On July 1, 2009, Wu, Hongyun; Li, Jianzheng; Wang, Xiuhua published a patent.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate The title of the patent was Veterinary composition containing chinese medicines and ceftiofur for treating avian bacterial and/or viral diseases. And the patent contained the following:
The title veterinary drug contains honeysuckle 300-400, Scutellaria baicalensis 300-400, Forsythia suspensa 700-800, ceftiofur 0.5-1.5, synergists 0.5-1, antibacterial factor 20-30, and lytic factor 5-15 weight part. The synergists contain trimethoprim lactate and sulbactam sodium at ratio of 1: (0.5-1). The antibacterial factor is Pirarubicin hydrochloride. The lytic factor is mixture of N-Me pyrrolidone, propanediol, and water for injection at weight ratio of 1:1:1. The preparation method comprises of (1) decocting Scutellaria baicalensis with water three times, combining decoction liquid, filtering, concentrating filtrate, adjusting pH to 1.0-2.0 with 2 mol/L HCl at 75-80°, keeping temperature for 30 min, standing for 10-13 h, filtering, stirring sediment with 6-8 fold water, adjusting pH to 7.0 with NaOH, adding ethanol, dissolving by stirring, filtering, adjusting filtrate pH to 1.5-2 with HCl, keeping at 55-65° for 30 min, standing for 10-13 h, filtering, washing sediment with ethanol, adjusting pH to 7.0, reclaiming ethanol; processing honeysuckle and Forsythia suspensa with same methods, mixing with above Scutellaria baicalensis extract, adding water, adjusting pH to 7.0 with NaOH, stirring, preserving at 4-8° for 72 h, filtering, and adjusting filtrate pH to 7.0 to obtain solution A for further use. The preparation method also comprises (2) mixing antibacterial factor with solution A under stirring at 500 r/min, filling, sterilizing at 100° for 30 min; (3) dissolving synergists with lytic factor, filling, sterilizing at 100° for 30 min; (4) adding ceftiofur, and split charging to obtain. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
The Article related to chinese medicine veterinary drug avian lonicera scutellaria forsythia, antiviral agent antibiotic ceftiofur pirarubicin, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia