Tag: 200-300

On October 17, 2000, Pamukcu, Rifat; Piazza, Gary A. published a patent.Recommanded Product: 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the patent was Preparation of thienopyrimidines for inhibiting neoplastic cell growth. And the patent contained the following:

Title compounds [I; R = (un)substituted phenyl(alkyl); R1,R2 = H, halo, alkyl, alkoxy, etc.; R1R2 = alkylene; R3 = (un)substituted cycloalkyl, -heterocyclyl, -(hetero)aryl, etc.] were prepared for inhibiting neoplastic cell growth (no data). Thus, 2,4-dichloro-6-methylthieno[2,3-d]pyrimidine was aminated by 3,4-methylenedioxybenzylamine to give I (R = 3,4-methylenedioxybenzyl, R1 = Me, R2 = H)(II; R3 = Cl) which was condensed with Et piperidine-4-carboxylate to give II (R3 = 4-ethoxycarbonylpiperidino). The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Recommanded Product: 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

The Article related to thienopyrimidine preparation neoplastic cell growth inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 4, 2022, Li, Jian; Li, Jiaming; He, Runfa; Liu, Jiasheng; Liu, Yang; Chen, Lu; Huang, Yubing; Li, Yibiao published an article.Related Products of 160377-42-4 The title of the article was Selective Synthesis of Substituted Pyridines and Pyrimidines through Cascade Annulation of Isopropene Derivatives. And the article contained the following:

Diverse substituted pyridines I (R = H, Me; R1 = n-Bu, thiophen-2-yl, 4-chlorophenyl, etc.) and pyrimidines II with high selectivity were obtained using a concise and efficient protocol. The reaction proceeds via metal-free cascade annulation of isopropene derivatives R1C(=CH2)CH2R. Using isopropene derivatives as C3 synthons, NH4I as the “N” source, and formaldehyde or DMSO as the carbon source, this reaction realizes the efficient formation of intermol. C-N and C-C bonds. The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Related Products of 160377-42-4

The Article related to methylpyridine preparation, pyrimidine preparation, isopropene formaldehyde tandem heterocyclization, dimethyl sulfoxide isopropene tandem heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 4, 1985, Boehm, Ralf; Haubold, Gudrun; Pech, Reinhard; Laban, Gunter published a patent.Quality Control of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the patent was Arylamino-substituted thieno[2,3-d]pyrimidines. And the patent contained the following:

Blood platelet aggregation inhibiting (no data) title compounds [I; R1 = R2 = Me; R1R2 = (CH2)4; R3 = R5 = H; R4 = R6 = aryl; R5R6N = saturated, monocyclic heterocydyl] were prepared by aminolysis of 2,4-dichlorothieno[2,3-d]pyrimidines. Thus, 2,4-dichloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine was refluxed 6 h with 2-MeC6H4NH2 in PrOH to give 2-o-toluidino derivative II (R7 = Cl). This was refluxed with morpholine to give II (R7 = morpholino). The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Quality Control of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

The Article related to blood platelet aggregation inhibition thienopyrimidinediamine, thienopyrimidinediamine, benzothienopyrimidinediamine, aminolysis chlorothienopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 14, 1998, Murugesan, Natesan; Barrish, Joel C.; Stein, Philip D. published a patent.Electric Literature of 160377-42-4 The title of the patent was Preparation of substituted biphenyl sulfonamides as endothelin antagonists. And the patent contained the following:

The title compounds [I; X, Y = N, O; R1, R2 = H, alkyl, alkoxy, OH, etc.; R3, R4 = H, alkyl, alkenyl, alkynyl, alkoxy, etc.; R5 = alkyl, alkenyl, alkynyl, etc.; R11-R14 = H, alkyl, alkenyl, alkoxy, etc.; J, K, T, U = N, C; p = 0-2] are prepared I are useful as endothelin antagonists for the treatment of endothelin-related disorders, hypertension, ischemia, atherosclerosis and related diseases (no data). Thus, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4′-(2-pyrimidinyl)-(1,1′-biphenyl)-2-sulfonamide (preparation given) was treated with aqueous HCl to provide 87% the title compound (II). The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Electric Literature of 160377-42-4

The Article related to sulfonamide biphenyl preparation endothelin antagonist, disorder hypertension ischemia atherosclerosis treatment sulfonamide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 160377-42-4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 4, 2021, Xu, Qing; Li, Zhe; Nilar, Shahul published a patent.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine The title of the patent was Preparation of thienopyrimidines as ferroportin inhibitors. And the patent contained the following:

The invention is related to the preparation of compounds I [R1, R2 = independently H, alkyl, halo, 5- or 6-membered heteroaryl; Z = N, CH; R6 = independently at each occurrence halogen, hydroxy, alkoxy, cycloalkyl, etc.; n = 0-3; Y1 = absent or present; Y1, if present, and Y2, and Y3 = independently selected N, CH, and C (when R6 is attached thereto); R3 = H, alkyl, hydroxyalkyl; R4 = CR4cR4dCONR4aR4b, CH2CH2NR4eR4f, CH2CH2OR4g; R4a = H, alkyl; R4b = H, alkyl, cycloalkyl, 5- to 7-membered heterocyclyl, C6-C10 aryl, and 5- to 10-membered heteroaryl; or NR4aR4b = 5- to 7-membered heterocyclyl; R4c i= H, alkyl, cycloalkyl, hydroxyalkyl; R4d = H, alkyl; or CR4cR4d = cycloalkyl or 5- to 7-membered heterocyclyl; R4e = H, alkyl, C5-C10 cycloalkyl, 5- to 7-membered heterocyclyl, and C6-C10 aryl; R4f = H, alkyl; NR4eR4f = 5- to 7-membered heterocyclyl; R4g = H, alkyl, cycloalkyl, 5- to 7-membered heterocyclyl, C6-C10 aryl, and 5- to 10-membered heteroaryl; wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl of R4b, R4c, R4e, and R4g is optionally substituted with 1-2 substituents; with th e exclusion of a specified compound], and pharmaceutical acceptable salts thereof. Pharmaceutical compositions comprising compounds I, and methods of administering compounds I for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries. Thus, II was prepared from 2,4-dichlorothieno[2,3-d]pyrimidine and Et 2-(methylamino)acetate hydrochloride using 4-methoxy-2-(tributylstannyl)pyridine and 5-amino-2-methoxypyridine.. II was tested in an in vitro ferroportin internalization assay (pEC50 = 6.6). The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

The Article related to thienopyrimidine preparation ferroportin inhibitor, preparation thienopyrimidine amino acid amide ferroportin inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Safety of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 11, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.HPLC of Formula: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. [Erratum to document cited in CA141:395506]. And the article contained the following:

Throughout the paper, the incorrect reagent names “phosphorus tribromide” and “phosphorus trichloride” should be replaced by the correct names “phosphoric tribromide” (POBr3) and “phosphoric trichloride” (POCL3). The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).HPLC of Formula: 785777-98-2

The Article related to erratum brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 7, 1999, Pamukcu, Rifat; Piazza, Gary published a patent.Product Details of 42518-42-3 The title of the patent was Inhibition of neoplastic cells by exposure to thienopyrimidines. And the patent contained the following:

A method for inhibiting growth of neoplastic cells comprises administration of title compounds [I; R1, R2 = H, A, OA, alkenyl, alkynyl, NO2, CF3, halo; R3, R4 = H, A, OA, halo, NO2, amino; R3R4 = OCH2CH2, OCH2O, OCH2CH2O; X = substituted 5-7 membered heterocyclyl, isocyclyl; A = H, alkyl; n = 0-3; with provisos]. Thus, 2,4-dichloro-6-methylthieno[2,3-d]pyrimidine, 3,4-methylenedioxybenzylamine, and Et3N were stirred in CH2Cl2 to give 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno[2,3-d]pyrimidine. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Product Details of 42518-42-3

The Article related to thienopyrimidine preparation neoplasm inhibitor, precancerous lesion treatment thienopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 42518-42-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 23, 2013, Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay published a patent.SDS of cas: 42518-42-3 The title of the patent was Thienopyrimidines, furopyrimidines, thienopyridines and furopyridines useful as potassium channel inhibitors and their preparation. And the patent contained the following:

The invention provides compounds of formula I which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula I and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof. Compounds of formula I wherein A is O and S; X, V and Z are independently N and CR4, wherein one of two of V, X and Z are N; R1 is (un)substituted alkyl, (un)substituted cycloalkyl, (un)substituted aryl and (un)substituted heteroaryl; R2 is H, halo, CN, CF3, etc.; R3 is H, halo, CN, CF3, (un)substituted alkyl, etc.; each R4 is independently H, halo, CN, CF3, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by N-alkylation of 2-(1-methylpyrrolidin-2-yl)ethanamine with 4-[4-(bromomethyl)-1-piperidyl]-5-phenyl-thieno[2,3-d]pyrimidine. The invention compounds were evaluated for their potassium channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of less than 500 nM. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).SDS of cas: 42518-42-3

The Article related to thienopyrimidine furopyrimidine thienopyridine furopyridine preparation potassium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 42518-42-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 1981, Yamaguchi, Hitoshi; Ishikawa, Fumiyoshi published an article.Formula: C8H6Cl2N2S The title of the article was Synthesis and reactions of 2-chloro-3,4-dihydrothienopyrimidines and -quinazolines. And the article contained the following:

Reaction of 2,4-dichlorothienopyrimidines and -quinazolines with NaBH4 gave the corresponding 2-chloro-3,4-dihydro derivatives, e.g. I, II, and III (R = Me, R1 = H; R = R1 = Cl). Some nucleophilic substitutions of I afforded 2-substituted derivatives; reaction of III (R = Me, R1 = H; R = R1 = Cl) with BrCH2CO2Et yielded selectively the corresponding 3-substituted compounds, which were converted to imidazoquinazolinones IV. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).Formula: C8H6Cl2N2S

The Article related to thienopyrimidine chloro dihydro reaction, quinazoline chloro dihydro reaction, imidazoquinazolinone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C8H6Cl2N2S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 27, 2004, Ondi, Levente; Lefebvre, Olivier; Schlosser, Manfred published an article.SDS of cas: 785777-98-2 The title of the article was Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates. And the article contained the following:

An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2- or 4-pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl)pyrimidines. The experimental process involved the reaction of 2,5-Dichloro-4-(trifluoromethyl)pyrimidine(cas: 785777-98-2).SDS of cas: 785777-98-2

The Article related to brominated trifluoromethylpyrimidine preparation, pyrimidine trifluoromethyl bromo preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 785777-98-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia