Tag: 300-400

On May 2, 2012, Guo, Yufan; Wang, Jiawei; Yang, Jing; Zhang, Ning; Zhang, Fengjun published a patent.Computed Properties of 23256-42-0 The title of the patent was Compound oral solution for treating mixed infection caused by Escherichia coli of poultry. And the patent contained the following:

The title oral solution is composed of distilled liquid from Houttuynia cordata 15-25L, amikacin sulfate 0.5-1, gentamycin sulfate 0.5-1, trimethoprim lactate 0.05-0.2, nicotinamide 3-8, dexamethasone sodium phosphate 0.01-0.05, sodium bisulfite 0.1-0.3kg, lactose 0.1-0.5L and water balance. The invented oral solution has good effects of anti-virus and anti-bacteria, and can resolve the continuous fever caused by infection of Escherichia coli. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to compound oral solution infection escherichia poultry, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 30, 1981, Lees, G. M.; Percy, W. H. published an article.COA of Formula: C17H24N4O6 The title of the article was Antibiotic-associated colitis: an in vitro investigation of the effects of antibiotics on intestinal motility. And the article contained the following:

Ampicillin Na [69-52-3] (1-800 μg/mL), doxycycline-HCl [10592-13-9] (1-20 μg/mL), mecillinam-HCl [32887-08-4] (1-800 μg/mL), and metronidazole [443-48-1] (0.5-200 μg/mL) did not affect intestinal motility in vitro in guinea pig ileum and rabbit colon. Clindamycin-HCl (I) [21462-39-5] (0.05-500 μg/mL), gentamicin sulfate (II) [1405-41-0] (5 μg-1 mg/mL), kanamycin sulfate (III) [25389-94-0] (0.025-500 μg/mL), pivmecillinam-HCl (IV) [32887-03-9] (1-20 μg/mL), and trimethoprim lactate (V) [23256-42-0] (5-200 μg/mL) all inhibited evoked and reflex responses of the guinea pig ileum, but only I and V also affected evoked responses of the rabbit colon. II and III appeared to have a predominantly prejunctional action, IV and V a predominantly postjunctional action; I had a prejunctional action at low concentrations and long exposure times, and a postjunctional action at high concentrations and short exposure times. The concentration of each antibiotic required to inhibit the peristaltic reflex of the guinea pig ileum was less than that required to inhibit its responses to elec. stimulation or exogenous acetylcholine or histamine but greater than the serum levels associated with their resp. use in therapeutic doses. A hypothesis is proposed whereby antibiotic-induced alterations in gastrointestinal motility could lead to the development of pseudomembranous colitis. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to antibiotic colitis induction, intestine motility antibiotic, Pharmacodynamics: Effects On Test Systems and Nonmammals and other aspects.COA of Formula: C17H24N4O6

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 30, 1980, Melby, Kjetil; Midtvedt, Tore published an article.Formula: C17H24N4O6 The title of the article was Effects of some antibacterial agents on the phagocytosis of phosphorus-32-labeled Escherichia coli by human polymorphonuclear cells. And the article contained the following:

Gentamicin [1403-66-3], trimethoprim lactate [23256-42-0] cephalothin [153-61-7], colistin [1066-17-7], erythromycin [114-07-8], oxytetracycline [79-57-2], and chloramphenicol [56-75-7] were studied in a phagocytic system. A radiolabeled strain of E. coli was used as test bacterium and human polymorphonuclear cells were used as phagocytes. Except for trimethoprim and cephalothin, there was a tendency towards depression of the process of phagocytosis in the presence of high concentrations of the various antibiotics. Colistin in a high concentration (83 μg/mL) exerted the most significant effect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Formula: C17H24N4O6

The Article related to phagocytosis antibiotic, Pharmacodynamics: Effects On Test Systems and Nonmammals and other aspects.Formula: C17H24N4O6

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Vaz, C. S. L.; Voss-Rech, D.; Pozza, J. S.; Coldebella, A.; Silva, V. S. published an article in 2014, the title of the article was Isolation of Campylobacter from Brazilian broiler flocks using different culturing procedures.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

Conventional culturing methods enable the detection of Campylobacter in broiler flocks. However, laboratory culture of Campylobacter is laborious because of its fastidious behavior and the presence of competing nontarget bacteria. This study evaluated different protocols to isolate Campylobacter from broiler litter, feces, and cloacal and drag swabs. Samples taken from com. Brazilian broiler flocks were directly streaked onto Preston agar (PA), Campy-Line agar (CLA), and modified charcoal cefoperazone deoxycholate agar (mCCDA) and also enriched in blood-free Bolton broth (bfBB) for 24 and 48 h followed by plating onto the different selective media. Higher numbers of Campylobacter-pos. cloacal and drag swab samples were observed using either direct plating or enrichment for 24 h before plating onto PA, compared with enrichment for 48 h (P < 0.05). Furthermore, direct plating was a more sensitive method to detect Campylobacter in broiler litter and feces samples. Anal. of directly plated samples revealed that higher Campylobacter levels were detected in feces streaked onto PA (88.8%), cloacal swabs plated onto mCCDA (72.2%), drag swabs streaked onto CLA or mCCDA (69.4%), and litter samples inoculated onto PA (63.8%). Preston agar was the best agar to isolate Campylobacter from directly plated litter samples (P < 0.05), but there was no difference in the efficacies of PA, mCCDA, and CLA in detecting Campylobacter in other samples. The isolated Campylobacter strains were phenotypically identified as Campylobacter jejuni or Campylobacter coli. The predominant contaminant observed in the Campylobacter cultures was Proteus mirabilis, which was resistant to the majority of antimicrobial agents in selective media. Together, these data showed that direct plating onto PA and onto either CLA or mCCDA as the second selective agar enabled the reliable isolation of thermophilic Campylobacter species from broiler samples. Finally, Campylobacter was detected in all broiler flocks sampled. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to campylobacter broiler litter feces cloacal drag swab brazil, campylobacter coli, campylobacter jejuni, proteus mirabilis, food safety, selective culture, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2011, Xu, Kefu published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Synergistic pharmaceutical composition for treating swine streptococcosis and preparation method thereof. And the patent contained the following:

Title pharmaceutical composition is prepared from (by%) amoxicillin 3-10, sulfadiazine sodium 5-15, trimethoprim (TMP) lactate 1-3, sodium carbonate 5, sodium bicarbonate 5-15, paracetamol 5-15, and anhydrous glucose in balance, by mixing for 1 h. In the composition, amoxicillin and sulfadiazine sodium are anti-pathogen constituents, can improve susceptibility of pathogen and reduce probability of drug resistance, and are effective to secondary bacterial infection; TMP lactate has remarkable synergism for amoxicillin and sulfadiazine sodium; sodium carbonate acts as cosolvent; sodium bicarbonate can reduce side effect of sulfadiazine sodium and prevent generation of crystalluria; and paracetamol has fast antifebrile and antiinflammatory effects. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to synergistic pharmaceutical composition swine streptococcosis veterinary preparation, amoxicillin sulfadiazine sodium trimethoprim lactate paracetamol, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 16, 2011, Xu, Kefu published a patent.Computed Properties of 23256-42-0 The title of the patent was Sulfamonomethoxine sodium and ampicillin sodium-containing medical composition for treating swine infectious atrophic rhinitis and its preparation method. And the patent contained the following:

The title medical composition is prepared from (by weight%) sulfamonomethoxine sodium 5-15, trimethoprim lactate 1-3, ampicillin sodium 3-8, sodium carbonate 5, sodium bicarbonate 5-15 and addnl. anhydrous glucose, and prepared by mixing above raw materials according to the formula. Sulfamonomethoxine sodium and ampicillin sodium as antigen components can effectively kill pathogenic microorganism and reduce drug resistance occurrence, and are effective for secondary infection, trimethoprim lactate has synergistic action on sulfamonomethoxine sodium and ampicillin sodium, sodium carbonate has solubilizing action on sulfamonomethoxine sodium and ampicillin sodium, and sodium bicarbonate alleviates side effect of sulfamonomethoxine sodium and prevents crystalluria occurrence. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to sulfamonomethoxine ampicillin swine infectious atrophic rhinitis, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 2, 2014, Liu, Yuanyuan; Hao, Zhihui; Wang, Yanling published a patent.Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Soluble powder for treatment of chicken coccidiosis and manufacture method thereof. And the patent contained the following:

The present invention provides soluble powder for treatment of chicken coccidiosis and manufacture method thereof. The drug is oral taken, contains sulfamethazine, trimethoprim lactate, lincomycin hydrochloride, and anhydrous glucose, can be used for treating chicken coccidiosis. The formulation can be blended or dissolved in water for applying. The powder soluble has low cost, good effect, suitable for industrial production The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to soluble powder chicken coccidiosis sulfamethazine lincomycin, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Name: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 22, 2015, Zhou, Chang; Li, Shouguo published a patent.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Environmentally friendly antirust paint having coating process without rust surface pretreatment. And the patent contained the following:

The present invention discloses environmentally friendly antirust paint having coating process without rust surface pretreatment. The paint is composed of (by parts) sodium antimonate 0.3-1, tetrahydrofurfuryl alc. 1-2, chromium methionine 0.3-1, glycerol polyoxyethylene ether cocoate 0.5-1, lanolin 2-3, magnesium powder 2-3, ammonium zirconium carbonate 1-2, fluorapatite 3-5, leveling and thickening agent of polyurethane pu-8080 1-2, oleic acid polyoxyethylene ester, 2-3, acrylate-silicone emulsion 70-80, antioxidant 168 0.8-1, anhydrous calcium chloride 1-2, additives 2-3, dimethicone 0.1-0.2, sodium CM-cellulose 1-2 and deionized water 5-10. The additive is composed of chlorinated polyether resin, calcium aluminate powder, zinc borate, propylene glycol Bu ether, trimethoprim lactate, sodium myristate soap, hydroxyethyl cellulose and deionized water. The antirust paint has the advantages of: excellent corrosion resistance, good antirust effect, high safety and low environmental pollution, and convenient use. The added additive can effectively improve the film wear resistance and flame retardancy, and enhance the protective effect to the matrix. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to environmentally friendly antirust paint coating process, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Quality Control of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2015, Gong, Canfeng published a patent.Synthetic Route of 23256-42-0 The title of the patent was Flame-retardant antimicrobial coating. And the patent contained the following:

The title flame-retardant antimicrobial coating is prepared from (by parts) furfuryl alc. resin 6-10, butylhydroxyanisole 15-30, polyhexamethylene guanidine 8-16, zirconite powder 10-25, trimethoprim lactate 8-10, bismaleimide resin 4-10, antimony trioxide 12-20, cobalt blue 0.5-1, chlorothalonil 0.1-0.5, magnesium stearate 5-15, isophorone diisocyanate 1-3, and deionized water 30-100. The invention also provides a preparation method of the flame-retardant antimicrobial coating. The inventive flame-retardant antimicrobial coating has good antimicrobial property and flame retardance. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Synthetic Route of 23256-42-0

The Article related to flame retardant antimicrobial coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Synthetic Route of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 14, 2015, Xia, Mingcai published a patent.COA of Formula: C17H24N4O6 The title of the patent was Hydrophobic wear-resistant coatings and their preparation method. And the patent contained the following:

The coatings contain trimethoprim lactate salt 0.6-1, polyethylene benzenesulfonic acid (sic) 0.5-1, allyl alc. 2-3, anhydrous CaCl2 1-2, polyacrylamide 2-3, MgCl2 2-4, phthalate 3-4, potassium dihydrogen phosphate 1-2, 2-thiobenzimidazole 1-2, triammonium molybdate 1-2, dry carbide slags 4-6, bentonite 10-13, hexamethylcyclotrisiloxane 80-100, Bu methacrylate 60-100, Et methacrylate 50-60, hexyl acrylate 130-200, deionized water 500-600, potassium persulfate 2-4, OP-10 3-4, and binders 3-6 parts. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).COA of Formula: C17H24N4O6

The Article related to hydrophobic wear resistant coating, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.COA of Formula: C17H24N4O6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia