Tag: 200-300

Bardhan, Sujata et al. published their research in Organic Letters in 2009 | CAS: 257280-25-4

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C10H7BrN2O

Heteroaryl ethers by oxidative palladium catalysis of pyridotriazol-1-yloxy pyrimidines with arylboronic acids was written by Bardhan, Sujata;Wacharasindhu, Sumrit;Wan, Zhao-Kui;Mansour, Tarek S.. And the article was included in Organic Letters in 2009.COA of Formula: C10H7BrN2O This article mentions the following:

The oxidative palladium-catalyzed cross-coupling of pyrimidines containing pyridotriazol-1-yloxy (OPt) as either a urea or an amide functional group with arylboronic acids in the presence of Cs2CO3 in DME containing 0.6-1.0% H2O is described for the preparation of heteroaryl ethers. The bromo substitution in the case of 3-(5-bromo-pyrimidin-2-yloxy)-3H-[1,2,3]triazolo[4,5-b]pyridine could serve as a handle for further elaborations such as Suzuki coupling for attaching varied aryl groups. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4COA of Formula: C10H7BrN2O).

5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.COA of Formula: C10H7BrN2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Niu, Yi et al. published their research in Hepatology (Hoboken, NJ, United States) in 2021 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C11H12N4O3S

Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia was written by Niu, Yi;Lin, Ziyou;Wan, Arabella;Sun, Lei;Yan, Shijia;Liang, Heng;Zhan, Siyue;Chen, Dongshi;Bu, Xianzhang;Liu, Peiqing;Chen, Ceshi;He, Weiling;Lu, Xiongbin;Wan, Guohui. And the article was included in Hepatology (Hoboken, NJ, United States) in 2021.Electric Literature of C11H12N4O3S This article mentions the following:

Hypoxia is a common feature of the tumor microenvironment (TME), which promotes tumor progression, metastasis, and therapeutic drug resistance through a myriad of cell activities in tumor and stroma cells. While targeting hypoxic TME is emerging as a promising strategy for treating solid tumors, preclin. development of this approach is lacking in the study of HCC. From a genome-wide CRISPR/CRISPR-associated 9 gene knockout screening, we identified aldolase A (ALDOA), a key enzyme in glycolysis and gluconeogenesis, as an essential driver for HCC cell growth under hypoxia. Knockdown of ALDOA in HCC cells leads to lactate depletion and consequently inhibits tumor growth. Supplementation with lactate partly rescues the inhibitory effects mediated by ALDOA knockdown. Upon hypoxia, ALDOA is induced by hypoxia-inducible factor-1α and fat mass and obesity-associated protein-mediated N6-methyladenosine modification through transcriptional and posttranscriptional regulation, resp. Anal. of The Cancer Genome Atlas shows that elevated levels of ALDOA are significantly correlated with poor prognosis of patients with HCC. In a screen of Food and Drug Administration-approved drugs based on structured hierarchical virtual platforms, we identified the sulfamonomethoxine derivative compound 5 (cpd-5) as a potential inhibitor to target ALDOA, evidenced by the antitumor activity of cpd-5 in preclin. patient-derived xenograft models of HCC. Our work identifies ALDOA as an essential driver for HCC cell growth under hypoxia, and we demonstrate that inhibition of ALDOA in the hypoxic TME is a promising therapeutic strategy for treating HCC. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Electric Literature of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Electric Literature of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Jiachao et al. published their research in Journal of Hazardous Materials in 2022 | CAS: 1220-83-3

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.COA of Formula: C11H12N4O3S

Polycyclic aromatic hydrocarbons (PAHs) and antibiotics in oil-contaminated aquaculture areas: Bioaccumulation, influencing factors, and human health risks was written by Zhang, Jiachao;Zhang, Xuanrui;Hu, Tao;Xu, Xueyan;Zhao, Decun;Wang, Xiaoli;Li, Lei;Yuan, Xianzheng;Song, Chao;Zhao, Shan. And the article was included in Journal of Hazardous Materials in 2022.COA of Formula: C11H12N4O3S This article mentions the following:

Polycyclic aromatic hydrocarbon (PAH) pollution caused by marine oil spills and antibiotic pollution caused by aquaculture industries were common environmental problems in the Yellow River Estuary, China. But few data are reported on the bioaccumulation and influencing factors of these two types of contaminants in aquaculture simultaneously. This study investigated the occurrence and bioaccumulation of PAHs and antibiotics in aquaculture areas of the Yellow River Estuary, and explored the factors affecting the bioaccumulation. 3-ring PAHs and fluoroquinolones were dominant contaminants in the study area. The concentrations of PAHs and antibiotics in lipid-rich tissues (fish viscus, shrimp head, and crab ovary) was higher than that in muscle. It indicated that the lipid content was an important factor affecting the bioaccumulation capacity. Physicochem. parameters (Kow and Dlipw) and the concentrations of PAHs or antibiotics also affected the bioaccumulation capacity of them. Meanwhile, biotransformation was a factor affecting the bioaccumulation of PAHs and antibiotics. The biotransformation (pyrene to 1-hydroxypyrene and enrofloxacin to ciprofloxacin) might explain the poor correlation between log bioaccumulation factor and log Kow/log Dlipw in fish. Risk assessment indicated that PAHs in mature aquatic products posed carcinogenic risks to human and enoxacin in sea cucumbers posed health risks to human. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3COA of Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.COA of Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hirota, Kosaku et al. published their research in Heterocycles in 1998 | CAS: 39513-47-8

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Convenient synthesis of pyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones was written by Hirota, Kosaku;Nakazawa, yukio;Kitade, Yukio;Sajiki, Hironao. And the article was included in Heterocycles in 1998.Quality Control of Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate The following contents are mentioned in the article:

Title compounds such as I (R = H, NH2, OH) were prepared from uracils such as II (R1 = CHO, CN, COOEt). This study involved multiple reactions and reactants, such as Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8Quality Control of Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate).

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fukui, Hideto et al. published their research in Heterocycles in 2002 | CAS: 157327-49-6

5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (cas: 157327-49-6) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride

Synthesis of the bicyclic secondary amines via dimethylaminomethylene ketones from 3-pyrrolidone and 4-piperidone was written by Fukui, Hideto;Inoguchi, Kiyoshi;Nakano, Jun. And the article was included in Heterocycles in 2002.Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride The following contents are mentioned in the article:

The reaction of N-protected 3-pyrrolidone and 4-piperidone with N,N-dimethylformamide di-Me acetal gave the dimethylaminomethylene ketones, which reacted with several types of hydrazines, amidines, and guanidine to afford the secondary amines having fused ring system. This study involved multiple reactions and reactants, such as 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (cas: 157327-49-6Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride).

5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (cas: 157327-49-6) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fukui, Hideto et al. published their research in Heterocycles in 2002 | CAS: 157327-52-1

6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine dihydrochloride (cas: 157327-52-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 157327-52-1

Synthesis of the bicyclic secondary amines via dimethylaminomethylene ketones from 3-pyrrolidone and 4-piperidone was written by Fukui, Hideto;Inoguchi, Kiyoshi;Nakano, Jun. And the article was included in Heterocycles in 2002.SDS of cas: 157327-52-1 The following contents are mentioned in the article:

The reaction of N-protected 3-pyrrolidone and 4-piperidone with N,N-dimethylformamide di-Me acetal gave the dimethylaminomethylene ketones, which reacted with several types of hydrazines, amidines, and guanidine to afford the secondary amines having fused ring system. This study involved multiple reactions and reactants, such as 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine dihydrochloride (cas: 157327-52-1SDS of cas: 157327-52-1).

6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-amine dihydrochloride (cas: 157327-52-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 157327-52-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dyer, Elizabeth et al. published their research in Journal of Heterocyclic Chemistry in 1972 | CAS: 39513-47-8

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 39513-47-8

Preparation of pyrimidine isocyanates was written by Dyer, Elizabeth;Nycz, Thomas J.;Long, Michael B.. And the article was included in Journal of Heterocyclic Chemistry in 1972.Application of 39513-47-8 The following contents are mentioned in the article:

Uracil-5-yl isocyanate and 1,3-dimethyluracil-5-yl isocyanate were prepared from the corresponding new carboazides. 1,3-Dimethyluracil-5-ylmethyl isocyanate obtained from the chloro compound and silver cyanate, was polymerized with an anionic initiator to the cyclic trimer. Attempts to isolate uracil-6-yl isocyanate, 1,3-dimethyluracil-6-yl isocyanate, 4-pyrimidinyl isocyanate, and 2,6-dichloro-4-pyrimidinyl isocyanate were unsuccessful. Ethyl carbamate derivatives were made from all new azides and isocyanates. Other new pyrimidine derivatives included N,N’-bis(4-pyrimidinylcarbonyl)hydrazine, N,N’-bis(1,3-dimethyluracil-5-yl)urea, N,N’-bis(1,3-dimethyluracil-6-yl)urea, and N,N’-bis(2,5,-6,-trichloro-4-pyrimidinyl)oxamide. This study involved multiple reactions and reactants, such as Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8Application of 39513-47-8).

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 39513-47-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Plesiewicz, Ewa et al. published their research in Biophysical Chemistry in 1976 | CAS: 39513-47-8

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.HPLC of Formula: 39513-47-8

Osmometric studies on self-association of pyrimidines in aqueous solutions: evidence for involvement of hydrophobic interactions was written by Plesiewicz, Ewa;Stepien, Elzbieta;Bolewska, Krystyna;Wierzchowski, K. L.. And the article was included in Biophysical Chemistry in 1976.HPLC of Formula: 39513-47-8 The following contents are mentioned in the article:

Vapor pressure osmometric studies were performed on stacking self-association of 25 uracil derivatives variously C- and N-substituted with polar and alkyl groups in aqueous solution at various temperatures The respective equilibrium association constants KSt were computed on the assumption of the isodesmic model of self-association Enthalpies of association for most of the compounds studied were obtained from the temperature-dependence of KSt, according to the van’t Hoff equation. Anal. of the equilibrium and thermodn. parameters in terms of the association mechanism demonstrated the involvement of classical hydrophobic interactions in the stabilization of complexes of di- and higher alkylated uracils. Data for the derivatives substituted with polar groups proved consistent with the predominant involvement of dipole-induced dipole forces in the association This study involved multiple reactions and reactants, such as Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8HPLC of Formula: 39513-47-8).

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.HPLC of Formula: 39513-47-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Whitehead, Calvert W. et al. published their research in Journal of the American Chemical Society in 1952 | CAS: 39513-47-8

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C9H12N2O4

The synthesis of 5-carbethoxyuracils was written by Whitehead, Calvert W.. And the article was included in Journal of the American Chemical Society in 1952.Formula: C9H12N2O4 The following contents are mentioned in the article:

To NaOEt from 2.3 g. Na in 150 cc. EtOH was added 6.0 g. urea, then 21.6 g. EtOCH:CH(CO2Et)2, the mixture let stand 7 days at room temperature, the EtOH removed in vacuo, the residue dissolved in 50 cc. cold H2O, and the solution acidified with dilute HCl to give 6 g. (21.8%) H2NCONHCH: C(CO2Et)2 (I), m. 207-9° (from EtOH). I (23 g.) in 200 cc. absolute EtOH containing 0.1 mol. NaOEt let stand 12 hrs. at room temperature, refluxed 5 hrs., the EtOH removed in vacuo, and the residue in 50 cc. acidified yielded 13 g. (72%) 5-carbethoxyuracil, m. 232° (from EtOH). CO(NHMe)2 (44 g.) and 108 g. I heated 24 hrs. at 120°, and the product recrystallized with charcoal from EtOAc gave 66 g. (62%) 1,3-dimethyl-5-carbethoxyuracil, m. 112° (from EtOH). H2NCONHMe (14.8 g.) and 43.2 g. I gave 16 g. (41%) 3-methyl-5-carbethoxyuracil (II), m. 221° (from EtOH). II (10 g.) and 50 cc. 10% aqueous NaOH heated 2 hrs. on a steam bath, and the mixture acidified with dilute HCl gave 8.5 g. (98%) 3-methyl-5-carboxyuracil (III), m. 242° (from EtOH). III (2 g.) heated 10 min. at 225° yielded 90% 3-methyluracil, m. 174-5° (from EtOH). H2NCONHPr (10.2 g.) and 21.6 g. I heated 12 hrs. at 110° yielded 50% PrNHCONHCH: C(CO2Et)2 (IV), b1 165-70°. IV (14.5 g.) and 2.88 g. NaOMe in 50 cc. MeOH let stand 48 hrs. at room temperature and then heated 6 hrs. at 80° gave 6 g. (56.5%) 3-propyl-5-carbomethoxyuracil, m. 205° (from EtOH). AmNHCONH2 (13.0 g.) and 21.6 g. I heated 24 hrs. at 120°, the resulting sirup added to 200 cc. absolute EtOH containing 0.1 mol. NaOEt, the mixture let stand 24 hrs. at room temperature, the EtOH removed in vacuo, and the residue taken up in 100 cc. H2O and 100 g. ice and acidified with dilute HCl yielded 6.2 g. (24%) 3-amyl-5-carbethoxyuracil, m. 152° (from aqueous EtOH). Similarly were prepared the following compounds (V), where R = H, R’ = Bu (VI), 53%, m. 152°, and R = H, R’ = C6H13, 50%, m. 140°. HOCH2CHEtNHCONH2 (11.6 g.) in 200 cc. absolute EtOH containing 0.1 mol. NaOEt and 21.6 g. I let stand 48 hrs. at room temperature and the mixture worked up as above yielded 21.0 g. (82%) 3-(1-hydroxymethylpropyl)-5-carbethoxyuracil, m. 161° (from EtOAc). Similarly were obtained the following V, where R = H (R’ given): Et, 82%, m. 219°; HO(CH2)2, 79%, m. 175-6°; CH2:CHCH2, 80%, m. 174°; iso-Bu, 62%, m. 167°; cyclohexyl, 49%, m. 282°; p-ClC6H4, 88%, m. 265°; p-MeOC6H4, 90%, m. 185-94°; p-MeC6H4, 97%, m. 235°; PhCH2, 90%, m. 215°; C7H15, 49%, m. 133°; PhCHMe, 77%, m. 130°; Ph(CH2)2, 84%, m. 228°; and C8H17, 48%, m. 130°. PhNHCONH2 (27.2 g.) and 43.2 g. I in 250 cc. absolute EtOH containing 0.2 mol. NaOEt let stand 3 days at room temperature, and the mixture worked up as usual yielded 46 g. (88%) 3-phenyl-5-carbethoxyuracil (VIII), m. 230-1° (from EtOH). VIII (5.2 g.) refluxed 2 hrs. with 100 cc. 5% aqueous NaOH, and the mixture cooled, filtered, and acidified yielded 2.5 g. 3-phenyl-5-carboxyuracil (IX), m. 243° (decomposition). IX (1.0 g.) heated 15 min. at 243° gave 0.6 g. 3-phenyluracil, m. 242-6° (from H2O). VI (20 g.) stirred vigorously at 40° with 3.4 g. NaOH in 150 cc. H2O and 12.9 g. Et2SO4 added dropwise during 1 hr., the mixture stirred another hr., the H2O removed in vacuo, and the residue extracted gave 14.5 g. (65%) 1-ethyl-3-butyl-5-carbethoxyuracil, m. 41-3°. Similarly were prepared from the corresponding monoalkyl derivatives of V the following V (R and R’ given): Me, Et, 76%, m. 116°; Me, iso-Pr, 78%, m. 98°; Me, Bu, < 50%, m. 60°; Me, iso-Bu, 72%, m. 119°; Et, iso-Bu, 65%, m. 90-90.5°; Me, p-ClC6H4, – , m. 141°; and Me, PhCH2, 76%, m. 79°. The above V heated 24-48 hrs. with 10% excess of an amine, the mixture cooled, and the product recrystallized from hot EtOAc gave the following 5-carbamyluracils (X) (R, R’, and Y given): Me, Me, NHMe, 100%, m. 196°; Me, Me, NHEt(XI), 95%, m. 158°; H, Pr, NHCONH2, (50%), m. 234°; H, HO(CH2)2, NHEt, 75%, m. 222° Me, Me, NH(CH2)2OH (XII), 100%, m. 151°; H, HO(CH2)2, NH(CH2)2OH, 60%, m. 185°; Me, Et, NH(CH2)2OH, 57%, m. 179°; Et, Me, NH(CH2)2OH, 70%, m. 123°; Me, Me, NHBu, 100%, m. 125°; Me, Me, NHCH2CHMe2 (XIII), 100%, m. 150.5°; Me, iso-Pr, NH(CH2)2OH (XIV), 93%, m. 114°; Me, Me, N(CH2CH2OH)2 (XV), 45%, m. 122°; Me, Me, NHAm, 100%, m. 115.5°; Me, iso-Bu, NH(CH2)2OH, 49%, m. 142°; Me, Me, NH(CH23N Me2, 86%, m. 89°; H, cyclohexyl, NH(CH2)2OH, 89%, m. 232°; Me, Me, NHC6H13, 79%, m. 121°; Me, Me, NH(CH2)3NEt2, 66%, m. 69.5°; and Me, Me, NHC7H15, 87%, m. 107°. Alk. hydrolysis of the above V with refluxing 5% aqueous NaOH gave the following XVI (R and R’ given): Me, Me (XVII), 90%, m. 183°; H, Et, 70%, m. 179°; H, Pr, 90%, m. 172-3°; Me, Et, 70%, m. 172°; H, iso-Pr, 69%, m. 192°; Me, CH2:CHCH2, 70%, m. 161-2°; H, iso-Bu, 80%, m. 211°; H, HOCH2CHEt, 90%, m. 166°; Me, Bu, 80%, m. 148°; Et, Bu, 95%, m. 107°; Me, Am, 74%, m. 152° H, p-ClC6H4, 98%, m. 255° (decomposition); H, p-MeC6H4, 90%, m. 240° (decomposition); and Me, C6H13, 66%, m. 151°. XII and XVII showed moderate diuresis in dogs with oral doses of 0.5-1 g.; XI, XIII, and XIV with intravenous doses of 5-10 mg.; XII caused marked diuresis with oral doses of 0.5-1 g.; and XII and XV with intravenous doses of 5-10 mg./kg. This study involved multiple reactions and reactants, such as Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8Formula: C9H12N2O4).

Ethyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (cas: 39513-47-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C9H12N2O4

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Vorbrueggen, Helmut et al. published their research in Organic Reactions (Hoboken, NJ, United States) in 2000 | CAS: 56632-83-8

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 56632-83-8

Synthesis of nucleosides was written by Vorbrueggen, Helmut; Ruh-Pohlenz, Carmen. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 2000.Reference of 56632-83-8 The following contents are mentioned in the article:

A review of the article Synthesis of nucleosides. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8