Tag: M.W=100-150

Cong, Han N’guyen published the artcileSeparation and characterization of the main methylated nucleobases from nuclear, cytoplasmic and poly(A)⁺ RNA by high-performance liquid chromatography and mass spectrometry, Category: pyrimidines, the publication is Journal of Chromatography B: Biomedical Sciences and Applications (1994), 661(2), 193-204, database is CAplus.

We were able to detect nine methylated nucleobases (3-methyluracil, 1-, 2-, 3- and 7-methylguanine, 1-, 2-, 3- and 6-methyladenine) in RNA from rat and calf liver, baker’s yeast, Torula and Euglena cells by using reversed-phase high-performance liquid chromatog. and thermospray mass spectrometry. Total cellular, nuclear, cytoplasmic and poly (A)⁺ RNA from rat liver showed marked methylation, mainly of 1- and 3-methylguanine, and 3- and 2-methyladenine. These bases were especially abundant in nuclear RNA and, to a lesser extent, in poly (A)⁺ RNA. In contrast, 7-methylguanine and 6-methyladenine were poorly represented in poly (A)⁺ RNA.

Journal of Chromatography B: Biomedical Sciences and Applications published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Category: pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Kosevich, M. V. published the artcileInteraction of calcium and copper ions with pyrimidine bases in frozen water solutions, COA of Formula: C5H6N2O2, the publication is Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina (2003), 29-39, database is CAplus.

Interaction of nucleic acid pyrimidine bases m₁³Ura, m₁¹Thy, Cyt with calcium and copper ions in frozen water solutions was studied using low temperature fast atom bombardment mass spectrometric technique. Inspection of systems with varied concentrations of bases and chlorides of the metals have shown that base-metal associates recorded in the mass spectra are connected with finely dispersed structure of the eutectic of the frozen samples. It was revealed that the rate of the interactions and types of the associates formed are dependent on the divalent metal type. Calcium ions showed higher yields of associates with the bases in the solid-frozen systems in comparison with dilute water solutions Calcium ions produced along with electrostatically bound complexes covalent ones by substitution of a proton of a base while copper ions produced only non-covalent low-abundant associates In the case of thymine base which is prone to self-association, the distinctions between calcium and copper interactions were preserved at the level of the base dimers.

Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, COA of Formula: C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Lomoth, R. published the artcileSpectral and kinetic identification of radical cations of pyrimidine bases by stepwise electron transfer, Formula: C5H6N2O2, the publication is Chemical Physics Letters (1998), 288(1), 47-51, database is CAplus.

Radical cations of methylated derivatives of uracil and thymine were generated by electron transfer to the parent radical cation, generated in acetone by nanosecond pulse radiolysis. The resulting transient absorption peaking around 400 and 550 nm is assigned to the radical cations of the pyrimidine bases. Direct kinetic and spectroscopic evidence for this assignment has been given by a subsequent electron transfer from triphenylamine to the pyrimidine radical cations yielding the characteristic absorption spectrum of the triphenylamine radical cation.

Chemical Physics Letters published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Formula: C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Riand, J. published the artcileMass spectrometry. Induced fragmentation by electron impact of amino and dimethylaminopyrimidines, Recommanded Product: N,N-Dimethylpyrimidin-4-amine, the publication is Journal of Heterocyclic Chemistry (1983), 20(5), 1187-90, database is CAplus.

Fragmentation patterns for I (R = R² = H, R¹ = NH₂; R = R¹ = NH₂, R² = H; R = R¹ = R² = NH₂; R= Me₂N, R¹ = R² = H; R = R² = H, R¹ = Me₂N; R = R¹ = Me₂N, R² = H; R = R¹ = R² = Me₂N) were determined and discussed.

Journal of Heterocyclic Chemistry published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, Recommanded Product: N,N-Dimethylpyrimidin-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Mahe, Yann published the artcileA minoxidil-related compound lacking a C6 substitution still exhibits strong anti-lysyl hydroxylase activity in vitro, Related Products of pyrimidines, the publication is Skin Pharmacology (1996), 9(3), 177-183, database is CAplus.

It has been previously reported that minoxidil inhibits the activity of lysyl hydroxylase (LH), an enzyme which catalyzes the formation of hydroxylysine, which is necessary for proper maturation of collagen at the transcriptional and enzymic levels. Using the reverse transcriptase-polymerase chain reaction, we confirmed that this inhibition occurred at least at the transcriptional level. Furthermore, we took advantage of this sensitive and rapid method to perform a quant. structure activity relation study using several compounds structurally related to minoxidil. We found that when the C6 of the pyrimidinyl moiety was substituted, it had to be by a tertiary nitrogen, i.e. an N-piperidin ring for the inhibition of LH mRNA synthesis to be observed Surprisingly, however, we found that 2,4-diamino-pyrimidin-3-oxide, a new compound lacking an organic moiety para to the nitroxide oxygen, also retained a high inhibitory effect on LH mRNA expression, comparable to that of minoxidil. We thus conclude that the presence of a substituent para to the nitroxide oxygen is dispensable for inhibition of LH mRNA to be observed in vitro. This brings new insights into the design of therapeutic agents useful in any condition where an overproduction of mature collagen is unwanted, i.e. accelerated wound healing, keloids and localized scleroderma.

Skin Pharmacology published new progress about 74638-76-9. 74638-76-9 belongs to pyrimidines, auxiliary class Pyrimidine, name is 2,4-Diaminopyrimidine-3-oxide, and the molecular formula is C4H6N4O, Related Products of pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Nyeki, A. published the artcileNAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios, HPLC of Formula: 608-34-4, the publication is British Journal of Clinical Pharmacology (2003), 55(1), 62-67, database is CAplus and MEDLINE.

Aims. (i) To compare the phenotyping of healthy subjects for NAT2 (N-acetyltransferase) and CYP1A2 activities with caffeine, by the simultaneous assay of the urinary metabolites AFMU and AAMU, and (ii) to ascertain whether NAT2 and CYP1A2 phenotyping is influenced by the use of AFMU or AAMU in the metabolite ratio. Methods. Thirty-five healthy subjects (16 men, 19 women) participated to the study. Caffeine metabolite concentrations were measured in urine collected 8 h after 2.5 mg kg^-1 caffeine intake using a new validated h.p.l.c. method. The metabolite ratios AFMU/1X, AFMU/(AFMU+1X+1U), AAMU/1X, AAMU/(AAMU+1X+1 U), and (AFMU+1U+1X)/17U, (AAMU+1U+1X)/17U were determined as indexes of NAT2 and CYP1A2 activity, resp. Results. Slow and rapid acetylators were similarly identified using the four NAT2 metabolite ratios in 139 out of 1.40 measurements. An appreciable amount of AAMU was present in urine that was immediately acidified and analyzed. Consequently, the ratio using AFMU was lower than that using total AAMU following transformation of AFMU in basic conditions. The proportion of AFMU in urine analyzed immediately expressed as AFMU/(AFMU+AAMU) ratio did not correlate with urine pH, but was a function of the acetylation phenotype, with a low intergroup variability (64±3% and 32±5%, for rapid and slow acetylators, resp.; P < 0.00001, ANOVA). Regarding CYP1A2 activity, a good correlation (r = 0.99) was observed between the metabolite ratios calculated from AFMU and AAMU, although the ratios calculated from AFMU were proportionately and systematically lower (P < 0.00001, paired t-test, slope 1.2). Conclusions. This study demonstrates that both AFMU and AAMU can be used for NAT2 and CYP1A2 metabolite ratio determinations The reported conversion of AFMU into AAMU is unlikely to explain the large amount of AAMU in urine that was acidified and analyzed immediately after voiding. The results suggest that AAMU is formed not solely through a nonenzymic hydrolysis in urine, but in vivo by a NAT2 phenotype-dependent pathway.

British Journal of Clinical Pharmacology published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, HPLC of Formula: 608-34-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Neunhoeffer, Hans published the artcileCycloaddition reactions with azabenzenes. X. Cycloaddition reactions with 1,3,5-triazines, Recommanded Product: N,N-Dimethylpyrimidin-4-amine, the publication is Chemische Berichte (1975), 108(12), 3877-82, database is CAplus.

Triazines I (R1, R2, R3 = H, Me, CO2Et, Cl) reacted with electron-rich dienophiles [MeCCNEt2, II, EtOC(NMe2):CHR3 (R3 = H, Me)] and with electron-poor dienophiles (MeO2CCCCO2Me) by a (4+2)-cycloaddition reaction to give pyrimidines III [R4 = R1, R5 = R3, R6 = Me, R7 = NEt2; R4 = R5 = H, R6 = H, CO2Me, R7 = OEt, NMe2, CO2Me; R6R7 = (CH2)3]. I (R3 = Me) reacted with EtOC(NMe2):CHR8 (R8 = H, Me) to give vinyltriazines I [R3 = CH:C(NMe2)CH2R8]. I [R3 = CH:C(NMe2)CH2] reacted with di-Me 1,2,4,5-tetrazine-3,6-dicarboxylate to give pyridazinyltriazines IV.

Chemische Berichte published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, Recommanded Product: N,N-Dimethylpyrimidin-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Portalone, Gustavo published the artcileThe crystal structure of 3-methyluracil from X-ray powder diffraction data, Category: pyrimidines, the publication is Journal of Molecular Structure (2002), 608(1), 35-39, database is CAplus.

The crystal structure of 3-methyluracil was determined ab initio from conventional monochromatic x-ray powder diffraction data. The crystals are orthorhombic, space group Pbnm, with a 6.6294(1), b 13.1816(3), c 6.53938(9) (Å); Z = 8. The structure was solved by direct methods and the final Rietveld refinement converged to R_p = 0.0398, R_wp = 0.0528, R_Bragg = 0.0294. The crystal structure exhibits endless chains of planar mols., connected via head-to-tail N-H…O H bonds.

Journal of Molecular Structure published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Category: pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Asanuma, Hiroyuki published the artcilePrecise recognition of nucleotides and their derivatives through hydrogen bonding in water by poly(vinyldiaminotriazine), Product Details of C5H6N2O2, the publication is Supramolecular Science (1998), 5(3-4), 405-410, database is CAplus.

In water, poly(2-vinyl-4,6-diamino-1,3,5-triazine) (PVDAT) selectively binds the derivatives of thymine and uracil through the formation of three hydrogen bonds with the diaminotriazine (DAT) residues. The nucleotides and dinucleotides are bound much more strongly than are nucleic acid bases, due to the addnl. interactions of their phosphates with the DAT residues. The binding constant of the thymidine 5′-monophosphate-PVDAT adduct (5400 M^-1) is one of the largest values ever reported for the artificial receptors in protic solvents. In contrast, cytosine and its monophosphate are hardly bound to PVDAT. A water-soluble vinyldiaminotriazine-acrylamide copolymer also forms hydrogen bonds with thymine in water, whereas the corresponding monomers do not. A polymer effect is predominantly important for the mol. recognition through hydrogen bonding in water.

Supramolecular Science published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Product Details of C5H6N2O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Gustavsson, Thomas published the artcileSinglet Excited-State Behavior of Uracil and Thymine in Aqueous Solution: A Combined Experimental and Computational Study of 11 Uracil Derivatives, Recommanded Product: 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is Journal of the American Chemical Society (2006), 128(2), 607-619, database is CAplus and MEDLINE.

The excited-state properties of uracil, thymine, and nine other derivatives of uracil have been studied by steady-state and time-resolved spectroscopy. The excited-state lifetimes were measured using femtosecond fluorescence upconversion in the UV. The absorption and emission spectra of five representative compounds have been computed at the TD-DFT level, using the PBE0 exchange-correlation functional for ground- and excited-state geometry optimization and the polarizable continuum model (PCM) to simulate the aqueous solution The calculated spectra are in good agreement with the exptl. ones. Experiments show that the excited-state lifetimes of all the compounds examined are dominated by an ultrafast (< 100 fs) component. Only 5-substituted compounds show more complex behavior than uracil, exhibiting longer excited-state lifetimes and biexponential fluorescence decays. The S₀/S₁ conical intersection, located at CASSCF (8/8) level, is indeed characterized by pyramidalization and out of plane motion of the substituents on the C5 atom. A thorough anal. of the excited-state potential energy surfaces, performed at the PCM/TD-DFT(PBE0) level in aqueous solution, shows that the energy barrier separating the local S₁ min. from the conical intersection increases going from uracil through thymine to 5-fluorouracil, in agreement with the ordering of the exptl. excited-state lifetime.

Journal of the American Chemical Society published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Recommanded Product: 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia