Tag: 300-400

On July 22, 2015, Wang, Bin; Li, Xuting; Li, Jinliang published a patent.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Composition for treating diarrhea in livestock and poultry and preparation method thereof. And the patent contained the following:

The title composition for treating diarrhea in livestock and poultry comprises norfloxacin lactate, mequindox, trimethoprim lactate, atropine and adjuvant (DMSO, etc.), and can be formulated into granules, tablets, powders, unguents or injections. The invention also provides a preparation method of the composition The inventive composition has quick action, good antimicrobial effect, reduced probability of drug resistance of bacteria, increased antimicrobial sensitivity, simple preparation process, and no drug residue, can prevent infection and secondary infection, and is suitable for treating diarrhea in livestock and poultry. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to veterinary medicine norfloxacin lactate mequindox trimethoprim atropine, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 2, 2014, Liu, Changdou published a patent.Electric Literature of 23256-42-0 The title of the patent was Compound dimetridazole premix for controlling avian enterovirus syndrome. And the patent contained the following:

The invention discloses compound dimetridazole premix for controlling avian enterovirus syndrome, comprising by weight%: dimetridazole 10-30, neomycin sulfate 4-10, decoquinate 2-8, lysozyme 10-30, etamsylate 0.5-5, lactic acid TMP 3-10, and pharmaceutically suitable excipients as balance. The invention adopts new and efficient decoquinate as the anticoccidial drugs, has special effect on intestinal infection dimetridazole and neomycin sulfate, has antibacterial, antiviral, anti-inflammatory pain, intestinal mucosa repair effect of lysozyme, efficient hemostatic drug etamsylate and drug synergistic agent in the compound preparation, and has treatment efficiency on avian enterovirus syndrome. The formula is reasonable, scientific, has simple preparation, wide application, can be used as the preferred drug for prevention and treatment of poultry intestinal toxin syndrome. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Electric Literature of 23256-42-0

The Article related to dimetridazole neomycin sulfate decoquinate avian enterovirus syndrome, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 1, 2007, Wei, Zongsheng; Geng, Qiangbin; Guo, Jianhua published a patent.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Compounded berberine sulfate injection and its preparation method. And the patent contained the following:

The title injection is composed of berberine sulfate 5-30, mequindox 5-35, trimethoprim lactate 1-25 and atropine 0.5-2 weight parts. The method for preparing the injection comprises dissolving berberine sulfate in hot injection water, stirring to obtain solution A, adding mequindox and niacinamide, stirring to obtain solution B, adding trimethoprim lactate and atropine, stirring, adjusting pH to 4-6 with 10% sulfuric acid, adsorbing with 0.1% activated C for 15-20 min and adding injection water to 1000 weight parts. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to antibacterial agent berberine sulfate injection preparation dysentery, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 5, 2014, there was a patent about bacterial infection.Recommanded Product: 23256-42-0 The title of the patent was Compound veterinary drug preparation for treating enteritis type colibacillosis of poultry. And the patent contained the following:

The invention belongs to compound veterinary drug preparation for treating enteritis type colibacillosis of poultry. The preparation comprises the following components: neomycin sulfate, TMP lactate, and glutamine as main components, and adjuvants, wherein neomycin sulfate 3.25 weight%, TMP lactate 0.81 weight%, glutamine 10 weight%, the adjuvant is glucose, the ratio of adjuvant is 85.94 weight%. The veterinary composition is used for treating enteritis type colibacillosis of poultry. The processing technol. of the composition includes grinding and sieving each component, weighing accurately according to the required proportion, mixing for 25 min, inspecting the semi-finished product quality, packaging, and inspecting the finished product quality to obtain the final product. The invention has obvious curative effect on enteritis type colibacillosis, has low drug resistance, safety, and low toxicity, and has very good popularization and application value. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to neomycin sulfate trimethoprim lactate glutamine powder colibacillosis, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 12, 2012, Zhou, Qingfu; Liu, Wenli published a patent.HPLC of Formula: 23256-42-0 The title of the patent was Doxycycline hydrochloride-containing composition for preventing and treating colibacillosis and chronic respiratory disease of poultry and preparation method thereof. And the patent contained the following:

Title composition is composed of doxycycline hydrochloride 10-15, colistin sulfate 10-20, tylosin tartrate 5-15, trimethoprim lactate 5-10, and anhydrous glucose 40-70 weight parts, and is prepared by mixing doxycycline hydrochloride, colistin sulfate and anhydrous glucose 20-30 weight parts for 5-10min, mixing tylosin tartrate, trimethoprim lactate and anhydrous glucose 10-25 weight parts for 5-10min, merging the two mixture, adding residual anhydrous glucose, mixing for 10-15min, and mixing uniformly. The doxycycline hydrochloride-containing composition can be used for preventing and treating colibacillosis and chronic respiratory disease of poultry and has advantages of simple preparation process and good therapeutic effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to doxycycline hydrochloride colibacillosis respiratory disease poultry, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 18, 2018, Zhang, Jiaojiao published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary composition for preventing and treating infectious pleuropneumonia and mycoplasma pneumonia in fowls. And the patent contained the following:

The title veterinary composition comprises (by weight parts) tylosin tartrate 8-10, aminopyrine 10-20, trimethoprim lactate 10-20, thenardite 8-12 and oral glucose 8-12. The inventive veterinary composition has good efficacy, no harm, no residue and convenient use, and can be used for preventing and treating infectious pleuropneumonia and mycoplasma pneumonia in fowls. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to veterinary drug fowl infectious pleuropneumonia mycoplasma pneumonia, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 8, 2013, Liu, Yuanyuan; Hao, Zhihui; Wang, Yanling published a patent.Recommanded Product: 23256-42-0 The title of the patent was Soluble powder for treating toxoplasmosis and its preparation method. And the patent contained the following:

This invention provides a soluble powder for treating toxoplasmosis and its preparation method. The title soluble powder comprises sulfamethazine, lactic acid TMP, lincomycin hydrochloride and anhydrous glucose, can be used for treating toxoplasmosis in animals. The formulation can be used after mixing or mixed with water. The soluble powder has low cost and good effect, and is suitable for industrialized production The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to soluble powder toxoplasmosis sulfamethazine lincomycin trimethoprim, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 15, 2014, Wang, Yuwan; Pan, Zhende; Peng, Xin; Guo, Qiang; Dai, Xiaoxi; Ren, Yanan; Shen, Li published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was A preparation method of tulathromycin emulsifiable injection. And the patent contained the following:

A tulathromycin emulsifiable injection (per litre) comprises tulathromycin 60-200 g, poloxamer 188 30-120 g, an antioxidant 0.3-0.6 g, and an oil medium in balance. A proper amount of hydrogenated castor oil and soybean lecithin can also be added in the injection. It is characterized in that emulsification occurs to the injection when meeting water (or fluid) to form a mixed system of emulsion droplets and oil. The injection has both quick-release and long acting effects, also has a high drug-loading amount, good stability, and good biocompatibility. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to tulathromycin emulsification injection veterinary drug poloxamer, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 13, 2021, Xie, Yanjun; Cao, Haifeng; Zhu, Yuandong; Zhu, Xuefeng; Cao, Yonghui; Liu, Guodong published a patent.Synthetic Route of 23256-42-0 The title of the patent was Preparation method of soluble florfenicol powder. And the patent contained the following:

The invention discloses a preparation method of soluble florfenicol powder. The soluble florfenicol powder is prepared from the following raw materials in parts by mas: 5-15 parts of florfenicol, 2-5 parts of beta-cyclodextrin, 3-7 parts of polyethylene glycol, 2-6 parts of silicon dioxide, 2-5 parts of acidic auxiliary materials and 2-3 parts of bactericidal ingredients. The florfenicol slow-release taste-masking preparation prepared by the process successfully solves the problem of poor palatability of florfenicol, masks the bitter taste of the medicine, increases the palatability, and greatly improves the appetite of animals; and according to the florfenicol slow-release taste-masking preparation, the drug florfenicol is successfully wrapped in the beta-cyclodextrin, so that the drug can be slowly released, the sustained-release effect is achieved, the drug action time is prolonged, the curative effect of the drug is improved, and the bioavailability is improved. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Synthetic Route of 23256-42-0

The Article related to florfenicol powder bioavailability sustained release formulation, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2009, Hu, Shuai; Ouyang, Wuqing; Yang, Xuefeng published an article.Formula: C17H24N4O6 The title of the article was Preparation and quality evaluation of compound tilmicosin nanoemulsion. And the article contained the following:

The aim of this paper was to study the preparation and quality evaluation of compound tilmicosin and trimethoprim lactate nanoemulsion (TMS-TMPL-NE). The formulations of TMS-TMPL-NE were optimized by protracting the pseudoternary phase diagrams, taking iso-Pr myristate (IPM), Tween 80, m(ethanol)/m(propylene glycol, PG) = 3, phosphoric acid, TMS and TMPL to prepare TMS-TMPL-NE. TEM and Particle Sizing System reviewed its shape and particle size distribution and constant temperature accelerated experimentation to verify its stability. TEM presented TMS-TMPL-NE as small spherical drops, evenly distributed, with mean diameter of 12.4 nm and polydispersity index of 0.051. The constant temperature acceleration experimentation showed that it was not delaminated, still clear and lucent. The optimal preparation procedure of TMS-TMPL-NE was simple, and the stability of the prepared nanoemulsion was good. It was expected to be applicable to the veterinarian clinic. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Formula: C17H24N4O6

The Article related to compound tilmicosin nanoemulsion preparation quality evaluation, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia