Tag: M.W=0-100

Quality Control of 5-Methylfuran-2(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Synthesis of Chiral γ,γ-Disubstituted γ-Butenolides via Direct Vinylogous Aldol Reaction of Substituted Furanone Derivatives with Aldehydes. Author is Sakai, Takaaki; Hirashima, Shin-ichi; Matsushima, Yasuyuki; Nakano, Tatsuki; Ishii, Daiki; Yamashita, Yoshifumi; Nakashima, Kosuke; Koseki, Yuji; Miura, Tsuyoshi.

In the presence of a quinine-derived squaramide-sulfonamide, aldehydes RCHO (R = 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-F3CC6H4, Ph, 4-MeC6H4, 4-MeOC6H4, 1-naphthyl, 2-naphthyl, 2-furanyl, cyclohexyl, BuCH2) underwent regioselective, diastereoselective, and enantioselective vinylogous aldol addition reactions with γ-substituted β,γ-butenolides such as γ-angelica lactone to yield anti-(hydroxymethyl)butenolides such as I (R = 4-ClC6H4, 3-ClC6H4, 2-ClC6H4, 4-BrC6H4, 4-F3CC6H4, Ph, 4-MeC6H4, 4-MeOC6H4, 1-naphthyl, 2-naphthyl, 2-furanyl, cyclohexyl, BuCH2) in up to 95% ee.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Formula: C5H6O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Access to chiral γ-butenolides via palladium-catalyzed asymmetric allylic C-H alkylation of 1,4-dienes.

Allylic C-H alkylation of 1,4-pentadienes with α-angelica lactones has been developed by tri-axial phosphoramidite-palladium catalysis. This reaction can tolerate a range of functional groups under mild conditions, furnishing versatile chiral γ,γ-disubstituted butenolides I (R = Me, i-Pr, Cy, etc.; Ar = C6H5, 4-MeC6H4, 4-FC6H4, etc.) in high yields with good to high levels of stereoselectivity.

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Pyrimidine | C4H4N2 – PubChem,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Deng, Ting; Tuo, Suxing; Yang, Huawu; Du, Wen; Chen, Bo; Yin, Xinqiang; Huang, Ping; Deng, Changjian; Gong, Shuguo; Lu, Hongmei; Tan, Xinliang; Zhong, Kejun researched the compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ).Recommanded Product: 591-12-8.They published the article 《Online analysis of aerosol components of heated tobacco products by GC-MS》 about this compound( cas:591-12-8 ) in Yancao Keji. Keywords: aerosol heated tobacco product GC MS. We’ll tell you more about this compound (cas:591-12-8).

In order to study the chem. composition of aerosols from heated tobacco products (HTPs) and to investigate the puff-by-puff release characteristics of aerosols from HTP samples, an online sampling device for HTP aerosols was developed by adopting a valve injection technique. Using this technique, HTP aerosols were directly introduced into gas chromatog.-mass spectrometry (GC-MS) by carrier gas (helium) through an inline heating transmission line without sample loss. The results showed that the online HTP aerosol anal. system had a stable performance and good reproducibility. The contents of acetone and 2-butanone determined in the aerosols of sample A by this method was in good accordance with the results reported by literature. With the proceeding of puffing, the releases of acetone and 2-butanone from the aerosols of sample B increased first and then decreased. This method is simple, efficient and suitable for the online anal. of the whole aerosols of HTPs and the puff-by-puff release characteristics of HTP aerosols.

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Pyrimidine | C4H4N2 – PubChem,
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Formula: C5H6O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Characterization of key aroma-active compounds in four commercial oyster sauce by SGC/GC x GC-O-MS, AEDA, and OAV. Author is Yu, Mingguang; Li, Ting; Song, Huanlu.

Oyster sauce (OS) is a common seasoning in Asian countries. Here, four types of OS with different components and ingredients were characterized by the switchable GC/GC x GC-olfactometry-mass spectrometry (SGC/GC x GC-O-MS) and sensory evaluation. A total of 27 key aroma-active compounds were screened by FD factor and OAVs in OS. Of them, pyrazines were predominated, 2,5-dimethyl-3-ethylpyrazine had the highest OAV and FD factor. Sensory evaluation showed that the overall flavor profile of OS is primarily composed of nutty/roast, caramel/sweet, cooked potato-like, fruity, burnt, and unpleasant notes such as rancid, mushroom-like, and fishy. Moreover, soy sauce exhibited a great impact on OS aroma. The principal component anal. (PCA) results based on the OAV values of key aroma-active compounds were consistent with the sensory evaluation results, suggesting that PCA based on the above method could accurately cluster and distinguish the samples with different aroma profiles. The odor notes of burnt, fruity and caramel-like/sweet contributed to WDM and JC clustering. Similarly, roast/nutty, cooked potato-like, and unpleasant odor notes contributed to clustering of LKK and HT.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 591-12-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Ozonolysis of α-angelica lactone: a renewable route to malonates. Author is DellAcqua, Andrea; Wille, Lukas; Stadler, Bernhard M.; Tin, Sergey; de Vries, Johannes G..

Industrially relevant intermediates such as malonic acid, malonates and 3-oxopropionates waseasily accessed by ozonolysis of α-angelica lactone, derived from the platform chem. levulinic acid. The roles of the solvent and of the quenching conditions were of key importance for the outcome of the reaction.

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Pyrimidine | C4H4N2 – PubChem,
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Related Products of 591-12-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about PON1 increases cellular DNA damage by lactone substrates. Author is Shangula, S.; Noori, M.; Ahmad, I.; Margison, G. P.; Liu, Y.; Siahmansur, T.; Soran, H.; Povey, A. C..

Paraoxonase 1 (PON1) is a high-d. lipoprotein (HDL)-associated enzyme that by hydrolyzing exogenous and endogenous substrates can provide protection against substrate induced toxicity. To investigate the extent to which PON1 provides protection against lactone induced DNA damage, DNA damage was measured in HepG2 cells using the neutral Comet assay following lactone treatment in the presence and absence of exogenous recombinant PON1 (rPON1). Low dose lactones (10 mM) caused little or no damage while high doses (100 mM) induced DNA damage in the following order of potency: α-angelica lactone > γ-butyrolactone > γ-hexalactone > γ-heptalactone > γ-octaclactone >γ-furanone > γ-valerolactone > γ-decalactone. Co-incubation of 100 mM lactone with rPON1, resulted in almost all cells showing extensive DNA damage, particularly with those lactones that decreased rPON1 activity by > 25%. DNA damage induced by a 1 h co-treatment with 10 mM α-angelica lactone and rPON1 was reduced when cells when incubated for a further 4 h in fresh medium suggesting break formation was due to induced DNA damage rather than apoptosis. These results suggest that in addition to its well-recognized detoxification effects, PON1 can increase genotoxicity potentially by hydrolyzing certain lactones to reactive intermediates that increase DNA damage via the formation of DNA adducts.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about The β-carotene-oxygen copolymer: Its relationship to apocarotenoids and β-carotene function, the main research direction is beta carotene oxygen copolymer preparation chem breakdown apocarotenoid preparation.Reference of 5-Methylfuran-2(3H)-one.

β-Carotene spontaneously copolymerizes with mol. oxygen to form a β-carotene-oxygen copolymer compound (“”copolymer””) as the main product, together with small amounts of many apocarotenoids. Both the addition and scission products are interpreted as being formed during progression through successive free radical β-carotene-oxygen adduct intermediates. The product mixture from full oxidation of β-carotene, lacking both vitamin A and β-carotene, has immunol. activities, some of which are derived from the copolymer. However, the copolymer’s chem. makeup is unknown. A chem. breakdown study shows the compound to be moderately stable but nevertheless the latent source of many small apocarotenoids. GC-MS anal. with mass-spectral library matching identified a min. of 45 structures, while more than 90 others remain unassigned. Newly identified products include various small keto carboxylic acids and dicarboxylic acids, several of which are central metabolic intermediates. Also present are glyoxal and Me glyoxal dialdehydes, recently reported as β-carotene metabolites in plants. Although both compounds at higher concentrations are known to be toxic, at low concentration, Me glyoxal has been reported to be potentially capable of activating an immune response against microbial infection. In plants, advantage is taken of the electrophilic reactivity of specific apocarotenoids derived from β-carotene oxidation to activate protective defenses. Given that the copolymer occurs naturally and is a major product of non-enzymic β-carotene oxidation in stored plants, by partially sequestering apocarotenoid metabolites, the copolymer may serve to limit potential toxicity and maintain low cellular apocarotenoid concentrations for signaling purposes. In animals, the copolymer may serve as a systemic source of apocarotenoids.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Category: pyrimidines. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Inverse-Electron-Demand Palladium-Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S-Ligand and Hydrogen Bonding.

Catalytic asym. cycloadditions of ambident Pd-containing dipolar species with nucleophilic dipolarophiles, namely, inverse-electron-demand cycloadditions, are challenging and underdeveloped. Possibly, the inherent linear selectivity of Pd-catalyzed intermol. allylations and the lack of efficient chiral ligands are responsible for this limitation. Herein, two cycloadditions of such intermediates with deconjugated butenolides and azlactones were accomplished by using a novel chiral hybrid P,S-ligand and hydrogen bonding [e.g., vinyl carbamate I + butenolide II → dihydroquinol-2-one III (92%, 93% ee, >95:5 d.r.)]. By doing so, highly functionalized, optically active dihydroquinol-2-ones were produced with generally high reaction efficiencies and selectivities. Preliminary DFT calculations were performed to explain the high enantio- and diastereoselectivities.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Cigar leaf differences from different producing areas based on aroma component analysis, the main research direction is cigar leaf aroma component.HPLC of Formula: 591-12-8.

In order to investigate the leaf aroma chem. differences for cigar samples from different producing areas, 79 aroma components in 47 cigar samples from different countries were determined In addition, the differences in contents and odor activity values of aroma components among Cuban cigars, foreign non-Cuban cigars and Chinese cigars were compared by significance tests. The results showed that there were significant differences in the contents of 43 aroma components among the cigars from different producing areas, and the differences in the contents of α-curcumene and cedrol were the most significant. The contents of degradation products from chlorophyll and cembranoids in Cuban cigars were higher, those of phenylalanines and labdanums in foreign non-Cuban cigars and that of chlorophyll in Chinese cigars were lower. The 79 aroma components had higher odor activity values in fruit and flower flavors. Cuban cigars had higher odor activity values in herbal spices, fruit, flower and other flavors. Foreign non-Cuban cigars had lower odor activity values in plant, fruit, nut, flower and other flavors. The discriminant functions established by taking the contents of aroma components as variables can distinguish the producing areas of com. cigars.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wei, Yunlong; Zhang, Hong; Wu, Xinxin; Zhu, Chen researched the compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ).Reference of 5-Methylfuran-2(3H)-one.They published the article 《Alkene Difunctionalization Triggered by a Stabilized Allenyl Radical: Concomitant Installation of Two Unsaturated C-C Bonds》 about this compound( cas:591-12-8 ) in Angewandte Chemie, International Edition. Keywords: radical alkynylalkenylation enynylalkenylation alkenes dual function sulfone reagent; alkene difunctionalization; alkyne; allenyl radical; radical reactions; rearrangement. We’ll tell you more about this compound (cas:591-12-8).

Radical-mediated difunctionalization of alkenes provides a promising approach to introduce one alkenyl or alkynyl group to target compounds However, simultaneous installation of two unsaturated C-C bonds via alkene difunctionalization remains elusive, attributable to the high instability and transient lifetimes of alkenyl and alkynyl radicals. Herein, we report the photocatalytic 1,2-alkynylalkenylation and 1,2-enynylalkenylation of alkenes for the first time, triggered by the intermol. addition of a stabilized allenyl radical to an alkene. A portfolio of strategically designed, easily accessible dual-function reagents are applied to a radical docking-migration cascade. The protocol has broad substrate scope and efficiently increases the degree of unsaturation

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Pyrimidine | C4H4N2 – PubChem,
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