Tag: 200-300

Ionic Liquid-Coated Nanoparticles (CaO@SiO₂@BAIL): A Bi-Functional and Environmentally Benign Catalyst for Green Synthesis of Pyridine, Pyrimidine, and Pyrazoline Derivatives was written by Sameri, Fatemeh;Bodaghifard, Mohammad Ali;Mobinikhaledi, Akbar. And the article was included in Polycyclic Aromatic Compounds in 2022.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A novel ionic liquid-coated nanomaterials (CaO@SiO₂@BAIL) was successfully synthesized by anchoring the 1-(3-(trimethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chlorozincate (II) bi-functional ionic liquid (BAIL) onto the surface of silica-coated CaO nanoparticles. The structure of catalyst was characterized using various anal. techniques such as Fourier-transform IR spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), WDS map scan, thermogravimetric (TGA), and inductively-coupled plasma-mass spectrometry (ICP-MS). The performances of prepared hybrid nanomaterial (CaO@SiO₂@BAIL) as a catalyst were evaluated for the efficient synthesis of the pharmaceutically valuable heterocyclic compounds A variety of pyridine, pyrimidine, and pyrazoline derivatives were synthesized in the presence of CaO@SiO₂@BAIL within green conditions. The presented method has several advantages such as high yields, low reaction times, and easy preparation of the catalyst. The bi-functional heterogeneous nanocatalyst can be reused at least six times without considerable loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Antibiotic resistance genes in Chishui River, a tributary of the Yangtze River, China: Occurrence, seasonal variation and its relationships with antibiotics, heavy metals and microbial communities was written by Wu, Tianyu;Zhang, Yuntao;Wang, Bin;Chen, Chao;Cheng, Zhentao;Li, Yancheng;Li, Jiang. And the article was included in Science of the Total Environment in 2022.Application of 1220-83-3 This article mentions the following:

The large-scale use and release of antibiotics may create selective pressure on antibiotic resistance genes (ARGs), causing potential harm to human health. River ecosystems have long been considered repositories of antibiotics and ARGs. Therefore, the distribution characteristics and seasonal variation in antibiotics and ARGs in the surface water of the main stream and tributaries of the Chishui River were studied. The concentrations of antibiotics in the dry season and rainy season were 54.18-425.74 ng/L and 66.57-256.40 ng/L, resp., gradually decreasing along the river direction. The results of antibiotics in the dry season and rainy season showed that livestock and poultry breeding were the main sources in the surface water of the Chishui River basin. Risk assessments indicated high risk levels of OFL in both seasons. In addition, anal. of ARGs and microbial community diversity showed that sul1 and sul3 were the main ARGs in the two seasons. The highest abundance of ARGs was 7.70 x 107 copies/L, and intl1 was significantly pos. correlated with all resistance genes (p< 0.01), indicating that it can significantly promote the transmission of ARGs. Proteobacteria were the dominant microorganisms in surface water, with a higher average abundance in the dry season (60.64%) than in the rainy season (39.53%). Finally, correlation analyses were performed between ARGs and antibiotics, microbial communities and heavy metals. The results showed that there was a significant pos. correlation between ARGs and most microorganisms and heavy metals (p< 0.01), indicating that occurrence and transmission in the environment are influenced by various environmental factors and cross-selection. In conclusion, the persistent residue and transmission of ARGs and their transfer to pathogens are a great threat to human health and deserve further study and attention. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocycles. 41. Preparation of substituted 3,4-dihydro-2(1H)-pyrimidinimines and 2-aminopyrimidines from guanidine and α,β-unsaturated ketones was written by Wendelin, Winfried;Harler, Anton. And the article was included in Monatshefte fuer Chemie in 1975.Related Products of 40230-24-8 This article mentions the following:

HN:C(NH2)2 reacted with RCOCR1:CHR3[R = Me, Ph3R1 = H, Me; R2 = H, Me, Ph, or R1R2 = (CH2)9] to give the unstable dihydropyrimidinimines I, which dehydrogenated to give the corresponding 2-pyrimidinamines II. The unstable I[R = Ph, R1 = H, R2 = Me; R-R2 = Me; R = Me, R1R2 = (CH2)4] were isolated as the corresponding stable 1H-2-pyrimidinium and 1H-2-quinazolinium picrates, whereas I(R = R2 = Ph, R1 = H) was isolated as its hydrochloride. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Evaluating sewer exfiltration in groundwater by pharmaceutical tracers after the 2016 Kumamoto earthquakes, Japan was written by Kobayashi, Jun;Kuroda, Keisuke;Miyamoto, Chinatsu;Uchiyama, Yukiko;Sankoda, Kenshi;Nakajima, Daisuke. And the article was included in Journal of Hazardous Materials in 2021.Computed Properties of C11H12N4O3S This article mentions the following:

In Apr. 2016, a series of earthquakes (M 7.3 on the Japan Meteorol. Agency scale) occurred in Kumamoto, Japan causing serious damage to underground sewerage networks. In this study, we evaluated sewer exfiltration in groundwater in the Kumamoto area after the earthquakes by using multiple tracers. We used 14 pharmaceuticals, including carbamazepine and crotamiton, and anthropogenic Gd as tracers, and we measured concentrations of these tracers from Sept. 2016 to Nov. 2017 seasonally. The detection frequency of caffeine, carbamazepine, crotamiton, ibuprofen, and anthropogenic Gd ranged from 29% to 45%, and the concentrations of the pharmaceuticals in the groundwater were lower than those in previous studies. The median of all pharmaceutical concentrations did not decrease, whereas the median of the sum of crotamiton and carbamazepine concentrations, which are quant. sewage markers, decreased with time. The sewer exfiltration rates in Sept. 2016 estimated using carbamazepine, crotamiton, and anthropogenic Gd were 0.59 ± 0.27%, 0.66 ± 0.47%, and 0.11 ± 0.18% of sewage dry weather flow, resp., indicating that the effect of the earthquakes on sewer exfiltration was small, probably because the damaged sewers were quickly repaired. This study demonstrated that a multiple-tracer approach is useful for evaluating sewer exfiltration after major earthquakes. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Computed Properties of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A nanocomposite adsorbent of metallic copper, polypyrrole, halloysite nanotubes and magnetite nanoparticles for the extraction and enrichment of sulfonamides in milk was written by Jullakan, Sirintorn;Bunkoed, Opas. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2021.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

A composite adsorbent composed of metallic copper (Cu), polypyrrole (PPy), halloysite nanotubes (HNTs) and magnetite nanoparticles (Fe3O4) was developed to extract and enrich sulfonamides by dispersive magnetic solid phase extraction The composite could adsorb sulfonamides via hydrogen bonding and hydrophobic, π-π and π-electron-metal interactions. The extraction conditions were optimized and the developed composite adsorbent was characterized and provided a large surface area that enhanced extraction efficiency for sulfonamides. Coupled with high performance liquid chromatog., the adsorbent was used to quant. determine sulfonamides found in milk samples. The response of the developed method exhibited linearity from 5.0 to 150.0μg kg-1 for sulfathiazole, and from 2.5 to 100.0μg kg-1 for sulfamerazine, sulfamonomethoxine and sulfadimethoxine. Limits of detection were between 2.5 and 5.0μg kg-1. Recoveries of sulfonamides in milk samples ranged from 83.0 to 99.2% with RSDs lower than 6%. The developed composite adsorbent showed good reproducibility and reusability. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

One-pot synthesis and in vitro microbiological evaluation of pyrimidinyl thiazolidinones catalyzed by activated fly ash in dry media was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2010.Recommanded Product: 40230-24-8 This article mentions the following:

Novel bioactive 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones were synthesized with good yields in a short reaction time by 1-pot multicomponent reaction of 2-amino-4,6-diarylpyrimidines, PhCHO, and thioglycolate under microwave irradiation in the presence of an activated fly ash catalyst in dry medium. The characterization of these compounds was performed by m.p., elemental anal., mass spectra, FT-IR, and ¹H and ¹³C NMR. In search for new leads toward potent antimicrobial agents, all the synthesized compounds were tested in vitro for their antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida 6, and Candida 51, and the results were discussed. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones was written by Cui, Xue;Ma, Jianting;Zeng, Tingting;Xu, Junyu;Li, Youbin;Wang, Xuesong. And the article was included in RSC Advances in 2021.Application of 40230-24-8 This article mentions the following:

A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R¹ = cyclopropyl, Ph, 4-MeC₆H₄, etc.; R² = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy was written by Goff, Dane;Zhang, Jing;Heckrodt, Thilo;Yu, Jiaxin;Ding, Pingyu;Singh, Raj;Holland, Sacha;Li, Weiqun;Irving, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Reference of 35265-83-9 This article mentions the following:

Axl tyrosine kinase has been shown to be involved in multiple pathways contributing to tumor development, angiogenesis, and metastasis. High Axl expression has been observed in many human tumors where it appears to confer aggressive tumor behavior. Here we present several series of dual Axl-VEGF-R2 kinase inhibitors based on extensive optimization of an acyl diaminotriazole. It was hypothesized that dual inhibition of these two receptor tyrosine kinases may have a synergistic affect in inhibiting tumor angiogenesis and metastasis. One of these mols., R916562 showed comparable activity to Sunitinib in two mouse tumor xenograft models and a mouse corneal micropocket model. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine (cas: 35265-83-9Reference of 35265-83-9).

2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine (cas: 35265-83-9) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 35265-83-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fate of antibiotics in engineered wastewater systems and receiving water environment: A case study on the coast of Hangzhou Bay, China was written by Bao, Yingyu;Li, Feifei;Chen, Lyujun;Mu, Qinglin;Huang, Bei;Wen, Donghui. And the article was included in Science of the Total Environment in 2021.Synthetic Route of C11H12N4O3S This article mentions the following:

The occurrence of man-made antibiotics in natural environment has aroused attentions from both scientists and publics. However, few studies tracked antibiotics from their production site to the end of disposal environment. Taking the coastal region of Hangzhou Bay as the study area, the fate of 77 antibiotics from 6 categories in two-step wastewater treatment plants (WTPs, i.e. pharmaceutical WTP and integrated WTP) was focused; and the antibiotics in both dissolved and adsorbed phases were investigated simultaneously in this study. The ubiquitous occurrence of antibiotics was observed in the two-step WTPs, with antibiotic concentrations following the order of PWTP (LOQ – 1.0 x 105 ng·L-1) > IWTPi (for industrial wastewater treatment, LOQ – 3.7 x 103 ng·L-1) > IWTPd (for domestic sewage treatment, LOQ – 1.3 x 103 ng·L-1). And the types of antibiotics detected in excess sludge and suspended particles were in accordance with those in wastewater. Quinolones were invariably dominant in both dissolved and adsorbed fractions. High removal efficiencies (median values >50.0%) were acquired for the dissolved quinolones (except for DFX), tetracyclines, β-lactams, and lincosamides. Anaerobic/anoxic/oxic achieved the highest aqueous removal of antibiotics among the investigated treatment technologies in the three WTPs. PWTP and IWTP removed 9797 and 487 g·d-1 of antibiotics, resp.; and a final effluent with 126.4 g·d-1 of antibiotics was discharged into the effluent-receiving area (ERA) of Hangzhou Bay. Source apportionment anal. demonstrated that the effluents of IWTPd and IWTPd contributed resp. 39.3% and 8.9% to the total antibiotics in the ERA. The results illustrate quant. the antibiotic flows from engineered wastewater systems to natural water environment, on the basis of which the improvements of wastewater treatment technologies and discharge management would be put forward. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Oxalic acid catalysed chromium(VI) oxidation of some 2-amino-4,6-diarylpyrimidines was written by Meenakshisundaram, S. P.;Gopalakrishnan, M.;Nagarajan, S.;Sarathi, N.. And the article was included in Catalysis Communications in 2007.SDS of cas: 40230-24-8 This article mentions the following:

Some 2-amino-4,6-diarylpyrimidines (APM), synthesized from chalcones and guanidine hydrochloride in presence of alkali by microwave irradiation in solvent-free conditions, were subjected to oxidation with chromium(VI)-oxalic acid complex (Cr(VI)-Oxa) in highly acidic solutions Oxalic acid (Oxa) offers the reaction a more favorable pathway and in the absence of oxalic acid the reaction is sluggish. The depletion of chromium(VI) shows a complicated kinetics involving a fast reaction to about 35% consumption followed by a slow one. Low dielec. constant of the medium facilitates the reaction. The investigations with 2-amino-6-(4-nitrophenyl)- 4-phenylpyrimidine and 2-amino-6-(4-methoxyphenyl)-4-phenylpyrimidine reveal that, irresp. of the nature of the substituents, the rates are higher than for the parent. APM is catalytically converted to the unusual product 3-hydroxy-1,3-diphenyl-propan-1-one. Consideration of the kinetic behaviors under different exptl. conditions and the product assignment provide valuable mechanistic insight into the system studied. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia