Tag: 300-400

On August 1, 2012, Ouyang, Wuqing; Zhou, Ying; Ouyang, Shenyu published a patent.Electric Literature of 23256-42-0 The title of the patent was Rifaximin and trimethoprim lactate compounded nanoemulsion and its preparation method. And the patent contained the following:

The compounded nanoemulsion is composed of surfactant 30-45, cosurfactant 1-10, oil phase 1-16, rifaximin 0.1-5, trimethoprim lactate 0.025-1.25 wt%, and addnl. deionized water. The surfactant is one or more of EL-40, RH-40, Tween-80, and poloxamer 188. The cosurfactant is one or more of anhydrous ethanol, 1,2-propanediol, glycerol, and polyethylene glycol-400. The oil phase is one or more of iso-Pr myristate, glyceryl triacetate, Et oleate, wheat germ oil, Et acetate, and Bu acetate. The preparation method comprises weighing surfactant, cosurfactant, oil phase, rifaximin, trimethoprim lactate and deionized water according to the formula, mixing surfactant with cosurfactant, then adding oil phase, mixing, adding rifaximin, mixing, adding trimethoprim lactate, mixing, and adding deionized water while stirring. This nanoemulsion is suitable for treatment of acute and chronic intestinal tract infection, diarrhea syndrome, etc., and has the characteristics of rapid and persistent effect, high safety and wide market prospect. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Electric Literature of 23256-42-0

The Article related to rifaximin trimethoprim lactate compounded nanoemulsion acute diarrhea composition, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 9, 2014, Liu, Changdou published a patent.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Compound levofloxacin hydrochloride soluble powder for treating respiratory system disease of poultry. And the patent contained the following:

The title compound levofloxacin hydrochloride soluble powder is prepared by mixing the following components: levofloxacin hydrochloride 2-10%, azithromycin 2-10%, Bufonis Venenum 2-6%, licorice extract 10-30%, Kameiding 3-9%, trimethoprim lactate 1-5%, and the balance of pharmaceutically applicable auxiliary materials (sucrose, anhydrous glucose, oral glucose, and/or starch). The invention adopts the latest market medicine, traditional Chinese medicinal extract, novel antiasthmatic medicine and medicine synergist compound into compound preparation, and has antiinflammatory, antibacterial, antiviral, heart tonifying, cough relieving, anti-allergic, poultry disease resistance and immunity increasing, damaged mucosa repairing, secondary infection controlling, and poultry respiratory system disease treating effects. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to levofloxacin hydrochloride soluble powder respiratory system disease poultry, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 17, 2010, Xu, Kefu published a patent.Computed Properties of 23256-42-0 The title of the patent was Pharmaceutical composition comprising sulfamonomethoxine sodium and olaquindox for treating chicken vibrionic hepatitis and preparation method thereof. And the patent contained the following:

The inventive pharmaceutical composition is prepared from (by weight percentage) sulfamonomethoxine sodium 5-20, olaquindox 2-15, trimethoprim lactate 1-4, glucurolactone 1-10, taurine 2-10 and anhydrous glucose in balance by pulverizing raw materials sep., and mixing for 1 h. The composition is used for treating chicken vibrionic hepatitis. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0

The Article related to veterinary sulfamonomethoxine sodium olaquindox chicken vibrionic hepatitis, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2009, Kim, S. A.; Lee, Y. M.; Hwang, I. G.; Kang, D. H.; Woo, G. J.; Rhee, M. S. published an article.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the article was Eight enrichment broths for the isolation of Campylobacter jejuni from inoculated suspensions and ground pork. And the article contained the following:

Aims: The efficiency of eight enrichment broths for the selective isolation of Campylobacter jejuni was compared to identify an optimal enrichment broth. Methods and Results: Brucella-FBP, Preston, Doyle and Roman, modified CCD (mCCD), Park and Sanders, Bolton, Hunt and Radle and Hunt broths were compared for their recovery of (i) Camp. jejuni in suspension, (ii) Camp. jejuni from inoculated ground pork, (iii) heat-injured Camp. jejuni (55°C for 20 min) in suspension and (iv) heat-injured Camp. jejuni from inoculated ground pork. Hunt broth and Bolton broth showed the highest and most rapid enrichment efficacy for the cell suspensions and ground pork, resp. Preston, Park and Sanders and mCCD broths had relatively high enrichment efficiencies, while Brucella-FBP broth was significantly inferior to the other broths (P < 0.05). Conclusions: Cell recovery from the eight enrichment broths was dependent on the sample type and the state of the cells. The use of the appropriate broth is important for the rapid and efficacious enrichment of Camp. jejuni. In particular, heat-injured Camp. jejuni require a longer cultivation time and a suitable enrichment broth. Significance and Impact of the Study: The results from the present study provide information for selecting the most appropriate enrichment broth for Camp. jejuni and may contribute to improved detection methods for the organism. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to meat pork campylobacter broth food contamination, Food and Feed Chemistry: Contaminants and Toxicants and other aspects.Recommanded Product: 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Alivizatos, A. S. published an article in 1987, the title of the article was Comparison of the antibiotic sensitivity in vitro of Spiroplasma kunkelii and Spiroplasma citri.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate And the article contains the following content:

The susceptibility of S. kunkelii (corn stunt spiroplasma, CSS) and S. citri to 17 antibiotics, was tested in vitro. The helical and nonhelical isolate of S. citri showed similar patterns of susceptibility to most antibiotics. However the helical isolate was more sensitive to trimethoprim (30 μg/mL) and more resistant to rhodomycin (10 μg/mL) and rifamycin (60 μg/mL) than the nonhelical isolate (180-240 μg/mL, 0.1-1 μg/mL, and 10-20 μg/mL resp.). S. kunkelii was more sensitive than S. citri to chlortetracycline-HCl (CSS 1.25 μg/mL, S. citri 10-15 μg/mL) and trimethoprim (CSS 5 μg/mL, S. citri 30 μg/mL for the helical isolate and 180-240 μg/mL for the nonhelical isolate), while its sensitivity to rhodomycin (10 μg/mL) and rifamycin (12.5 μg/mL) was similar to that of the helical and nonhelical isolate of S. citri, resp. The sensitivity of S. kunkelii to the other 13 antibiotics (erythromycin, tetracycline-HCl, chloramphenicol, kanamycin, streptomycin, neomycin, nalidixic acid, trimethoprim lactate, polymyxin-B, nystatin, thallium acetate, cycloheximide, penicillin-G) was similar to that of S. citri. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

The Article related to spiroplasma antibiotic susceptibility, Microbial Biochemistry: Antimicrobial Sensitivity and other aspects.Reference of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 1988, Nadeau, M.; Lariviere, S.; Higgins, R.; Martineau, G. P. published an article.Product Details of 23256-42-0 The title of the article was Minimal inhibitory concentrations of antimicrobial agents against Actinobacillus pleuropneumoniae. And the article contained the following:

Forty-five isolates of Actinobacillus pleuropneumoniae were tested for susceptibility to 12 antimicrobial agents using a microdilution method for the minimal inhibitory concentration (MIC) determinations The results confirmed the high prevalence of A. pleuropneumoniae strains resistant to antibiotics determined earlier using the disk diffusion method (Kirby-Bauer method). While 36% of the isolates were resistant to the penicillins, 47% were resistant to chloramphenicol and 68% were resistant to tetracycline. MICs for the resistant isolates were approx. 32-times higher than those for the susceptible isolates to the above antibacterial agents. The isolates were in general weakly susceptible or resistant to spectinomycin, lincomycin, tiamulin, and spiramycin whereas most of them were susceptible to gentamicin, trimethoprim, and erythromycin. The susceptibility pattern was similar throughout the 1980 to 1984 period. The 14 serotype-5 isolates were more resistant to tetracycline but less resistant to chloramphenicol and the penicillins than the 28 serotype-1 isolates. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Product Details of 23256-42-0

The Article related to antibiotic resistance actinobacillus, Microbial Biochemistry: Antimicrobial Sensitivity and other aspects.Product Details of 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 22, 2008, Baele, Margot; Haesebrouck, Freddy published a patent.HPLC of Formula: 23256-42-0 The title of the patent was In vitro cultivation of Helicobacter species. And the patent contained the following:

The present invention relates to media and methods for the isolation and cultivation of “”Candidatus Helicobacter suis”” and isolates of “”Candidatus Helicobacter suis”” obtainable by these methods. The present invention further relates to the use of these bacteria for the manufacture of antigen preparations and vaccines. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to culture media helicobacter, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kirchmeier, R. L.; Upton, R. P. published an article in 1978, the title of the article was Simultaneous determination of vancomycin, anisomycin, and trimethoprim lactate by high pressure liquid chromatography.Category: pyrimidines And the article contains the following content:

A reverse phase, high pressure liquid chromatog. method for the rapid, accurate, precise, and simultaneous determination of vancomycin [1404-90-6], anisomycin [22862-76-6], and trimethoprim lactate [23256-42-0] was developed, and applied to the determination of these compounds in antibiotic mixtures No chem. methods for the determination of anisomycin have previously been reported. The methods reported in the literature for the determination of vancomycin, and/or trimethoprim lactate are imprecise, nonspecific, or time consuming, and do not allow the simultaneous quant. of anisomycin, vancomycin, and trimethoprim. Precision of the high pressure liquid chromatog. assay was found to be ±1.8%, ±1.1%, and ±2.2% for vancomycin, anisomycin, and trimethoprim lactate, resp. (two standard deviations relative to the average). The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Category: pyrimidines

The Article related to vancomycin anisomycin trimethoprim determination, chromatog anisomycin trimethoprim vancomycin, Pharmaceutical Analysis: Natural Drug Materials and other aspects.Category: pyrimidines

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On April 11, 2012, Xu, Kefu published a patent.HPLC of Formula: 23256-42-0 The title of the patent was Veterinary drug composition for treating enterovirus syndrome of poultry and preparation method thereof. And the patent contained the following:

Veterinary drug composition for treating enterovirus syndrome of poultry and preparation method thereof are provided. The composition is composed of sulfaquinoxaline sodium 5-20, ciprofloxacin hydrochloride 5-15, trimethoprim lactate 1-4, vitamin K3 1-5, NaHCO3 5-20% and addnl. anhydrous glucose. The composition is prepared by pulverizing and sieving the materials resp., mixing according to proportion, then stirring uniformly. Sulfaquinoxaline sodium has strong therapic effect for Eimeria tenella combined with trimethoprim lactate to realize synergism to enhance greatly anti-coccidia ability, ciprofloxacin hydrochloride has strong effect of treating bacterial infection in enterovirus syndrome, so that cause of enterovirus syndrome can be aimingly treated. Vitamin K3 can control the adverse side effect of intestinal tract bleeding caused by enterovirus syndrome, and sodium hydrogen carbonate can reduce the kidney injury to poultry caused by sulfaquinoxaline sodium. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).HPLC of Formula: 23256-42-0

The Article related to poultry enterovirus syndrome veterinary drug preparation, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.HPLC of Formula: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adarve Garcia, E.; Escario, J.; Martinez Fernandez, A. R. published an article in 1982, the title of the article was Antitoxoplasmic effect of Lactotrim, sulfamethoxazole, and robenidine.Recommanded Product: 23256-42-0 And the article contains the following content:

The i.p. ED50 of Lactotrim (I) [23256-42-0] in mice infected with Toxoplasma gondii was 11 mg/kg. I.p. treatment with sulfamethoxazole (II) [723-46-6] (4-128 mg/kg) (alone was ineffective against the infection. Combined treatment with I and II (1:5; by weight) appeared synergistic, the ED50 being 8 mg/kg. robenidine  [25875-51-8] Alone had an i.p. ED50 of 55 mg/kg; its 50% combination with I had an ED50 of 20 mg/kg. A combination of the 3 drugs (50% robenidine and 50% of the 1:5 mixture of I and II) had an ED50 of 18 mg/kg. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Recommanded Product: 23256-42-0

The Article related to antitoxoplasmic lactotrim sulfamethoxazole robenidine, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 23256-42-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia