Tag: M.W=0-100

109-12-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-12-6, name is Pyrimidin-2-amine, molecular formula is C4H5N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1), weighing 1.008g 2-amino pyrimidine (10.6mmol), 1.480g chloro acetyl chloride (13.1mmol), 1.779g potassium carbonate (12.9mmol) and 13 ml dichloromethane;(2), will step one (1) weighed in 2-amino pyrimidine, potassium carbonate and two-thirds the volume of dichloromethane (about 9 ml) with nitrogen protection device is of the three-port flask, in 0 C under the condition of stirring to dissolve;(3), will step one (1) weighed chloroacetic chloride in and the remaining dichloromethane (about 4 ml) in the constant voltage dropping funnel, then with a constant acceleration of 0.25 ml/min into the three-port flask, 20 min the completion of the dropping, the continued after dropping 0 C stirring reaction under the conditions of 3h, obtaining a reaction product;(4), using vacuum filtration device, step a (3) in the obtained after filtering the reaction product is the reaction product of in addition to the solvent, each with 10 ml deionized water washing the product, washing a total of 5 times, at a temperature of 45 C the product under the conditions of drying, drying time is 5h, the lime-green powdery solid, lime-green powdery solid is acetyl-2-amino pyrimidine, weighing mass is 1.550g, yield 85.22%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-12-6, Pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qiqihar University; Wang, Liyan; Liu, Shifu; Tian, Ying; He, Xianyou; Zhang, Hui; (10 pag.)CN105906572; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

109-12-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-12-6, name is Pyrimidin-2-amine, the common compound, a new synthetic route is introduced below.

General procedure: 0.5 mol% ruthenium(II) catalyst was stirred with 4 mmol ofKOH in toluene. To this mixture, 2 mmol of alcohol and 2 mmolof amine were added and the temperature was raised up to120 C. The progress of the reactions was monitored using TLC.As soon as the reaction was completed, the mixture was cooledto room temperature and added 3 mL of distilled water. The combinedmixture was extracted with CH2Cl2 and dried by addingmagnesium sulfate. The crude product was purified by columnchromatography (n-hexane/EtOAc) and characterized by 1H NMRspectral analyses. The 1H NMR data obtained for the catalytic productswere compared with literature [19].

Statistics shows that 109-12-6 is playing an increasingly important role. we look forward to future research findings about Pyrimidin-2-amine.

Reference:
Article; Prakash, Govindan; Ramachandran, Rangasamy; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Sanmartin, Jesus; Inorganica Chimica Acta; vol. 427; (2015); p. 203 – 210;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

591-55-9 , The common heterocyclic compound, 591-55-9, name is 5-Aminopyrimidine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of X-Phos (0.04 equiv) and Pd2(dba)3 (0.02 equiv) in toluene (15 vol) was bubbled with nitrogen and heated to 60 C for 15 min. (2S,4R)-1-(2-(3-Acetyl-5-bromo-1H-indol-1-yl)acetyl)-4-fluoro-N-phenethylpyrrolidine-2-carboxamide(1.2 equiv) and sodium tert-butoxide (1.4 equiv) was added to the reaction mixture and the reaction mixture was heated to 100 C for 16 h. After completion of the reaction, the reaction mixture was quenched with water. The resulting mixture was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous Na2S04, filtered and then concentrated. The residue was purified by column chromatography on silica gel using DCM/MeOH to give (2S,4R)-l-(2-(3- acetyl-5-(pyrimidin-5-ylamino)-lH-indol-l-yl)acetyl)-4-fluoro-N-phenethylpyrrolidine-2- carboxamide. NMR (400 MHz, DMSO-ifc) delta 8.56 (s, 1H), 8.49 – 8.47 (m, 3H), 8.23 (s, 1H), 8.19 – 8.12 (m, 1H), 8.01 (s, 1H), 7.43 (d, J = 8.8 Hz, 1H), 7.27 – 7.09 (m, 5H), 5.50 – 5.31 (m, 2H), 5.15 (d, J= 17.2 Hz, 1H), 4.35 – 4.31 (m, 1H), 4.19 – 3.85 (m, 2H), 3.56 – 3.40 (m, 1H), 3.24 – 3.13 (m, 1H), 2.72 – 2.66 (m, 2H), 2.41 (s, 3H), 2.41 – 2.33 (m, 1H), 2.01 – 1.98 (m, 1H).

According to the analysis of related databases, 591-55-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (319 pag.)WO2017/35351; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

591-55-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 591-55-9, name is 5-Aminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 5-aminopyrimidine (CAS No. 591-55-9) (2.00 g, 21.0 mmol, 1 equivalent), triethylamine (14.7 mL, 105 mmol, 5 equivalents), EDC (7.26 g, 37.9 mmol, 1.8 equivalents), N,N-dimethyl-4-aminopyridine (0.257 g, 2.10 mmol, 0.1 equivalents) and DCM (60.0 mL) was added dropwise 3-(t-butoxy)-3-oxopropionic acid (CAS No. 40052-13-9) (4.86 mL, 31.5 mmol, 1.5 equivalents), and the mixture was stirred at room temperature for 3 days. To the reaction mixture were added water and ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution. The organic layer was dried over magnesium sulfate, filtered, and then concentrated under reduced pressure. The residue was purified with silica gel column chromatography (silica gel, 25%-71% ethyl acetate/n-heptane) to afford the title compound (4.73 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 1.52 (s, 9H), 3.44 (s, 2H), 8.98 (s, 1H), 9.03 (s, 2H), 9.77 (br. s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 591-55-9, 5-Aminopyrimidine.

Reference:
Patent; Eisai R&D Management Co., Ltd.; Kurokawa, Toshiki; Yoshida, Yu; Shin, Kogyoku; Kobayashi, Yoshihisa; Fukumoto, Hironori; Takeda, Kunitoshi; Ohashi, Yoshiaki; Kotake, Makoto; Shibuguchi, Tomoyuki; Watanabe, Toru; Kita, Yoichi; Hirota, Shinsuke; Fukuyama, Takashi; Kamada, Yasuaki; (59 pag.)US2017/137436; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

591-55-9 , The common heterocyclic compound, 591-55-9, name is 5-Aminopyrimidine, molecular formula is C4H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (2,6-dimethylpyridin-4-yl)(4-(l-(/ra5-4-hydroxycyclohexyl)-6- (methylsulfonyl)-liT-pyrazolo[3,4-d]pyrimidin-3-yl)-5,6-dihydropyridin-l(2H)-yl)methanone (100 mg, 0.20 mmol) in THF (10 mL) was added a 1.0 M solution of lithium bis(trimethylsilyl)amide (LiHMDS) in THF (0.78 mL, 4.0 equiv.) at -70 C followed by slow addition of pyrimidin-5-amine (37 mg, 0.39 mmol). The reaction mixture was stirred at -70 C. After complete conversion, the reaction mixture was quenched with water (10 mL), extracted with EtOAc (3 x 10 mL), dried (Na2S04), and concentrated. The residue was purified by column chromatography with ethyl acetate/hexane and methanol/water to provide (2,6- dimethylpyridin-4-yl)(4-(l-(/ra5-4-hydroxycyclohexyl)-6-(pyrimidin-5-ylamino)-liT- pyrazolo[3,4-i/]pyrimidin-3-yl)-5,6-dihydropyridin-l(2i7)-yl)methanone (13 mg, 12%) as a pale solid.

According to the analysis of related databases, 591-55-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; FRYE, Stephen; (113 pag.)WO2019/222509; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 591-55-9, name is 5-Aminopyrimidine. A new synthetic method of this compound is introduced below., 591-55-9

General procedure: Ethyl 2-[(2-fluorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate. Diethyl malonate (1.0 mL, 6.6 mmol) was addeddropwise to a solution of sodium hydride (60% w/w in oil, 317 mg,7.9 mmol) in anhydrous tetrahydrofuran (12 mL) that was cooledwith ice bath. The mixture was heated at reflux for 6 min. Aftercooling with ice bath, the reaction mixture was treated dropwisewith chloroacetyl chloride (0.58 mL, 7.2 mmol) and stirred in the icebath for 1 h, and then stirred at 45 C for 1 h. The reaction mixturewas cooled in the ice bath again, and then 2-fluoroaniline (0.76 mL,7.9 mmol) was added dropwise. After stirring at ambient temperaturefor 17 h, the reaction mixture was heated at reflux for 2.5 h.The reaction mixture was allowed to cool to ambient temperature,diluted with aqueous saturated sodium bicarbonate solution, andextracted with ethyl acetate twice and with chloroform. Theorganic layerwaswashed with brine, dried over sodium sulfate andconcentrated. The residue was triturated with ethanol-hexane toafford the title compound as a pale yellow solid (0.58 g, 33%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,591-55-9, 5-Aminopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Irie, Takayuki; Asami, Tokiko; Sawa, Ayako; Uno, Yuko; Hanada, Mitsuharu; Taniyama, Chika; Funakoshi, Yoko; Masai, Hisao; Sawa, Masaaki; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 406 – 418;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 591-55-9, name is 5-Aminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 591-55-9

Example 52: (R)-3-(l-Phenyl-cycloheptanecarbonyIoxy)-l-(pyrimidin-5- ylcarbamoylmethyl)-l-azonia-bicyclo[2.2.2]octane chloridea) 2-ChloiO-/V-pyrimidin-5-yl-acetamide 5-Aminopyrimidine (450 mg) was suspended in DCE (2 mL) and acetonitrile (2 mL) : microwave vial. Chloroacetyl chloride (0.377 mL) was added with stirring. The vial sealed and the reaction mixture was heated in the microwave at 800C for 5 minutes. T solid was filtered off, washed with acetonitrile (2 x 5 mL), DCE (2 x 5 mL) and penta x 30 mL) and then partioned between saturated sodium bicabonate and DCE (50 mL/* mL ) ensuring the aqueous layer was still basic. The organic layer was separated and t aqueous layer was extracted with DCE (2 x 75 mL). The combined organic layer was over magnesium sulfate and evaporated to give the sub-titled compound (200 mg) as i yellow solid.1H NMR (400 MHz, DMSO-D6): delta 10.71 (s, IH), 9.00 (s, 2H), 8.93 (s, IH), 4.35 (s, _

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 591-55-9, 5-Aminopyrimidine.

Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY LIMITED; WO2009/138707; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

591-55-9, A common compound: 591-55-9, name is 5-Aminopyrimidine,molecular formula is C4H5N3, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

REFERENCE EXAMPLE 9 To 10 ml of dimethyl sulfoxide was added 1.40 g (12.5 mmol) of potassium tert-butoxide, and to the solution was added 951 mg (10.0 mmol) of 5-aminopyrimidine while cooling with water. After stirring at room temperature for 1 hour, 0.54 ml (5.0 mmol) of 2-fluorobenzonitrile was added thereto while cooling with water, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into ice-water, and the mixture was adjusted to pH 7.0 with 1 N hydrochloric acid, and filtered. The filter residue was dissolved in 200 ml of acetone, and the acetone solution was filtered. The filtrate was dried over magnesium sulfate, and the solvent was removed by distillation under reduced pressure to obtain 0.53 g (2.70 mmol) of 5-[N-(2cyanophenyl)amino]pyrimidine. Mass Spectrum (m/z): 196 (M+) NMR Spectrum (DMSO-d6, TMS internal standard) delta: 7.12 (1 H, t, J=7 Hz), 7.35 (1 H, d, J=8 Hz), 7.57-7.60 (1 H, m), 7.76 (1 H, dd, J=8 Hz, 1 Hz), 8.61 (2 H, s), 8.78 (1 H, s), 8.84 (1 H, s)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 591-55-9.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5538976; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-12-6, name is Pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. 109-12-6

The 2-aminopyrimidine (2.5g, 26.29mmol) was dissolved in acetonitrile (25mL) was added N- bromosuccinimide (4.6g, 27.9mmol) under ice-cooling, stirred in the dark overnight at room temperature. Recovery of the solvent under reduced pressure, washed with water (100 mL) was washed, filtered off with suction, and dried in vacuo to give a white solid. Yield: 97%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-12-6, Pyrimidin-2-amine.

Reference:
Patent; Zhejiang University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Liu, Tao; Li, Jia; Hu, Yongzhou; Gao, Anhui; Dong, Xiaowu; Zhou, Yubo; Song, Pinrao; Tong, Lexian; (59 pag.)CN106588884; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

109-12-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-12-6, name is Pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

A 5 L three-necked round bottom flask was charged with 2-aminopyrimidine (285.30 g, 3 mol), N-bromosuccinimide (1.17 kg, 6.6 mol), acetonitrile 2 L and methanol 1 L. The mixture in the reaction flask was stirred at 70 C for 6 hours. TLC and HPLC confirmed the reaction was complete. After the reaction was completed, the solvent was removed by rotary evaporation to give the crude product. The crude product was concentrated by evaporation and recrystallized to give the pure product 2-amino-5-bromopyrimidine. After drying, the yield was 90.48% and the purity was 99.05% (HPLC).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-12-6, Pyrimidin-2-amine.

Reference:
Patent; Shandong Youbang Biochemical Technology Co., Ltd.; Geng Xuanping; Zhang Xianglong; Cheng Wei; Lai Xinsheng; Lai Chao; Lai Ziteng; (4 pag.)CN106632079; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia