ZGA marker gene MuERV-L. Metformin treatment reduced RIF1 levels, and partially improved ZGA activation status by rescuing epigenetic modification remodeling in oocytes and preimplantation embryos of obese mice. RIF1 knockdown experiments employing Trim-Away methods showed that RIF1 degradation altered the H3K4me3 and H3K9me3 enrichment and then triggered the MuERV-L transcriptional activation. Moreover, ChIP-seq data anal. of RIF1 knockouts also showed that RIF1 mediates the transcriptional regulation of MuERV-L by changing the enrichment of H3K4me3 and H3K9me3 rather than by altered DNA methylation. Elevated RIF1 in oocytes caused by maternal obesity may mediate abnormal embryonic epigenetic remodeling and increase metabolic risk in offspring by regulating histone modifications on MuERV-L, which can be partially rescued by metformin treatment.

Related Products of 554-01-8, 5-Methylcytosine is a methylated form of the nucleobase cytosine occurring predominantly in cytosine-phosphate-guanine (CpG) islands that are produced by DNA methyltransferases and may regulate gene expression. Like cytosine, the DNA sequence containing 5-methylcytosine (5-mC) is able to be replicated without error and 5-mC can pair with guanine in double stranded DNA. However, DNA sequences containing a high local concentration of 5-mC may be less transcriptionally active than areas with higher ratios of unmodified cytosine.
5-Methylcytosine belongs to the class of organic compounds known as hydroxypyrimidines. These are organic compounds containing a hydroxyl group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. 5-Methylcytosine exists as a solid, slightly soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 5-methylcytosine is primarily located in the cytoplasm. 5-Methylcytosine can be biosynthesized from cytosine. Outside of the human body, 5-methylcytosine can be found in tea. This makes 5-methylcytosine a potential biomarker for the consumption of this food product.
5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It derives from a cytosine.
5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei., 554-01-8.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: 2-Chloropyrimidine.

Iqbal, S. A.;Yuan, K.;Cid, J.;Pahl, J.;Ingleson, M. J. research published ã€?Controlling selectivity in N-heterocycle directed borylation of indolesã€? the research content is summarized as follows. Electrophilic borylation of indoles with BX₃ (X = Cl or Br) using N-heterocyclic directing groups installed at N1 can proceed at the C2 or the C7 position. The six membered heterocycle directing groups utilized herein, pyridines and pyrimidine, result in indole C2 borylation being the dominant outcome (in the absence of a C2-substituent). In contrast, C7 borylation was achieved using five membered heterocycle directing groups, such as thiazole and benzoxazole. Calculations on the borylation of indole substituted with a five (thiazole) and a six (pyrimidine) membered heterocycle directing group indicated that borylation proceeds via borenium cations with arenium cation formation having the highest barrier in both cases. The C7 borylated isomer was calculated to be the thermodynamically favored product with both five and six membered heterocycle directing groups, but for pyrimidine directed indole borylation the C2 product was calculated to be the kinetic product. This is in contrast to thiazole directed indole borylation with BCl₃ where the C7 borylated isomer is the kinetic product too. Thus, heterocycle ring size is a useful way to control C2 vs. C7 selectivity in N-heterocycle directed indole C-H borylation.

1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., Recommanded Product: 2-Chloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Recommanded Product: 2-Chloropyrimidine.

Irving, Charles D.;Floreancig, Jack T.;Gasonoo, Makafui;Kelley, Alexandra S.;Laulhe, Sebastien research published �Synthesis of Imide and Amine Derivatives via Deoxyamination of Alcohols Using N-Haloimides and Triphenylphosphine� the research content is summarized as follows. A deoxyamination methodol. of activated and unactivated alcs. is presented. The reaction is mediated by phosphonium intermediates generated in situ from N-haloimides and triphenylphosphine. The protocol allows for the synthesis of phthalimide and amine derivatives in moderate to good yields at room temperature A series of NMR experiments have provided insight into the reactive intermediates involved and the mechanism of this deoxyamination reaction.

1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., Recommanded Product: 2-Chloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tupitsyn, I. F.; Zatsepina, N. N.; Kolodina, N. S.; Kirova, A. V. published the artcile< Nuclear quadrupole resonance and infrared spectroscopic studies of electron interactions in polysubstituted azines>, HPLC of Formula: 6554-61-6, the main research area is NQR nitrogen heterocycle chlorine; pyridine pyrimidine NQR IR; substituent effect NQR IR pyridine.

35Cl NQR frequencies (νCl) and integral intensities (A) of ir absorption bands of stretching vibrations of aromatic C-H bonds of polysubstituted N heterocycles, e.g., chloropyridines, chloropyrimidines, were correlated with inductive and resonance substituent constants Electronic effects of the heteroatoms and substituents on νCl and A were additive.

Reaktsionnaya Sposobnost Organicheskikh Soedinenii published new progress about IR spectra. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, HPLC of Formula: 6554-61-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Khamouli, Saida; Belaidi, Salah; Zinebalmi; Medjahed, Sihem; Belaidi, Houmam published the artcile< Property/activity relationships and drug likeness for pyrimidine derivatives as serine/threonine protein kinase B inhibitors>, Related Products of 6554-61-6, the main research area is pyrimidine derivative serine threonine protein kinase inhibitor drug property.

The equilibrium geometry and electronic structures of the pyrimidine, were determined and analyzed with ab initio/HF, and DFT method. In the present work, the calculated values, namely net charges, MESP contours/surfaces has also been drawn to explain the electronic activity of Pyrimidine. QSAR properties, Lipinski′s parameters, Lipophilic Efficiency (LipE), are reported and discussed to understand the biol. activity of the Pyrimidine Derivatives

Journal of Bionanoscience published new progress about Absorption. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Related Products of 6554-61-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Semin, G. K.; Babushkina, T. A.; Mamaev, V. P.; Krivopalov, V. P. published the artcile< Chlorine-35 nuclear quadrupole resonance in chloropyrimidines>, Category: pyrimidines, the main research area is nuclear quadrupole resonance chloropyrimidine.

The nuclear quadrupole resonance (NQR) spectra of 35Cl in 2- and 5-chloro-, 2,4-, 4,6-, 4,5-, and 2,5-dichloro-, 4,5,6-, 2,4,5-, and 2,4,6-trichloropyrimidines and tetrachloropyrimidine were measured at 77°K and calculated by the published additivity method to study the electron d. distribution on C atom of the ring and effect of the substituents. The additivity method of calculating the NQR frequencies of 35Cl is valid for the chloro substituted pyrimidines. It was used to determine electron d. distribution on various C atoms in the pyrimidine ring. The relative role of various mechanisms of the transmission throughout the ring of the effect of substituents is discussed.

Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk published new progress about Electron configuration. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Papavassiliou, G. C.; Yiannopoulos, S. Y.; Zambounis, J. S. published the artcile< Bis(diazino)tetrathiafulvalenes and similar π-donors>, Safety of 4,5-Dichloropyrimidine, the main research area is tetrathiafulvalene bisdiazino; bispyrazinotetrathiafulvalene preparation charge transfer conductivity.

Bis(pyrazino)tetrathiafulvalene (I), bis(quinoxalino)tetrathiafulvalene, bis(pyrimidino)tetrathiafulvalenes, bis(pyridazino)tetrathiafulvalenes, bis(pyrazino)tetraselenafulvalene, and bis(quinoxalino) tetraselenafulvalene were prepared These compounds were found to be π-donors and gave charge transfer salts. The perchlorate salt of I was found to be a 3-D conductor. Thus, 2,3-dimercaptopyrazine was treated with SOCl2 to give the dithiocarbonate II, which was treated with (EtO)3P to give I.

Molecular Crystals and Liquid Crystals published new progress about Electric conductivity. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Safety of 4,5-Dichloropyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ferris, J. P.; Joshi, P. C.; Lawless, J. G. published the artcile< Chemical evolution. XXIX. Pyrimidines from hydrogen cyanide>, Related Products of 15837-41-9, the main research area is pyrimidine formation prebiosis; hydrogen cyanide pyrimidine formation.

Dilute (0.1M) solutions of HCN condensed to oligomers at pH 8-9. Hydrolysis of these oligomers at pH 8.5 or with 6N HCl yielded 4,5-dihydroxypyrimidine as the most abundant pyrimidine product along with orotic acid and 5-hydroxyuracil. Thus, the 3 major N-containing classes of biomols. could have originated from HCN on the primitive earth. The observation of the formation of orotic acid and 4-aminoimidazole-5-carboxamide by the hydrolysis of the HCN oligomers suggested that once the initially formed pyrimidines and purines were consumed, those life forms persisted which evolved enzymes for the conversion of these intermediates to the pyrimidines and purines present in contemporary RNA.

BioSystems published new progress about Molecular evolution. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Related Products of 15837-41-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

O’Brien, Darrell E.; Weinstock, Louis T.; Springer, Robert H.; Cheng, Chia-Chung published the artcile< Pyrimidines. XIX. Pyrimidol[4,5 - e]dihydro - 1,3-oxazines and related compounds>, Category: pyrimidines, the main research area is PYRIMIDO DIHYDRO OXAZINES; OXAZINES PYRIMIDO DIHYDRO.

A number of 2-substituted 4,5-dihydroxy-6-(substituted aminomethyl)pyridimines (I) were prepared from the corresponding 2-substituted 4,5-dihydroxypyrimidines by a new pyrimidine Mannich reaction. The structure of I was proved by an independent synthesis. Further study of this reaction led to the synthesis of pyrimido[4,5-e]dihydro-1,3-oxazines (II). 24 references.

Journal of Heterocyclic Chemistry published new progress about Mannich reaction. 15837-41-9 belongs to class pyrimidines, and the molecular formula is C4H4N2O2, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia