Tag: 200-300

Protonation constants of 2-amino-pyrimidine derivatives was written by Al-Hajjar, F.;Dagga, F. Abu;Hameed, Z.. And the article was included in Annual Research Report – Kuwait Institute for Scientific Research in 1977.Electric Literature of C16H13N3 This article mentions the following:

The basicity constants of I (R = H, 4-Me, 4-Cl, 3-Br, 4-MeO, 4-NO₂, 3-NO₂) and II were correlated linearly with Hammett σ constants I (R = 4-NO₂, 3-NO₂) were most basic; I (R = 4-MeO) was least basic. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

COVID-19 Pandemic Impacts on Humans Taking Antibiotics in China was written by Hu, Yu;Wei, Xianping;Zhu, Qingqing;Li, Lingxiangyu;Liao, Chunyang;Jiang, Guibin. And the article was included in Environmental Science & Technology in 2022.Related Products of 1220-83-3 This article mentions the following:

The outbreak of the novel coronavirus 2019 (COVID-19) pandemic has resulted in the increased human consumption of medicines. Antibiotics are of great concern due to their adverse effects, such as increased bacterial resistance and dysbiosis of gut microbiota. Nevertheless, very little is known about the changes in self-medication with antibiotics during the COVID-19 pandemic and the resultant potential health risks. Herein, we examined the concentration profiles of some commonly used antibiotics in human urine collected from several geog. regions in China between 2020 and 2021. Antibiotics were found in 99.2% of the urine samples at concentrations ranging from not detected (nd) to 357 000 (median: 10.2) ng/mL. During the COVID-19 pandemic, concentrations of urinary antibiotics were remarkably higher than those found either before the pandemic or in the smooth period of the pandemic. Moreover, elevated levels of antibiotics were determined in urine samples from the regions with more confirmed cases. The exposure assessment showed that hazard index values >1 were determined in 35.2% of people. These findings show that human exposure to antibiotics increased during the COVID-19 pandemic, and further research is imperative to identify the public health risks. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Related Products of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simultaneous analysis of 21 sulfonamides, trimethoprim, ormetoprim, and dapsone in fish and shrimp samples by LC-MS/MS using the QuEChERS method was written by Hong, Songhee;Kwon, Namji;Kang, Hui-Seung;Jang, Eunyoung;Kim, Hyojeong;Han, Eunyoung. And the article was included in International Journal of Environmental Analytical Chemistry.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Antibiotics and antibacterials, including sulfonamides, are components of the veterinary armamentarium used to prevent and treat diseases in seafood. However, the accumulation of veterinary drug residues in seafood can cause food safety concerns. This study aimed to verify the quant. anal. method for sulfonamides, trimethoprim, ormetoprim, and dapsone in seafood and to apply it to fish and shrimp distributed in Korean market. In the present study, three types of matrixes (shrimp, flatfish, and eels) were used to detect drugs (n = 25) (sulfonamides (n = 21), trimethoprim, ormetoprim, dapsone, and monoacetyldapsone). Matrixes were extracted with acetonitrile and mixed with 2 g of magnesium sulfate and 1 g of sodium acetate. After agitation, supernatants were mixed with 300 mg of C18 and centrifuged again. Then the supernatant was evaporated, dissolved in 50% methanol, and filtered through a PTFE filter. Extracts (5 μl) were then injected into the liquid chromatog.-tandem mass spectrometry system. The method was validated in terms of limit of detection, limit of quantitation, decision limit, decision capability, matrix effects, intra/inter-day accuracies, precisions, and stabilities and the method was applied to fish and shrimp sold in the Korean market. The validation results were found to be satisfactory. As a result of applying the validated method to fish and shrimp samples purchased from the Korean market, sulfacetamide, sulfadimethoxine, sulfamethoxazole, and sulfanilamide were detected in shrimp samples. The devised method for analyzing antibiotics in seafood samples enables antibiotic detection in fish samples distributed in the global market and should aid the adoption of preventative measures. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Elucidation and evaluation of substituted pyrimidines was written by Umaa, K.;Ramanathan, M.;Krishnakumar, K.;Kannan, K.. And the article was included in Asian Journal of Chemistry in 2009.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

The title compounds I (R¹ = H, Cl, Me, MeO; R² = H, Cl, Me, MeO) were synthesized via condensation of acetophenones R¹C₆H₄C(O)Me with aromatic aldehydes R²C₆H₄CHO followed by cyclocondensation of the intermediate chalcones with guanidine hydrochloride. The compounds I were evaluated for antimicrobial and antimycobacterial activity using Kirby bauer method and Alamar blue assay technique. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Novel and simple analytical method for simultaneous determination of sulfonamide, quinolone, tetracycline, macrolide, and chloramphenicol antibiotics in soil was written by Shi, Xiaomeng;Zhang, Shan;Zhang, Yanwei;Geng, Yue;Wang, Lu;Peng, Yi;He, Zeying. And the article was included in Analytical and Bioanalytical Chemistry in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The multiclass determination of antibiotic residues in the soil is challenging because of its complex physicochem. properties. In this study, a simple anal. method was developed to simultaneously extract and determine 58 antibiotics from the soil. A novel acidity-regulated extraction-partition-concentration protocol was established for the simultaneous extraction of five classes (23 sulfonamides, 18 quinolones, five tetracyclines, eight macrolides, and four chloramphenicols) of antibiotics from the soil. Compared to traditional methods, the sample preparation efficiency was significantly improved by four times (45 min vs. 230 min) by optimizing the extraction method and omitting the time-consuming solid-phase extraction (SPE) procedure. The ultra-high-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method was optimized to determine the 58 antibiotics in a single run by applying pos./neg. switching acquisition mode in less than 10 min with the baseline separation of sulfameter and sulfamethoxypyridazine. Suitable recoveries, ranging between 60 and 120%, were obtained for most antibiotics, with RSD <20%. The limits of quantification (LOQ) of the method were 2μg/kg and 5μg/kg. Thus, this study provides a simple, reliable, and economical method for accurately and rapidly determining a multiclass of antibiotics in the soil. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Syringe purification with UPLC-MS/MS for detection of antibiotics in tea garden soil after long-term application of manure was written by Zheng, Binyu;Song, Ningying;Wu, Huizhen;Tong, Jianying;Sun, Nabo. And the article was included in Analytical Methods in 2022.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

The residue of antibiotics in the soil is becoming more and more common, which may affect the normal growth of plants and organisms. The aim of this study was to investigate the residues of antibiotics in tea gardens’ soil after a long-term application of manure. An ultra-high performance liquid chromatog.-tandem mass spectrometry method was developed to simultaneously determine the residues of 32 antibiotics in the soil of tea gardens after fertilization. The samples were extracted with methanol-acetonitrile and purified with C18 at the same time. Then, mixed dispersive sorbents dispersed in a syringe were used for the second purification The results showed that the antibiotics have a good linear relationship within the range. The recovery rate is 70.1-120.3%. The applicability of the method was demonstrated by analyzing 30 real samples (with a detection rate of 43.3%). The method is a simple and environmentally friendly method for the anal. of multiple antibiotics in soils, and it could provide a basis for the risk assessment of antibiotics in agricultural environments and the standard application of organic fertilizers in tea gardens. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Quality Control of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

An efficient synthesis of 4-chloro-2-pyrrolino[2,3-d]pyrimidin-6-one and its 7-substituted analogues was written by Vaid, Radhe K.;Spitler, Jeremy T.;Boini, Sathish;May, Scott A.;Hoying, Richard C.. And the article was included in Synthesis in 2012.Formula: C7H6Cl2N2O2 This article mentions the following:

An efficient synthesis of I [R = H] was achieved in four steps starting from di-Me malonate in 23% overall yield. This synthesis was demonstrated on 100 g scale to obtain I [R = H] in 98.5% purity. Similarly, I [R = 2,4-(MeO)₂C₆H₃, PhCH(Me)] were synthesized by the reaction of Me 2-(4,6-dichloropyrimidin-5-yl)acetate with an appropriately substituted benzylamine. In the experiment, the researchers used many compounds, for example, Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6Formula: C7H6Cl2N2O2).

Methyl 2-(4,6-dichloropyrimidin-5-yl)acetate (cas: 171096-33-6) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C7H6Cl2N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and characterization of some new 2-amino-4-(4′-substituted)-6-(4”-substituted)diphenyl pyrimidines was written by Hasan, Aurangzeb;Khaleeq, Musfirah;Riaz, Uzma. And the article was included in Asian Journal of Chemistry in 2010.Safety of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Synthesis and characterization of some novel 2-amino-4-(4′-substituted)-6-(4”-substituted)diphenylpyrimidines was carried out by the conversion of variably substituted acetophenones and benzaldehydes into corresponding chalcones followed by cyclization with guanidine hydrochloride in the presence of an oxidizing agent. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Safety of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A general and practical bifunctional cobalt catalytic system for N-heterocycle assembly via acceptorless dehydrogenation was written by Tian, Haitao;Xue, Wenxuan;Wu, Jingtao;Yang, Ziguang;Lu, Hongcheng;Tang, Conghui. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C16H13N3 This article mentions the following:

A novel and highly-efficient N-heterocycle assembly methodol. catalyzed by a cobalt-N,N-bidentate complex had been established. The cobalt complex was unprecedented, phosphine-free and easily-prepared, and was used in the synthesis of pyrimidines such as I [R = NH₂, Ph; Ar¹ = Ph, 2-MeOC₆H₄, 2-naphthyl, etc.; Ar² = Ph, 2-thienyl, 4-MeC₆H₄, etc.], quinolines such as II [R¹ = H, 8-Me; R² = H, Me; R³ = t-Bu, Ph, 2-naphthyl, etc.], imidazoles III [R⁴ = H, Me; R⁵ = H, Me, Cl; R⁶ = H, Me, Cl; R⁵R⁶ = CH=CH-CH=CH; Ar³ = Ph, 2-MeC₆H₄, 3-ClC₆H₄, etc.], quinoxalines such as IV [R⁷ = H, 5-Me, 6,7-di-Me, 6,7-di-Cl] and indole from readily available alcs. and amines via acceptorless dehydrogenation. More importantly, all N-heterocycles were obtained under nearly identical reaction conditions, which further demonstrated the generality and practicability of the catalytic system. Mechanistically, this cobalt complex formed a catalytic active species upon base treatment and was capable of realizing the alc. AD process via metal-ligand cooperation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Electric Literature of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity was written by Kayathi, Narendra Babu;Panga, Siva Sankar;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of the Iranian Chemical Society in 2021.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A library of benzazolyl pyrimidinyl carbamothioates I [X = NH, S, O; R = H, Me, Cl, etc.] were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35 kHz and tested for antimicrobial activity. Compounds I [X = NH, S; R = Cl, O₂N] displayed prominent antibacterial activity against Bacillus subtilis, while compounds I [X = NH, S; R = O₂N] showed excellent antifungal activity against Aspergilus niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia