Tag: 200-300

Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in Wuhan, China was written by Chen, Xiangping;Lei, Lei;Liu, Sitian;Han, Jian;Li, Ruiwen;Men, Jun;Li, Lin;Wei, Lin;Sheng, Yaqi;Yang, Lihua;Zhou, Bingsheng;Zhu, Lizhong. And the article was included in Science of the Total Environment in 2021.Related Products of 1220-83-3 This article mentions the following:

The consumption of pharmaceuticals and personal care products (PPCPs) for controlling and preventing the COVID-19 would have sharply increased during the pandemic. To evaluate their post-pandemic environmental impacts, 5 categories of drugs were detected in lakes and WWTP-river-estuary system near hospitals of Jinyintan, Huoshenshan, and Leishenshan in the 3 regions (Regions J, H and L) in Wuhan, China. The total amount of PPCPs (ranging 2.61-1122 ng/L in water and 0.11-164 ng/g dry weight in sediments) were comparable to historical reports in Yangtze River basin, whereas the detection frequency and concentrations of ribavirin and azithromycin were higher than those of historical studies. The distribution of concerned drugs varied with space, season, media, and water types: sampling sites located at WWTPs-river-estuary system around 2 hospitals (Regions L and J) usually had relatively high waterborne contamination levels, most of which declined in autumn; lakes had relatively low waterborne contamination levels in summer but increased in autumn. The potential risks of detected PPCPs were further evaluated using the multiple-level ecol. risk assessment (MLERA): sulfamethoxazole and azithromycin were found to pose potential risks to aquatic organisms according to a semi-probabilistic approach and classified as priority pollutants based on an optimized risk assessment. In general, the COVID-19 pandemic did not cause serious pollution in lakes and WWTPs-river-estuary system in Wuhan City. However, the increased occurrence of certain drugs and their potential ecol. risks need further attention. A strict source control policy and an advanced monitoring and risk warning system for emergency response and long-term risk control of PPCPs is urgent. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Determination of sulfonamide antibiotics in fish and shrimp samples based on magnetic carbon nanotube dummy molecularly imprinted polymer extraction followed by UPLC-MS/MS was written by Gao, Lei;Qin, Dongli;Chen, Zhongxiang;Wu, Song;Tang, Shizhan;Wang, Peng. And the article was included in Electrophoresis in 2021.Reference of 1220-83-3 This article mentions the following:

In this study, a novel purification method using magnetic solid-phase extraction (MSPE) based on magnetic carbon nanotube dummy molecularly imprinted polymer (MCNTMIP) nanocomposite was investigated for separation and enrichment of sulfonamide antibiotics (SAs) in fish and shrimp samples. The MCNTMIP nanocomposite was successfully synthesized by applying carbon nanotubes as supporting template, methacrylic acid as functional monomer, sulfabenzamide as the dummy template for SAs, and ethylene glycol dimethacrylate as crosslinking agent, then was characterized by Fourier-transform IR spectrometry and vibrating sample magnetometry. The adsorption performance of MCNTMIP was evaluated by binding experiments, including static adsorption, kinetic adsorption, and selectivity recognition study. The results confirmed that an imprinted polymer layer was successfully constructed on the surface of the MCNTMIP and this sorbent has advantages of simple magnetic separation, specific mol. recognition, and high adsorption capacity. Combined with ultra-high performance liquid chromatog. tandem mass spectrometry (UPLC-MS/MS), we developed a rapid, sensitive, efficient MSPE method for detecting SAs analytes. Under the optimal conditions, the limits of detection were low to 0.1μg/kg, and the recoveries of SAs analytes were ranged between 90.2 and 99.9%. In addition, the precision values were ranged between 0.5 and 9.1%. This method was successfully applied to analyze SAs in fish and shrimp samples with satisfactory recoveries. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A radical approach for the selective C-H borylation of azines was written by Kim, Ji Hye;Constantin, Timothee;Simonetti, Marco;Llaveria, Josep;Sheikh, Nadeem S.;Leonori, Daniele. And the article was included in Nature (London, United Kingdom) in 2021.Product Details of 40230-24-8 This article mentions the following:

B functional groups are often introduced in place of aromatic C-H bonds to expedite small-mol. diversification through coupling of mol. fragments^1-3. Current approaches based on transition-metal-catalyzed activation of C-H bonds are effective for the borylation of many (hetero)aromatic derivatives^4,5 but show narrow applicability to azines (N-containing aromatic heterocycles), which are key components of many pharmaceutical and agrochem. products⁶. Here the authors report an azine borylation strategy using stable and inexpensive amine-borane⁷ reagents. Photocatalysis converts these low-mol.-weight materials into highly reactive boryl radicals⁸ that undergo efficient addition to azine building blocks. This reactivity provides a mechanistically alternative tactic for sp² C-B bond assembly, where the elementary steps of transition-metal-mediated C-H bond activation and reductive elimination from azine-organometallic intermediates are replaced by a direct, Minisci⁹-style, radical addition The strongly nucleophilic character of the amine-boryl radicals enables predictable and site-selective C-B bond formation by targeting the azine’s most activated position, including the challenging sites adjacent to the basic N atom. This approach enables access to aromatic sites that elude current strategies based on C-H bond activation, and led to borylated materials that would otherwise be difficult to prepare The authors have applied this process to the introduction of amine-borane functionalities to complex and industrially relevant products. The diversification of the borylated azine products by mainstream cross-coupling technologies establishes aromatic amino-boranes as a powerful class of building blocks for chem. synthesis. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Product Details of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Product Details of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine-2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-ones via a rearrangement was written by Varga, Laszlo;Nagy, Tamas;Kovesdi, Istvan;Benet-Buchholz, Jordi;Dorman, Gyorgy;Urge, Laszlo;Darvas, Ferenc. And the article was included in Tetrahedron in 2003.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

The reaction of chalcones R¹COCH:CHR² [R¹, R² = Ph, 2-furyl, 2-thienyl, 4-FC₆H₄; R¹ = Ph, R² = 2-MeOC₆H₄, 4-MeOC₆H₄, 3,4-(MeO)₂C₆H₃; etc.] with guanidine was investigated in the presence of H₂O₂ as an oxidizing agent. Depending on the order of the addition, either 4,6-diarylpyrimidin-2-ylamine I or 2-amino-5,5-disubstituted-3,5-dihydroimidazol-4-one II was obtained. The structures of the imidazolinones II (R¹ = R² = Ph) and III were elucidated by NMR spectroscopy and X-ray crystallog. and a mechanism of its formation was proposed. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Antibiotic resistance genes are enriched with prolonged age of refuse in small and medium-sized landfill systems was written by Chen, Zaiming;Yao, Lihua;Sun, Feng;Zhu, Yisong;Li, Na;Shen, Dongsheng;Wang, Meizhen. And the article was included in Environmental Research in 2021.Recommanded Product: 1220-83-3 This article mentions the following:

Landfills are sites for the disposal of waste over decades. The dynamics of contaminants during landfill treatment influence the functions and environmental risks of the landfill systems, but the patterns of these dynamics are not fully characterized, especially for antibiotic resistant genes (ARGs), an emerging contaminant of global concern. Here, seventeen typical ARG subtypes were quant. investigated in refuse samples from small and medium-sized landfills with ages of <3 years, ~5 years, and 8-10 years. The abundance of ARGs, including tetM, tetX, blaPER, emrB, sul1 and sul2, increased significantly (p < 0.05), approaching 8- to 304-fold on average, from refuse of < 3years to that of 8-10 years, while there was no obvious change (p > 0.05) in abundance for other ARGs, including tetQ, tetW, ampC, blaCTX-M, blaSHV, emrA, mefA, qnrD, qnrS, and mexF. Accordingly, resistance to tetracyclines, macrolides, and sulfonamides increased with landfill age, while resistance to β-lactams and quinolones remained unchanged. The increase in ARG abundance with increasing refuse age was probably related with the increased horizontal gene transfer (HGT) (indicated by the increased abundance of mobile gene elements) and the enhanced co-selective pressure (suggested by the increased contents of heavy metals). These results indicated a potential risk from ARG enrichment with an increase in refuse age in small and medium-sized landfills, which should be managed to ensure landfill safety. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence of antibiotics and antibiotic resistance genes and their correlations in river-type drinking water source, China was written by Liu, Yanhua;Chen, Yu;Feng, Mengjuan;Chen, Jianqiu;Shen, Weitao;Zhang, Shenghu. And the article was included in Environmental Science and Pollution Research in 2021.Synthetic Route of C11H12N4O3S This article mentions the following:

The occurrence and distribution of antibiotics and antibiotic resistance genes (ARGs) in natural water has attracted worldwide attention. Antibiotic and ARG pollution in the surface water of drinking water sources might directly/indirectly affect human health. In this study, the distribution of 38 antibiotics, 10 ARGs, 2 integrons, and 16S r DNA in river-type water sources in a large city of China were monitored in winter, which was a period with high level of antibiotic pollution. The results showed that 20 antibiotics were detected with different detection frequencies. The antibiotic pollution in Dec. 2019 was relatively high, with the total concentrations of antibiotics ranging from 281.95 to 472.42 ng/L, followed by that in Jan. 2020 (191.70-337.29 ng/L) and Nov. 2019 (161.25-309.72 ng/L). Sulfacetamide was dominant in Nov. 2019 (23.52-219.00 ng/L) and in Jan. 2020 (113.18-209 ng/L), while norfloxacin in Dec. 2019 (146.72-290.20 ng/L). All the target antibiotics posed low or medium risk for aquatic organisms, and posed low health risk for mankind. Sul1 and erm36 were the predominant ARGs, and intI1 was the predominant integron in drinking water sources. Only tetA showed pos. correlations with its corresponding antibiotic (tetracycline). The rest of ARGs showed no correlations with antibiotics or pos. / neg. correlations with their non-corresponding antibiotics. Overall, the antibiotics and ARG pollution in these water sources was relatively low. These findings provided some reference data for the distribution of antibiotics and ARGs in river-type drinking water sources of large cities in China. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Synthetic Route of C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Synthetic Route of C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Antibiotics, antibiotic resistance genes and microbial community in grouper mariculture was written by He, Lu-Xi;He, Liang-Ying;Gao, Fang-Zhou;Wu, Dai-Ling;Ye, Pu;Cheng, Yu-Xiao;Chen, Zi-Yin;Hu, Li-Xin;Liu, You-Sheng;Chen, Jun;Ying, Guang-Guo. And the article was included in Science of the Total Environment in 2022.HPLC of Formula: 1220-83-3 This article mentions the following:

Increasing use of feed and medicine in mariculture could cause neg. environmental impacts such as habitat modification, microbial disease development and antibiotic resistance. Here we investigated contamination of antibiotics and antibiotic resistance genes (ARGs), and composition of microbial community in grouper mariculture systems in Hainan province, China. Result showed detection of various antibiotic residues with the dominance of fluoroquinolones and tetracyclines in the six grouper cultivation systems. The concentrations of the detected antibiotics in the grouper mariculture water were significantly higher than those in the original seawater. Some of the detected antibiotics such as enrofloxacin, ciprofloxacin, ofloxacin, oxytetracycline and erythromycin in the mariculture water and/or sediment would pose high resistance selection risks. Sulfonamides resistance genes sul1 and sul2 were found to be predominant in water and sediment, while tetracycline resistance genes were prevalent in fish gill and gut. The dominant bacterial phyla in water and sediments were Bacteroides, Actinomycetes, and Proteobacteria, while the dominant ones in fish gill and gut were the Proteobacteria. Genera of Vibrio and Mycobacterium in the core microbiota were important zoonotic pathogens, and there was a significant pos. correlation between Vibrio and ARGs. Phyla of Proteobacteria, Actinomyces, and Cyanobacteria were pos. correlated to ARGs, indicating that these microorganisms are potential hosts of ARGs. The putative functions of microbiome related to antibiotic resistance and human diseases were significantly higher in fish than in the mariculture environment. This study suggests that mariculture system is a reservoir of ARGs, and the use of antibiotics in mariculture could induce the increase of antibiotic resistance and the prevalence of opportunistic pathogens. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3HPLC of Formula: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Development and validation of a solid phase extraction-UPLC-MS/MS method for the determination of fifty-nine antimicrobials in commercial organic fertilizers and amended soils was written by Zhi, Hui;Cheng, Hefa. And the article was included in Microchemical Journal in 2022.Related Products of 1220-83-3 This article mentions the following:

Com. organic fertilizers often contain high levels of antimicrobials that can be released into agricultural soils and pose potential ecol. risks, and there is a significant need to quantify their occurrence in these products. However, the presence of high contents of organic matter, nutrient salts, and trace metals in com. organic fertilizers pose significant challenges for the extraction and anal. of antimicrobials, especially when multiple compounds are targeted. This study developed a robust and sensitive multi-residue method for the determination of fifty-nine antimicrobials, belonging to four different classes, in com. organic fertilizers and amended soils. The method was based on ultrasonic extraction with a mixture of EDTA-McIlvaine buffer/methanol/acetonitrile/acetone (5:2:2:1 by volume), solid phase extraction (SPE) using SAX and HLB cartridges in series, followed by UPLC-MS/MS anal. in the dynamic multiple reaction monitoring (MRM) mode. The performance of the optimized extraction method was good for fifty-nine antimicrobials with a median recovery rate of 46 and 84% in com. organic fertilizers and amended soils, resp. The matrix effects were between 105 and 109% in com. organic fertilizers and 102-140% in amended soils, which are indicative of the effectiveness of pretreatment procedures and the accuracy of instrumental anal. The method had good linearity (R2 > 0.99), and the detection limits and method quantification limits for fifty-nine antimicrobials in com. organic fertilizers were 0.002-0.206 ng/g (median 0.026 ng/g) and 0.006-0.684 ng/g (median 0.086 ng/g), resp. This robust and practical method effectively eliminates the matrix effects of com. organic fertilizer and could be used for routine determination of multiple classes of antimicrobial residues in com. organic fertilizers and amended soils. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Occurrence and distribution of antibiotics in coastal water of the Taizhou Bay, China: impacts of industrial activities and marine aquaculture was written by Wang, Ning;Shen, Weitao;Zhang, ShengHu;Cheng, Jie;Qi, Dan;Hua, Jing;Kang, Guodong;Qiu, Hui. And the article was included in Environmental Science and Pollution Research.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The occurrence, spatial distribution, and source anal. of antibiotics in global coastal waters and estuaries are not well documented or understood. Therefore, the distribution of 14 antibiotics in inflowing river and bay water of Taizhou Bay, East China Sea, was studied. Thirteen antibiotics, excluding roxithromycin (ROM), were all detected in inflowing river and bay water. The total antibiotic concentrations in bay water ranged from 3126.62 to 26,531.48 ng/L, which were significantly higher than those in the inflowing river (17.20-25,090.25 ng/L). Macrolides (MAs) and sulfonamides (SAs) were dominant in inflowing river (accounting for 24.40% and 74.9% of the total antibiotic concentrations, resp.), while SAs in bay water (93.6% of the total concentrations). Among them, clindamycin (CLI) (concentration range: ND-8414 ng/L, mean 1437.59 ng/L) and sulfadimidine (SMX) (ND-25,184.00 ng/L, mean concentrations: 9107.88 ng/L) were the highest in those surface water samples. Source anal. showed that MAs and SAs in the inflowing river mainly came from the wastewater discharge of the surrounding residents and pharmaceutical companies, while SAs in the bay water mainly came from surrounding industrial activities and mariculture. However, the contribution of the inflowing river to the bay water cannot be ignored. The risk assessment showed that SMX and ofloxacin (OFX) have potential ecol. risks. These data will support the various sectors of the environment in developing management strategies and to prevent antibiotic pollution. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of some novel 1,8-naphthyridine chalcones as antibacterial agents was written by Saleh, Mohanad Y.;Al-Barwari, Alyaa S. M. O.;Ayoob, Alaa I.. And the article was included in Journal of Nanostructures in 2022.Formula: C16H13N3 This article mentions the following:

In this research SiO₂ nanoparticles was applied for synthesis of some new 2-chloro-1,8-naphthyridine-3-carbaaldehyde through Vilsmeier-Haack cyclization of N-(pyridine-2-yl)acetamide has been reported and transformation to new chalcones containing morpholine ring from reaction of 2-morpholine-3-formyl-1,8-naphthyridine and 2-aminoacetophenone to produce E-3-(2-morpholino-1,8-naphthyridine3-yl)-1-(4-aminophenyl) prop-2-en-1-one through Claisen-Schmidt reaction by using (Nano silicon dioxide imidazolidin sulfite Pr silyl trifloroacetate) as catalyst. which on treatment with N-chloroacetyl-4,6- di-Ph pyrimidinyl amine gave compound I [X = N; R = 3,5-(Ph)₂]. E-3-(2-morpholino-1,8-naphthyridine3-yl)-1-(4-aminophenyl)prop-2-en-1-one treated with chloro acetyl arylamine in presence of small amount of carbonate in DMF gave compound I [X = C; R = H] . The structures of the final compounds were confirmed by IR and ¹HNMR. These compounds were evaluated for their antibacterial activity against gram pos. and gram-neg. bacteria using dilution procedure showed activity against the bacteria under study; 1,8-naphthyridine derivatives boost the fluoroquinolone antibiotics efficiency against multi-resistant bacteria and therefore appealing prospects for development of treatments against bacterial infections caused by multidrug-resistant strains. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia